Bentiromide is used to examine whether the pancreas is working as it should. It is used as a screening test for exocrine pancreatic insufficiency and monitoring the inadequacy of supplemental pancreatic therapy. It is administered orally as a noninvasive test. The amount of 4-aminobenzoic acid and metabolites released through urine is taken as a measure of the chymotrypsin secreting activity of the pancreas.
A healthy pancreas should produce the right chemicals in proper proportions, to digest the produced food.
The pancreas contains exocrine glands that are responsible for secreting enzymes essential for digestion. These enzymes include chymotrypsin and trypsin that digests proteins, amylase that digests carbohydrates, and lipase that breaks down fats and lipids. As food enters the stomach, these pancreatic juices are secreted into the pancreatic duct. The pancreatic duct joins with the bile duct to form the ampulla of Vater, which is located in the duodenum, the first portion of the small intestine. The common bile duct originates in the gallbladder and the liver and secretes another important digestive juice called bile. The bile and the pancreatic juices are then released into the duodenum to help the body digest proteins, carbohydrates and fats.
The endocrine component of the pancreas is made up of islet cells (islet of Langerhans) that produce and release essential hormones directly into the bloodstream. Two of the key pancreatic hormones are insulin, which is responsible for lowering the body's sugar level, and glucagon, which is responsible for raising the blood's sugar levels. Maintaining the right blood sugar levels is critical to the functioning of key organs such as the liver, brain, and kidneys.
As already mentioned, bentiromide is administered orally as a single dose. After taking the medication, all of your urine is collected for up to six hours. The total amount is measured and a sample saved for further examination of the concentration of 4-aminobenzoic acid and other metabolites. Your healthcare provider may repeat this test after every seven days.
Whether bentiromide needs to be prescribed is a decision for your healthcare provider to make. It is important that the benefits of this test outweigh its potential risks. Here are some of the factors that should influence the decision to perform this test:
Along with the intended effects, a medicine may also cause some undesired effects. While not all these side effects may occur, it is important that you seek direction from your healthcare provider if their severity becomes life-threatening.
Some bentiromide may not need medical attention. These side effects usually go away as the body adjusts to medication. Also, your healthcare provider may be able to advise you on ways to manage these side effects. However, if the side effect, like shortness of breath or breathing difficulty, intensifies, make sure that you seek emergency help as soon as you can.
Other side effects not mentioned here may occur in some patients. Call your doctor for help or questions on these side effects. You may also report the side effects to the FDA through 1-800-FDA-1088.
Bentiromide dosage does vary from patient to patient. Make sure you follow your doctor's prescription or read the directions on the label for proper use. The following information is only the average bentiromide dosage. If your dose is different, do not change it without the approval of your healthcare provider.
The amount of bentiromide administered also depends on the following factors:
Bentiromide overdose is unlikely. However, if you suspect overdose, be sure to seek direction from your healthcare provider. You may also report bentiromide overdose to the local Drug and Poisons Center in your area.
Seek direction from your healthcare with respect to a missed dosage. Do not double dose to make up for a missed bentiromide dosage.
Although certain medications should never be used together, in some cases two different medications may be used even if an interaction might occur. In such cases, your doctor may propose a change of dose or suggest other precautions necessary to counter interactions.
When you are taking bentiromide, it is specifically important that your healthcare provider know if you are using any of the following:
Eating certain types of food while on some medications may cause interactions to occur. Use of alcohol and tobacco too may cause interactions. Discuss with your healthcare provider the use of bentiromide with food, alcohol and tobacco.
The existence of the following medical conditions may affect the use of bentiromide. Be sure to inform your doctor if you have any of the following medical conditions as they may cause false test results:
Store the medication in a cool dry place away from moisture and direct sunlight. All drugs should be stored in the containers they were bought in. Keep all medicines out of children's reach. All unused and expired medication should be disposed of appropriately.
Bentiromide is a diagnostic agent used for testing exocrine pancreatic insufficiency. The screening test can also be done to monitor the efficiency of supplemental pancreatic therapy among other conditions. Administered orally, the pancreas breaks down bentiromide just the same way it breaks down food. After breakdown, part of the agent is passed out of the body with urine. By measuring the levels of bentiromide in the urine, your healthcare provider can tell how well your pancreas is working. Urine samples are taken six hours after taking the medication. This test is repeated after every seven days.
Like other medications, bentiromide does have side effects. Some of these side effects are mild and usually go away as the body adjusts to medication. However, other side effects, like shortness of breath, may require medical attention depending on severity. Consult your healthcare provider about bentiromide side effects and how you can manage them.
Bentiromide is no longer available in the U.S market as it was withdrawn in October 1996.