Amlodipine and Olmesartan

Proven to lower high blood pressure (hypertension), Amlodipine and Olmesartan are a blend of medicines that when combined, work together to effectively lower your risk of heart attacks and strokes. Prescribed to patients who experience high blood pressure, Amlodipine and Olmesartan is a calcium blocker that will widen and relax blood vessels. In turn, this helps to reduce the workload for your heart and arteries, consequently improving their health.

Overview

Otherwise known by its brand name Azor, Amlodipine and Olmesartan is an oral medication taken in the form of a tablet. Used to treat hypertension, it can be either taken alone or alongside other medications, as recommended by your doctor. It is only available with your doctor’s prescription.

An effective calcium channel blocker (CCB), Amlodipine will affect the travel of calcium into your heart and blood vessel cells. Due to this, amlodipine reduces your heart’s workload by relaxing the blood vessels and increasing its supply of blood and oxygen.

Olmesartan is known as an angiotensin II receptor blocker (ARB). ARBs work by stopping the effects of a hormone called ­angiotensin II in your body which can cause blood vessels to tighten, in turn restricting movement of blood and oxygen to the heart. As a result of this, Olmesartan works to relax blood vessels which lowers blood pressure and expands the supply of blood and oxygen to the heart.

Long-term high blood pressure is damaging to the body, in time causing the heart and arteries to not function correctly. This is harmful to the blood vessels of the heart, kidneys and brain and can cause strokes, heart failure and kidney failure. For those with high blood pressure, it is important to lower this hypertension and reduce its life-threatening risks. According to recent studies by Azor, high blood pressure affects a large number of the population, affecting one out of every three adults over the age of 20.

Once you have been prescribed Amlodipine and Olmesartan, it is vital that you take this medication exactly as prescribed by your doctor. It is important to not alter your amounts or take the medication for any duration longer or shorter than advised. For the best results, it is essential that you inform your doctor of any changes in your circumstances or whether you encounter any other illnesses as this may impact your treatment.

Conditions treated

  • High blood pressure (hypertension)

Type of medicine

  • Amlodipine is a calcium channel blocker
  • Olmesartan is an angiotensin II receptor antagonist

Side effects

Amlodipine and Olmesartan have the potential to cause adverse side effects, with the most common effects being mild enough to pose no impact to your daily routine.

The most common adverse reaction alerted to healthcare professionals is edema, which is the buildup of fluid in some tissues within the body. This tends to result in a slight and often painless swelling under the skin, that is usually found in the arms, legs or ankles. It can be reduced by lessening your salt intake or by taking medication to alleviate excess bodily fluid. However, if you notice any chest pain, difficulty in breathing or a shortness of breath, make sure to alert your doctor immediately, as these can be signs of a pulmonary edema, which is very serious.

Other common and easily managed side effects include bloating of the face, arms, hands, lower legs or feet and weight gain. You may also notice a feeling of warmth, redness of the face, neck or arms and sometimes the upper chest.

Less common side effects have been found to include unusual tiredness or weakness, dizziness, hair loss and a mild skin rash or itchiness. These side effects are less serious but can be unpleasant. If you experience any of these side effects, discuss how they can be managed and maintained by your doctor. These may lessen or disappear during your treatment, and once your body adjusts to the Amlodipine and Olmesartan. However, if these side effects continue causing bother or discomfort, make sure to bring it to the attention of your doctor.

In rare circumstances, Amlodipine and Olmesartan can start a serious condition that will deteriorate skeletal muscle tissue and can lead to serious kidney failure. If you experience any muscle pain, tenderness, dark coloured urine, nausea, vomiting, weakness and a fever, it is important that you contact your doctor immediately.

If any other side effects include the sensation of fainting, heart palpitations or a pounding heartbeat, yellowing of the skin and eyes (jaundice), difficulty or the reduction of urinating, pain radiating from your arm to your shoulder or nausea, chest pain and heaviness, contact your healthcare professional urgently as these are all indicators of uncommon and serious side effects. Abdominal or stomach pain, diarrhea and light-coloured stools are also reactions that should be brought to the attention of your healthcare professional.

