Amlodipine and Benazepril

When prescribed as a combination medicine, Amlodipine and Benazepril are used to treat patients with high blood pressure.

Overview:

Although Amlodipine and Benazepril are used to treat high blood pressure individually, the drugs work in different ways. They can be used as a combination medicine, therefore, and have a high success rate when it comes to reducing blood pressure.

As a calcium channel blocker, Amlodipine reduces blood pressure by changing the movement of calcium into the heart cells and the cells of the blood vessels. As a result, the blood vessels become more relaxed and blood pressure is reduced. When blood pressure is reduced, the supply of blood and oxygen to the heart is increased and there is less strain on the heart muscle.

Benazepril is classified as an angiotensin-converting enzyme (ACE) inhibitor. The medication affects specific chemicals which cause the blood vessels to tighten. When these chemicals are stopped, or inhibited, the blood vessels loosen and blood is able to travel more easily around the body.

As high blood pressure, or hypertension, can cause various other health complications to occur, it’s vital that patients with high blood pressure are given adequate treatment. If left untreated, high blood pressure may result in heart attacks, heart disease, kidney failure, stroke and/or loss of vision. Also associated with damage to the brain and other parts of the body, high blood pressure can have a significant effect on patients.

By using Amlodipine and Benazepril as a combination medication, physicians can take a two-pronged approach to lowering blood pressure. As a result, patients benefit from an adequate reduction and are able to stabilize their blood pressure more quickly.

Although patients are often advised to make lifestyle changes in order to reduce high blood pressure, a treatment regimen generally involves the use of medications as well. When Amlodipine and Benazepril is used appropriately, it will successfully reduce high blood pressure and, therefore, lower the risk of further health issues arising.

Conditions Treated:

  • High blood pressure (Hypertension)

Type of Medicine:

  • Amlodipine:
    • Calcium channel blocker
  • Benazepril:
    • Angiotensin-converting enzyme (ACE) inhibitor

Side Effects:

Patients taking any type of medication should always make a note of any side effects which occur. Although they may not affect the efficacy of the medication, it may be advisable to inform your physician if you experience side effects when taking this medication.

When taking Amlodipine and Benazepril, patients may exhibit signs of side effects which require medical attention. Although they are not particularly common, you should seek medical help if you experience any of the following when taking Amlodipine and Benazepril:

  • Confusion
  • Dizziness, lightheadedness, or fainting
  • Fast or irregular heartbeat
  • Nervousness
  • Numbness or tingling in the hands, feet, or lips
  • Shortness of breath
  • Swelling of the ankles, feet, or lower legs
  • Weakness or heaviness of the legs
  • Bleeding gums
  • Chills
  • Fever
  • Nausea or vomiting
  • Nosebleeds
  • Pale skin
  • Sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • Stomach pain or bloating with fever, nausea, or vomiting
  • Swelling of the face, mouth, hands, or feet
  • Trouble with swallowing or breathing (sudden) or hoarseness
  • Unusual bleeding or bruising
  • Unusual tiredness or weakness
  • Yellow eyes or skin
  • Chest pain
  • Heartburn
  • Pain or burning in the throat

More common side-effects can also occur when taking Amlodipine and Benazepril. In the majority of cases, these will not cause complications and will subside as your body becomes used to the medication. Of course, if side effects persist or worsen, patients should seek medical help. Common side effects associated with the treatment may include:

  • Cough (dry and continues)
  • Feeling of warmth
  • Redness of the face, neck, arms, and occasionally upper chest
  • Sleepiness
  • Acid or sour stomach
  • Belching
  • Blistering, crusting, irritation, itching, or reddening of the skin
  • Body aches or pain
  • Cracked, dry, or scaly skin
  • Decreased interest in sexual intercourse
  • Difficulty having a bowel movement (stool)
  • Frequent urination
  • Inability to have or keep an erection
  • Increased volume of pale, dilute urine
  • Indigestion
  • Lack or loss of strength
  • Loss in sexual ability, desire, drive, or performance
  • Muscle or bone pain
  • Shakiness in the legs, arms, hands, or feet
  • Stomach discomfort or upset
  • Sudden sweating
  • Swelling
  • Tender, swollen glands in the neck
  • Trembling or shaking of the hands or feet
  • Trouble with sleeping
  • Voice changes

Although it’s not uncommon for patients to experience some side effects when taking a course of medication, they should not have a debilitating effect. If side effects are particularly pronounced or troublesome, it’s always advisable to seek medical assistance.

