Azilsartan and Chlorthalidone

Azilsartan and chlorthalidone is an effective drug that comes in tablet form and is prescribed to adults for high blood pressure.

Overview

Azilsartan and chlorthalidone treats hypertension (high blood pressure). It is manufactured under the US brand name Edarbyclor. High blood pressure places additional pressure on the arteries and heart. If it persists, the arteries and heart may begin to malfunction. This can severely harm the blood vessels within the kidneys, heart, and brain, which can cause heart failure, stroke, or kidney failure to be the outcome. It is incredibly beneficial for everyone to keep their blood pressure as regulated and low as possible, as this can directly lower the possibility of heart attack and stroke.

Azilsartan hinders a material within the body that triggers blood vessels to constrict (tighten); the type of medication is angiotension II receptor blocker. Azilsartan helps the body by giving the blood vessels a rest. This raises the overall reserve of oxygen and blood that the body has available.

Chlorthalidone is a water pill; more appropriately referred to as a thiazide-like diuretic. It lowers the total water level within the body by raising the urine flow, which directly aids in the process of reducing blood pressure.

This medication can only be obtained with a prescription from your doctor, and is only currently offered in tablet form.

High blood pressure treatment can also be comprised of weight control and dietary changes in the kinds of foods that the patient is allowed to eat, specifically kinds of foods that are extra high in salt (sodium). Consult your physician prior to drastically altering your diet. Your healthcare professional can explain which methods of treatment are most applicable and crucial for you.

The majority of individuals with high blood pressure will not likely be aware of symptoms taking place (if they do occur). Many symptoms of high blood pressure are difficult to identify. For this reason, it is imperative that the medication is taken precisely as prescribed, that regular checkups with your physician take place to monitor the reaction you are having (if any), and to monitor how your body is reacting to this particular medicine.

It is important to keep in mind that this medication will not completely treat high blood pressure, although it is extremely effective for controlling it. Azilsartan and chlorthalidone must be taken as prescribed if the patient intends to reduce their blood pressure and they must ensure that they can keep it low. Medication for high blood pressure may need to be taken for the remainder of the patient’s life. Kidney disease, stroke, blood vessel disease, and heart failure can be caused if people have high blood pressure and they do not get it treated.

Condition treated

  • High blood pressure

Type of medicine

  • Angiotension II receptor blocker
  • Thiazide-like diuretic

Side Effects

Medications can also have unwarranted side effects that occur along with the important benefits. The following side effects can occur for patients who take azilsartan and chlorthalidone. Consult your physician right away if the following side effects take place.

Less Common Side Effects – Medical Attention Required

  • Weakness/tiredness (unusual)
  • Vomiting/nausea
  • Vision blurred
  • Urine decrease
  • Tingling/numbness in the lips, hands, or feet
  • Thirst increase
  • Sweating
  • Shortness of breath
  • Heartbeat irregularity
  • Faintness, lightheadedness, dizziness when standing or sitting abruptly
  • Fainting
  • Dry mouth
  • Cramps/muscle pain
  • Convulsions
  • Confusion
  • Appetite loss

Side Effects (Incidence Not Known) – Medical Attention Required

  • Knee, toe, or ankle joint pain
  • Joint swelling or stiffness
  • Stomach, side, or lower back pain
  • Lower leg/feet swelling

Occasionally, side effects take place and these do not require medical care. These side effects can subside with treatment as the body becomes more accustomed to the prescription. Your physician can possibly recommend methods for counteracting or decreasing the occurrence of certain side effects. If the patient has questions regarding any of the subsequent side effects or if they become bothersome, consult your medical care provider.

More Common Side Effects – Medical Attention Not Required

  • Dizziness

Rare Side Effects – Medical Attention Not Required

  • Muscle spasm
  • Strength (loss or lack of)
  • Diarrhea
  • Cough

Side Effects (Incidence Not Known) – Medical Attention Not Required

  • Loss of appetite
  • Rash
  • Headache
  • Stomach cramps

Additional side effects could occur for certain patients that are not on this list. If the patient becomes aware of other effects, consult your physician.

Contact your physician regarding medical advice for any side effects. The FDA also accepts reports of side effects at 1-800-FDA-1088.

Dosage

Azilsartan and chlorthalidone will be prescribed differently for individual patients. The instructions on the medication bottle and the doctor’s instructions both should be followed at all times. This article only describes the average quantities of azilsartan and chlorthalidone. If your prescribed dose varies, do not adjust it unless instructed by the doctor.

The quantity of azilsartan and chlorthalidone prescribed is dependent on how strong the medication is. The frequency of doses that must be taken, how long it takes to take the medication, as well as the allotted time between each dose will be impacted by the medical issue that caused the need for the medication.

This medicine must be taken consistently to get the best results. As a way to remember to take the medication regularly, try to take it orally every day at the same time as the previous day. Patients must still take this medicine even if they are feeling better. The entire benefit of azilsartan and chlorthalidone cannot be gained until the patient has been on the medicine for a few weeks.

Oral Dosing Information (Tablets)

For patients with high blood pressure:

Adults: Take one tablet once per day. Your physician may increase the dose as necessary. The dose is typically never greater than 25 milligrams (mg) of chlorthalidone and 40 mg of azilsartan.

