Antihemophilic factor (AHF) injection helps to stop and improve severe bleeding occurrences in patients with hemophilia A. This is a bleeding problem that could be related to a surgery or a wound (trauma). The human body instinctively creates AHF because it aids the blood in the formation of blood clots, which better encourages bleeding to stop. This also causes it to stop occurring as much in the future.
Hemophilia A occurs when the body cannot produce an adequate amount of AHF. Blood cannot form clots correctly if it already does not have sufficient AHF and becomes injured. If the body bleeds internally, it can bleed into and harm the joints and muscles. The aim of the AHF injection is to raise the AHF levels within the blood.
AHF comes in several forms. Human blood naturally makes it, and it can also be manmade through a recombinant process. There are likely not any unsafe viruses such as human immunodeficiency virus (HIV), the virus that instigates acquired immunodeficiency syndrome (AIDS), hepatitis B, or hepatitis C in the AHF that comes from human blood. Artificial AHF does not contain such diseases, either.
A patient must obtain a prescription for an antihemophilic factor (AHF) injection to receive it. A doctor can also give additional advice and will be sure that the patient will have a reduced chance of experiencing side effects from potential food or medicine interactions.
There are several brand names for the antihemophilic factor (AHF) injection, including:
When contemplating whether or not an individual should have an injection, they should compare and contrast the side effects of the medication against how much it will help the patient. The doctor and the patient must work together to figure out if this is the right decision for the patient. See the summary on Warnings and Interactions for more information.
Be sure the physician is informed if there are any allergic or uncommon reactions to the medication including hives, skin rash, or any other skin abnormalities. Stop using the medication immediately if an allergic reaction occurs and consult a doctor. The health care professional needs to also be aware of any other allergies (for example to animals, foods, preservatives, or dyes).
Any allergies to mice, antihemophilic factor (human) should be disclosed to the physician. Allergies to drugs similar to this medication should also be disclosed to the physician.
The closure of the container (vial) is comprised of natural, dry rubber (a byproduct of latex). This can trigger an allergic reaction for individuals who are sensitive around latex. Be sure to let the doctor know if the patient has a latex allergy prior to receiving this medication.
The following side effects may not occur for patients, but if they occur they will require medical attention. Consult a physician immediately if any of these side effects are experienced:
Occasionally, side effects happen to patients but these do not require medical care. As the body becomes more familiar with the medication and learns how to react to it, these side effects can improve on their own. It is important to consult a physician with all side effects experienced, if any. A doctor will know how to prevent or reduce certain side effects, and can discuss bothersome symptoms or answer questions.
Consult a physician if any of these side effects are especially bothersome, or if you have general questions about them:
Some patients may experience additional side effects that are unlisted. It is highly important to always consult a healthcare professional if other side effects are noticed.
Consult a physician for medical direction. Side effects may also be reported to the FDA (1-800-FDA-1088).
A trained health professional or doctor will give this medicine to the patient in a clinic or hospital setting. The medication is given by means of a needle into a vein of the patient.
Patients who will not need to be in a clinic or hospital can receive the medication at home. The doctor or physician will be sure the patient or caretaker is familiar with how to get ready to inject the medication. It is important that the patient or caretaker understands every step of instructions prior to giving an injection. The dose can be adjusted according to the area that is bleeding. Be sure not to exceed the rate or amount of medication in the physician’s instructions.
The only brand of medication that should be used is the one that was prescribed by the doctor. Various brands are prepared differently, and they may even have dissimilar doses.
There is an instruction manual that is distributed with each package of the medication. Ensure all instructions are followed and read cautiously. Consult a physician if there are any questions.
Note: Be sure to use the medication within 3 to 4 hours of being mixed. Do not store this medication for later use. Do not store the medication in the refrigerator.
Be sure not to use needles and syringes more than once. Dispose of needles in a disposable container that is puncture-resistant, or follow disposal instructions from your physician.
Different patients will require different doses of this medication. Be sure to abide by the prescription label directions and the doctor’s orders. Consult your physician to find out how much is right for you.
The strength of the medication determines how much medicine can be taken in one dose. The total number of doses taken per day, the length of time it takes to take the medicine, and the total time between each dose are dependent on the patient’s unique medical issue for which they need the medication.
For patients with hemophilia A who experience bleeding occurrences:
Patients can receive dosage information from their physician only. The dose is calculated from the kind of bleeding episode and body weight.
Consult a pharmacist or doctor for information.
Contact the poison control center immediately or get medical care as fast as possible. Be sure to have information ready regarding when the overdose occurred, what was taken, and how much.