In some instances, patients will experience side effects soon after commencing treatment with Amlodipine and Benazepril. Patients can, however, begin to experience side effects after they have been taking the medication for weeks or months. Although this isn’t uncommon, patients should contact their doctor if they begin to experience any new side effects while taking the medication.

Dosage:

Available in a variety of dosage formats, the starting dose for Amlodipine and Benazepril is normally one capsule per day, containing 2.5 mg of Amlodipine and 10mg of Benazepril. Although the dose can be increased, the maximum dose usually given is 10mg Amlodipine and 40mg Benazepril daily.

Although the above information is an appropriate starting dose for healthy adults, the starting dose may be reduced when prescribed to elderly patients. Similarly, if children are prescribed Amlodipine and Benazepril, their starting dose will depend on their age and weight, as well as their symptoms.

If a dose of Amlodipine and Benazepril is missed, it may be possible to take the missed dose. If the next dose is not due for some time, for example, the patient can take the missed dose and continue with treatment as normal. If the next dose is due in 12 hours or less, however, the dose should be missed completely and the patient should take the next dose at the normal time.

If you miss a dose of Amlodipine and Benazepril and are unsure how to continue taking the medication, you should seek medical advice from your doctor or your pharmacist. It is not appropriate to take a double dose of Amlodipine and Benazepril, even if a dose has been missed.

In all cases, patients should take Amlodipine and Benazepril as instructed by their physician.

Potential Drug Interactions:

In some instances, it is not safe to take certain medications alongside others. In most cases, Amlodipine and Benazepril should not be taken with Aliskiren and/or Sacubitril. If no other alternatives are available, your doctor may alter your dose and/or the way you take the medication in order to reduce the risk of drug interactions occurring.

While Amlodipine and Benazepril is not usually prescribed in conjunction with the following medications, it may be appropriate to prescribe both medications in some cases:

  • Alteplase, Recombinant
  • Amiloride
  • Amiodarone
  • Atazanavir
  • Azathioprine
  • Azilsartan
  • Azilsartan Medoxomil
  • Candesartan Cilexetil
  • Canrenoate
  • Ceritinib
  • Clarithromycin
  • Clopidogrel
  • Conivaptan
  • Cyclosporine
  • Dantrolene
  • Digoxin
  • Domperidone
  • Droperidol
  • Eliglustat
  • Eplerenone
  • Eprosartan
  • Everolimus
  • Idelalisib
  • Irbesartan
  • Lacosamide
  • Lithium
  • Losartan
  • Mercaptopurine
  • Olmesartan Medoxomil
  • Piperaquine
  • Potassium
  • Simvastatin
  • Sirolimus
  • Spironolactone
  • Tacrolimus
  • Tegafur
  • Telaprevir
  • Telmisartan
  • Triamterene
  • Trimethoprim
  • Valsartan

When taken with Amlodipine and Benazepril, the following medications may increase the risk of side effects occurring. Due to this, doctors may prescribe a treatment regime which deviates from the standard dosing procedures. In addition to this, your physician may prescribe additional medication in order to alleviate any side-effects which occur. The medications which may increase the risk of side effects include:

  • Aceclofenac
  • Acemetacin
  • Amtolmetin Guacil
  • Azosemide
  • Bromfenac
  • Bufexamac
  • Bumetanide
  • Bupivacaine
  • Bupivacaine Liposome
  • Capsaicin
  • Celecoxib
  • Choline Salicylate
  • Clonixin
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Droxicam
  • Ethacrynic Acid
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Furosemide
  • Gold Sodium Thiomalate
  • Ibuprofen
  • Indinavir
  • Indomethacin
  • Ketoprofen
  • Ketorolac
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Nesiritide
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Phenylbutazone
  • Piketoprofen
  • Piretanide
  • Piroxicam
  • Proglumetacin
  • Propionic Acid
  • Propyphenazone
  • Proquazone
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sodium Salicylate
  • Sulindac
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Torsemide
  • Valdecoxib

Patients should inform their physician if they are taking any of the above medications, or if they have taken them in the past.

