Belinostat is an anticancer medicine that's used to treat people suffering from peripheral T-cell lymphoma, a fast-growing and rare non-Hodgkin lymphoma (NHL) variety.
Belinostat is in a class of drugs known as histone deacetylase inhibitors. It works by stopping enzymes responsible for making T-cells becoming cancerous. T-cells are a kind of immune cells. Belinostat is intended for people whose condition has relapsed (returned after treatment) or didn't respond to earlier treatment (refractory).
Belinostat comes in an injectable variety to be given straight into a vein via an IV by a healthcare provider. Belinostat is available under the brand name Beleodaq and doesn't come as a generic medication.
Belinostat is given once daily on the first to fifth day of 21 days of treatment.
Notify your healthcare giver if you have diarrhea, vomiting, or nausea. You doctor can prescribe drugs to relieve or prevent these symptoms. Limiting activity, eating many small meals, or not eating before taking the drug may help ease some of the effects. Headache, tiredness, constipation, dizziness, or decreased appetite may also occur. Make sure to tell your healthcare giver promptly should any of the above effects get worse or persist.
People using Belinostat may suffer severe side effects. However, a doctor will prescribe this medication to you because he/she has considered its benefits to be greater than the possibility of side effects. Your doctor may decrease your risk through careful monitoring. Tell your physician promptly if you suffer any serious effects, including:
This medicine may weaken your ability to battle infections, possibly making you highly likely to develop a serious but rarely fatal infection or worsening any infection you suffer from. Tell your physician promptly if you develop any symptoms of infection, such as a cough, chills, fever, and a sore throat. In rare cases, Belinostat may cause serious and potentially fatal liver disease. Seek medical assistance promptly if you have these symptoms of liver failure, including:
Sometimes Belinostat causes side effects because of tumor lysis syndrome (rapid damage of cancer cells). To decrease your risk, your physician may add a drug and advise you to take lots of fluids. Let your physician know immediately if you have these symptoms:
These are not all the possible side effects of Belinostat. If you have other effects different from the above, get in touch with your healthcare professional.
Belinostat is injected through an IV into a vein. A healthcare professional will give this injection.
Belinostat must be slowly injected, and the IV mixture can require at least half an hour to finish.
Belinostat is administered in a 3-week treatment cycle (21 days), and you may only receive the medication in the first five days of every cycle. Your physician will decide how long you'll be treated with Belinostat.
You may take another drug to prevent nausea, diarrhea, or vomiting while you're receiving Belinostat.
You'll need regular medical tests to ensure Belinostat isn't causing harmful effects. Your doctor will need to test your blood every week in each treatment cycle. Depending on the outcome of these tests, your cancer therapies may be delayed.
Belinostat can reduce blood cells that assist your body to battle infections and promote blood clotting. This can increase your chances of falling ill from being around people who are ill or bleeding from an injury.
Since Belinostat is administered by a healthcare giver in a medical environment, it's unlikely that an overdose will occur.
Belinostat does have risks if not taken as prescribed.
If you suddenly stop using Belinostat or don't use it at all, your lymphoma won't get better and will likely worsen. Lymphoma may eventually cause death.
If you don't take Belinostat on schedule or miss doses, your medicine may not work effectively or may cease working altogether. For Belinostat to work effectively, your body needs to have a certain amount of it at certain times.
If you have missed a dose, contact your clinic or doctor to know when you should go in to get your next dose. Make sure to keep all your scheduled appointments.
How do you tell if Belinostat is working? Well, if this medication is working you will not be able to feel anything. Your doctor will carry out blood tests to see how your condition is responding to Belinostat.
Belinostat may interact with other herbs, vitamins, or medications you might be using. An interaction refers to a case where a substance alters the way a medication works. This can prevent the medication from working well or cause harm. Your healthcare professional will anticipate interactions with your present drugs. Always make sure to notify your physician about all drugs, vitamins, or herbs you're using. Especially inform your physician if you take the following medications:
Stay away from people with infections or sickness. Notify your doctor as you soon as you get signs of infection.
Avoid activities that can up your risk of injury or bleeding. Use extra caution to prevent bleeding when brushing your teeth or shaving.
Belinostat can pass into bodily fluids like vomit, urine, and feces. After receiving a dose, wait at least 2 days before your bodily fluids can touch your hands or any other surface. Caregivers will need to wear rubber gloves when cleaning up patients' bodily fluids, changing diapers, or handling contaminated laundry or trash. Wash your hands prior to and after taking off gloves. Wash dirty linens and clothes separately from other clothes.
Other medicines can interact with Belinostat, such as over-the-counter and prescription medicines, herbal products, and vitamins. Tell all your healthcare professionals about all drugs you're currently using and any drug you begin or stop using.
Your doctor will closely monitor your progress while you're receiving Belinostat. This will enable your doctor to find out if the drug is working well and to determine if you need to continue receiving it. You may need blood tests to check for undesirable effects.
If you're pregnant, using Belinostat may harm your unborn child. Instead, use an effective birth control method to prevent you from falling pregnant. If you have gotten pregnant while taking Belinostat, notify your doctor immediately.
Belinostat can be released into human milk, possibly causing side effects in a breastfeeding child. Talk to your physician if you're breastfeeding. You and your physician will need to decide between discontinuing this drug and stopping breastfeeding.
Belinostat use in children has not been researched. It shouldn't be taken by patients younger than 18.
Belinostat can temporarily reduce the number of platelets and white blood cells in your blood, making you more likely to get an infection.
Wash your hands regularly. Tell your healthcare provider if you've ever suffered an infection that wouldn't disappear or one that kept recurring. See your doctor promptly if you think you're developing an infection or if you suffer chills or fever, hoarseness or cough, lower side or back pain, or difficult or painful urination.
See your physician as soon as possible if you have tenderness or pain in the upper part of your stomach, dark urine, dark stools, loss of appetite, vomiting, nausea, or yellow skin or eyes. These symptoms might point to a serious liver condition. This medication can make liver problems even worse. Your physician will check your liver function. He or she may delay your treatment, decrease your dose, or tell you to stop taking Belinostat.
Belinostat may trigger a serious kind of reaction known as tumor lysis syndrome. You may be given a medication to help prevent such a reaction. Call your doctor promptly if you notice a change or decrease in quantity of urine, stiffness, swelling, or joint pain, lower side/ stomach/back pain, fast weight gain, swelling of lower legs or feet, or unexplained tiredness/weakness.
Belinostat can cause vomiting, diarrhea, or nausea. You doctor can give you medications to prevent this. Contact your physician if these symptoms persist after taking your dose.
Not applicable. Belinostat is administered in a clinic or hospital and is not kept at home.
Medications for treating cancer are quite strong and can bring about numerous side effects. Some common Belinostat side effects include nausea, vomiting, anemia, fever, and fatigue. So, before you receive Belinostat, be sure to understand all the benefits and risks involved. It's vital that you work with your doctor closely during your treatment.
The existence of other medical issues may affect the function of Belinostat. Make sure to let your healthcare giver know if you suffer from other medical issues, especially:
Honor all of your doctor and lab appointments. You doctor will organize certain laboratory tests to monitor your body's reaction to Belinostat injection.
Ask your pharmacist/doctor any questions you might have about Belinostat.
Use Belinostat as instructed by your physician. Read all information provided. Follow all directions carefully.