Bepotastine Besilate (Ophthalmic)

Bepotastine Besilate works to prevent the effects of certain inflammatory substances in the eye to combat the symptoms of allergic conjunctivitis.


Bepotastine Besilate is administered as an eye drop. It works to prevent the effects of certain inflammatory substances that can irritate the eye. These substances are created by cells in the eyes and can cause allergic reactions. Bepotastine Besilate is used to treat the itching of the eye, which occurs as a symptom of allergic conjunctivitis.

This medicine must be prescribed by your doctor and should be administered directly into the eye as instructed. Do not exceed the prescribed dose.

This medicine is not for continued use and should be used only for the treatment of allergic conjunctivitis. It is not to be used for the treatment of irritation that is caused by contact lenses. Inform your doctor if you wear contact lenses before using this treatment.

Condition treated

  • Allergic conjunctivitis

Type of medicine

  • Antihistamine

Side Effects

When undergoing treatment with Bepotastine Besilate it is possible that unwanted side effects may occur. If they do occur then you may need to seek medical attention, although some side effects do not require this.

The following side effects could be a sign of a reaction to the medication and should be reported to a medial professional immediately:

  • Redness of the eyes
  • Soreness of the eyes
  • Rash on your body
  • Itching
  • Swelling of the lips
  • Swelling of the tongue
  • Swelling of the throat

Other side effects may occur that do not usually require you to seek medical attention, although they can be alleviated in some cases. Some side effects will go away as your body gets used to the treatment. If any of the following side effects do become bothersome then you should inform your healthcare professional, but these symptoms are not usually a cause to seek medical advice:

  • Strange taste in your mouth
  • Fever
  • Aching muscles
  • Headache
  • Sore throat
  • Blocked nose
  • Runny nose
  • Unusual tiredness
  • Unusual weakness

Other side effects that are not listed here may occur. If other side effects do occur, inform your doctor or healthcare professional and ask to receive medical advice.


You will be informed by your eye doctor the dosage of this medicine that you should administer and of how often you should administer it. Do not use this medicine for longer or more frequently than your doctor has prescribed. Bepotastine Besilate eye drops are for short-term use only and you should stop using it when the symptoms have abated.

The dose of this medicine will be different depending on the patient and the severity of the infection. It will also depend on the strength of the medicine you are prescribed. The following doses are guidelines only. Follow your doctor's instructions for use of this medicine and ensure you read the label for instructions.

Adults, teenagers and children aged 2+ can use one drop of Bepotastine Besilate in the affected eye up to twice a day.

Children under the age of 2 should use a dose as directed by the doctor.

If a dose of this medicine is missed then you should administer it as soon as possible.

Do not take double doses of this medicine.

Instructions for the use of eye drops:

  • Ensure your hands and face are clean.
  • Shake the bottle of eye drops with it held upside down.
  • Remove the lid with the bottle remaining upside down.
  • Tip your head to look up at the ceiling and gently pull the lower eyelid down with your forefinger.
  • Uses the eye drops in the space created at the bottom of the eye and then gently close your eye.
  • Keep your eye shut for 2 minutes.
  • Replace the lid on the bottle.
  • Clean your hands thoroughly once again and remove any medication that may be on them.
  • Avoid touching the eye and any surface with the eye drop applicator.


Before using any medication it is important to consider other aspects of your life that may interact with the drug. Medicines can interact with one another and certain conditions can make the side effects of medications worse. Before taking Bepotastine Besilate you should inform your doctor if you have any of the following conditions:

Allergies - Any allergies that you have could cause interaction with the medication. This is particularly important if you have reacted to this type of medication before. Allergies to dye, foods, animals and other substances should also be shared with your eye doctor before treatment.

Pregnancy - There are no adequate studies to determine effect. Consult your doctor before using any medication as a pregnant woman.

Breastfeeding - There are also no adequate studies to determine the risks of breastfeeding. Consult your doctor to weigh the benefits against the potential risks.

Drug interactions - Medicines can react with one another or stop each other from working. Inform your healthcare professional if you are taking any other medication including medication that is sold over the counter, herbal remedies and vitamin supplements. Inform your doctor if you are taking any other antihistamine medications in particular.

Other interactions - Other habits such as alcohol consumption, use of tobacco and certain diets can also affect the way a drug works. Inform your doctor of your habits to determine any effect.


When undergoing treatment with this medication your eye doctor will need to carry out regular checks to ensure that it is working effectively and that you are not experiencing any unwanted side effects.

If you wear contact lenses they must be removed before using these eye drops. After using the medicine you should wait for at least 10 minutes before putting the lens back into your eye. If there is reddening of the eyeball then you should not put your lenses back in. This medicine is not for use to treat irritation caused by lenses.

If your symptoms worsen when taking this treatment you should inform your doctor. Symptoms should improve within a few days of beginning the treatment.

A very serious allergic reaction to this medication is rare but can occur. If you begin to show signs of an allergic reaction to this medication then you should seek medical attention immediately. Signs of a serious allergic reaction will include some or all of the following:

Inform any healthcare professional of your use of this medication before undergoing any other treatment. This includes any surgery, dental work or any new prescriptions that you are to be given.


Store the medicine as received in a closed container at room temperature. Keep the medicine away from heat, moisture and direct sunlight at all times. Prevent this medicine from freezing.

Keep out of the reach of children at all times.

Once the symptoms are gone you should dispose of the remaining medicine. Never keep outdated medicine. Dispose of the medicine properly as instructed in the manufacturer's instructions or ask your doctor how you should dispose of the unwanted medicine.


Bepotastine Besilate is administered through the ophthalmic route via the use of eye drops. Bepotastine Besilate must be prescribed by a doctor but can be self-administered by the patient.

Bepotastine Besilate is suitable for use from the age of 2+ although doctors may still prescribe it to those aged under 2 in certain cases.

The eye drop is an antihistamine used for the treatment of the itching symptoms of allergic conjunctivitis. This is a short-term treatment and should not be used for a long period of time. Symptoms should be relieved in just a few days. If this is not the case, inform your medical professional.

This eye drop is not suitable for the treatment of irritation caused by contact lenses. If you are a user of contact lenses you should inform your doctor of this. The eye drop cannot be administered while contact lenses are in the eye and ideally you would wear glasses during the period of treatment to allow for faster recovery.

Severe allergic reactions to this medication are very rare but can occur. If you react badly to this medication then you should seek immediate medial attention. Severe allergic reactions can affect the breathing passage, so rapid treatment will be required.

This medication does not have many interactions with other drugs or medication but you should inform your doctor of any other medications you are taking or of any other medical conditions that you may have. Before using, inform your doctor of any allergies that you are aware of having and inform your doctor if you are taking any other antihistamine treatments.

Last Reviewed:
December 22, 2017
Last Updated:
April 04, 2018