Amlodipine is a high-demand medication that, when combined with other drugs, treats high blood pressure, also called hypertension. When you have hypertension, your arteries and heart must work harder. Over time, this can cause the arteries and heart to malfunction. There is a ripple effect of damage from hypertension that can impact the heart, brain and kidneys and cause heart failure, stroke or kidney failure. To reduce the risks of high blood pressure, Amlodipine works to lower your blood pressure to protect your organs.
Amlodipine does this by acting as a calcium channel blocker (CCB). It impacts how calcium moves into the cells that make up your heart and blood vessels. By doing so, the drug allows the blood vessels to relax, which lowers your blood pressure. When your blood pressure is lower, the blood supplies more blood and oxygen to your heart.
Amlodipine is used with another kind of drug, called an angiotensin-converting enzyme, or ACE inhibitor. With the help of this drug, your body can ignore a substance that makes blood vessels constrict. Lower blood pressure doesn’t strain the heart or arteries.
You can only get amlodipine with a prescription from your doctor. In addition, a treatment regimen for hypertension may require other changes. For instance, weight control is a key factor for some people who get their blood pressure under control. Dietary factors that help ensure this medicine has the optimal effect include reducing the amount of sodium you consume. However, check with your doctor prior to making life and diet changes.
It is important to understand that this medicine only helps control high blood pressure and does not act as a cure for the disease. As long as the real causes remain unresolved, you are dependent on your medication to keep the condition under control.
Therefore, continue to take the medication, even if you feel better. Take steps to lower your blood pressure, then keep it down. Once they get on hypertension medications, many take it for as long as they live to combat heart failure, strokes, blood vessel disease and kidney disease.
Take Amlodipine with or without food, although some people may be prone to nausea if they take it on an empty stomach. For optimal results, set a time and take your medicine at the same times.
NORVASC has undergone strict testing and proven safe in 11,000 patients in U.S. and abroad during clinical trials. NORVASC was well-tolerated in patients who received a dosage of up to 10 mg daily. Most negative results during therapy mild and not life-threatening. In controlled trials that compared NORVASC (up to 10 mg) to placebo therapy, the trial was stopped for individuals due to side effects in 1.5% of those receiving NORVASC. This compares favorably against the 1% patients taking the placebo and reporting similar side effects.
Sometimes, medicine may bring about unforeseen effects. These side effects will not necessarily happen to all people who use these drugs, nor will having one of these side effects determine that any of the others will occur. If you’re experiencing any of these side effects, check with your doctor to determine if you should seek medical attention.
Some side effects that don’t typically require the attention of a healthcare professional can dissipate as your body gets used to the medicine. Consult with your doctor for options on reducing your discomfort or preventing these side effects from occurring altogether. The following symptoms may occur after you begin using these drugs. Take any questions to your doctor as soon as possible:
As previously stated, these rarer side effects may not occur for all users and you shouldn’t get all or even several of these symptoms in a normal reaction. After you call your doctor, call the FDA to help them understand your side effect. The number is 1-800-FDA-1088.
This product is available in the following dosage forms:
You can expect to have a customized dosage based on your level of hypertension and other factors. Your doctor may request additional directions be printed on the prescription label.
Follow your doctor's verbal or written instructions as well as directions on the pharmacy label. Below, there is a sample of average doses of this medicine. If your prescription is higher or lower, feel free to discuss the reasons with a healthcare specialist. Don’t risk your health by changing the dosage without your doctor’s express directions to do so.
As a reminder, there are different forms of this medicine that can impact the amounts of the dosages. Your doctor may decide, for example, to have you take fewer or more doses of lower strength for your hypertension.
Your doctor will most likely start you out on one capsule that has 2.5 milligrams amlodipine daily. This is called the initial dose. Depending on whether this reduces your high blood pressure sufficiently, the doctor might adjust that up or down. Here is one potential scenario.
If your hypertension persists, your doctor can increase the dose and split the dosage as follows.
When you forget a dose, take it as soon as you remember, but don’t double up on your regular dosage to catch up. Also, if it’s been longer than 12 hours since your last dose, skip it and wait for the next dose. Take it at the usual time and be as consistent as possible
Your doctor will usually wait at least two weeks before suggesting any changes. This gives your body a chance to adapt to the dosage. He may increase or decrease the strength, depending on how your body reacts. Once you reach the target blood pressure goal, you will likely be prescribed that dosage if it continues to control your blood pressure levels.
Amlodipine may not provide the reductions expected in African-Americans.
