Anti-Inhibitor Coagulant Complex (Intravenous)

Anti-inhibitor coagulant complex is used to treat hemophilia and other blood disorders in order to halt bleeding after surgical incidences, injury, or another occasion where blood loss is caused.


The anti-inhibitor coagulant complex is a generic treatment. The brand names for this medicine are the FEIBA brands and Autoplex T. It belongs to the Antihemophilic Agent class. Other antihemophilic drugs that are similar to the anti-inhibitor coagulant complex include desmopressin, tranexamic acid, DDAVP, Advate, and Eloctate.

The anti-inhibitor coagulant complex contains coagulation factors which help stop the bleeding in patients with hemophilia. This medicine is administered by a licensed healthcare professional by placing the needle into the vein. Patients can also give themselves injections provided they receive proper instructions from their doctors. It is only available by prescription.

How the medicine is given is quite simple. The person who administers it needs to mix it with sterile water and give it to the patient immediately. When the anti-inhibitor coagulant complex gets injected into the veins, it decreases bleeding and improves the blood clots. Normally, this medicine is given once every 6 to 12 hours until the bleeding stops. If you take the drug as a routine prevention of bleeding, you may receive it every other day.

Conditions treated

  • Hemophilia A and Hemophilia B
  • Bleeding episodes from surgeries in hemophiliac patients

Type of medicine

  • Powder for Solution

Side Effects

The side effects that come with the anti-hemophiliac drug include:

  • Allergic reactions, such as rash and hives
  • High blood pressure
  • Dizziness
  • Feeling very tired or weak.
  • Fever or chills
  • Joint pain
  • Blood in the urine or stools
  • Chest pain
  • Shortness of breath
  • Coughing up blood
  • Dark-colored urine or pale stools
  • problems with vision, speech, or walking
  • Swelling of the face, around the eyes, or mouth
  • Wheezing, trouble breathing, or chest tightness
  • Yellowing of your skin or the whites of your eyes
  • Rapid heartbeat
  • Slurred speech

There are also some side effects that are less serious than the ones listed above including back pain, headache, and tiredness. Any questions or concerns you have about the side effects should be addressed with your doctor before and during your treatment.


The general dosage for adults less than 65 years of age is anywhere between 50 to 100 units/kg/dose. It varies somewhat when treating these conditions on these body locations:

  • Joint hemorrhage: 50 to 100 units/kg
  • Mucous membrane bleeding: 50 to 100 units/kg
  • Soft tissue hemorrhage (eg, retroperitoneal bleed): 100 units/kg
  • Other severe hemorrhages (eg, intracranial hemorrhage): 100 units/kg
  • Hemorrhage due to acquired hemophilia 50 to 100 units/kg

The anti-inhibitor coagulant complex is also used to treat patients before and after surgery to protect them from excessive bleeding. These are the following dosage guidelines:

  • Preoperative: 50 to 100 units/kg.
  • Postoperative: 50 to 100 units/kg

The general dosing guidelines for pediatric and geriatric patients are either the same or similar to the ones for adults. If you missed a dose of the medication, you should consult with either your doctor or your pharmacist. If you take too much dose, you need to contact the local poison center or dial 911.

When it is time to throw the drug away, it is not a good idea to discard it by way of a toilet or by a drain unless you are told by a healthcare professional that it is okay to do it. It should be discarded when it is expired or no longer needed.

After you mix the powder with the sterile water, you should take it right away and not put it in the refrigerator. It should be administered within three hours after it reaches room temperature. After it is mixed, give the medicine right away. This medicine should be used only once and it should be thrown away even if it has some medicine left after the injection.

When throwing away, make sure you are doing it responsibly. There may be some laws in your state that regulate the how prescription medicine should be discarded. It is your responsibility to be familiar with the laws and abide by them. You may need to talk with your physician or your pharmacist about the best and safe way to discard the medicine.

Do not take the medicine if it changes colors or has particles in it. You must obtain new medicine.


