Aspirin and Dipyridamole

Aspirin and Dipyridamole is used by patients who’ve had a transient ischemic attack or “mini stroke” or a full stroke caused by a blood clot.

Overview:

Aspirin and Dipyridamole is a prescription medication. It comes as an extended-release pill that is taken by mouth. It’s normally taken twice daily, in the morning and evening. The capsule must be swallowed whole. You must not open, break, chew, or crush the capsules.

This drug combines two medications: Aspirin and Dipyridamole. Therefore, it is important to understand the medications in the combination as they each could have unique traits.

This medication is taken to prevent strokes in patients who’ve suffered a “mini stroke” known as transient ischemic attack, or a full stroke caused by a blood clot. Sometimes this is called “secondary stroke prevention”.

Aspirin and Dipyridamole belongs to a drugs class known as antiplatelets. Platelets reside in the blood and they’re essential for helping your blood clot (they stick together and develop a clot). This drug is a mix of two different medicines that combine to help prevent platelets from forming a clot. Once your risk of clots is reduced, your risk of suffering a stroke is also lowered.

Carefully follow the instructions found on your prescription, and ask your pharmacist or doctor to clarify for you any part you don’t understand. Take this medication exactly as instructed. Don’t take it more times than prescribed or take it in smaller or larger quantities.

While Aspirin and Dipyridamole decreases your chances of suffering a stroke, it doesn’t do away with that risk. Keep on taking the medication even if you get better. Don’t stop taking the medicine without consulting your physician.

Conditions treated:

  • Prevents stroke

Type of medicine:

  • Antiplatelet

Side effects:

Aside from its positive effects, Aspirin and Dipyridamole can bring about some undesirable effects. Of course not all of the effects below can occur, but for those that occur, you may need immediate medical attention. See your physician right away if you notice the following effects when using Aspirin and Dipyridamole.

More common:

  • Vomiting
  • Stomach/abdominal pain

Less common:

  • Memory loss
  • Double vision
  • Rectal bleeding
  • Unexplained nosebleeds or bloody mucous
  • Confusion
  • Seizures (convulsions)
  • Black, tarry, or bloody stools
  • Difficult breathing
  • Speaking difficulty
  • Inability to speak
  • Slow speech
  • Inability to move facial muscles, legs, or arms
  • Pale skin
  • Red or purple spots on skin
  • Unusual bruising/bleeding
  • Vomiting coffee-grounds like material or blood

Rare:

  • Chills
  • Cough
  • Abdominal/stomach fullness
  • Blood in urine
  • Nausea
  • Recurrent fever
  • Noisy breathing
  • Watering of eyes
  • Loss of appetite
  • Itching, redness, swelling, or pain in the eyelid or eye
  • Deep, purple bruise
  • Gaseous stomach/abdominal pain
  • Clay-colored stools
  • Collection of blood under skin
  • Hives or skin rash (severe)
  • Yellow skin or eyes

Get emergency assistance straight away if you have any of these overdose symptoms while using Aspirin and Dipyridamole.

  • Blurred vision
  • Flushes
  • Hearing loss
  • Sweating
  • Restlessness
  • Irregular or rapid heartbeat
  • Continuing buzzing or ringing, or other unusual noise in ears
  • Lightheadedness, faintness, or dizziness when suddenly standing up
  • Warm feeling
  • Unusual tiredness/weakness

Some Aspirin and Dipyridamole side effects may happen that generally don’t need treatment. They may disappear while your body adapts to Aspirin and Dipyridamole. Your healthcare provider may also help you find ways to reduce or prevent some of the effects. Make sure to see your doctor if any of these effects continue, bother you, or you need more information about them.

More common:

  • Headache
  • Diarrhea
  • Acid/sour stomach
  • Belching
  • Heartburn
  • Indigestion
  • Difficulty with moving
  • Swelling, redness, or pain in the joints
  • Muscle pain/stiffness
  • Stomach upset or discomfort

Less common/rare:

  • Back pain
  • Loss of taste
  • Rectal swelling or pain
  • Loss of energy or strength
  • Tenderness in stomach area
  • Unusual drowsiness or sleepiness
  • Burning sensation in the stomach or chest

Dosage:

Read the leaflet with patient information if issued by your pharmacist prior to taking Aspirin and Dipyridamole, and every time you have a refill. Ask your pharmacist or doctor any questions you may have.