Before taking Amlodipine and Benazepril, you should inform your physician of any other medication you are taking. In addition to this, your doctor will need to know if you take any over-the-counter medication, vitamins, herbal supplements, consume alcohol, smoke cigarettes or use recreational drugs. These substances can affect the way medications work, so it’s vital that you inform your physician if you provide the appropriate information.

Warnings:

It’s also important to discuss your medical history with your doctor prior to taking Amlodipine and Benazepril. There are some conditions which may prevent you from taking this medication, so it’s essential that your physician is aware of any pre-existing conditions or illnesses.

If the patient suffers from any of the following conditions, they should advise their physician immediately:

  • Angina and/or chest pain
  • Electrolyte imbalance
  • Fluid imbalances, sometimes caused by vomiting, diarrhea and/or dehydration
  • Liver disease
  • Kidney disease or kidney problems
  • Angioedema
  • Aortic stenosis
  • Heart disease
  • Diabetes, particularly if patient is taking Aliskiren
  • Heart failure

Patients with congestive heart failure may experience kidney problems when taking Amlodipine and Benazepril, for example. If the physician feels it is appropriate to prescribe the medication, regular monitoring can ensure that there are no adverse effects.

If patients have ever experienced an allergic reaction to the following substances, they should inform their doctor before taking Amlodipine and Benazepril:

  • Amlodipine
  • Benazepril
  • Captopril
  • Enalapril
  • Fosinopril
  • Lisinopril
  • Moexipril
  • Perindopril
  • Quinapril
  • Ramipril
  • Trandolapril

Whilst elderly patients can be suitable for treatment with Amlodipine and Benazepril, they may be more likely to suffer from pre-existing liver, heart or kidney problems. If so, the suitability of Amlodipine and Benazepril should be assessed and, if treatment is commenced, regular monitoring should occur.

Although pregnant patients can be subscribed Amlodipine and Benazepril, the treatment is not without risks. As Amlodipine and Benazepril presents a risk to the fetus, the treatment should not usually be prescribed to patients who are pregnant. If the patient is facing a life-threatening medical condition or serious disease, it may be appropriate to use Amlodipine and Benazepril, despite the risks.

If you become pregnant while taking Amlodipine and Benazepril combination medication, you should contact your physician immediately.

Although the use of Benazepril only poses a minimal risk when taken by patients who are breastfeeding, the effects of Amlodipine on the infant are unknown. Due to this, patients who are breastfeeding should avoid taking Amlodipine and Benazepril combination medication, unless the benefits outweigh the associated risks. If you are breastfeeding and have been prescribed Amlodipine and Benazepril, you should discuss the treatment with your physician prior to taking any medication.

As Amlodipine and Benazepril can impair your thinking and cognitive function, patients should determine whether they can safely drive and/or operate heavy machinery when taking this medication. If the patient’s reactions are delayed, for example, they should refrain from these activities.

If patients become dehydrated while taking Amlodipine and Benazepril, their blood pressure may become too low. If the patient suffers from on-going vomiting, sweating and/or diarrhea, medical assistance should be sought. If left untreated, their blood pressure may fall to a dangerous level and they may be at risk of developing an electrolyte imbalance.

Consuming alcohol can also lower your blood pressure in some situations. Due to this, patients are generally advised not to drink alcohol while taking Amlodipine and Benazepril combination medication.

To assess the efficacy of the treatment, patients should have their blood pressure checked on a regular basis. In addition to this, doctors may want to carry out regular kidney and liver function tests. When taking this medication, it’s vital that patients attend follow-up appointments.

Patients should continue to take Amlodipine and Benazepril as advised by their doctor, even if they feel well. In many cases, high blood pressure does not present any symptoms but this does not mean that you should stop your treatment regime, unless advised to do so by a medical professional.

