Aspirin and Omeprazole (Oral)

Aspirin and Omeprazole can be prescribed as a combination medication and is used when patients are at risk of suffering from heart and/or blood vessel problems.


Although Aspirin can be used in numerous ways, it is often prescribed to patients who are at risk of certain conditions. Often given to patients who are at risk of heart problems, such as heart attacks or strokes, Aspirin can successfully reduce the risk of heart and blood vessel issues occurring.

Aspirin inhibits platelets in the blood from clotting. Whilst some level of clotting is normal, if blood clots within the blood vessels, it can prevent blood from getting to and from the heart. If a blood clot blocks the artery completely, it's likely that the patient will suffer a heart attack. Alternatively, if a blood clot moves within the blood vessel, it may travel to other areas of your body and cause significant damage, such as a stroke.

For patients with a history of heart problems or patients with a significant risk of developing heart problems, Aspirin can be an ideal preventative measure.

Similarly, patients with a high level of cholesterol or plaque in their blood vessels may be at increased risk of suffering heart issues. When fatty deposits build up within a blood vessel, the vessel is effectively narrowed. Also known as atherosclerosis, this condition brings complications of its own. If a patient's blood vessels are already narrowed and a clot occurs, the risk of a heart attack may be increased. In addition to this, there is the risk that a fatty deposit in the blood vessel will burst, leading to a blood clot blocking the artery very quickly.

By reducing the ability of the blood to clot, Aspirin can help to avoid further complications occurring. Although Aspirin is an effective antiplatelet agent, it could be harmful to patients who are at risk of developing a stomach ulcer.

Non-steroidal anti-inflammatory drugs, such as Aspirin, can cause damage to the gastroduodenal mucosa and, as a result, a stomach ulcer may occur. Omeprazole is a proton pump inhibitor and reduces the amount of acid in the stomach. By doing so, Omeprazole can prevent patients from developing stomach ulcers.

As the risk of suffering from a stomach ulcer increases if the patient takes Aspirin on a long-term basis, using Omeprazole helps to prevent additional problems for developing.

Although some patients may be prescribed Aspirin and Omeprazole as a full treatment regime, it is often used in conjunction with other treatments and surgical procedures.

Whilst Aspirin and Omeprazole can be prescribed separately, it is often more efficient to prescribe them as a combination medication. When given in this way, doctors can be sure that patients are receiving the correct amount of each medication.

In addition to this, patients are able to take fewer tablets each day, which makes the combination medication a more convenient form of treatment. Furthermore, using Aspirin and Omeprazole as a combination medication negates the risk of the patient forgetting to take the Omeprazole and developing a stomach ulcer as a result.

Conditions Treated


  • Heart conditions, such as heart attacks
  • Blood vessel conditions, including Atherosclerosis
  • Strokes and Transient Ischemic attacks


  • Gastroesophageal reflux disease (GERD)
  • Erosive esophagitis
  • Excess stomach acid

Type of Medicine


  • Non-Steroidal Anti-Inflammatory Drug (NSAID)
  • Antiplatelet Agent


  • Proton Pump Inhibitor

Side Effects

When taking a combination medication, such as Aspirin and Omeprazole, it's important to remember that side-effects can be caused by either, or both, active ingredients. Although these side-effects are fairly rare, patients should seek immediate medical help if they experience:

  • Unusual bruising or bleeding
  • Bloody or black, tarry stools
  • Blood in urine
  • Bloody vomit
  • Vomit that looks like coffee grounds
  • Severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps
  • Frequent nosebleeds
  • Fever
  • Changes in urination, swelling of the hands and feet, rash, itching, or having breath that smells like ammonia
  • Yellowing of the skin or eyes
  • Dark urine
  • Pain or discomfort in right upper stomach area
  • Shortness of breath, lightheadedness, muscle weakness, pale skin, feeling tired, mood changes, or numbness
  • Seizures, dizziness, muscle aches, or hand or feet spasms
  • Joint pain
  • Rash, especially a rash on the cheeks or arms that gets worse in sunlight

In some instances, patients may also suffer from:

In most instances, these side-effects are relatively mild and do not last for a long time. If side-effects are severe or prolonged, patients should seek advice from their physician.


Generally, Aspirin and Omeprazole is prescribed in the form of a delayed release tablet. This means that the active ingredients are released throughout the day, once the tablet has been consumed. As a delayed release medication, Aspirin and Omeprazole provides appropriate treatment on a continuous basis.