Take Aspirin and Dipyridamole by mouth (orally) with or without meals as ordered by your doctor, normally twice a day (morning and evening). Make sure to swallow the whole capsule. Don’t chew or crush the capsules or you’ll release the entire medication at once, putting you at a higher risk of its side effects.

Take Aspirin and Dipyridamole with 8 ounces (1 glass) of water unless directed otherwise.

Some factors that determine dosage include your response to treatment and medical condition. Use Aspirin and Dipyridamole on a regular basis to get the most out of it. Take the medicine at the same time every day so you can remember.

Don’t attempt to replace this drug combination by taking aspirin and dipyridamole separately. You won’t be able to have the slow-release form and right dose, so the separate medicines wouldn’t work as effectively as this combination drug. For more information, see your pharmacist.

Interactions:

Aspirin and Dipyridamole can interact with certain medications, vitamins, or herbs you may be using. That’s why your physician should administer all your medicines carefully. If you’d like to know about how Aspirin and Dipyridamole can interact with anything else you’re taking, consult with your healthcare providers.

Note: You can minimize the risk of medicine interactions by filling all your prescriptions at one pharmacist. This way, a pharmacist will be able to check for potential drug interactions.

Don’t take Aspirin and Dipyridamole with alcohol. If you take at least 3 alcoholic drinks daily, don’t take this medication or you’ll increase your risk of bleeding.

Medicines that could interact with Aspirin and Dipyridamole

Drugs for heart conditions:

Adenosine - Aspirin and Dipyridamole may up adenosine levels in your body. Thus, this may affect the work of adenosine on your heart. Your physician may reduce your adenosine dose to prevent side effects.

Blood pressure medications
Beta-blockers
Diuretics
ACE (angiotensin-converting enzyme)

When used with Aspirin and Dipyridamole, these medicines might not work as effectively to reduce blood pressure levels.

Acetazolamide - Aspirin and Dipyridamole can make your body take longer to get rid of acetazolamide. Therefore, acetazolamide will accumulate in your body, which may increase the risk for toxicity and side effects.

Blood–thinning medicines:

  • Heparin
  • Warfarin
  • Clopidogrel
  • Apixaban
  • Ticlopidine
  • Prasugrel
  • Rivaroxaban
  • Dabigatran
  • Enoxaparin
  • Dalteparin
  • Ticagrelor

Taking Aspirin and Dipyridamole together with other blood-thinning medicines can increase your chances of bleeding.

Anti-seizure medications:

  • Valproic acid
  • Phenytoin

Aspirin may affect anti-seizure medication levels in your body. In other words, the anti-seizure medications you take might not work as effectively to control seizures. Your physician may need to alter your doses of anti-seizure medications.

Medications for treating myasthenia gravis:

  • Pyridostigmine
  • Dipyridamole may weaken the effects of myasthenia gravis medications. In other words, they might not work as effectively to treat myasthenia gravis.
  • Methotrexate - Aspirin can hinder the kidneys from getting rid of methotrexate, which may cause the medication to accumulate in the body. This may increase the risk of toxicity and side effects.

NSAIDs (non-steroidal anti-inflammatory drugs):

  • Ibuprofen
  • Naproxen
  • Fenoprofen
  • Diclofenac
  • Indomethacin
  • Etolodac
  • Sulindac
  • Ketoprofen

The combination of NSAIDs and Aspirin can increase your chances of bleeding or weaken the functioning of your kidneys.

Diabetes drugs:

  • Metformin
  • Glipizide
  • Glyburide
  • Glimepiride
  • Natiglinide
  • Repaglinide
  • Pioglitazone
  • Rosiglitazone

Aspirin may increase diabetes drug levels in your body, which may lead to hypoglycemia (low levels of blood sugar).

Gout medications:

  • Sulfinpyrazone
  • Probenecid

Aspirin may hinder the effects of the above gout medicines, which may increase your chances of suffering gout attacks.

This list of drug interactions is by no means complete. There could be other drugs that might interact with this medication. Let your healthcare providers know about all the drugs you’re currently using, such as minerals, vitamins, prescription, nonprescription, and herbal medications. You should never start taking a new drug without informing your doctor.

