Atenolol and Chlorthalidone

Atenolol and Chlorthalidone in combination are used by medical professionals as a solution to treat high blood pressure (hypertension), which can cause many negative effects and impact on the heart and body in high-risk ways.

Overview:

Atenolol and Chlorthalidone is an effective medication for the treatment of hypertension. Hypertension can add to the workload of the patient’s heart and arteries, leading to a reduction in function over time. This high blood pressure can cause damage to the blood vessels within the heart, brain, and kidneys over time. This can result in the patient suffering heart failure, a stroke or kidney failure. In addition, hypertension can lead to an increased risk of heart attack.

All of these symptoms and issues can be prevented or reduced by controlling the blood pressure of the patient, reducing hypertension. Atenolol and Chlorthalidone are two medications that are used in combination for this purpose.

Atenolol is a beta-blocker type medication. This drug works by altering the response from the brain to certain nerve impulses in some parts of the body, such as the heart. As a result of taking Atenolol, the heart beats slower. This then decreases the blood pressure.

When the hypertension is lowered by beta-blockers, the amount of blood and oxygen that reaches the heart is increased, reducing the risk of issues and illnesses caused by hypertension.

Chlorthalidone is a thiazide diuretic type medication (water pill). It acts to reduce the amount of water within the body. Diuretics do this by increasing the flow of urine, which then helps to lower blood pressure and reduce the risk of hypertension and related illnesses.

Both Atenolol and Chlorthalidone are only available via recommendation and prescription of a medical professional.

Conditions Treated:

  • High blood pressure (hypertension)

Type of Medicine:

  • Beta-blocker
  • Thiazide diuretic
  • Oral capsule tablets

Side Effects:

Along with the needed effects of the medication, taking Atenolol and Chlorthalidone may result in unwanted side effects, some of which may be more harmful than others.

Although only some of these side effects may occur, and not all are likely or can only be attributed to this medication, if they occur during the time the patient is taking Atenolol and Chlorthalidone, they should seek medical attention with a suitable professional:

More common side effects

  • Cold arms or legs
  • Difficult or labored breathing
  • Shortness of breath
  • Tightness in chest
  • Wheezing

Less common side effects

  • Chest pain or discomfort
  • Chills
  • Cold sweats
  • Confusion
  • Dizziness, faintness, or light-headedness when getting up from lying or sitting position
  • Leg pain
  • Light-headedness, dizziness, or fainting
  • Slow or irregular heartbeat
  • Unusual tiredness or weakness

Uncommon side effects

  • Black, tarry stools
  • Bleeding gums
  • Blood in urine or stools
  • Feeling that others are watching you or controlling your behavior
  • Feeling that others can hear your thoughts
  • Fever
  • General feeling of discomfort, illness, or weakness
  • Paleness or cold feeling in fingertips and toes
  • Pinpoint red spots on skin
  • Seeing, hearing, or feeling things that are not there
  • Severe mood or mental changes
  • Skin irritation or rash, including rash that looks like psoriasis
  • Tingling or pain in fingers or toes when exposed to cold
  • Unusual behavior
  • Unusual bleeding or bruising

Should the patient take an increased dose of Atenolol and Chlorthalidone without the recommendation of a medical professional, either purposefully or accidentally, they may experience symptoms of overdose.

Should any of the following symptoms occur, emergency help should be contacted immediately:

  • Blurred vision
  • Decreased urination
  • Dry mouth
  • Increase in heart rate
  • Muscle cramps or pain
  • Numbness, tingling, pain, or weakness in hands or feet
  • Rapid breathing
  • Seizures
  • Sunken eyes
  • Sweating
  • Thirst
  • Trembling
  • Weakness and heaviness of legs
  • Wrinkled skin

Other side effects of Atenolol and Chlorthalidone that occur as a result of the dosage or prescription may not require medical attention. These types of side effects are often either minor, which can be further determined by a medical professional, or may go away over time as the patient’s body adjusts to the drugs.

