Benazepril and hydrochlorothiazide (Oral)

Benazepril and hydrochlorothiazide are a combination of drugs that are used for the treatment of high blood pressure or hypertension in patients.

Overview

Patients suffering from high blood pressure or hypertension can be treated with the combination of benazepril and hydrochlorothiazide.

High blood pressure or hypertension in a patient will put excess strain on the heart and arteries in a patient. If left untreated, this can cause damage to the organs and lead to a wide range of medical conditions that can have very serious complications. Patients with hypertension are at risk of developing heart disease, blood vessel disease, strokes or kidney failure.

The use of benazepril and hydrochlorothiazide will lower the blood pressure in the patient and reduce the risks of developing these medical conditions. Benazepril and hydrochlorothiazide do not, however, cure high blood pressure. These medications are a temporary method through which the blood pressure can be reduced, to allow the patient to bring their blood pressure down naturally. The patient should take steps to lower the blood pressure naturally in conjunction to this medication. Ceasing use of this medication will put the patient at risk of contracting a serious condition once again.

Benazepril is an angiotensin-converting enzyme (ACE) inhibitor. The treatment with benazepril works by preventing the production of an enzyme that would normally cause blood vessels to tighten. By blocking this enzyme, the blood vessels are forced to relax. This opens the arteries and allows the blood to flow more slowly, meaning that it can absorb more oxygen from the lungs. This oxygen can then be transported to the heart and brain.

Hydrochlorothiazide is a thiazide diuretic. It works to increase the excretion of urine from the body and, in doing so, reduces the amount of water in the body and blood. This reduction in water content reduces pressure and assists in improving circulation.

Benazepril and hydrochlorothiazide are only available with a doctor's prescription and are administered as a tablet.

This medication should not be used by pregnant women wherever this is possible. In life-threatening situations, however, the risks of not using the treatment can outweigh the risks of use. If you are a woman using this medicine, you should use effective methods of contraception and take steps to prevent yourself from becoming pregnant.

Condition(s) treated

  • Hypertension
  • High blood pressure

Type of medicine

  • Benazepril - Antiotensin-converting enzyme inhibitor (ACEI)
  • Hydrochlorothiazide - Thiazide diuretic (water pill)

Side effects

This medication can have serious side effects on the patient. While not all side effects need to be medically treated, in some cases, this will be necessary. All side effects should be reported to your doctor when you go for your regular check up.

You should check with your doctor immediately if you experience any of the following conditions, which may be symptoms of a serious problem:

  • Blurring of the vision
  • Confusion or disorientation
  • Decreased urination frequency of volume
  • Dizziness, lightheadedness or feeling of faintness when changing from a lying or sitting position to standing
  • Dry mouth or feeling of dehydration
  • Irregular heartbeat or arrhythmic heart rate
  • Muscle cramps or pain in muscles
  • Numbness, tingling, pain, or weakness in the hands or feet
  • Rapid breathing or labored breathing
  • Seizures or convulsions
  • Sunken eyes or appearance of extreme tiredness
  • Sweating when cold
  • Thirstiness
  • Trembling
  • Unusual tiredness
  • Unusual weakness
  • Weakness and heaviness in the legs
  • Wrinkled skin

The following side effects, which do not necessitate medical attention, may also occur. In cases where these side effects cause undue bother or ongoing pain, you can talk to your doctor about how they may be alleviated or reduced.

  • Coughing
  • Decreased appetite for sexual intercourse
  • Excessive muscle toning
  • Feeling the your surroundings or self are in a state of constant movement
  • Inability to get or maintain an erection
  • Loss in sexual ability or performance
  • Loss of sexual drive or desire
  • Muscle stiffness
  • Muscle tightness
  • Nausea
  • Sensation of turning when still
  • Sleepiness or unusual tiredness

Other side effects may occur that are not listed here. Inform your doctor of any other side effects that you are experiencing.