Warnings:

Before you take Aspirin and Dipyridamole, let your healthcare providers know of any allergies you have to Aspirin or Dipyridamole. Also let them know if you have allergies to NSAIDs (e.g. naproxen, ibuprofen), other salicylates (e.g. choline salicylate), or if you have got any other allergies. Aspirin and Dipyridamole may have some inactive ingredients, which could trigger allergic reactions or several other problems. For more details, have a conversation with your pharmacist.

Before taking Aspirin and Dipyridamole, let your pharmacist or other healthcare provider know your medical past, especially of bleeding problems (such as low platelets, vitamin K deficiency, hemophilia), aspirin-sensitive asthma (worsening breathing with stuffy or runny nose after using aspirin or other non-steroidal anti-inflammatory drugs), heart problems (such as heart attack, angina), hypotension (low blood pressure), nasal growths (nasal polyps), stomach problems (e.g. heartburn, ulcers), liver disease, kidney disease, bleeding in the brain, a certain muscle condition (myasthenia gravis), rhinitis, and asthma syndrome.

Aspirin and Dipyridamole can make you feel dizzy. Taking this drug with marijuana or alcohol can make you even dizzier. Make sure you don’t use heavy machinery, drive a vehicle, or carry out any task that needs attentiveness until you are able to do it safely. If you’re taking marijuana, let your physician know.

Aspirin and Dipyridamole can bring about stomach bleeding. Taking this medication daily together with alcohol and cigarettes can increase your chances of experiencing stomach bleeding. Limit your alcohol intake and quit smoking. Discuss with your pharmacist or doctor how much drink you may safely have.

Before you have an operation, let your dentist or doctor know about all drug products you’re using, such as nonprescription and prescription drugs, vitamins, minerals, and herbal drugs. Make sure to mention some of these medications:

  • Acetazolamide (Diamox)
  • Ambenonium (Mytelase)

Angiotensin-converting enzyme inhibitors:

  • Benazepril (Lotensin)
  • Enalapril (Vasotec)
  • Captopril (Capoten)
  • Lisinopril (Prinivil, Zestril)
  • Fosinopril (Monopril)
  • Quinapril (Accupril)
  • Ramipril (Altace)
  • Trandolapril (Mavik)
  • Moexipril (Univasc)

Anticoagulants/blood thinners:

  • Heparin
  • Warfarin (Coumadin)

Beta-blockers:

  • Bisoprolol (Zebeta)
  • Acebutolol (Sectral)
  • Betaxolol (Kerlone)
  • Carvedilol (Coreg)
  • Metoprolol (Lopressor)
  • Labetalol (Normodyne)
  • Penbutolol (Levatol)
  • Carteolol (Cartrol)
  • Pindolol (Visken)
  • Propranolol (Inderal)
  • Timolol (Blocadren)
  • Nadolol (Corgard)
  • Atenolol (Tenormin)
  • Sotalol (Betapace)

Diabetes medications:

  • Acetohexamide (Dymelor)
  • Glimepiride (Amaryl)
  • Repaglinide (Prandin)
  • Glyburide (Glynase, DiaBeta, Micronase,)
  • Tolbutamide (Orinase)
  • Chlorpropamide (Diabinese)
  • Tolazamide (Tolinase)
  • Glipizide (Glucotrol)

Diuretics (“water pills”):

  • Bumetanide (Bumex)
  • Furosemide (Lasix)
  • Hydrochlorothiazide (Hydrodiuril)
  • Torsemide (Demadex)
  • Metolazone (Zaroxolyn)
  • Chlorthalidone (Hygroton)
  • Ethacrynic acid (Edecrin)
  • Chlorothiazide (Diuril)
  • Triamterene (Dyrenium)
  • Indapamide (Lozol)
  • Amiloride (Midamor)
  • Spironolactone (Aldactone)

NSAIDs :

  • Diclofenac (Cataflam)
  • Diflunisal (Dolobid)
  • Celecoxib (Celebrex)
  • Choline salicylate (Arthropan)
  • Flurbiprofen (Ansaid)
  • Ibuprofen (Motrin, Advil, Nuprin, etc)
  • Naproxen (Aleve, Naprosyn)
  • Magnesium salicylate (Nuprin, Doan's, Backache)
  • Meclofenamate
  • Ketorolac (Toradol)
  • Nabumetone (Relafen)
  • Meloxicam (Mobic)
  • Piroxicam (Feldene)
  • Oxaprozin (Daypro)
  • Sulindac (Clinoril)
  • Tolmetin (Tolectin)
  • Indomethacin (Indocin)
  • Ketoprofen (Oruvail, Orudis)
  • Etodolac (Lodine)
  • Mefenamic acid (Ponstel)
  • Fenoprofen (Nalfon)