A doctor may be able to provide you with methods or ways to reduce or prevent unwanted side effects such as the following:

More common side effects

  • Discouragement
  • Feeling sad or empty
  • Irritability
  • Lack of appetite
  • Loss of interest or pleasure
  • Tiredness
  • Trouble concentrating
  • Trouble sleeping

Less common side effects

  • Diarrhea
  • Feeling of constant movement of self or surroundings
  • Nausea
  • Sensation of spinning
  • Unusual drowsiness, dullness, or feeling of sluggishness

Uncommon side effects

  • Decreased interest in sexual intercourse
  • Disturbed color perception
  • Double vision
  • Hair loss, thinning of hair
  • Halos around lights
  • Headache
  • Inability to have or keep an erection
  • Loss of sexual ability, desire, drive, or performance
  • Loss of vision
  • Night blindness
  • Overbright appearance of lights
  • Pain of penis on erection
  • Tunnel vision

For any serious side effects experienced as listed above, or any symptoms indicating an allergic reaction to the medication(s) such as difficulty breathing, hives, and swelling of the patient’s face, lips, tongue, or throat, aim to receive emergency medical attention as soon as possible by dialling 911 or immediately travelling to a place where medical support can be provided.

Dosage:

Atenolol and Chlorthalidone dosage is dependent on the decision of the medical professional who prescribes the drug, in addition to varying depending on the needs of the patient.

An average dosage of this combination, when used for the initial treatment of hypertension, is 50 mg of Atenolol and 25 mg of Chlorthalidone for an adult. For maintenance purposes, the average dosage can have an increase of up to 50 mg for Atenolol, up to 100 mg from 50 mg.

TENORETIC is the US brand name for medication containing a combination of Atenolol and Chlorthalidone, and is available in the following dosages:

  • TENORETIC 100 TABLET: 100 mg Atenolol / 25 mg Chlorthalidone
  • TENORETIC 50 TABLET: 50 mg Atenolol / 25 mg Chlorthalidone

The medication comes as a capsule to take orally, and is taken once per day as per the advice of the patient’s doctor or a relevant medical professional. Dosage may be increased from 50 mg Atenolol to 100 mg if the medication is not proving to be effective in its treatment of hypertension with the lower dose.

If the patient misses a dose of this medicine, they are advised to take it as soon as possible. However, if it is almost time for the next dose, for example, the following day, the missed dose should be skipped and the regular dosing schedule resumed. Doubling doses is not recommended or advisable unless specified by the patient’s doctor.

Interaction:

Many medications can interact negatively with other drugs within the human body, both with those currently being taken and those that have been taken recently, which can lead to altering effects of the medication and even increased side effects that can cause the drug to become ineffective or even cause harm/problems for the patient.

Patients and physicians should keep an up-to-date list of all medications and diagnostic drugs currently in use in order to prevent issues with negative drug interaction, and in order to build a fully realized picture of the patient’s medical history and any current or past reactions to drugs that may influence the medical professional’s decision to prescribe Atenolol and Chlorthalidone as a viable medication.

It’s of high importance that the patient’s doctor is made aware of every medication within their system, from long-term drugs to over the counter items, and makes a medical professional aware of their current and recent usage to ensure that treatment is less likely to cause harm and is effective.

Although certain medicines are not recommended to be used together at all, in other cases two medicines may be required to be used together even if interaction may occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in extenuating circumstances. If both medicines are prescribed in combination with Atenolol and Chlorthalidone, a medical professional may decide to change the dose or how often one or both of the medicines are used together:

  • Aceclofenac
  • Acemetacin
  • Acetyldigoxin
  • Amtolmetin Guacil
  • Arsenic Trioxide
  • Aspirin
  • Bepridil
  • Bromfenac
  • Bufexamac
  • Celecoxib
  • Choline Salicylate
  • Clonidine
  • Clonixin
  • Crizotinib
  • Deslanoside
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Digitalis
  • Digitoxin
  • Digoxin
  • Diltiazem
  • Dipyrone
  • Dofetilide
  • Dronedarone
  • Droperidol
  • Droxicam
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoldopam
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Fingolimod
  • Flecainide
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Ibuprofen
  • Indomethacin
  • Ketanserin
  • Ketoprofen
  • Ketorolac
  • Lacosamide
  • Levomethadyl
  • Lithium
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Metildigoxin
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta-Cyclodextrin
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Rivastigmine
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sodium Salicylate
  • Sotalol
  • Sulindac
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Valdecoxib
  • Verapamil