Anti-inhibitor coagulant interacts with aminocaproic acid (Amicar) or tranexamic acid (Cyklokapron), so you should not take these medications 12 hours after you receive FEIBA NF. It is the same with any other drugs that affect the blood. You should also do not take aspirin if you are suffering from hemophilia since it will increase bleeding. Notify your doctor if you take these medications before the treatment begins, especially VIIa or Novoseven.

Certain medicines should not be taken when you are eating certain types of food nor should you take them when you consume alcohol or tobacco. Otherwise, you may have interactions that can be hazardous to your health. If you consume tobacco or alcohol, you should discuss this with your physician before he or she starts the treatment.

You should also discuss with your doctor on all the medications that you take. That includes prescription, OTC, vitamins, and herbal remedy and natural medicine. After you notify your physician about your medicine, they will have to decide whether they should change the dosage of certain drugs, stop the treatment of certain drugs, or not make any changes at all.


There are several adverse effects that you need to be aware of when considering pursuing this coagulant treatment. By taking this drug, you are most likely at risk for blood clots or bleeding. Blood clots can occur when patients stay in bed for a long time as a result of a surgery or illness. Your physician must devise a plan to protect you from blood clots during your recovery.

You are also at risk if you suffer from these medical conditions: atherosclerosis, or the hardening of the arteries; injuries; a serious blood infection; or a history of blood clotting conditions and cardiovascular diseases.

When receiving the medicine, it is important that it does not get injected into your veins too quickly; otherwise, you will endure headaches, flushing, or changes in blood pressure and heartbeat. It must be administered slowly.

If you do not understand how to use the injection, do not administer it yourself. Instead, ask a healthcare professional to do it for you.

The anti-inhibitor coagulant complex can cause anaphylaxis and other life-threatening allergic reactions that require immediate medical attention.

Some of the packaging materials contain dry natural rubber which can be hazardous to patients who are allergic to latex. It is important to notify your provider if you're suffering from allergies and other medical conditions that may have negative interactions with the treatment.

This drug consists of coagulation substance and human blood. As a result, there is a possibility that patients will receive certain viruses although the chance of getting a virus from this medication through blood is low. The risk is low because the testings of human donors for certain viruses and of the drug manufacturing are always conducted as required.

There is no testing nor sufficient evidence that suggest the anti-inhibitor coagulant complex is unsafe for pregnant women and their unborn infants. There have been no traces of the drug in the human milk after the administration. However, that does not mean it is 100% safe. It is not known fully if the medication can harm you and your baby directly or indirectly. Your physician should know if you are pregnant or plan on becoming pregnant and they should exercise with caution when administering the medicine.


The drug should be stored at less than 25°C or 77°F in the original package and it should be kept away from the light. While you should store it in low temperature, it should not be in the freezer. You can also store the medicine at room temperature for no more than six months. If you have already stored this medicine at room temperature, do not return it to the refrigerator. Ask your pharmacist if you have any questions or concerns about storing the medication.


Once your doctor administers the anti-inhibitor coagulant complex to you, they will monitor the treatment regularly to see how it will react to your body and to make sure it works properly. It is very crucial that you keep all appointments to ensure the success of the monitoring. The lists of the side effects and the interactions listed above are not complete. Contact your provider for the complete listing. If you take the right dosage and follow your doctor's orders on managing your treatment, the drug should be a success.

Your provider may have to make some adjustments to the current medications that you take before starting the coagulant treatment. They may have to adjust the dosage or the frequency or they may have to prescribe some alternative to certain drugs. It could depend on the medical condition and your medical history.

You can administer the medicine either by yourself or by someone else other than your doctor (e.g. family member, caregiver). You should discuss with your doctor about this arrangement so that they will teach you how to give the injection. It is never a good idea for patients to inject themselves when they do not know how to do it properly and safely. It is very important that you learn as much about this medication as you can in order to make an informed decision that can make a positive impact on your health.

Last Reviewed:
December 22, 2017
Last Updated:
April 04, 2018
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