Children: Physician must determine dose.

Missed Dose

If a patient accidentally misses a dose of this medication, it should be taken right away. If it is closer in the dosage schedule to the next dose, the missed dose should remain skipped and the normal dosage schedule should be followed again. Never double doses of azilsartan and chlorthalidone.

Directions and Unpackaging

Only take this prescription as recommended by a doctor. Never take an amount that is greater or less than what the physician recommended. Never take a dose that is more frequent or less frequently than instructed by the physician. These actions can increase the possibility of negative side effects.

A booklet of patient directions will always be included with azilsartan and chlorthalidone. Be sure to carefully read and understand the medication and instruction summary before taking this medicine.

Interactions

Drug Interactions

Some prescriptions should never be combined; but in other circumstances, several medications can be used at the same time even if there this a possibility of an interaction occurring. Under these circumstances, your physician may decide to adjust the dose or take additional precautions. It is imperative to inform your physician if you are currently taking any of the following prescription medications. The following interaction summaries are not all-inclusive, but have been determined based on likely significance of the interactions.

It is not recommended to combine azilsartan and chlorthalidone with any of the subsequent medications. Your physician may choose not to treat you with azilsartan and chlorthalidone, or they may adjust other medications that are prescribed.

  • Aliskiren

It is not typically suggested to combine azilsartan and chlorthalidone with any of the medications on the following list, but some situations may require it. If both medications are prescribed at the same time, the dose for one or both of the medications may be adjusted.

  • Valdecoxib
  • Trimethoprim
  • Trandolapril
  • Tolmetin
  • Tolfenamic Acid
  • Tiaprofenic Acid
  • Tenoxicam
  • Sulindac
  • Sotalol
  • Sodium Salicylate
  • Salsalate
  • Salicylic Acid
  • Rofecoxib
  • Ramipril
  • Quinapril
  • Proquazone
  • Propyphenazone
  • Proglumetacin
  • Piroxicam
  • Piketoprofen
  • Phenylbutazone
  • Perindopril
  • Parecoxib
  • Oxyphenbutazone
  • Oxaprozin
  • Nimesulide Beta Cyclodextrin
  • Nimesulide
  • Niflumic Acid
  • Nepafenac
  • Naproxen
  • Nabumetone
  • Morniflumate
  • Moexipril
  • Metildigoxin
  • Meloxicam
  • Mefenamic Acid
  • Meclofenamate
  • Lumiracoxib
  • Loxoprofen
  • Lornoxicam
  • Lithium
  • Lisinopril
  • Levomethadyl
  • Ketorolac
  • Ketoprofen
  • Ketanserin
  • Indomethacin
  • Ibuprofen
  • Fosinopril
  • Flurbiprofen
  • Flufenamic Acid
  • Fluconazole
  • Floctafenine
  • Flecainide
  • Feprazone
  • Fepradinol
  • Fenoprofen
  • Felbinac
  • Etoricoxib
  • Etofenamate
  • Etodolac
  • Enalaprilat
  • Enalapril
  • Droxicam
  • Droperidol
  • Dofetilide
  • Dipyrone
  • Digoxin
  • Digitoxin
  • Digitalis
  • Diflunisal
  • Diclofenac
  • Dexketoprofen
  • Dexibuprofen
  • Deslanoside
  • Clonixin
  • Choline Salicylate
  • Ceritinib
  • Celecoxib
  • Captopril
  • Bufexamac
  • Bromfenac
  • Bepridil
  • Benazepril
  • Aspirin
  • Arsenic Trioxide
  • Amtolmetin Guacil
  • Acetyldigoxin
  • Acemetacin
  • Aceclofenac

The possibility of certain side effects may be increased if any of the following drugs are combined with azilsartan and chlorthalidone, but the combination may prove to be the most optimal form of treatment. Your physician may adjust the dosage for at least one of the drugs if both medications are prescribed for combined use.

  • Warfarin
  • Valdecoxib
  • Tolmetin
  • Tolfenamic Acid
  • Tiaprofenic Acid
  • Tenoxicam
  • Sulindac
  • Sodium Salicylate
  • Salsalate
  • Salicylic Acid
  • Rofecoxib
  • Proquazone
  • Propyphenazone
  • Propionic Acid
  • Proglumetacin
  • Piroxicam
  • Piketoprofen
  • Phenylbutazone
  • Parecoxib
  • Oxyphenbutazone
  • Oxaprozin
  • Nimesulide Beta Cyclodextrin
  • Nimesulide
  • Niflumic Acid
  • Nepafenac
  • Naproxen
  • Nabumetone
  • Morniflumate
  • Meloxicam
  • Mefenamic Acid
  • Meclofenamate
  • Lumiracoxib
  • Loxoprofen
  • Lornoxicam
  • Licorice
  • Ketorolac
  • Ketoprofen
  • Indomethacin
  • Ibuprofen
  • Gossypol
  • Flurbiprofen
  • Flufenamic Acid
  • Floctafenine
  • Feprazone
  • Fepradinol
  • Fenoprofen
  • Felbinac
  • Etoricoxib
  • Etofenamate
  • Etodolac
  • Droxicam
  • Dipyrone
  • Diflunisal
  • Diclofenac
  • Dexketoprofen
  • Dexibuprofen
  • Clonixin
  • Choline Salicylate
  • Celecoxib
  • Bufexamac
  • Bromfenac
  • Amtolmetin Guacil
  • Acemetacin
  • Aceclofenac

Other Interactions

Some prescription drugs should not be taken at or near mealtime due to the possibility of potential interactions occurring. The use of tobacco or alcohol can also increase the chance of interactions taking place. Patients should discuss the use of tobacco, alcohol, and food with their doctor and should find out how it affects taking the azilsartan and chlorthalidone medication.

