Aminosalicylate Sodium

Aminosalicylate sodium is taken to treat, prevent, control, and improve medical conditions like tuberculosis (TB), ulcerative colitis, and Crohn’s disease.


Aminosalicylate sodium is taken together with other medicines to treat tuberculosis (TB). Active tuberculosis treatment requires taking several medicines together for at least 6 months. Aminosalicylate sodium may be taken as part of that combined drug treatment. Aminosalicylate sodium is also referred to as anti-tuberculosis antibiotic. It works to stop or slow down bacterial growth.

This antibiotic only treats bacterial infections. It won’t treat viral infections, including flu, common cold, etc. Misuse or unnecessary use of any antibiotic may make it less effective.

Don’t take Aminosalicylate sodium if the granules have become purple or dark brown or if the pack is swollen. This may indicate that the medicine hasn’t been stored properly. For storage directions, turn to the storage section.

Take this medicine by mouth, usually twice or thrice every day as instructed by your physician. This medication must be taken together with acidic food to work properly in your body. Simply open the pack and sprinkle the dose onto any acidic food like juice (e.g. tomato, orange, grape, grapefruit, cranberry, punch, and apple juice), applesauce, or yogurt. Don’t mix it in other types of food. If you mix the granules with juice, stir the mixture and drink it immediately. The granules won’t dissolve in the mixture. Don’t chew or crush the granules prior to or while swallowing. Also don’t prepare a dose in advance. If you’ve got questions about how this medication should be taken, talk to your physician or pharmacist.

Aminosalicylate sodium dosing will depend on your response to treatment, age, and medical condition.

For the best outcome, take this medication at evenly spaced intervals. To serve as a reminder, take this medicine at the same time each day.

Continue to take Aminosalicylate sodium until you finish the whole prescribed amount, even if your symptoms fade away after some days. Discontinuing the medicine too early may cause the infection to return.

Talk to your physician if your medical condition doesn’t get better or if it becomes worse.

Conditions treated:

  • Tuberculosis
  • Ulcerative colitis
  • Crohn’s disease

Type of medicine:

  • Salicylate

Side effects:

Along with its vital effects, Aminosalicylate sodium may bring on several unwanted effects. Even though not all of the side effects below may happen, if they happen they may require medical intervention.

Check with your physician as soon as you can if you feel any of these effects while using Aminosalicylate sodium.

More common:

  • Itching or skin rash
  • Fever
  • Joint pains
  • Unusual weakness/tiredness

Less common:

  • Backache
  • Headache
  • Severe abdominal pain
  • Lower back pain
  • Paleness of skin
  • Burning or pain while urinating
  • Sore throat
  • Yellow skin or eyes

Check with your physician immediately if you feel any of these effects after using Aminosalicylate sodium.

Less common with high-dose, long-term therapy:

  • Puffy, dry skin
  • Unusual weight gain
  • Changes in monthly periods (menstrual cycle)
  • Reduced sexual ability in men
  • Swelling of front area of the neck

Some Aminosalicylate sodium side effects can occur that generally don’t require medical care. These side effects might disappear during treatment, with your body adjusting to the drug. Moreover, your physician may show you how to prevent or ease some of the side effects. Make sure to check with your physician if any of these effects persist, trouble you or if you’ve got questions about them.

More common:

  • Loss of appetite
  • Diarrhea
  • Mild stomach pain
  • Nausea and vomiting

Other Aminosalicylate sodium side effects not mentioned above may occur in some people as well. If you feel any other effects, talk to your physician right away.

Get medical advice about Aminosalicylate sodium side effects from your doctor. You may inform the FDA about the side effects at 1-800-FDA-1088.


Each dose of Aminosalicylate sodium is different for different individuals. Follow your physician’s orders or instructions on the label. This information only includes the average Aminosalicylate sodium doses. If you’re prescribed a different dose, don’t alter it unless your physician tells you to.

The amount of drug that you use will depend on the drug’s strength. In addition, the amount of doses you take per day, the time between each dose, and the duration of using the medication depends on the condition for which you’re taking the medication.

For treating tuberculosis, adults and kids aged 12 and over should take 3.3-4 grams of the medication every 8 hours, or 5-6 grams of the medication every 12 hours. The medication must be combined with other medications used for treating TB.

For younger kids, the dose depends on their weight and a doctor is the one to determine that. Depending on the dose size, the medication can be administered every 6-8 hours. This medication must be combined with others used for treating TB.

If you forget to take an Aminosalicylate sodium dose, take it immediately when you remember. But if it’s about time for the next Aminosalicylate sodium dose, forgo your missed dose and return to your normal dosing plan. Don’t take double doses.


The effects of certain medications can change when you take other medications or herbal products together. This can heighten your risk for adverse side effects or may make your medications not work properly. The drug interactions below can occur, but don’t always happen. Your physician or pharmacist can prevent or control interactions by close monitoring or changing your way of taking medications.