If you notice any signs of an allergic reaction, you must report them to your doctor urgently for treatment. Signs of an allergic reaction include difficulty in breathing, hives and swelling of the face, lips, tongue or throat.

Dosage

Amlodipine and Olmesartan tend to be prescribed as substitution therapy for those who have been maintained on the individual components. It is also given to those who aren’t adequately controlled with one of the elements, or an element that falls into the same antihypertensive class.

More noticeably, it is commonly found to be given as a starter treatment in patients who are presumed to need more than one antihypertensive medicine to control or maintain high blood pressure.

The Amlodipine and Olmesartan dosage that your doctor will prescribe will depend on a range of factors including any other illnesses or diseases that you may have, as well as your weight and general health.

In particular, patients undergoing dialysis or suffering from kidney or liver disease will need extra caution and care when taking this medication. In some cases, Amlodipine and Olmesartan will be stopped and an alternative treatment sourced.

The usual adult dose for hypertension is initially 5 mg Amlodipine and 20 mg Olmesartan. This should be taken twice a day in the form of oral tablets. This initial dose may be increased after one to two weeks of therapy, as decided by your doctor and your response to the medication.

Patients can be given up to 10 mg Amlodipine and 40 mg once a day, but should never exceed this dose.

Interactions

Before starting your course of Amlodipine and Olmesartan it is essential that you alert your doctor to any other medications that you are taking. To be on the safe side, make sure to inform them of any herbal remedies, medicines or supplements that you are also taking, as they may interact or alter the success of your medication.

In some cases, other medications are necessary to be taken alongside Amlodipine and Olmesartan, however, the dosage of either medication may be altered to ensure your safety and the best treatment.

Medicines that may seriously affect Amlodipine and Olmesartan include:

  • Colesevelam
  • Indinavir
  • Aliskiren
  • Benazepril
  • Domperidone
  • Enalaprilat
  • Fosinopril
  • Idelalisib
  • Lisinopril
  • Moexipril
  • Piperaquine
  • Quinapril
  • Ramipril
  • Simvastatin
  • Tegafur
  • Telaprevir

It is especially important to inform your doctor or any non-steroidal anti-inflammatory drugs (NSAIDs) that you are taking as these can interact negatively with Amlodipine and Olmesartan. This medication includes all variants of aspirin, ibuprofen, naproxen, celecoxib, diclofenac, Pennsaid and Meloxicam. If you are ever unsure whether your medication falls into the NSAID category, make sure to discuss it with your doctor for peace of mind.

Any other heart medication that you are taking must also be reported to your doctor, as it may need discontinuing or your dosage changing to ensure that Amlodipine and Olmesartan are as efficient as possible.

Potassium supplements or salt substitutes can affect the possibility of edema as well as have other impacts on your medication, so need to be alerted to your doctor. If you are also on diuretics (water pills) or any other medicines that lower blood pressure, also make sure that your doctor is made aware.

Dietary and lifestyle factors that may impact this medication should be considered before starting your treatment. Alcohol can exacerbate side effects of drowsiness and warmth, causing potential discomfort and impact on tasks. If you have consumed any alcohol, it is vital that you do not drive or operate any machinery that may be impacted by drowsiness. If you are a smoker, it is also important to discuss the effects of tobacco on Amlodipine and Olmesartan as it is likely to be detrimental and not recommended. You will also need to reduce and be mindful of your salt intake as patients taking Amlodipine and Olmesartan are likely to experience edema. A reduction in the amount that you urinate is also a common side effect and one which salt can impact.