Other medicines:

  • Methotrexate (Mexate, Folex, Rheumatrex)
  • Probenecid (Benemid)
  • Pyridostigmine (Mestinon)
  • Depakene
  • Depakote
  • Valproic acid
  • Neostigmine (Prostigmin)
  • Phenytoin (Dilantin)
  • Sulfinpyrazone (Anturane)

Your doctor may order you to stop taking Aspirin and Dipyridamole 10 days prior to your operation. Don’t stop using this medicine before you talk to the doctor that prescribed it.

The level of aspirin in Aspirin and Dipyridamole might not be sufficient enough to ward off a heart attack. To prevent a heart attack with aspirin, be sure to consult your healthcare giver for advice.

As this drug has aspirin in it, children and teens younger than 18 must not use aspirin if they’ve got flu, chickenpox, or any undiagnosed condition or if they have received a vaccine recently. In such cases, using aspirin increases the chances of one developing Reye’s syndrome, a serious but rare illness.

Older people may be more vulnerable to the effects of Aspirin and Dipyridamole, especially bleeding and dizziness.

Aspirin should not be used during pregnancy. This drug should only be taken if it is absolutely necessary in the first six months of pregnancy. Women should avoid Aspirin and Dipyridamole during the final three months of pregnancy as it may affect the unborn child or cause several problems during delivery. Please discuss the medicine’s benefits and risks with your physician.

Aspirin and Dipyridamole has been shown to pass into human milk. If you’re using this medication, breastfeeding is not recommended. Talk to your physician before breastfeeding.

Storage:

Keep Aspirin and Dipyridamole in its original container.

Keep the container away from kids and tightly closed.

Keep Aspirin and Dipyridamole at room temperature.

Keep this drug away from too much moisture and heat (don’t keep it in the kitchen or bathroom).

Throw away any unused drug or one that’s no longer needed.

Talk to your local pharmacist about how to properly discard this medication.

Summary:

Strokes occur when there’s blockage of an artery or vein in the brain caused by blood clots. Aspirin and Dipyridamole will thin your blood and prevent the formation of blood clots. It’s only administered where there’s a greater risk of these problems occurring.

Aspirin and Dipyridamole is only available with a doctor’s prescription. It comes in the form of a capsule or extended release capsule, and under the brand name Aggrenox.

You may suffer headaches when you start taking Aspirin and Dipyridamole for the first time but these are usually temporary. If the headaches are too severe, tell your doctor. He/she may reduce your dose briefly.

Do not take Aspirin and Dipyridamole without informing your doctor about your pregnancy. This medication could harm your unborn child. Find an effective birth control option and notify your physician if you get pregnant during treatment.

Do not share Aspirin and Dipyridamole with anyone else. Lab and medical tests (e.g. blood counts, bleeding times, liver and kidney function) may be done regularly to check your progress or look for side effects. Honor all your lab and medical appointments.

Aspirin shouldn’t be administered to a kid or teenager with fever, particularly if the kid has symptoms of chicken pox or flu. Aspirin may cause a severe and sometimes deadly condition known as Reye’s syndrome in kids.

Stop using Aspirin and Dipyridamole and contact your doctor as soon as you notice any bleeding symptoms in your stomach and/or intestines. These symptoms include fainting or weakness, black, tarry, or bloody stools, coughing up blood, as well as vomiting something that resembles coffee grounds.

Avoid taking alcohol while using Aspirin and Dipyridamole. Drinking may increase your chances of stomach bleeding. Seek your doctor’s advice if you drink more than 3 alcoholic beverages a day and want to use this medication.

Unless your healthcare provider says otherwise, continue your usual diet while taking this medication.

If an overdose occurs, get in touch with the nearest poison control center as soon as possible at 1-800-222-1222. If the victim is not breathing or has passed out, call your local emergency services immediately using the number 911.

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Last Reviewed:
December 22, 2017
Last Updated:
December 22, 2017