To help your pharmacist and physician give you proper medical care, make sure to inform them about all the medical products you’re using, such as herbal products, over-the-counter drugs, and prescription drugs, before commencing treatment with Aminosalicylate sodium. While using this drug, don’t start, change, or stop the dose of other medications you’re taking without your doctor’s permission.

Aminosalicylate sodium may reduce the quantity of substances like vitamin B12 in the body. Your physician may direct you to use a dietary supplement while using this medication. Get the details from your doctor.

This medicine may interfere with some laboratory tests, for example, urine tests for bilirubin/ketones, and albumin, potentially producing false test results. Be sure to tell all your healthcare providers and laboratory personnel that you’re using Aminosalicylate sodium.

Certain drugs shouldn’t be taken when eating meals or eating some foods since interactions might occur. Interactions can also occur when certain medications are taken with alcohol or cigarettes. Discuss the use of Aminosalicylate sodium with your healthcare provider.

This article doesn’t list all potential interactions with Aminosalicylate sodium. List all the products you’re using and share it with your pharmacist or doctor to minimize your risk for severe drug problems.


Before taking Aminosalicylate sodium, let your healthcare giver know about all your medications, over-the-counter products (herbal supplements, vitamins, etc.), pre-existing diseases, allergies, and current health status (for example upcoming surgery, upcoming surgery, etc.). Some medical conditions can make you more prone to Aminosalicylate sodium side effects.

Take the medication as ordered by your physician or follow the instructions on the product’s packaging. Dosage will depend on your condition. Let your physician know if your problem worsens or persists. Important points of counseling are listed below.

  • Impaired hepatic function
  • Gastric ulcer

If your symptoms persist within two or three weeks, or they get worse, consult your doctor.

Don’t use Aminosalicylate sodium within six hours of using rifampin. Using these two medications too short time apart can prevent rifampin from working effectively.

For people with diabetes, this medication can cause false results with certain urine sugar results. Talk to your physician before altering your diet or your dose of diabetes medication.

Use carefully in patients with renal or hepatic dysfunction, patients with CHF, patients with gastric ulcer, and patients with sodium restrictions.

Before using Aminosalicylate sodium, tell your physician/pharmacist your medical history of a particular enzyme problem (G6PD), stomach ulcer, kidney disease, or liver problems.

Aminosalicylate sodium may make live bacterial vaccines like thyroid vaccine not work properly. Don’t take any vaccinations/immunizations while using Aminosalicylate sodium unless your physician tells you.

The presence of certain medical conditions may affect Aminosalicylate sodium use. Be sure to inform your physician if you’ve got any other conditions, especially:

  • Severe kidney disease—patients with this condition may experience more side effects
  • Severe liver disease—patients with this condition may suffer more side effects
  • Stomach ulcer—using Aminosalicylate sodium can cause stomach irritation
  • Heart disease/other circulatory issues—the sodium in this medication may cause or exacerbate heart or circulation issues.
  • G6PD (Glucose-6-phosphate dehydrogenase deficiency)—Aminosalicylate sodium can cause or exacerbate this blood condition.

Aminosalicylate sodium should be used during pregnancy only when there aren’t alternatives and the benefits are more than the risks.

Aminosalicylate sodium is excreted into breast milk. However, the effects of the medicine on nursing babies are unknown.


  • Store the medication at room temperature in a sealed container
  • Keep the medicine away from direct light, moisture, and heat
  • Keep the medication from freezing
  • Don’t keep expired medication or medication that’s no longer needed
  • Keep the medicine out of the reach of kids


Aminosalicylate sodium can be used with meals or after meals or combined with an anti-acid if it messes up your stomach.

To help treat your tuberculosis and get rid of it completely, it’s vital that you continue taking Aminosalicylate sodium for the entire duration of your treatment even if your condition improves after a couple of weeks. As tuberculosis may take a long period of time to go away, you may need to take Aminosalicylate sodium every single day for up to a couple of years or more. Don’t stop taking this medication too soon or your symptoms may reappear.

Aminosalicylate sodium produces the best results when there’s a consistent amount in your blood. To ensure that your amount is constant, don’t skip any dose. In addition, it’s best to have the doses at uniformly spaced intervals day and night. If you’re supposed to take three doses daily, for example, you should space the doses around 8 hours apart. Of course, this may interfere with your sleep as well as other daily activities. If that’s the case, or you need assistance in planning the right times to take Aminosalicylate sodium, check with your physician.

Don’t take discolored Aminosalicylate sodium tablets, i.e. ones that are brown or purple. See your pharmacist for a fresh prescription instead. Don’t stop using this medication without your doctor’s permission.

Report these symptoms to your doctor as soon as possible: fever, abdominal pain, persistent sore throat, unusual bruising or bleeding, and persistent vomiting or nausea. Inform your doctor if you’re pregnant or plan to be pregnant. You should not use Aminosalicylate sodium while breastfeeding as it's known to pass into human milk.

Last Reviewed:
December 10, 2017
Last Updated:
February 09, 2018