Belladonna Alkaloids and Phenobarbital (Oral)

As an antispasmodic, Belladonna Alkaloids and Phenobarbital is intended to treat patients who are suffering from severe digestive system problems such as abdominal pain, cramping, ulcers and irritable bowel syndrome (IBS).

Overview

For patients that are suffering from the painful effects of irritable bowel syndrome or other digestive system problems that involve cramping and ulcers, Belladonna Alkaloids and Phenobarbital medications can provide substantial relief. The combination of these active ingredients brings on a mild state of sedation as well as inducing anticholinergic/antispasmodic effects to provide relief from the worst symptoms of IBS and other digestive system problems. It is a powerful prescription-grade drug and is only to be used with extreme caution as a result of a concern for its serious side effects and its potential to worsen other conditions.

Belladonna Alkaloids and Phenobarbital drugs are somewhat controversial and have been pulled from the shelf in the past. One concern when prescribing this drug is that barbiturates such as phenobarbital can be extremely habit-forming and in the decades since this drug was put on the market alternative competing medications have emerged. These are the remedies that are often prescribed to new patients while long-time users maintain their prescriptions. When used correctly and not abused, this medication can provide substantial and long-term relief for the debilitating effects of digestive disorders.

Conditions Treated

Type of Medicine

  • Antispasmodic
  • Barbituate

Side Effects

Along with the intended effect of treating gastrointestinal distress, taking Belladonna Alkaloids and Phenobarbital tablets can result in serious side effects. These side effects may not necessarily occur for every patient, but if they do the patient should seek immediate medical attention.

Rarely, this medication can induce the following side effects:

  • Eye pain
  • Jaundice
  • Skin rash
  • Unusual bruising
  • Flu-like symptoms

Additionally, Belladonna Alkaloids and Phenobarbital doses have been known to cause short-term side effects related to the body adjusting to a new prescription. When the body adjusts to the dose, these side-effects can often subside without the need for any medical treatment. However, if the symptoms persist or are more severe than inspected your health care provider may need to adjust the prescription or switch to an alternative treatment. Ask your doctor if you have any questions about these effects and how concerned you should be when they emerge.

Common side effects that can occur when first taking the medication include:

Less common temporary side effects that have been observed include the following physical and mental conditions:

  • Headache
  • Blurred vision
  • Increased sensitivity of eyes to sunlight
  • Unusual tiredness or weakness
  • Loss of memory
  • Bloated feeling
  • Nausea or vomiting
  • Difficulty swallowing
  • Difficult urination
  • Decreased flow of breast milk

Dosage

The dose of Belladonna Alkaloids and Phenobarbital needed for the treatment of a specific digestive system disorder will vary based on the individual, disorder, severity of the condition, and physical condition of the patient. The following guidelines are only the recommendations of the manufacturer and patients should follow all doctors orders and the directions that come with the prescription. If your dose is different than that which is listed do not make any effort to change it without your doctor's advice. Additional considerations may include the strength of the dose, the number of doses per day, the duration of the prescription or the reason for the prescription. This medication has additional considerations such as the potential for abuse, dependence, and overdose. Any alterations to the prescription must be undertaken with caution under the direct supervision of a physician.

For patients suffering from stomach and intestinal problems, an oral dose of Belladonna Alkaloids and Phenobarbital tablets or capsules comes in the following doses:

  • Adults and teenagers: 1-2 capsules 2-4 times daily. Doctors may prescribe additional doses based on severity of condition
  • Children: Dose determined by an expert pediatrician.

Some patients may be unable to take the medication in a capsule or tablet form. There is also a liquid solution that can be administered in the following doses:

  • Adults and teenagers: 1-2 teaspoons (5-10ml) 3-4 times daily. Doctors may adjust the dose as necessary.
  • Children: Dose is determined by the body weight of the child and must be determined by a pediatrician. An average dose is between a half milliliter and 7.5ml every 4-6 hours. Doctors may adjust dose based on various conditions.

Additionally, the medicine can be administered in a chewable tablet form. The dosage guidelines for this method are as follows.

  • Adults and teenagers: 1-2 tablets 3-4 times a day. Doctors may adjust the dose as necessary.
    Children 2-12 years old: Chew one-half a tablet 3-4 times a day. Doctors may adjust the dose as necessary.
    Children under 2 years old: Use is not recommended.

Extended-release tablets are also available for this medication and come with the following dosage guidelines:

  • Adults and teenagers- 1 tablet every 8-12 hours. Doctors may adjust dosage as needed.
    Children- Use is not recommended

In the event that a dose of the medication is missed, patients should take the dose as soon as possible. However, if it is close to the time of the next dose the danger of overdose outstrips the potential ill effects of the missed dose. In this instance, skip to the next dose at the prescribed time and return to your regular dosing schedule. Under no circumstances should a double dose of this medication be taken at any interval in the dosing schedule.