Warnings

Amlodipine and Olmesartan poses a serious threat to pregnancies, having been proven to cause fetal toxicity and injury to developing fetuses. It acts directly on the renin-angiotensin system (RAS), a hormone system that controls blood pressure and fluid balance and is known to cause injury and death to a developing fetus. Consequently, women of childbearing ages should always be informed of the damage that this drug can cause and pregnancies should be reported as soon as possible. If you do become pregnant whilst taking Amlodipine and Olmesartan, it is advised to stop taking the medication right away and inform your doctor. Patients should consider their likelihood to have children at the time of their treatment and should discuss any options with partners and healthcare professionals. It is also important to use effective birth control whilst taking this medication to avoid fetal toxicity.

To ensure that you can safely take this medication, it is also important to make your doctor aware of any conditions that you may have including kidney disease, liver disease, diabetes, angina, congestive heart failure or if you have recently experienced a heart attack. If you are on dialysis or receiving alternative treatment for the above illnesses, this must also be discussed with your doctor and taken into consideration.

It is also advised that anyone who has an allergy to (Norvasc) or olmesartan (Benicar) does not use this medication. If you are taking a beta-blocker, it is important that you do not suddenly stop using it without speaking to your doctor. It is likely that your doctor will decide to slowly wean you off the beta blocker by reducing its dosage. Stopping a beta blocker too quickly can cause serious heart problems and is always advised against.

As this medicine’s safety has not been established in those younger than 18 years, it is predominantly given to patients who are above this age. If you are over 75 years of age, please inform your doctor as this may have an impact on the side effects and success of its treatment.

Storage

As with all medication, it is important that you keep Amlodipine and Olmesartan out of the reach of children and vulnerable adults. Amlodipine and Olmesartan should be stored in a safe, cool and dry location such as a medicine cabinet or set of drawers. Its ideal storage temperature is 20°C to 25°C. If being stored in a controlled medical environment, Amlodipine and Olmesartan may have a minimum temperature of 15°C or maximum temperature of 30°C.

If any of your tablets appear to be damaged or look like they have been tampered with, throw them away and consult your doctor.

Summary

Amlodipine and Olmesartan have the ability to improve the health of a patient's heart and arteries, contributing to the avoidance of life-threatening diseases such as strokes, heart attacks and heart failure. For long-term hypertension sufferers, this gives the possibility of an improved, healthier lifestyle as well as the possible extension of life.
Due to its simple and easy oral administration, it can become an essential part of anyone’s daily routine as well as be managed effectively and with ease. However, oral administration can also have its setbacks, being easy to forget or alter the dose for some patients. Therefore it requires plenty of commitment and responsibility to benefit from the best results.

Its most common side effects are relatively minor, not causing much impact on the user’s life, however, the less common side effects can be bothersome for most. Hair loss and rashes can impact a person’s confidence as well as comfort. When taking this medication, it is important to have good communication with your doctor so that you can manage, treat and avoid any side effects.

Because Amlodipine and Olmesartan are taken orally in the form of tablets, strong communication and regular visits with your doctor are also important. With good communication, you will be able to ensure that you maintain the most effective dosage and treatment.

It is vital that a patient discusses their likelihood or desire to become pregnant if taking this medication, as Amlodipine and Olmesartan cause death or severe injury to fetuses in the second and third trimester. For this reason, it is advised that patients do not become pregnant whilst taking this medication.

With the effective use of Amlodipine and Olmesartan, a patient's hypertension can be maintained and reduced, enabling them to make positive changes to their life and potentially start enjoying new or beloved activities that they were unable to partake in before.

To achieve the best results from Amlodipine and Olmesartan, it is important that you are diligent with your treatment routine and are mindful of any dietary or lifestyle factors that may affect your treatment. Avoid alcohol, and foods that are high in salt and tobacco. Most importantly, maintain great communication with your healthcare professional. This medication tends to be used as an initial treatment for hypertension and can be the start of a new, healthier lifestyle as well as an increased life expectancy.

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Last Reviewed:
December 10, 2017
Last Updated:
February 09, 2018
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