In certain cases, some medicines should not be combined under any circumstances. Other times, two medications can be used simultaneously even if there is a chance of possible interaction. During instances where it is okay to combine the medications, the doctor may adjust the dose of one or may take other precautions.
Discuss with your doctor the use of the medication with food, tobacco, or alcohol use.
Blood tests could be required before, during, or after this medication is being received. It is important to be sure the medicine is working the way it should be. The doctor must monitor the patient closely during this time.
Allergic reactions can occur while this medication is being administered, and after the patient has had the injection. Anaphylaxis is one allergic reaction that can occur. Anaphylaxis is extremely dangerous as it is deadly and demands emergency medical care. Consult a doctor immediately if the patient is experiencing itching, difficulty breathing, rashes, hoarseness, lightheadedness, swelling (mouth, face, or hands), difficulty swallowing, or dizziness after the medication is administered.
It is important to have an identification (ID) card expressing that the patient has hemophilia A. The type of medication should be printed on this card, and it should be carried everywhere in a purse or wallet. A physician can answer any questions regarding the type of identification that should be carried.
Consult a doctor immediately if the patient has symptoms of parvovirus infection. These symptoms include runny nose, chills, drowsiness, fever, joint pain, or rash.
Seek medical attention right away if there is tenderness or pain in the upper stomach, loss of appetite, pale stools, atypical weakness or tiredness, dark urine, yellow skin or eyes, or nausea. These symptoms could be first signs of liver issue.
This medication is naturally made from donated human blood. There is a very low risk of receiving a transmitted virus after taking this medication. Donated blood and donors are tested to ensure the risk of transmission is low. Discuss any concerns with your doctor.
Discuss traveling plans with your doctor as soon as possible as adequate medicine should be prescribed for treatment while traveling.
There have not yet been pediatric-specific studies that have demonstrated problems limiting the effectiveness of antihemophilic factor injection for children. It has not yet been confirmed whether or not this medication is effective and safe for children. There is no information presented regarding the age of a patient taking Hemofil® M.
There have not been any geriatric-specific issues identified when studying the correlation of age to side effects of Advate®, Eloctate™, Kogenate® FS, Kovaltry®, Novoeight®, or Xyntha®.
Age-related medical issues are more likely to take place for patients who are elderly. These types of issues require additional caution and a change in dose. There is not any documentation regarding the correlation of age to the side effects of antihemophilic factor injection for patients who are geriatric.
An adverse effect is present in animal studies but similar research in pregnant women has not been done, or there are no similar studies in pregnant women and no animal studies have taken place. Discuss with your doctor if you are pregnant or plan on becoming pregnant. There are some risks and benefits that will need to be discussed regarding the use of this medication while pregnant.
While breastfeeding, compare and contrast the risk of using antihemophilic factor injection. This medication has shown to pose a slight risk to the baby if used while breastfeeding. However, adequate studies are not present when defining risk to the baby to determine what the risk is. Be sure to weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Keep out of reach of children.
Be sure to cautiously follow all directions regarding storage of this medication. Various brands of human antihemophilic factor may have different storage directions specific to the brand.
Store the diluent and medication in the container it came in and keep it in the refrigerator. It should not be frozen. Prior to dosage, the items should be taken out of the refrigerator and brought to room temperature. The AHF products can alternatively be stored at room temperature for 3-12 months at a time.
Note the expiration date on the label and do not store the medication any longer than that date. Certain medications allow for the medication to be kept at room temperature until the date on the expiration label, or several months; whichever comes first. Carefully follow the storage information on the directions label.
If this medication is stored at room temperature, it should not be moved into the refrigerator. If the medication is moved out of the refrigerator to be stored at room temperature, be sure to note the date it is removed from the fridge on the container. The brand of medication will determine how long the medicine can be stored at room temperature.
The AHF products should be kept out of bright light and away from heat. Any medication that is leftover should be disposed of after the expiration date. Consult a physician to determine how leftover medication should be disposed of if it is not used.
Antihemophilic Factor (Intravenous Route) is a medication that is helpful in the treatment and prevention of serious bleeding episodes for patients with hemophilia A. These patients may be experiencing bleeding episodes due to an injury or surgery. Individuals should examine the risks and benefits clearly prior to taking this medication. The doctor must ensure the medication will not cause any adverse effects, which is why an accurate medical history is important to share. Individuals with allergies must take extra caution to alert their physician of these as well.
Patients must carefully watch out for side effects and report them to their healthcare professional if they experience any. Certain side effects do not require immediate medical care, but it is important to be proactive. Ensure to always follow the directions on the container, and consult the physician with any questions regarding dosage or general information regarding an antihemophilic factor (AHF) injection.