Dosage

This medication is not a first resort for treatment of high blood pressure. It is intended for use only after other medicines have been tried and have not worked, or have caused side effects that were not manageable. The use of this medication is a serious undertaking and other avenues should be trialled first wherever possible.

This medication should always be prescribed alongside advice on how the blood pressure can be lowered naturally. This product is not a cure for high blood pressure, and the patient should work to lower their blood pressure naturally so that their use of this medication can cease. This can be achieved through weight loss, reducing your salt intake, reducing your fat intake and increasing the amount of exercise you carry out. Your doctor will be able to advise on how best to lower your heart rate.

Patients taking this medication may often feel well. It is very important, however, that they do not stop taking this medication unless instructed to do so. Cessation of this medication by the patient will cause the blood pressure to rise rapidly and, when this happens, the patient can be put at serious risk of a heart attack, a stroke, heart failure, blood vessel disease and kidney failure. You should only change the dose of this medication as instructed by a doctor.

If you miss a dose, then you should take it as soon as possible when you remember, unless it is close to the time of your next dose. In such cases, you should skip the dose and return to your usual dosing schedule. Under no circumstances should you ever take a double dose of this medication.

The following dosages are guidelines only and you should always follow the dosing information given to you by your doctor.

Adults: one tablet daily. This may be increased but should never exceed 20mg of benazepril and 25mg of hydrochlorothiazide.
Children: use and dosage will be determined individually by the doctor.

Interactions

Benazepril and hydrochlorothiazide can interact with other medication or medications that you may be taking. In some cases, the use of this medication in conjunction with another is prohibited, due to interactions that could cause harmful side effects to the body. In other cases, medicines that interact may still be used together, but doses may need to be adjusted. This medication can also increase the side effects experienced from both the use of other medications and this medication. You should inform your doctor of all medication you are taking, including herbal remedies, vitamin supplements, prescribed medicines and over the counter medicines.

The use of benazepril and hydrochlorothiazide with the following medication is not recommended and your doctor may wish to change one or more of the medications:

  • Aliskiren
  • Dofetilide
  • Sacubitril

The use of the following medicines in conjunction with benazepril and hydrochlorothiazide is not normally recommended, but both may be prescribed in some circumstances as using both may remain the best course of treatment for your individual health needs. Your doctor may wish to change the dose of either of the medications in these cases.

  • Aceclofenac
  • Acemetacin
  • Acetyldigoxin
  • Alteplase, Recombinant
  • Amiloride
  • Amphetamine
  • Amtolmetin Guacil
  • Arsenic Trioxide
  • Aspirin
  • Azathioprine
  • Azilsartan
  • Azilsartan Medoxomil
  • Bromfenac
  • Bufexamac
  • Candesartan Cilexetil
  • Canrenoate
  • Celecoxib
  • Choline Salicylate
  • Clonixin
  • Cyclophosphamide
  • Deslanoside
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Digitalis
  • Digitoxin
  • Digoxin
  • Dipyrone
  • Droperidol
  • Droxicam
  • Eplerenone
  • Eprosartan
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Everolimus
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Flecainide
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Ibuprofen
  • Indomethacin
  • Irbesartan
  • Ketanserin
  • Ketoprofen
  • Ketorolac
  • Levomethadyl
  • Lithium
  • Lornoxicam
  • Losartan
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Mercaptopurine
  • Methotrexate
  • Metildigoxin
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Olmesartan Medoxomil
  • Ouabain
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Phenylbutazone
  • Piketoprofen
  • Piroxicam
  • Potassium
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Proscillaridin
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sirolimus
  • Sodium Salicylate
  • Sotalol
  • Spironolactone
  • Sulindac
  • Telmisartan
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Triamterene
  • Trimethoprim
  • Valdecoxib
  • Valsartan

When using the following medications, the risk of certain side effects can be increased. You may still be prescribed with both, but extra caution should be taken, and doses and frequencies may need to be adjusted to your specific needs.