If the patient is due to undergo surgery or any medical procedures, they should tell their doctor and/or consultant that they are taking Amlodipine and Benazepril combination medication. If necessary, the doctor will advise whether or not the medication should be stopped temporarily or if the dose should be altered. Patients should not make these changes unless they are advised to do so.

On rare occasions, patients may experience an allergic reaction as a result of taking Amlodipine and Benazepril. Signs of an allergic reaction may include trouble breathing, swelling of the tongue, lips, throat and face, wheezing, chest pain and/or collapse. If an allergic reaction occurs, it should be treated as a medical emergency. As an allergic reaction can be life-threatening, it is essential that medical assistance is obtained swiftly.

When treating high blood pressure (hypertension), doctors may advise the patient to consume a no-sodium or a low-sodium diet. As some salt substitutes contain potassium, these should be avoided by patients taking Amlodipine and Benazepril. Patients should discuss dietary changes with their physician to ensure that they are safe.

Storage

When Amlodipine and Benazepril is prescribed as a combination medication, the patient is normally given the medicine in capsule form. These capsules will either be given in a medicine jar with a child-proof cap or in a blister pack. Due to this, patients can store the medication at home and take it as instructed.

When storing medication at home, however, it is essential that the tablets or capsules are placed in a secure location. No one else should be able to access the medication, particularly children and/or pets. Using a lockable medicine box or cabinet can help to keep medications secure when they are stored in the home.

Amlodipine and Benazepril combination medication should be stored at room temperature and shouldn’t be frozen or heated. It should also be kept out of direct light and away from moisture. If the medication is exposed to excess moisture, the tablets or capsules may begin to disintegrate. By placing the medication in a clean and dry location, patients can ensure that it remains usable.

When the course of treatment has finished, Amlodipine and Benazepril can be disposed of. Similarly, if the medication reaches its use-by date, it should no longer be kept. Patients should always take care when disposing of medication, however. It should not normally be disposed of alongside other household waste. Instead, patients should seek advice from their pharmacist or another medication professional, so that the safest disposal method can be used.

Summary

High blood pressure, or hypertension, is an extremely common condition. Although patients may experience symptoms, such as fatigue, headaches, chest pain and difficulty breathing, patients do not always exhibit symptoms of hypertension. In fact, hypertension may not be symptomatic until the patient’s blood pressure becomes extremely high.

As high blood pressure is associated with a number of serious health problems, it’s important that it is identified, even if the patient isn’t exhibiting any specific symptoms. By carrying out thorough health checks, physicians can often identify instances of hypertension, before a subsequent medical condition occurs.

Although Amlodipine and Benazepril can be prescribed separately, they are often given as a combination medication. While both drugs successfully lower the patient’s blood pressure, they use two different mechanisms to achieve this aim. This generally means that using both Amlodipine and Benazepril is more effective than using just one drug.

By prescribing Amlodipine and Benazepril as a combination medication, rather than as separate medications, it simply means that patients are required to take fewer capsules per day. For patients who may already be taking other medications, it can significantly reduce the amount of tablets and/or capsules they are required to take. Due to this, Amlodipine and Benazepril combination medication is more convenient for the patient.

While this form of treatment can be an effective way to resolve hypertension, it is often prescribed in addition to other advice. Doctors will often ask about a patient’s lifestyle, diet and activity levels once high blood pressure has been diagnosed. In most cases, lifestyle changes are advised.

If the patient successfully alters their diet and increases the amount of exercise they do, it can have a considerable impact on their blood pressure. In some cases, the dose of Amlodipine and Benazepril may even be reduced as a result of beneficial lifestyle changes made by the patient.

Once Amlodipine and Benazepril has been prescribed, patients should, therefore, receive regular monitoring. As well as checking for potential adverse effects, physicians can modify the dose of the medication, if it is necessary to do so.

By following their prescribed treatment regime and adopting a healthier lifestyle, patients can successfully reduce their blood pressure by taking Amlodipine and Benazepril as a combination medication.

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Last Reviewed:
December 10, 2017
Last Updated:
December 22, 2017