Using this drug with any of the following medications may cause an increased or exacerbated risk of certain side effects. However, using both medicines together may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Aceclofenac
  • Acemetacin
  • Acetyldigoxin
  • Albiglutide
  • Alfuzosin
  • Alogliptin
  • Amiodarone
  • Amtolmetin Guacil
  • Arbutamine
  • Aspirin
  • Bromfenac
  • Bufexamac
  • Bunazosin
  • Canagliflozin
  • Celecoxib
  • Chlorpropamide
  • Choline Salicylate
  • Clonixin
  • Dapagliflozin
  • Deslanoside
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Digitoxin
  • Digoxin
  • Dipyrone
  • Disopyramide
  • Doxazosin
  • Droxicam
  • Dulaglutide
  • Empagliflozin
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Exenatide
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Glimepiride
  • Glipizide
  • Glyburide
  • Gossypol
  • Ibuprofen
  • Indomethacin
  • Insulin Aspart, Recombinant
  • Insulin Degludec
  • Insulin Detemir
  • Insulin Glargine, Recombinant
  • Insulin Glulisine
  • Insulin Human Inhaled
  • Insulin Human Isophane (NPH)
  • Insulin Human Regular
  • Insulin Lispro, Recombinant
  • Ketoprofen
  • Ketorolac
  • Licorice
  • Linagliptin
  • Liraglutide
  • Lixisenatide
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Metformin
  • Metildigoxin
  • Mibefradil
  • Miglitol
  • Morniflumate
  • Moxisylyte
  • Nabumetone
  • Naproxen
  • Nateglinide
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta-Cyclodextrin
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Phenoxybenzamine
  • Phentolamine
  • Phenylbutazone
  • Piketoprofen
  • Pioglitazone
  • Piroxicam
  • Pramlintide
  • Pranoprofen
  • Prazosin
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Quinidine
  • Repaglinide
  • Rofecoxib
  • Rosiglitazone
  • Salicylic Acid
  • Salsalate
  • Saxagliptin
  • Sitagliptin
  • Sodium Salicylate
  • St John's Wort
  • Sulindac
  • Tamsulosin
  • Tenoxicam
  • Terazosin
  • Tiaprofenic Acid
  • Tolazamide
  • Tolbutamide
  • Tolfenamic Acid
  • Tolmetin
  • Trimazosin
  • Urapidil
  • Valdecoxib
  • Vildagliptin
  • Warfarin

Using this medication is not known to conflict with any particular foods or other items. However, consultation with a doctor is recommended, and based on this information a medical professional may decide to amend the dose or frequency at which you take this drug, or give you special guidelines about how to use this medication with this interaction and what to expect.

The presence of other pre-existing medical issues or conditions may affect the use of this medicine or how it functions. Make sure you inform a medical professional if you have any other medical condition, including but not limited to the following conditions:

  • Angina (severe chest pain)
  • Anuria (not able to form urine)
  • Bradycardia (slow heartbeat)
  • Heart block
  • Heart failure
  • Pheochromocytoma (adrenal gland tumor), untreated
  • Blood vessel disease (circulation problems)
  • Gout
  • Hyperuricemia (high uric acid in the blood)
  • Hypochloremia (low chloride in the blood)
  • Hypokalemia (low potassium in the blood)
  • Hyponatremia (low sodium in the blood)
  • Systemic lupus erythematosus
  • Diabetes
  • Hyperthyroidism (overactive thyroid)
  • Hypoglycemia (low blood sugar)
  • Kidney disease
  • Liver disease
  • Lung disease (e.g., asthma, bronchitis, emphysema)
  • Sympathectomy

Warnings:

If the patient suffers from any of the following conditions, they should inform their doctor immediately prior to taking any medication containing Atenolol and Chlorthalidone to avoid any complications or issues:

  • A heart problem such as a slow heart rate or heart block
  • Inability to urinate
  • Allergy to sulfa drugs (such as Septra, Bactrim, Smx-Tmp, Sulfatrim and others).