  • Aceclofenac
  • Acemetacin
  • Amtolmetin Guacil
  • Azosemide
  • Bepridil
  • Bromfenac
  • Bufexamac
  • Bumetanide
  • Bupivacaine
  • Bupivacaine Liposome
  • Capsaicin
  • Carbamazepine
  • Celecoxib
  • Cholestyramine
  • Choline Salicylate
  • Clonixin
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Droxicam
  • Ethacrynic Acid
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Furosemide
  • Ginkgo
  • Gold Sodium Thiomalate
  • Gossypol
  • Ibuprofen
  • Indomethacin
  • Ketoprofen
  • Ketorolac
  • Licorice
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Nesiritide
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Phenylbutazone
  • Piketoprofen
  • Piretanide
  • Piroxicam
  • Proglumetacin
  • Propionic Acid
  • Propyphenazone
  • Proquazone
  • Rofecoxib
  • Salicylic Acid
  • Salsalate
  • Sodium Salicylate
  • Sulindac
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolfenamic Acid
  • Tolmetin
  • Topiramate
  • Torsemide
  • Valdecoxib

The use of benazepril and hydrochlorothiazide may also be impacted by other medical conditions from which you may be suffering. You should inform your doctor of all medical conditions that you experience, and this is particularly important in the following cases:

  • Any history of reaction to ACE inhibitors used in the past
  • Anuria (the inability to pass urine)
  • Diabetic patients taking aliskiren
  • Allergy to sulfa drug

Increased caution should be used when patients suffer from the following:

  • Asthma, as the medication may increase risk of allergic reactions
  • Collagen vascular disease
  • Kidney disease, as the medication may increase risk of blood problems in these patients
  • Congestive heart failure, as the medication can cause kidney failure
  • Diabetes
  • Kidney problems, as the medication can lead to an increased risk of potassium overdose
  • Electrolyte imbalance
  • Fluid imbalance
  • Glaucoma
  • Gout
  • Hypercalcemia
  • Hypercholesterolemia
  • Hypertriglyceridemia
  • Kidney disease
  • Liver disease
  • Myopia
  • Systematic lupus erythematosus (SLE)

Not all drug interactions or medical interactions may have been listed herein. Inform your doctor of all conditions from which you suffer before use.

Warnings

In deciding to use this medicine, you should consider the benefits of doing so in relation to the potential risks. You should discuss risks with your doctor and together you should consider the following factors:

Allergies

You should inform your doctor of any allergies from which you suffer. This includes allergies to medications, dyes, preservatives, cleaning products, animals and other substances. If you have every reacted violently to ACE inhibitors then you should not use this medication.

Use of this medication can, in rare cases, cause anaphylaxis. Should this occur, you will need to seek emergency medical attention. Symptoms of anaphylaxis can include:

  • Swelling
  • Difficulty breathing
  • Confusion
  • Dizziness
  • Fever
  • Vomiting
  • Nausea
  • Fainting
  • Rash
  • Itching
  • Difficulty swallowing
  • Hoarseness

Pregnancy

This medication has been demonstrated to be harmful to the fetus. Use by pregnant women should be avoided where possible; however, in life-threatening situations, the benefits for treatment may outweigh the potential risks. If you are pregnant, then inform your doctor before taking this medication. If you become pregnant whilst taking this medication, then inform your doctor straight away. When taking this medication, you should use an effective form of birth control. Discuss the best methods of contraception with your doctor.

Breastfeeding

The risks of infant exposure from breastfeeding are unknown. Discuss breastfeeding during use with your doctor.

The following serious potential side effects from this medication should be considered before beginning treatment. When taking this medication you may experience dizziness, lightheadedness and faintness when changing from a lying or sitting position to standing. You should ensure that you know how you react to this medication before driving or operating any machinery when taking the medication.

If you feel dizzy at any point, then you should lie down so that you do not faint and cause more serious injury. Sit for a short period and then get up slowly to prevent the dizziness from returning. If you do faint, then you should cease use of the medication temporarily and consult a doctor right away.