Interactions with Other Medical Issues

The occurrence of other medical issues can impact the effectiveness of this medication. Be sure to inform your physician of other medical issues, specifically:

  • Anuria (inability to pass urine)
  • Diabetic patients who are also prescribed to take Tekturna® should not take azilsartan and chlorthalidone
  • Congestive heart failure (severe) - kidney problems may follow
  • Electrolyte imbalances (e.g., low sodium/potassium in the body)
  • Gout
  • Fluid imbalances (caused by vomiting, diarrhea, or dehydration)
  • Kidney issues
  • Liver disease – take caution; conditions can be intensified

Warnings

Your physician must carefully monitor the progress of the patient regularly to ensure the medication is functioning effectively. Urine and blood tests can be conducted to monitor unwarranted results.

Pregnant women who take azilsartan and chlorthalidone can cause harmful effects for the unborn baby. Women taking azilsartan and chlorthalidone should ensure they are using a suitable birth control to avoid becoming pregnant. Women who suspect they have become pregnant while taking this prescription should consult their physician immediately.

Lightheadedness, dizziness, or fainting can take place, especially when a patient gets up quickly from a sitting or lying position. This can also occur after the initial dose of the prescription is taken. Ensure you are aware of your personal reaction to this medication prior to driving, operating machinery, or other activities that could be dangerous if you are not fully alert. Lie down immediately if you experience dizzy feelings so that you do not faint, and then take several minutes to sit prior to standing to ensure the dizziness will not return. Consult your physician immediately if fainting occurs.

Consult your physician immediately if you become sick at all while on this prescription, specifically with vomiting, diarrhea, or nausea. An excess of water can be lost which can cause low blood pressure to take place. Sweating can also cause excess water to be lost, so it is important to stay hydrated while the weather is hot or during periods of intense exercise.

Low potassium within the blood stream (hypokalemia) can take place after patients use this medication. Consult with your physician immediately if any of these symptoms occur: heightened thirst, dry mouth, vomiting, muscle cramps, or nausea.

Other medications should be avoided unless your physician has approved them. This refers specifically to medications that are available over the counter for asthma, colds, appetite control, hay fever, cough, and sinus problems, as these medications typically raise blood pressure.

If your condition becomes worse or does not progress (blood pressure increases or stays high), be sure to inform your physician.

Specific Demographic Use

When contemplating whether or not a patient should take a medication, they should weigh the positive aspects against the negative properties. Your physician will help you to decide if azilsartan and chlorthalidone is right for you. Consider the following warnings prior to use.

Allergies

Inform your physician if there are any unexpected allergic reactions after taking this medication. Also inform your doctor if you have additional kinds of allergies, specifically to animals, preservatives, dyes, or foods. Carefully read the ingredients on the medication package.

Pediatric

There have not yet been suitable studies on the association of age to the results of the azilsartan and chlorthalidone combination for children. It has not yet been determined if this medication is both safe and effective for children.

Geriatric

There have not yet been suitable studies on any problems that may arise after elderly patients take azilsartan and chlorthalidone. There has not been any research signifying whether or not this combination is inadequate in its effectiveness for the elderly.

Pregnancy

There has been a risk to the fetus demonstrated in research that has taken place on pregnant women who have taken azilsartan and chlorthalidone. Nevertheless, the therapy properties that azilsartan and chlorthalidone have may balance the possible risk when a life-threatening situation is at hand.

Breastfeeding

There has not been adequate research conducted to present what (if any) risk occurs for the infant when the mother takes azilsartan and chlorthalidone at the same time that she is breastfeeding.

Storage

Azilsartan and chlorthalidone must be stored out of children’s grasp. Medication that is no longer required or outdated should not be kept. Consult with your medical professional to find out how to properly dispose of unused medication.

Keep the medication in its original container and keep it closed at all times. It should be stored a safe distance from moisture, heat, frozen temperatures, and direct light.

Summary

Azilsartan and chlorthalidone is an effective treatment for high blood pressure, currently available in tablet form only. This medication cannot completely treat high blood pressure, but can control it very well. This medicine may be prescribed for patients who are dedicated to lowering their blood pressure and keeping it low. It is important to regulate blood pressure as high blood pressure can cause kidney disease, stroke, blood vessel disease, and heart failure. Consult your physician with any questions you may have about this drug.

Resources
Last Reviewed:
December 24, 2017
Last Updated:
February 09, 2018