If you think you may have overdosed and are having trouble breathing, have someone call 911 right away. Look for the following symptoms: fainting, very fast or slow pulse, dizziness.
Prescriptions of amlodipine are specific to the individual they were prescribed for. Sharing medication with others puts their health at risk.
Some medicines shouldn’t be assigned together as part of your daily regime. This is because of known and unknown interactions that can happen when mixing medication. When taking these medications for high blood pressure, make sure your doctor is aware of all the medicines and supplement you are using together. This is especially true in the case of certain drugs that can interact with your amlodipine. The following medicines are listed due to their individual risks, they are not inclusive of all such interactions with all drugs.
Using these hypertension drugs with the following can be harmful to your health and isn’t recommended. Your doctor can try to prescribe something with a similar benefit.
Don’t combine these two drubs with:
There are some other drugs that are less risky, but still aren’t recommended for use with these medications. If you are required to combines any of the following with your high blood pressure medication, ask your doctor to explain any associated risks before agreeing to do so. In the case risky combinations of medicines that can’t be avoided, your doctor may have to reduce the dosages on one or all the medications.
Here is a list of some of the medicines to avoid pairing with the amlodipine:
Using these medication with the following listed medicines can increase the likelihood of some side effects. However, some of them treat certain conditions that are also life-threatening. but using both drugs may be the only alternative to treat both illnesses.
Using tobacco or alcohol while taking these medicines can put your mental health at risk.
When you decide to use any medication, the risks of using it are compared to those of not using it. Unfortunately, as in the case of these medications, you are taking your life in your own hands This decision should include discussion with you doctor on the following topics:
If you have or develop allergic symptoms after taking these mediations, tell your health care professional. If you have any known or suspected allergies to medicines, tell your doctor. Let him know of any allergies you have related to dyes, preservatives, animals or foods. Read the medication package labels carefully.
There is a gap in the knowledge base, when it comes to studies performed in the pediatric age group, to determine the efficacy of amlodipine. The safety of using them to treat children with high blood pressure hasn’t been established.
In regard to the elderly, not enough studies have been performed to suitably determine if there are any problems specific to this age group that would impact the dependability of prescribing these drugs to geriatric patients. When elderly patients have liver and kidney conditions, extra care should be taken as a precautionary measure, including a downward adjustment of their dosage and the frequency in taking the medications.
There is a risk to the fetus in all trimesters, according to available studies. The benefit of these drugs in a life-threatening event could outweigh this risk.
There isn’t enough information to determine the risk to the baby if the mother is taking amlodipine while breastfeeding. So, that leaves it up to the mother and her doctor to weigh the risks and make a decision.
Studies indicate a minimal risk associated with using this drug while breastfeeding. Ask your doctor to provide her opinion based on your health and the proposed risk to your baby.
If you have other medical problems that could exacerbate your hypertension, the efficacy of these medicines may be reduced. Inform your doctor of any of the following conditions:
The following heart conditions can impact the effects of these drugs.
Congestive heart failure can lead to kidney problems or cause side effects related to heart failure to worsen. If you have experience angioedema (swollen face, tongue, arms, or legs) with other medicines, that increases the likelihood of experiencing it again.
Diabetic patients taking aliskiren (Tekturna®) shouldn’t use this medicine. There are several other considerations if you have diabetes. including
Keep your amlodipine in a closed container and it’s safe to store them at room temperature. Don’t place them near moisture, heat or direct light. Prevent freezing. In addition:
Store out of reach of children and avoid using expired medication. Expose of any medicine you haven’t used and don’t share this medicine with anyone else.
Amlodipine can be an effective alone or in combination with other medicines when it comes to treating your high blood pressure (hypertension).
This product includes a second drug to have the expected results. Amlodipine is the calcium channel blocker. It helps you keep your high blood pressure in check. Under this medication, your blood vessels relax so that your blow flows more freely.
Lowering your high blood pressure will facilitate the prevention of strokes, heart attacks and kidney problems. Amlodipine is well received by most patients and perform within the accepted tolerances and so are widely prescribed.
NORVASC is the brand name for the besylate salt of amlodipine, which produces an effective, long-acting calcium channel blocker.
Amlodipine besylate’s chemical descriptions is: 3-Ethyl-5-methyl with the following (±)-2-[(2-aminoethoxy)methyl]-4-(2- chlorophenyl)-1, 4-dihydro-6-methyl-3 monobenzenesulphonate, 5-pyridinedicarboxylate.
It’s chemical formulation, or empirical formula is written as: C20H25CIN2O5•C6H6O3S