For many patients, the standard dose is 1 delayed release tablet each day. Typically, tablets will contain 81 or 325mg of Aspirin and 40mg of Omeprazole.

Every patient will receive specific dosage instructions from their physician, however, so their treatment regime may differ from the standard dose specified. It's important that patients follow their physician's instructions when taking Aspirin and Omeprazole.

Children can be given Aspirin and Omeprazole if their physician believes it is an appropriate treatment for them. The standard dose for child patients is likely to differ, however, and will be dependent on their age and weight.

If a patient misses a dose of Aspirin and Omeprazole, they may be able to take the missed dose. They will only be able to do this if a minimal amount of time has elapsed, however. If it is almost time for the next dose to be administered, the missed dose should be skipped. Double doses of Aspirin and Omeprazole should not be taken under any circumstances.

If a dose has been missed and patients are unsure how to continue taking their medication, they should seek help from a medical professional, such as their physician or pharmacist.

If the medication is taken incorrectly or an overdose is suspected, it's vital to seek urgent medical help. Symptoms, such as blurred vision, confusion, dry mouth and/or increased sweating, may be indicative of an overdose of the active ingredients. It's essential that instances of overdose are treated as a medical emergency.

As well as seeking urgent medical assistance, patients can contact the Poison Control Center on 1-800-222-1222, if they suspect they have taken the wrong dose or have taken too much Aspirin and Omeprazole.

Potential Drug Interactions

Aspirin and Omeprazole could interact with other medications if they are taken at the same time. Due to this, patients should advise their physician of any medications, vitamins or herbal supplements they are taken or have taken in the recent past.

Patients should not generally be prescribed Aspirin and Omeprazole if they are taking:

  • Defibrotide
  • Dichlorphenamide
  • Influenza Virus Vaccine, Live
  • Ketorolac
  • Rilpivirine

Similarly, it is not usually advisable to prescribe patients Aspirin and Omeprazole if they are taking:

  • Acarbose
  • Aceclofenac
  • Acemetacin
  • Alipogene Tiparvovec
  • Alteplase, Recombinant
  • Amiloride
  • Amineptine
  • Amitriptyline
  • Amitriptylinoxide
  • Amoxapine
  • Amtolmetin Guacil
  • Anagrelide
  • Anisindione
  • Apixaban
  • Argatroban
  • Atazanavir
  • Bendamustine
  • Bendroflumethiazide
  • Benzthiazide
  • Beta Glucan
  • Bivalirudin
  • Bosutinib
  • Bromfenac
  • Bufexamac
  • Bumetanide
  • Celecoxib
  • Chlorothiazide
  • Chlorpropamide
  • Chlorthalidone
  • Choline Salicylate
  • Cilostazol
  • Citalopram
  • Clomipramine
  • Clonixin
  • Clopamide
  • Clopidogrel
  • Clorazepate
  • Clozapine
  • Conivaptan
  • Cyclopenthiazide
  • Cyclosporine
  • Dabigatran Etexilate
  • Danaparoid
  • Dasabuvir
  • Dasatinib
  • Delavirdine
  • Desipramine
  • Desirudin
  • Desvenlafaxine
  • Dexibuprofen
  • Dexketoprofen
  • Diazoxide
  • Dibenzepin
  • Diclofenac
  • Dicumarol
  • Diflunisal
  • Digoxin
  • Dipyrone
  • Dothiepin
  • Doxepin
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Eplerenone
  • Eptifibatide
  • Erlotinib
  • Escitalopram
  • Eslicarbazepine Acetate
  • Ethacrynic Acid
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Feverfew
  • Floctafenine
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • Furosemide
  • Gefitinib
  • Ginkgo
  • Glimepiride
  • Glipizide
  • Glyburide
  • Gossypol
  • Heparin
  • Hydrochlorothiazide
  • Hydroflumethiazide
  • Ibuprofen
  • Imipramine
  • Indapamide
  • Indinavir
  • Indomethacin
  • Ketoconazole
  • Ketoprofen
  • Ledipasvir
  • Lepirudin
  • Levomilnacipran
  • Lithium
  • Lofepramine
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Melitracen
  • Meloxicam
  • Metformin
  • Methotrexate
  • Methyclothiazide
  • Metolazone
  • Milnacipran
  • Morniflumate
  • Mycophenolate Mofetil
  • Mycophenolic Acid
  • Nabumetone
  • Naproxen
  • Nateglinide
  • Nefazodone
  • Nelfinavir
  • Nepafenac
  • Niflumic Acid
  • Nilotinib
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nortriptyline
  • Ombitasvir
  • Opipramol
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Paritaprevir
  • Paroxetine
  • Pazopanib
  • Pemetrexed
  • Pentosan Polysulfate Sodium
  • Pentoxifylline
  • Phenindione
  • Phenprocoumon
  • Phenylbutazone
  • Piketoprofen
  • Piracetam
  • Piroxicam
  • Polythiazide
  • Pralatrexate
  • Pranoprofen
  • Prasugrel
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Protein C
  • Protriptyline
  • Repaglinide
  • Reteplase, Recombinant
  • Ritonavir
  • Rivaroxaban
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Saquinavir
  • Sertraline
  • Sodium Salicylate
  • Spironolactone
  • Sulindac
  • Tacrolimus
  • Tenoxicam
  • Tianeptine
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticlopidine
  • Tirofiban
  • Tolazamide
  • Tolbutamide
  • Tolfenamic Acid
  • Tolmetin
  • Torsemide
  • Treprostinil
  • Triamterene
  • Trichlormethiazide
  • Trimipramine
  • Valdecoxib
  • Varicella Virus Vaccine
  • Velpatasvir
  • Venlafaxine
  • Vilazodone
  • Vismodegib
  • Voriconazole
  • Vortioxetine
  • Warfarin
  • Xipamide