If you develop a sickness or begin vomiting while taking this medication, then you should inform a doctor. These conditions can cause you to lose water from the body and, in conjunction with the use of hydrochlorothiazide, there is a risk of dehydration.

You could develop a low count of white blood cells during treatment. If you experience a sore throat, fever or chills, then you should contact your doctor.

You may experience changes in blood sugar levels. If you notice any changes, then inform your doctor.

This medication can trigger serious liver problems. The following are symptoms of liver problems and should be reported to a doctor immediately:

  • Stomach pain
  • Intestinal pain
  • Pale stools
  • Dark urine stream
  • Lack of hunger
  • Sickness
  • Unusual tiredness
  • Unusual weakness
  • Yellow skin
  • Yellow eyes

You can also develop problems with your eyes during this treatment. Changes to your vision that occur when you take this treatment should be reported to a doctor straight away.

You may need to stop taking this medication several days before you undergo any other treatment. This includes elective surgeries, eye surgeries, dental surgeries and medical tests. Inform any medical professionals that you interact with of your use of this treatment.

Hyperkalemia may occur with use of this medication. If you experience any of the following, then you should contact your doctor:

  • Stomach pain
  • Intestinal pain
  • Confusion or disorientation
  • Difficulty breathing
  • Weakness in the legs
  • Numbness or tingling in extremities

Do not take any vitamin supplements unless approved by your doctor when taking this medication.

Do not take any medications alongside this medicine unless approved by your doctor. This is particularly important with medicines that are sold over the counter to treat:

  • Appetite control
  • Asthma
  • Colds
  • Coughs
  • Hay fever
  • Sinus or nasal problems

These medications will often have the affect of raising your blood pressure and can counter the effects of this treatment.

Storage

This medication should be stored out of reach of children at all times. Store it in a sealed container at room temperature and away from heat, moisture and direct light. Prevent this medication from being frozen.

Dispose of outdated and unwanted medicine appropriately. Your healthcare professional will be able to direct you about correct methods of disposal.

Summary

The use of benazepril and hydrochlorothiazide is for the treatment of hypertension or high blood pressure in patients. This medication uses a combination of drugs to lower the blood pressure.

High blood pressure, when left untreated, can cause serious medical conditions to occur, including heart disease, kidney disease, blood vessel disease and strokes. By lowering blood pressure in patients, benazepril and hydrochlorothiazide reduce these risks.

Benazepril and hydrochlorothiazide do not, however, cure high blood pressure. This treatment is a temporary method for lowering the blood pressure and should be prescribed along with advice on how best to lower the blood pressure naturally. This can be achieved by lowering stress levels, reducing salt intake, lowering fat intake, eating healthier foods, losing weight and exercising. Your doctor will be able to advise you on the best steps that you can take in order to lower your blood pressure naturally.

Stopping use of benazepril and hydrochlorothiazide suddenly without naturally lowering the blood pressure in the patient will expose them to an increased risk of serious medical conditions. When taking this medication, it is common to feel healthy and normal, but the cessation of treatment will expose you to serious risk. No changes to the use of this medication should be made without first discussing them with a doctor.

Benazepril and hydrochlorothiazide is a two-fold treatment that works in two disparate ways. Benazepril works by blocking the production of a natural enzyme in the body which causes contraction of the blood vessels. In stopping this enzyme, the blood vessels are forced to relax and the blood pressure is lowered. Hydrochlorothiazide is a diuretic that increases the passing of urine from the body. This, in turn, removes more water from the body and from the blood stream. By taking water out of the blood stream, the volume of blood is reduced and thus the pressure is relieved.

Any conditions, including sickness or diarrhea, that may cause you to lose more water than usual should be reported to a doctor when you are taking this medication.

This medication has been shown to be harmful to a fetus. Pregnant women should not take this medication and steps should be taken to prevent pregnancy while the treatment is in use. In cases where a woman's life is threatened, the benefits of the use of this medication in pregnant women can outweigh the risks of exposing the fetus to the treatment. The potential risks of treatment whilst breastfeeding are unknown.