Interactions

As with all medications, Belladonna Alkaloids and Phenobarbital doses have potential to interact unfavorably with other medications, supplements, substances, and medical conditions. This is a risk factor that needs to be considered and mitigated by your physician when determining your treatment plan. In the event that known interactions are known to occur, your doctor may deem the risk necessary or may adjust dosages or replace medications to ensure your conditions are treated with the least possible risk. While taking Belladonna Alkaloids and Phenobarbital, please be aware that there are is a substantial list of medications that are known to have adverse reactions when used in tandem. It is imperative that you inform your physician of any and all medications, supplements, and treatments that you are taking or may begin taking during the course of the prescription.

Below is a list of the known medications that have a potentially significant reaction with Belladonna Alkaloids and Phenobarbital. This is not an all-inclusive list and it is important you ask your physician about any medication that is not listed. Use of any of these medications is not recommended, although your doctor may decide if they need to be taken together and what additional precautions may be necessary.

  • Ambenonium
  • Atazanavir
  • Boceprevir
  • Cobicistat
  • Darunavir
  • Dasabuvir
  • Elvitegravir
  • Ombitasvir
  • Paritaprevir
  • Potassium
  • Ranolazine
  • Rilpivirine
  • Ritonavir
  • Telaprevir
  • Voriconazole

Additionally, these medications also come with a note of caution when used with Belladonna Alkaloids and Phenobarbital. While the interactions may not have as high a degree of severity, your doctor may wish to adjust their dose or find an alternative prescription.

  • Acenocoumarol
  • Alprazolam
  • Amobarbital
  • Anisindione
  • Aprobarbital
  • Axitinib
  • Bosutinib
  • Bromazepam
  • Bromopride
  • Buprenorphine
  • Bupropion
  • Butabarbital
  • Butalbital
  • Butorphanol
  • Calcifediol
  • Carbinoxamine
  • Carisoprodol
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chlorzoxazone
  • Clarithromycin
  • Clobazam
  • Clonazepam
  • Clorazepate
  • Clozapine
  • Cobimetinib
  • Codeine
  • Daclatasvir
  • Dantrolene
  • Deferasirox
  • Delavirdine
  • Diazepam
  • Dicumarol
  • Dihydrocodeine
  • Donepezil
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Doxylamine
  • Dronedarone
  • Elbasvir
  • Erlotinib
  • Eslicarbazepine Acetate
  • Estazolam
  • Ethchlorvynol
  • Etravirine
  • Fentanyl
  • Fluconazole
  • Flunitrazepam
  • Flurazepam
  • Grazoprevir
  • Halazepam
  • Hydrocodone
  • Hydromorphone
  • Ifosfamide
  • Imatinib
  • Ketazolam
  • Ledipasvir
  • Lopinavir
  • Lorazepam
  • Lormetazepam
  • Meclizine
  • Medazepam
  • Meperidine
  • Mephenesin
  • Mephobarbital
  • Meprobamate
  • Metaxalone
  • Methocarbamol
  • Methohexital
  • Methoxyflurane
  • Midazolam
  • Mifepristone
  • Morphine
  • Morphine Sulfate Liposome
  • Nifedipine
  • Nimodipine
  • Nitrazepam
  • Olaparib
  • Orlistat
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Pentazocine
  • Pentobarbital
  • Periciazine
  • Phenindione
  • Phenobarbital
  • Phenprocoumon
  • Piperaquine
  • Prazepam
  • Primidone
  • Quazepam
  • Remifentanil
  • Saquinavir
  • Secobarbital
  • Simeprevir
  • Sirolimus
  • Sodium Oxybate
  • Sofosbuvir
  • Sonidegib
  • Sufentanil
  • Sunitinib
  • Tacrolimus
  • Tapentadol
  • Temazepam
  • Teniposide
  • Tenofovir Alafenamide
  • Thiopental
  • Tiotropium
  • Tolvaptan
  • Tramadol
  • Triazolam
  • Ulipristal
  • Velpatasvir
  • Venetoclax
  • Zolpidem

Using any of the following medicines at the same time as Belladonna Alkaloids and Phenobarbital may come with an increased risk of certain side-effects common to one or both medications. However, the use of either or both drugs may be the best treatment available. Your doctor may prescribe them together at their discretion.