In some instances, however, doctors may proceed with Aspirin and Omeprazole treatment, even if the patient is taking one of the drugs listed above. If the potential benefits of the treatment outweigh the risks associated with the possible interaction, this can be a viable course of action.

If a patient is prescribed Aspirin and Omeprazole when taking one the above medications, their dosage instructions may be altered in order to reduce the chance of an interaction occurring.

The following medications may increase the chance of side-effects occurring when they are taken in conjunction with Aspirin and Omeprazole:

  • Acebutolol
  • Armodafinil
  • Atenolol
  • Betamethasone
  • Betaxolol
  • Bisoprolol
  • Captopril
  • Carbamazepine
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Cortisone
  • Delapril
  • Dexamethasone
  • Digoxin
  • Disulfiram
  • Enalaprilat
  • Enalapril Maleate
  • Esmolol
  • Fluconazole
  • Ginkgo Biloba
  • Imidapril
  • Iron
  • Labetalol
  • Levobunolol
  • Levothyroxine
  • Lisinopril
  • Methylprednisolone
  • Metipranolol
  • Metoprolol
  • Nadolol
  • Nebivolol
  • Nitroglycerin
  • Oxprenolol
  • Paramethasone
  • Penbutolol
  • Pindolol
  • Practolol
  • Prednisolone
  • Prednisone
  • Probenecid
  • Propranolol
  • Raltegravir
  • Sotalol
  • St John's Wort
  • Streptokinase
  • Tamarind
  • Temocapril
  • Tenecteplase
  • Timolol
  • Tipranavir
  • Triamcinolone
  • Triazolam
  • Valproic Acid
  • Warfarin

Although doctors may still prescribe Aspirin and Omeprazole alongside these medications, they may want to monitor any side-effects which occur. Often, the treatment can be modified to minimize the side-effects and additional medication may be suitable to relieve side-effects.

When Aspirin and Omeprazole is prescribed with Warfarin, for example, the patient's International Normalized Ratio may need to be monitored carefully. Warfarin is used to thin the blood and regular tests must be taken to ensure that the blood remains at an appropriate level of coagulation. As Aspirin also reduces the blood's ability to coagulate or clot, it could increase the effect of Warfarin and impact on the patient's INR levels. By monitoring the patient carefully, doctors can still prescribe Aspirin and Omeprazole alongside Warfarin and other medications, providing they think the treatment carries justifiable benefits.


If the patient has ever experienced an allergic reaction when taking Aspirin, Omeprazole, Ibuprofen or other non-steroidal anti-inflammatory drugs, they should inform their physician before taking Aspirin and Omeprazole.

Similarly, patients should discuss their medical history with their doctor prior to taking this medication. They are some conditions which may prevent Aspirin and Omeprazole from being prescribed or they may alter the treatment regimen the patient is prescribed. Patients should inform their doctor if they have ever suffered from:

  • Alcohol abuse or history of
  • Bleeding problems (e.g. hemophilia)
  • Cutaneous lupus erythematosus
  • Diarrhea
  • Hypomagnesemia (low magnesium in the blood)
  • Kidney disease
  • Liver disease
  • Osteoporosis (bone problems)
  • Stomach ulcers or bleeding
  • Systemic lupus erythematosus (SLE)
  • Aspirin-sensitive asthma
  • Aspirin sensitivity
  • Viral infections in children, suspected

Taking Aspirin and Omeprazole alongside cranberry and/or Ethanol can be harmful and should, therefore, be avoided.

