Adenovirus Vaccine, Live (Oral)

Adenovirus live vaccine is used to prevent febrile acute respiratory disease (ARD), which can be caused by the adenovirus types 4 and 7.

Overview

Adenovirus type 4 and type 7 live vaccine is used to prevent febrile acute respiratory disease (ARD) that is caused by adenovirus type 4 and type 7. The vaccine works by stimulating the body to produce its own protection in the form of antibodies that work to fight against the virus.

This vaccine is generally given to military personnel, aged 17 to 50 years.

Conditions treated

  • Febrile acute respiratory disease

Type of medicine

  • live vaccine
  • tablet form

Side-effects

You should tell your doctor if you have ever suffered from any unusual or allergic reactions to adenovirus vaccine or any other form of medication. You should also inform your doctor if you have any known allergies to any foods, dyes, animals, or preservatives. Be sure to tell your doctor if you are already taking any form of medication, including herbal supplements or vitamins.

In addition to its needed effects, a medicine can sometimes cause unwanted side effects. Many people suffer no side effects at all, but if they do occur, you may require medical attention. If you become unwell or begin to notice any of the following side effects, notify your doctor or nurse straight away.

Some people suffer from generalised aches, pains, and chills within a few hours of taking the vaccine. You may also develop a cough and feel as though you are coming down with the ‘flu'. Other effects can include a fever of over 100.5 degrees F, together with a runny or blocked-up nose, sore throat, sneezing, a loss of voice, headaches, ear congestion, and difficulty breathing. You may also feel tired and weak.

It is not uncommon for people who have received the adenovirus vaccine to develop diarrhea and to feel nauseous. You may also suffer from upper stomach or abdominal pains and vomiting. Some patients complain of muscle pain or stiffness and have difficulty in moving around freely. Joint pain may also be experienced, together with shooting pains through the arms and legs.

Many of these side effects resolve themselves naturally within a few days as your body adjusts to the medication. Your health care professional or nurse will be able to give you some more information and advice on how to reduce some of the side effects or even prevent them altogether.

Not all the side effects that have been experienced by adenovirus vaccine patients have been mentioned above. If you begin to suffer from any other unusual side effects or feel unwell, it is advised that you seek the advice of your doctor or nurse.

Dosage

This vaccine is taken by mouth and it should only be given to you by a nurse or other trained health professional. You must swallow each of the tablets you are given whole, without breaking, chewing or crushing them.

The information that follows outlines only the average recommended doses of adenovirus vaccine. The dosage of this medicine will vary between patients. Always follow your health professional's instructions or the directions on the product label. Do not change the dose that you are prescribed, unless you are told to do so by your doctor. The dose that you are prescribed will also depend on the strength of the medication. The number of daily doses that you are required to take and their frequency will also vary, depending on the medical condition for which you are using the product.

Adenovirus live vaccine is given in enteric coated tablet form and should be used as a preventative measure for febrile acute respiratory disease.

Adults and teenagers from age 17 to age 50 should take two tablets as one single dose. Children under the age of 17 should take this medication as directed by their doctor.

This medication must be given on a fixed schedule. If you forget to take your medicine or miss a dose, contact your doctor or pharmacist for further instructions. Do not double dose. In the event that you or someone you know overdoses on this medication, you should seek medical attention immediately, or call 911 for emergency assistance.

Interactions

Never take other medicines with the adenovirus vaccine unless you have discussed them with your doctor first. This includes any prescription and non-prescription drugs, over-the-counter medication, herbal and vitamin supplements.

Some medicines should not be used together as they may interact to cause or exacerbate side-effects. In other cases, it may be necessary to use two or more drugs together, even though a degree of interaction may occur. In this case, your doctor may decide to change the dose or to take other precautions as necessary.

When your doctor prescribes this vaccine for you, it is extremely important that you let your health care professional know if you are taking any of the following medications. It is not recommended that adenovirus vaccine is used with any of the following. You should note that this list is not all-inclusive.

If you are already taking any of the following medicines, your doctor may recommend changing some of your medication or using a different vaccine.

  • Azathioprine
  • Deflazacort
  • Etanercept
  • Certolizumab Pegol
  • Fingolimod
  • Everolimus
  • Immune Globulin
  • Golimumab
  • Leflunomide
  • Infliximab
  • Mycophenolic Acid
  • Secukinumab
  • Rilonacept
  • Ustekinumab
  • Sirolimus
  • Teriflunomide
  • Trabectedin
  • Abatacept

Some medicines should not be taken at meal times or when eating certain foodstuffs as interactions can sometimes occur. Using tobacco or alcohol with certain medicines can also cause side-effects or harmful interactions to occur. Before you receive your adenovirus live vaccine you should discuss with your healthcare professional the use of this medication with tobacco, alcohol or certain types of food.

Warnings

This vaccine should be administered only by a doctor or other health care professional. When you decide to use a vaccine, you should weigh the risks against the benefits. This is a decision that should be made following close consultation with your doctor.

The presence of other medical conditions may affect the suitability of this vaccine. Be sure to tell your doctor if you have any other medical problems, particularly if you have suffered severe allergic reactions, such as anaphylaxis, when you have been given this vaccine in the past. Tell your doctor if you have problems with swallowing a whole tablet without crushing or chewing it.

If you suffer from vomiting or diarrhea, you should tell your doctor and wait until these conditions have been remedied before receiving the vaccine. This vaccine may not be as effective in patients with a compromised immune system, for example those who are suffering from HIV, cancer, or who are taking cancer or steroid medications.

You must see your doctor regularly for check-ups to make sure that the vaccine is working correctly and to report any unusual side-effects that you have noticed.

There is a possibility that this vaccine could cause problems during pregnancy. You should therefore not take this medication if you are pregnant. You should not plan to get pregnant for at least six weeks following receipt of this vaccine, without checking with your health professional first. If you think that you have become pregnant following taking this vaccine, contact your doctor immediately. You may be instructed by your doctor to join a pregnancy registry for patients who are receiving this vaccine.

You should be aware that this vaccine contains live viruses that are shed in your stools for up to 28 days following receipt of the medication. This means that the disease could spread to other people during this time. Your doctor will recommend ways to help prevent spreading the virus to other people, including washing your hands thoroughly and frequently, especially immediately following a bowel movement.

It is important that you avoid close contact with people who are at a high risk of catching adenovirus for at least 28 days after you have received this vaccine. The most vulnerable people include pregnant women, children under the age of seven, and anyone who has a weakened or compromised immune system that makes them more prone to catching infections.

The adenovirus vaccine contains albumen, which is derived from human blood. Some human blood products contain viruses that have been transmitted to patients who have received them. The risk of contracting a virus from medication that contains human blood derivatives has been greatly reduced over recent years, thanks to the compulsory testing of human blood donors for certain viruses and rigorous testing of these medicines during their manufacture. Although the risk of contracting a virus through the vaccine is very low, you should talk to your doctor if you have any concerns in this regard.

Storage

Always store your medication at room temperature and in a sealed container. Keep the medication away from direct sunlight and direct heat sources. Do not allow the packaging or the contents to get wet. Do not freeze.

Keep the medication well away from pets and children. In the event that a pet eats the vaccine tablets, contact your veterinary surgeon for advice.

If you have medication that is out of date or is no longer required, do not dispose of it by putting it in your trash or flushing it down the toilet. Ask your doctor or hospital physician how you should safely dispose of any unwanted or out-of-date drugs.

Summary

Adenovirus type 4 and type 7 live vaccine is used to prevent febrile acute respiratory disease (ARD) that is caused by adenovirus type 4 and type 7. The vaccine is given in tablet form, usually to service personnel aged from 17 to 50.

It is not uncommon for patients who have received the vaccine to experience temporary side-effects that can be compared to ‘flu-like' symptoms, including a head cold and generalised aches and pains. If you experience these or any other unusual side-effects, contact your doctor or nurse for more advice. In general, any side-effects usually resolve within a few days without the need for medical intervention.

There are a number of medical conditions and drugs that interact adversely with adenovirus vaccine, so be sure to mention any pre-existing medical conditions that you suffer from to your doctor before taking the vaccine, as well as any medication or supplements that you are taking.

Adenovirus live vaccine is a safe and effective preventative treatment. Always discuss any concerns or reservations that you may have with your nurse or doctor before taking the vaccine.