Ardeparin (Subcutaneous)

Ardeparin is a medication that can be taken via injection or solution. It is used to prevent a condition in which harmful blood clots form in the blood


Ardeparin is a medication used to prevent a blood clot issue called deep venous thrombosis, which is a condition where harmful blood clots form in the blood vessels of the legs and can travel towards your lungs. This can consequently cause them to become lodged within the blood vessels around and inside the lungs, a condition known as 'pulmonary embolism'. Ardeparin is often used for many days after a knee surgery such as knee replacement. You are at highest risk of forming blood clots when you are unable to walk. Ardeparin can also be used for a variety of other conditions, as determined by your doctor.

Conditions treated?

  • Prevent deep venous thrombosis
  • Prevent pulmonary embolism

Type of medicine?

  • Anticoagulant
  • Low molecular weight heparin
  • Subcutaneous route injection

Side Effects

As with all medications, along with the intended effects, there can be some unwanted side effects. Most side effects are harmless, but if they begin to deteriorate or you find yourself experiencing serious side effects, it is important that you inform your physician or doctor immediately. Below the side effects associated with Ardeparin are listed in terms of, 'less common' and rare'.

If you experience ANY of these side effects, STOP taking your medication immediately and seek urgent medical attention.

  • Prolonged bleeding from cuts
  • Black or red, or dark brown urine
  • Shortness of breath
  • Black or red tarry stools
  • Unexplained swelling, discomfort, or pain, especially in the abdomen, chest muscles or joints
  • Unusual bruising
  • Difficulty with breathing or swallowing
  • Weakness
  • Vomiting of blood or coffee ground material


  • Pain in the back area
  • Leg weakness
  • Pricking, burning tickling, or tingling sensation
  • Numbness
  • Rash that consists of pinpoint, purple-red spots that often start at the legs
  • Problems with bladder or bowel function

Consult your doctor if you appear with a skin rash, itching, hives or develop a fever.

Common side effects that do not require medical attention include general feelings of nausea, pain at the injection site and vomiting.

These side effects may disappear during treatment as your body begins to adjust to the Ardeparin. If your side effects are bothering you, consult with your healthcare professional on different ways to reduce or prevent some of these side effects.

Remember you can report any side effects to the FDA at 1-800-FDA-1088.


The dose of ardeparin will vary for different patients, depending on a variety of factors such as weight, age, height etc. Make sure you follow the directions on the label or your doctor's orders correctly. The following information only acts as a guide to the average doses of ardeparin. Do not change your dose to reflect these numbers, unless your doctor tells you to do so.

The amount of medicine that you take also depends on the strength of the medicine dosage, the length of time you take the medicine, the number of doses you take each day, the time allowed between doses, and which medical problem you are using the medicine for.

For injection dosage form:

For prevention of pulmonary embolism (lung clots) and deep venous thrombosis (leg clots):

  • Adults - The dose is given every 12 hours for up to 14 days after surgery.
  • Children - The specific use and dose must be determined by your physician.

If you find you have missed a dose of ardeparin, take your dose immediately unless it's almost time for your next dose. In this case, you should skip the missed dose and go back to your regular schedule of dosage. Under no circumstances should you take a double dose.

To administer, lie or sit down before receiving the injection. Begin by lifting a fold of skin and insert the needle completely into the fold at a 45 to 90-degree angle. Before injecting the medicine, pull back on the plunger a little to be sure that no blood is drawn back into the syringe. This will ensure that the needle is not in an artery or vein. Make sure you continue to pinch the skin until the injection is complete. To help prevent and lessen the effects of bruising, do not rub the area after injecting the medication.

This is only a guide to administration and your doctor will give you detailed advice on how to administer your relevant dosage.

Always remember to put used syringes in a disposable, puncture-resistant container or alternatively contact your healthcare professional and dispose of them as directed.


There are a variety of medications that can interact with the use of Ardeparin. When you are taking ardeparin, it is essential that you inform your healthcare professional if you are taking any of the medicines listed below.

Using this medicine with any of the following medicines is not recommended:

  • Defibrotide

Using this medicine with any of the following medicines is USUALLY NOT recommended, but may be required in some cases. Consult your doctor as they may change or alter dosage:

  • Aceclofenac
  • Acemetacin
  • Abciximab
  • Alteplase, Recombinant
  • Amtolmetin Guacil
  • Alipogene Tiparvovec
  • Anistreplase
  • Antithrombin, Recombinant
  • Bemiparin
  • Anagrelide
  • Bromfenac
  • Celecoxib
  • Bufexamac
  • Choline Salicylate
  • Citalopram
  • Clopidogrel
  • Collagenase, Clostridium histolyticum
  • Dexibuprofen
  • Clonixin
  • Dexketoprofen
  • Diflunisal
  • Diclofenac
  • Dipyridamole
  • Droxicam
  • Eptifibatide
  • Dipyrone
  • Escitalopram
  • Edoxaban
  • Etodolac
  • Etoricoxib
  • Felbinac
  • Etofenamate
  • Feprazone
  • Floctafenine
  • Fenoprofen
  • Fepradinol
  • Flufenamic Acid
  • Fluoxetine
  • Fluvoxamine
  • Flurbiprofen
  • Ibuprofen
  • Ketoprofen
  • Ibuprofen Lysine
  • Levomilnacipran
  • Iloprost
  • Indomethacin
  • Ketorolac
  • Lornoxicam
  • Lumiracoxib
  • Loxoprofen
  • Mefenamic Acid
  • Meclofenamate
  • Meloxicam
  • Nabumetone
  • Morniflumate
  • Nadroparin
  • Naproxen
  • Niflumic Acid
  • Nepafenac
  • Nimesulide
  • Nintedanib
  • Nimesulide Beta Cyclodextrin
  • Orlistat
  • Oxyphenbutazone
  • Oxaprozin
  • Parecoxib
  • Paroxetine
  • Piracetam
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Proglumetacin
  • Prasugrel
  • Propionic Acid
  • Proquazone
  • Propyphenazone
  • Reteplase, Recombinant
  • Salicylic Acid
  • Salsalate
  • Rofecoxib
  • Sertraline
  • Streptokinase
  • Sodium Salicylate
  • Sulfinpyrazone
  • Sulindac
  • Tenoxicam
  • Tenecteplase
  • Tiaprofenic Acid
  • Tirofiban
  • Ticlopidine
  • Tolmetin
  • Treprostinil
  • Valdecoxib
  • Urokinase
  • Vilazodone
  • Vortioxetine
  • Vorapaxar

Interactions with other medical problems

The presence of other medical problems can have an impact on the use of Ardeparin. Ensure you inform your doctor if you have any other medical problems, especially:

  • Bleeding problems
  • Eye problems caused by high blood pressure or diabetes
  • Heart infection
  • Liver disease
  • High blood pressure (hypertension)
  • Kidney disease
  • Stomach or intestinal ulcer (active)
  • Stroke (the risk of bleeding may be increased)

You should also inform your doctor or physician if you have consumed heparin or ardeparin before and whether you reacted to either of them with thrombocytopenia, which is a low platelet count in the blood, or if you are aware that new blood clots formed when you were receiving the medicine.


There are some things to be aware of before you start taking Ardeparin. Always remember to inform your doctor of all medications you are currently taking, whether they are prescription drugs or herbal drugs.

Allergic reactions

Inform your physician or doctor if you've ever had any allergic or unusual reactions to this medicine or any other medicines. You need to inform your healthcare professional about any other allergies you may have, such as to dyes, food, animals or preservatives. Don't withhold any important information.

Do not take aspirin, ibuprofen (Advil, Motrin, Nuprin, etc), ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Anaprox, Aleve and others), indomethacin, or any other nonsteroidal anti-inflammatory medication without consulting with your doctor beforehand. This is because of the risk associated with these medicines to increase bleeding when taken with ardeparin.

Do not use this medication if you....

  • Have uncontrolled active bleeding
  • Have a very low level of platelets in your blood
  • Are allergic to pork products
  • Can't have accurate blood testing done during and prior to dosing

Before using ardeparin, tell your doctor if you...

  • Have high blood pressure that is not being well controlled
  • Have bacterial endocarditis
  • You are on a waiting list to have an invasive procedure, such as surgery
  • Have a stomach ulcer
  • Have haemophilia or another associated blood disorder
  • Have eye problems due to high blood pressure or diabetes
  • Have kidney disease or liver disease

Pregnancy and the use of Ardeparin

Ardeparin is in the FDA pregnancy category C, meaning that it's not known whether the use of ardeparin during pregnancy will harm an unborn baby. It's therefore imperative that you do not take ardeparin without speaking with your doctor first if you are pregnant.

Specifically, results show findings that: "Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women."

For those who have already given birth, it's not known if ardeparin passes through to the breast milk you are feeding your child so it's important you do not use this medication without consulting your doctor if you're breastfeeding a baby.


This medication needs to be stored in a closed container at room temperature, away from moisture, direct light and heat. Ensure you prevent it from freezing. Always remember to keep out of reach of children and if you finish your dosage early for whatever reason, contact your local pharmacy to find out what is the best way to dispose of the medication for a healthy environment.


Ardeparin, when taken correctly, can help prevent the build-up of blood clots in the body, which could lead to pulmonary embolism. It is important to note that, if taken incorrectly, there could be a result of bleeding when ardeparin is taken with any of the other medications listed above. It also cannot be used in people with particular conditions, especially related to blood issues. It is therefore imperative that you inform your doctor or physician about all the different medications you are currently taking and give them a complete health history of both you and any health issues within the family. Once it is determined that it is safe for you to take Ardeparin, then you have a good chance of the medication working to prevent blood clots.

Please be aware that this medication is only available via direct prescription from your doctor or physician. Be aware that the effects of the medication are different on adults and children. Studies on the use of Ardeparin have been conducted only in adult patients, and there is no specific information that compares the use of ardeparin in other age groups with the use in children. It's therefore sensible to weigh up the positives and negatives of choosing to use Ardeparin in children with no known results. Your doctor may decide to choose an alternative medication route in the event of medication needed to prevent blood clots. It is generally not recommended for pregnant women, however, discuss with your physician or doctor for an alternative route or solution. Do not go ahead and take the medication without prior advice.

Last Reviewed:
December 22, 2017
Last Updated:
April 04, 2018