When taking this medication, patients should have regular consultations with their physician. This ensures their treatment can be monitored and modified, if necessary.

Patients of an Asian descent may require a lower dose of Aspirin and Omeprazole. If relevant, they should consult their doctor prior to taking the medication and discuss whether a lower dose would be appropriate.

Consuming alcohol whilst taking Aspirin and Omeprazole could increase the risk of liver damage occurring. Patients who drink three or more alcoholic drinks on a daily basis should inform their doctor.

When Aspirin and Omeprazole is taken for long periods of time, patients may have difficulty in absorbing vitamin b12. If a vitamin b12 deficiency occurs, patients can experience a wide range of symptoms, such as disturbed vision, depression and/or tingling and numbness. If patients suspect they have a vitamin b12 deficiency, tests should be carried out and supplementation offered, if necessary.

If Aspirin and Omeprazole is taken for over a year, patients may be at an increased risk of developing hypomagnesemia. Patients who are also taking Digoxin or diuretics may be more prone to this condition. Symptoms, such as convulsions, tremors, fast or uneven heartbeat and/or muscle spasms should be investigated immediately. Patients should inform their medical professional that they are taking Aspirin and Omeprazole if hypomagnesemia is suspected.

Patients are not normally advised to take Aspirin and Omeprazole whilst pregnant, particularly in their last trimester, as it can put the fetus at risk of harm. Similarly, breastfeeding whilst taking Aspirin and Omeprazole could be harmful to the infant and is not, therefore, advised. If the patient becomes pregnant whilst taking this medication, they should contact their doctor immediately.

Taking Aspirin and Omeprazole can affect the fertility of female patients. If the patient is considering having children in the future, they should discuss this with their physician before taking this medication.

In some patients, Aspirin and Omeprazole may increase the risk of fractures to the hip, wrist and/or spine. Patients who are aged 50 or over, have taken Aspirin and Omeprazole for over a year and/or patients who are prescribed high doses of the medication, may be most likely to suffer from this particular complication.

In most circumstances, patients are advised to decrease their dosage slowly when they have finished treatment, rather than stopping the medication suddenly. When discontinuing Aspirin and Omeprazole, it's important that patients follow their physician's instructions.

If patients are due to undergo any surgical procedures, including dental work, they should inform the relevant medical professional that they are taking Aspirin and Omeprazole. As they may be required to suspend treatment, it's important that patients inform the relevant personnel at the earliest available opportunity.


As heart and blood vessel problems are a leading cause of premature death, it's vital that these issues are treated adequately. As well as having other medical uses, Aspirin is an extremely effective way to reduce the risks of heart and blood vessel conditions occurring. By reducing the clotting ability of the blood, patients are less likely to suffer from heart attacks, strokes and other complications when taking Aspirin.

Furthermore, Aspirin is a cost-effective medication and is widely available. In addition to its efficacy, this ensures that it remains one of the most popular forms of preventative treatment.

As the continued use of Aspirin has been associated with the development of stomach ulcers, using it in conjunction with Omeprazole is advisable. Whilst still benefiting from the Aspirin, patients can reduce the risk of suffering stomach complications by also taking a proton pump inhibitor, such as Omeprazole.

As these two medications are often prescribed simultaneously, patients can be given Aspirin and Omeprazole as a single, combination medication. As well as ensuring that patients have access to the appropriate dose, using a combination medication reduces the number of tablets patients are required to take on a daily basis.

In addition to this, prescribing Aspirin and Omeprazole as a combination medication places less pressure on the patient. By combining both active ingredients into one tablet or capsule, physicians ensure that patients do not suffer unnecessary complications due to confusion or skipped doses.

Appropriate for patients with a history of heart problems, as well as patients who may have a high risk of these issues occurring, Aspirin and Omeprazole is a popular and widely-used treatment. By helping to reduce instances of heart attack, strokes, and arterial blockages, Aspirin and Omeprazole can be used in numerous clinical environments and can successfully increase life expectancy.

Last Reviewed:
December 23, 2017
Last Updated:
April 05, 2018