This paste is used to treat aphthous ulcers, also known as canker sores, in the mouth. It is available with prescription only and should not be used for longer than 10 days unless directed by your doctor. It will offer pain relief and help to alleviate the sores.


Amlexanox is a paste that can be prescribed to treat aphthous ulcers. Aphthous ulcers are also known as canker sores and are small, shallow and painful sores that appear in the mouth, making eating and talking uncomfortable.

There are two types of canker sores. Simple canker sores can occur up to four times a year and occur in people aged 10 to 20 typically. This paste can be used for the treatment of these sores. Complex canker sores are less common and appear recurrently. They can be a sign of underlying immune system problems and cannot always be treated with this paste.

The exact cause of most canker sores is unknown but citric acids from oranges, fruits and vegetables can trigger a canker sore and make it worse once they have occurred. The citric acid will make the sores sting. They can also be caused by sharp abrasions from a sharp tooth, dental equipment or braces, for example. Where the skin is damaged canker sores can occur.

Some canker sores are caused by underlying health conditions which should be treated independently. Impaired immune system, nutritional problems and celiac disease are all common factors leading to the development of canker sores.

Canker sores are not the same as cold sores, although the two are often confused. Unlike cold sores, canker sores are not caused by a virus. They are often confused as they recur in a similar manner and affect the area in and around the mouth.

Treatment with Amlexanox should not exceed 10 days unless directed by a doctor. Amlexanox should be used with extreme caution in children.

Condition treated

  • Aphthous ulcers
  • Canker sores

Type of medicine

  • Oral Mucous Membrane
  • Paste

Side Effects

Medicine can cause unwanted side effects as well as the needed effects. Not all of the side effects may be experienced and in some cases no side effects will occur. In some cases side effects will require medical attention and you should report all bothersome side effects to your medical professional as early as you are able to.

With the use of Amlexanox it is common that no unwanted side effects will occur and those that do would not normally require medical attention. The following side effects may occur and your healthcare professional can advise you on ways to alleviate them.

  • Burning local to application point
  • Stinging local to application point
  • Pain local to application point
  • Inflammation of mucous membranes
  • Diarrhea
  • Nausea
  • Numbness of the mouth

If you experience any of these vary rare side effects you should contact your doctor immediately and stop using Amlexanox. These can be signs of serious reactions to the medication or other complications.

  • Skin rash
  • New mouth ulcers
  • White patches
  • Sores inside your mouth or on your lips

If other side effects not listed here occur contact your healthcare professional for advice.


This medicine will be administered with different doses for different patients. You should follow your doctor’s instructions and be sure to read the manufacturer instructions closely. Do not exceed the dose that is recommended to you by a healthcare professional.

To apply follow these steps:

  • Wash your hands and brush your teeth thoroughly.
  • Squeeze a small amount of the paste onto your fingertip.
  • Apply gentle pressure while dabbing the paste onto each sore in your mouth.
  • Wash your hands between each application and immediately after application. Do not use the same finger to apply cream to more than one sore. Do not touch the paste with the finger that has been applied to the sore.
  • Use the medicine only for 10 days. If the canker sore has not healed in this time, check back with your doctor.
  • Keep the paste away from eyes. If you do get any paste in your eyes, wash them with water immediately. If any irritation occurs, contact your doctor.

The amount of medicine that you take will depend on the strength of the medicine. This will also vary the frequency at which you should use the paste and the length of time that you use the paste for.

The average dosage recommended for treatment of canker sores is as follows:

  • Adults – Application to each canker sore in the mouth up to four times per day. It is recommended that the paste is applied after you have brushed your teeth. Ideal times to use the paste are after breakfast, after lunch, after dinner and before you go to bed. Brush your teeth before application each time and ensure your hands are clean too.
  • Children – Use and dose by children should be determined by the prescribing doctor. Dose should be applied to the child by an adult.

If you miss a dose of Amlexanox you should apply it as soon as possible unless it is close to your next dose. In this case you should skip the mixed dose and go back to the usual dosing schedule. You should not extend the period that you use the paste for in this case.


Certain medicines should not be taken in conjunction with one another. While there are no specific interactions with Amlexanox it is important to tell your doctor if you are taking any other medication when you are prescribed the paste. In some cases different medicines will stop another working and in the most extreme cases they can react violently with one another causing adverse effects. Make sure you tell your doctor about any medicines or drugs you have been taking. You should also tell your doctor about any underlying health issues that you may have.


It is important to tell your doctor about any underlying medical problems that you have. Amlexanox will help to cure a canker sore in a healthy patient, but it will not fix any underlying issues. Where the cause of the canker sore is related to immune system problems it is not known if the paste will work properly. You should be sure to tell your doctor if this is the case for you.

Do not use this medicine if you are allergic to Amlexanox or have reacted badly to it in the past.

Before using, be sure to tell your doctor if you are allergic to any drugs. If you have a weak immune system or any conditions that may cause a weak immune system then it is important to tell your doctor. Inform your doctor if you are undergoing cancer treatment too.

Amalexanox is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant.

It is not known if Amlexanox passes into breast milk or could harm a nursing baby. Tell your doctor if you are breast feeding before taking the medication and weigh the positives and negatives of doing so.


This medicine should be kept in a closed container away from direct sunlight and moisture. Keep the medicine at room temperature and prevent from freezing.

Medicine should be kept out of reach of children at all times.

Do not keep the medicine once it has expired or once your course of treatment has completed. Out of date medicine should be disposed of appropriately according to manufacturer instructions.


Amlexanox is an oral mucous membrane for the treatment of aphthous ulcers, also known as canker sores, in the mouth. This painful condition is alleviated by the cream over time.

The paste is available only with a prescription from a doctor and should be used for no longer than 10 days.

Adverse side effects are uncommon when using this paste, but you should contact a medical professional if some side effects occur using the paste.

When canker sores are caused by underlying immune or nutritional problems, this paste may not be effective. If you have any underlying medical conditions then you should be sure to tell your doctor before you begin administering the paste.

To apply the paste simply use a clean finger. Application should be carried out shortly after brushing your teeth and should ideally be carried out after meal times and before bed.

The paste should be stored in a cool, dark place and kept out of reach of children at all times. Keep the paste away from direct sunlight.

Before receiving a prescription you should inform your doctor of any other medical issues or conditions that you have. If you are taking any other medications, be sure to inform your doctor of these too.

Amlexanox should not be given to children except under the direct instruction of a doctor. Effectiveness in children has not been confirmed.

Last Reviewed:
December 10, 2017
Last Updated:
February 09, 2018
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