To help ensure the patient is a suitable candidate for this medication, they should ensure their doctor is aware of any conditions that may affect this medication of influence the medical professional’s decision to prescribe Atenolol and Chlorthalidone as a solution for hypertension:

  • A history of heart disease
  • Circulation problems, coronary artery disease (hardened arteries)
  • (Chest pain) Angina
  • Bronchitis, Asthma or other lung disorder
  • Cirrhosis or other liver disease
  • Kidney disease
  • A thyroid disorder
  • Diabetes
  • Lupus
  • An electrolyte imbalance (such as low levels of potassium in your blood)
  • Gout
  • Psoriasis
  • Pheochromocytoma (Adrenal Gland Tumor

Atenolol and Chlorthalidone are not recommended for use during pregnancy, and in studies has been proved to potentially cause harm to an unborn baby. This medication has FDA pregnancy category D, and it is recommended that high-effectiveness birth control is used when undergoing treatment with Atenolol and Chlorthalidone.

Should the patient fall pregnant when undergoing treatment, is already pregnant or is planning to get pregnant, a relevant medical professional should be informed as soon as possible in order to discuss and decide the best way forward. It has also been proved that this medication can pass into breast milk, and as such is not suitable for use when nursing an infant.

Storage:

Atenolol and Chlorthalidone should be stored in the container it came in, tightly closed, and out of reach of children. This medication should be stored in a cool, dry place with a controlled temperature of 20-25°C (68-77°F). Atenolol and Chlorthalidone are dispensed in tight, light-resistant containers.

Unused or unneeded medications should be disposed of in the appropriate way to guarantee that pets, children, and other people cannot consume them by accident, as this may cause harm. However, you should not flush this or any other drugs down the toilet. Rather, the best way to dispose of your medication is through a medication take-back program. Talk to a pharmacist or a local garbage/recycling department to learn more about take-back programs in the local community.

All medication, including Atenolol and Chlorthalidone, should be kept out of reach and sight of children as a best practice. This is because many containers, including weekly pill minders and containers for eye drops, creams, patches, and inhalers, are not designed to be child-resistant. Though this is not the case with Atenolol and Chlorthalidone, to protect young children from poisoning or other medication-related illness, always ensure safety caps are locked and immediately place the medication in a safe place after use.

Summary:

Atenolol and Chlorthalidone is a combination of the medications Atenolol (US brand name Tenormin) and Chlorthalidone (US brand name Hygroton) and is used as an effective treatment of hypertension, or high blood pressure.

Continual high blood pressure can cause damage to many blood vessels within the body, including the heart, brain, and kidneys. This dangerous condition can result in the patient suffering heart failure, a stroke or kidney failure as well as an increased risk of heart attack.

Atenolol is a beta-blocking agent type medication that works to block the effects of adrenergic drugs such as adrenaline or epinephrine, on nerves within the sympathetic nervous system. Due to this, Atenolol functions to reduce the heart rate in patients and is useful in treating abnormally rapid heart rhythm. This medication also reduces the force of contraction of heart muscle and lowers blood pressure, making it an effective medication for hypertension.

Chlorthalidone, the second medication within the combination, is a diuretic (water pill). It functions on the patients’ body by reducing the kidneys' ability to hold on to salt and water, therefore increasing the kidneys' production of urine (diuresis). Chlorthalidone is used as a treatment to remove excess salt and water from the body and also to treat high blood pressure.

Atenolol and Chlorthalidone is an oral tablet drug that is typically taken once per day by mouth, as prescribed by the patients’ doctor. This medication is not recommended for use with many heart-related conditions as well as during pregnancy and when breastfeeding.

The FDA has approved Atenolol and Chlorthalidone for the treatment of hypertension since June 1984.

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Last Reviewed:
December 23, 2017
Last Updated:
December 22, 2017
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