  • Amprenavir
  • Arbutamine
  • Betamethasone
  • Bexarotene
  • Cannabis
  • Carbamazepine
  • Chlorpromazine
  • Cortisone
  • Desogestrel
  • Dexamethasone
  • Dienogest
  • Digitoxin
  • Drospirenone
  • Estradiol Cypionate
  • Estradiol Valerate
  • Ethinyl Estradiol
  • Ethosuximide
  • Ethynodiol Diacetate
  • Etonogestrel
  • Felodipine
  • Ginkgo
  • Granisetron
  • Griseofulvin
  • Lamotrigine
  • Leucovorin
  • Levomethadyl
  • Levonorgestrel
  • Medroxyprogesterone Acetate
  • Mestranol
  • Methylprednisolone
  • Metoprolol
  • Norelgestromin
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Ospemifene
  • Oxcarbazepine
  • Prednisone
  • Quinidine
  • Quinine
  • Risperidone
  • Rufinamide
  • Telithromycin
  • Theophylline
  • Thioridazine
  • Tiagabine
  • Topiramate
  • Valproic Acid
  • Verapamil
  • Warfarin

Warnings

There are several warnings that need to be heeded before taking Belladonna Alkaloids and Phenobarbital. It will add to the effects of alcohol and other substances characterized as depressants. Examples include antihistamines, sedatives, and other ingredients found in most over-the-counter cough syrups as well as medications intended for the treatment of allergies and nervous system disorders. This is a concern when you are seeking out elective surgery or dental work, as most anesthetics used by these procedures are classified as such. Prescription medication with narcotic properties and those prescribed for pain such as painkillers and muscle relaxers can also be affected by this prescription. Check with your doctor, pharmacist or dentist before taking any of these medicines.

Do not take this medicine if you have taken antacids or medicine for the treatment of diarrhea within the last hour, as the antacid properties will inhibit the effectiveness of the belladonna alkaloids.

The Belladonna alkaloids in this medication are known to cause a decrease in sweating which can lead to a dangerous increase in body temperature. Take care when exercising or exposing yourself to extreme heat while taking this medicine as a heat-related injury such as heat exhaustion or com/health/heat-stroke/">heat stroke could result. This is especially important when treating children or the elderly with this medication.

This medicine may also cause photosensitivity and those taking the medication should wear sunglasses outdoors may help prevent discomfort or eye injury. Blurred vision, dizziness, and faintness caused by this medication can make patients less alert than they would be under normal conditions, and care should be taken not to drive or operate machinery if they are unaware of what effect the medication will have. Dry mouth, nose, and throat that is caused by this medication can be temporarily relieved by melting ice in the mouth or chewing sugar-free gum. However, if this condition persists for more than two weeks schedule a check-up with your dentist. Increased dryness of the mouth may increase the likelihood of dental conditions including gum disease.

If you experience any of the following medical issues while taking this medicine immediately inform your doctor:

Certain medical conditions may affect your physician's decision to prescribe this medication, so fully disclose all of the following conditions:

The Phenobarbital in this medication is known to be habit-forming. Individuals that are prone to addiction or are currently struggling with an addiction can develop a physical or psychological dependence on this drug. This dependence can result in delirium or convulsions during an abrupt withdrawal period. In addition, there is a danger of overdose that comes with this drug. Signs of symptoms of a potential overdose include the following:

  • Headache
  • Nausea
  • Vomiting
  • Dilated pupals
  • Blurry vision
  • Hot and dry skin
  • Dizziness
  • Thirst
  • Dry mouth
  • Difficulty swallowing
  • Labored breathing

If there are any of these signs of overdose immediate emergency care is required.

Storage

Keep this medicine in a secure location out of the reach of children and away from unauthorized persons who may take it for recreational effects. It should be stored in a closed container at room temperature and kept away from heat, moisture, and direct sunlight. This medication should not be frozen. Dispose of this medication immediately if it is expired or no longer needed.

Summary

Belladonna Alkaloids and Phenobarbital combination doses come in an elixir, tablet, extended release tablet, capsule, and liquid form. It is typically marketed under the brand name Donnatal or a generic equivalent and is intended for the treatment of cramping and spasms in the stomach and intestines. Although it is also prescribed for the treatment of stomach ulcers, recent findings have found the effectiveness of this as a treatment to be dubious and subject to further study. Although Belladonna Alkaloids and Phenobarbital combination drugs have proven a very effective and well-established treatment for such digestive system problems as IBS and Crohn's disease, it comes with many concerns related to the potential for addiction and chemical dependence. Although it has been used regularly since the 1930's there remain concerns regarding its prescription and regular use for the treatment of certain digestive system disorders.

Recent moves by the FDA have put the future of this drug as a valid treatment option into serious doubt. When side effects, chemical dependency issues, and a host of adverse interactions are taken into consideration it may not be outweighed by its potential to provide relief. However, for those who have been taking the medication for a long duration, ceasing use may be a difficult process that can lead to severe withdrawal and other health issues. This medication should only be used under explicit instructions by your primary care physician and all warnings should be considered before beginning a new prescription if you have never taken the medication before. Until more study is done regarding the concerns that the FDA has expressed regarding this medication it may be wise to avoid it and seek out treatment with other comparable medications that are currently on the market.

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Last Reviewed:
December 24, 2017
Last Updated:
April 05, 2018
Content Source: