Antihemophilic Factor (Recombinant Porcine Sequence)

Antihemophilic factor temporarily raises factor VIII levels in blood to help with clotting.


Antihemophilic factor refers to a protein that occurs naturally in the blood and helps the blood to clot. Hemophilia develops when there's a deficiency of antihemophilic factor VIII. Antihemophilic factor medication temporarily increases factor VIII in blood to promote clotting.

Antihemophilic factor must not be used by people suffering from von Willebrand disease.

It can also be used for other purposes not covered in this article.

If you've ever had a serious allergic reaction to this medication in the past, don't use it. Also don't use it if you're allergic to beef or mouse proteins.

Your body may create antibodies against this medication, reducing its effectiveness. Call your physician if Antihemophilic factor seems to be ineffective in stopping your bleeding.

Carefully follow all directions on how to store Antihemophilic factor. Each brand of this medicine may have specific directions about storage at room temperature or in a refrigerator, and for a specific number of months only.

Before you take Antihemophilic factor, have your blood clotting condition diagnosed as a lack of factor VIII. This medication won't treat von Willebrand disease.

Your doctor may advise that you have a hepatitis vaccination prior to using Antihemophilic factor.

Some Antihemophilic factor brands aren't recommended for use by anybody under the age of 18. If you have questions about certain brands of Antihemophilic factor, ask your pharmacist.

Talk to your physician about the benefits and downsides of using Antihemophilic factor.

Conditions treated

  • Hemophilia A
  • Factor VII deficiency-related bleeding
  • Hemophilia A-related bleeding

Type of medicine

  • Antihemophilic agent

Side effects

Apart from its desirable effects, Antihemophilic factor can cause several undesirable effects. All of the side effects below may not occur, but if they occur they'll need medical attention.

Check with your physician right away if you feel any of these Antihemophilic factor side effects while using the medication.

More common:

Less common/rare:

  • Changes in face skin color
  • Chills
  • Irregular or fast breathing
  • Nausea
  • Tightness in chest
  • Hives/skin rash/itching
  • Swelling/puffiness around the eyes or in the eyelids
  • Troubled breathing
  • Unusual tiredness/weakness
  • Sensation of warmth, burning, heat, tightness, numbness, or tingling

Frequency unknown:

  • Bluish color of skin, fingernails, nail beds, palms, or lips
  • Blurred vision
  • Chest pain/discomfort
  • Cough
  • Confusion
  • Noisy breathing
  • Fast or deep breathing with dizziness
  • Trouble swallowing
  • Irregular, fast, or pounding heartbeat or pulse
  • Lightheadedness, dizziness, or faintness when suddenly standing up
  • Labored or difficult breathing
  • Numbness of the hands, feet, as well as around the mouth
  • Irregular or slow heartbeat
  • Sweating
  • Swelling or puffiness of the face, eyelids, tongue, lips, or around the eyes
  • Swelling of the throat, tongue, or face
  • Unusual weakness/tiredness

Some of the Antihemophilic factor side effects often don't require treatment. They may clear during treatment as the body gets used to Antihemophilic factor. In addition, your healthcare giver may recommend ways to prevent or ease some of the side effects. See your healthcare giver if you have questions about any of these side effects, if they are bothersome, or if they persist.

More common:

Less common:

  • Diarrhea
  • Swelling, burning, or stinging at the injection area
  • Lightheadedness or dizziness
  • Nosebleed
  • Vomiting
  • Bad taste in mouth or dry mouth
  • Loss or lack of strength
  • Redness of face


  • Change in taste
  • Loss of taste

Frequency unknown:

  • Stomach or abdominal pain
  • Feeling of warmth
  • Irritability
  • Increased sweating
  • Bone or muscle pain
  • Redness of eye
  • Redness of the neck, face, arms, and rarely, upper chest
  • Trouble seeing


Read all instructions on the prescription label and follow them. Don't use Antihemophilic factor in smaller or bigger quantities or for longer periods than recommended. Always verify the medicine's strength on the prescription label to ensure you're taking the correct potency.

Antihemophilic factor is injected via an IV into a vein. Your doctor may show you how an IV is used at home. Don't self-administer this medication if you don't know how to give the injection and correctly dispose of IV tubing, needles, and other tools used.

Read all information about the patient, medication guides, as well as instruction sheets provided. Ask your pharmacist or physician any questions you have.

Always keep your hands clean before preparing and administering an injection.

Antihemophilic factor is available in the form of a powder that must be combined with a liquid before it's used. If you're administering the injections on your own at home, make sure you know how to correctly mix and store Antihemophilic factor.

After mixing Antihemophilic factor with a liquid, store the solution at room temperature then use it within three hours. Don't put the solution in a refrigerator.

Only put your medication in a syringe when you're ready to inject yourself. A single-use vial should only be used once. Once you've measured your dose, discard this vial, even if it has some medicine in it.

Don't use Antihemophilic factor if there are particles in it or if it has changed colors. Get new medication from your pharmacist.

Only use a disposable syringe and needle once. Follow all local or state regulations about discarding used syringes and needles.

Be sure to monitor your pulse prior to and during injection. If it becomes rapid or slows down, wait until it returns to normal to give your injection.

While using Antihemophilic factor, you might need regular blood tests.

You may develop antibodies against the medication, decreasing its effectiveness. Contact your physician if this medication seems unable to control your bleeding.

It's vital to follow the dosage schedule as instructed by your healthcare giver. If you happen to miss one dose, call the healthcare giver to create a new schedule. Don't take double doses to catch up.

If you suspect an overdose, get in touch with your local poison control agency or seek medical care immediately. Be willing to describe what was taken, the amount, and when it occurred.


Your pharmacist/healthcare provider may already have an idea of any potential medication interactions and could be checking you for them. Check with your pharmacist or doctor first before you begin, stop, or alter the dose of any medicine.

Before using Antihemophilic factor, tell your pharmacist/physician about all of the drugs you're taking, be it over-the-counter, prescription, or herbal.

List all the medications you're using and share this list with your pharmacist and doctor.


Don't use Antihemophilic factor if you've had a serious allergic reaction to it before, or if you're allergic to rodent or beef proteins.

Before using this drug, you must have your blood clotting problem diagnosed as a lack of Factor VIII. If you have von Willebrand disease, Antihemophilic factor won't help you.

It's unclear whether Antihemophilic factor will be detrimental to an unborn child. Inform your physician if you're planning to get pregnant or are already pregnant while taking this medicine.

It's also unclear whether Antihemophilic factor could harm a breastfeeding baby or if it passes into human milk. Don't take this medicine without letting your doctor know you're breastfeeding.


All brands

If you're taking this medicine at home, keep unopened containers in the refrigerator or at room temperature.

Don't freeze this medication.

Keep the drug in its original container.

Protect the medication from light and heat.

If kept at room temperature, write down when this was done.

Keep all medications somewhere safe. Keep them far away from kids and pets.

Consult your pharmacist on how to dispose of unused medications.

Kovaltry & Novoeight

If kept at room temperature, dispose of unused bottles after 1 year or after the date of expiry, whichever comes first.

Don't keep the medication in a fridge after it's been kept at room temperature.


If kept at room temperature, dispose of unused bottles after three months or after the date of expiry, whichever comes first.

Don't keep Antihemophilic factor in the fridge if it has been kept at room temperature.


Tell all your healthcare givers that you take Antihemophilic factor. This includes your doctor, dentist, nurse, and pharmacist.

If you're allergic to latex, let your doctor know.

Allergic reactions may happen but rarely.

Have your blood tested as recommended by your doctor.

Call your doctor immediately if your regular dose doesn't seem to work as it should.

Antihemophilic factor is developed from human plasma and may contain viruses that can cause disease. The medication is tested, screened, and treated to minimize its risk of carrying an infection. Speak to your doctor about the benefits and risks of Antihemophilic factor.

Talk to your physician before you travel. You'll need to carry enough of the medication while traveling.

Tell your physician if you're allergic to medications like Antihemophilic factor, any other medications, foods, or other ingredients. Discuss the allergy with your doctor and what symptoms you had, including rash, itching, hives, shortness of breath, cough, wheezing, swelling of lips, face, throat, or tongue, etc.

Last Reviewed:
December 23, 2017
Last Updated:
April 02, 2018
Content Source: