Betamethasone and Clotrimazole (Topical)

Clotrimazole and betamethasone is prescribed for fungus infections to hinder the development of the fungus.


Clotrimazole and betamethasone is a prescription medication that remedies fungus infections. It is a topical combination medicine that inhibits the progression of the fungus. Betamethasone aids in alleviating itching, swelling, redness, and additional uneasiness of fungus illnesses. Betamethasone is a steroid, cortisone-like medication, also known as a corticosteroid.

The US manufactured brand name for this medication is Lotrisone. The Canadian manufactured brand name for this medication is Lotriderm, and Pms-Clotrimazole and Betamethasone.

This medication is offered in both lotion and cream forms.

Conditions treated

Type of medicine

  • Corticosteroid

Side Effects

Medications can trigger unwanted side effects along with the benefits that the medication brings. The following lists detail potential side effects that could occur. They may not occur, but if these side effects do take place they require medical care right away.

Consult your physician right away if any of these side effects take place:

Less Common Side Effects' Medical Care Required

  • Skin irritation that was not present prior to beginning use of this medication (redness, dryness, peeling, itching, burning, or blistering)
  • Itching, crawling, burning, prickling, numbness, tingling feelings, œpin and needle sensations
  • Hives

Rare Side Effects' Medical Care Required

  • Swelling
  • Stinging
  • Side or lower back pain
  • Rash
  • Hoarseness or cough
  • Difficulty or pain during urination
  • Chills or fever

Side Effects (Frequency Unknown) ' Medical Care Required

  • Vomiting
  • Stomach pain
  • Skin softening
  • Scaling and redness near the mouth
  • Reddish purple lines on the legs, face, arms, groin, or trunk
  • Nausea
  • Irritability
  • Full or round trunk, neck, or face
  • Dry mouth
  • Abnormal weakness or tiredness
  • Abdominal pain

Certain patients may experience additional side effects that are not included on this list. Consult your medical professional if additional side effects take place. Contact your physician if you need medical advice regarding side effects of clotrimazole and betamethasone. The FDA also accepts reports of side reports, they can be reached at 1-800-FDA-1088.


Prior to Use

Before taking any prescription drug, the patient must compare the risks of taking the medication with the pros, benefits, and relief the drug will provide. The patient and doctor must make this decision together. Consider the following aspects prior to taking clotrimazole and betamethasone.


Let your physician know if you have had allergic reactions in the past, whether it was to clotrimazole and betamethasone or to another medication. Also inform your doctor if you have allergies to other things, including animals, preservatives, dyes, or foods. In regards to products that are sold over the counter, be sure to read the ingredients and label thoroughly.


It is not suggested for children under 17 to use Lotrisone® lotion.


There have not yet been suitable research studies performed to determine problems for elderly patients that would impact the effectiveness of clotrimazole and betamethasone. It is important to note that elderly patients tend to have a higher chance of developing skin ulcers or to have thinning skin, so they should take extra caution when applying clotrimazole and betamethasone lotion.

Dosing Information

Patients must only take this medication in according with the directions given by the physician. Never take a larger dose of this medication than prescribed. Never take this medication more frequently than prescribed. Skin irritation and unwarranted side effects can occur when instructions are not followed.

There should be an informational patient booklet that came with the medication packaging. Consult your physician with any questions you may have. Follow all directions carefully.

This medication should only be used on skin. Keep it away from your mouth, nose, eyes, underarms, face, or vagina.

Do not stop applying this prescription lotion as the infection may not completely clear up without the full treatment length. The symptoms may clear up quickly, but the lotion should still be applied. If the infections are taking longer than expected to subside, this medication should be continued daily for a period of at least several weeks. Symptoms may come back if the patient stops using this medication too early. Try not to neglect any doses of this medication.

Directions for Use

  1.  Wash hands prior to and after applying this cream.
  2. Spread a thin layer of cream to the area of the skin that is affected.
  3.  Rub lotion in softly.

Never wrap the affected area of the skin with a bandage or other materials unless a physician instructs you to do so. It is important to wear clothing that is loose enough so that the affected skin portion is not covered or tightly wrapped. Ensure the medication is completely dry prior to getting dressed.

This medication should not be used to treat tinea corporis or tinea cruris longer than 2 weeks. For tinea pedis specifically, it should not be used longer than 4 weeks unless otherwise instructed by your physician.

Average Dose

Different patients will have different doses of this medication prescribed to them by their physician. Follow only the orders given to you by your physician or the instructions on the label. Never change your dose unless your medical professional instructs you to change it.

The strength of the medication determines the total amount of medication that patients should take. The amount of doses that patients should take per day, the time between doses, and how long it takes the patient to take this medication is dependent on the medical issue for which they are prescribed the medication.

Topical doses (lotion or cream) for tinea corporis and tinea cruris:

  • Adults and teenagers over 17: Apply ointment to affected skin twice daily, one time in the morning and one time in the evening. This should be done for one week.
  • Children under 17: Not recommended for use.

Topical doses (lotion or cream) for tinea pedis:

  • Adults and teenagers over 17: Apply ointment to affected skin twice daily, one time in the morning and one time in the evening. This should be done for two weeks.
  • Children under 17: Not recommended for use.

Missed Dose

If a patient misses an application of this medication, it should be applied right away. Alternatively, if it is closer to the scheduled next dose, the missed dose should be skipped and the patient should return to the normal dosing schedule.


Drug Interactions

Some medications should never be combined, but other medications can be used at the same time, despite the possibility of interaction. The physician may decide to adjust the dose if they approve the combination of drugs, or additional precautions could be warranted.

Your medical professional should be informed if patients are applying any of the following medications. The following list of medications is comprised of medicines according to their significance. This list is not all-inclusive. It is not suggested to use clotrimazole and betamethasone with the following medications ointments. Your physician may adjust the other medications you take, or may not end up treating you with clotrimazole and betamethasone.

Physicians do not suggest for patients to combine use of clotrimazole and betamethasone ointment with the following medications. Certain cases may necessitate the combination of specific drugs. In rare cases where multiple medication ointments are prescribed at the same time, your physician will likely adjust the dosage or frequency of either medication.

  • Valdecoxib
  • Tolmetin
  • Tolfenamic Acid
  • Tiaprofenic Acid
  • Tenoxicam
  • Sulindac
  • Sodium Salicylate
  • Salsalate
  • Salicylic Acid
  • Rofecoxib
  • Proquazone
  • Propyphenazone
  • Proglumetacin
  • Pranoprofen
  • Pixantrone
  • Piroxicam
  • Piketoprofen
  • Phenylbutazone
  • Parecoxib
  • Oxyphenbutazone
  • Oxaprozin
  • Nimesulide Beta Cyclodextrin
  • Nimesulide
  • Niflumic Acid
  • Nepafenac
  • Naproxen
  • Nadroparin
  • Nabumetone
  • Morniflumate
  • Meloxicam
  • Mefenamic Acid
  • Meclofenamate
  • Lumiracoxib
  • Loxoprofen
  • Lornoxicam
  • Ketorolac
  • Ketoprofen
  • Indomethacin
  • Ibuprofen
  • Flurbiprofen
  • Flufenamic Acid
  • Floctafenine
  • Feprazone
  • Fepradinol
  • Fenoprofen
  • Felbinac
  • Etoricoxib
  • Etofenamate
  • Etodolac
  • Droxicam
  • Dipyrone
  • Diflunisal
  • Diclofenac
  • Dexketoprofen
  • Dexibuprofen
  • Clonixin
  • Choline Salicylate
  • Celecoxib
  • Bupropion
  • Bufexamac
  • Bromfenac
  • Bemiparin
  • Amtolmetin Guacil
  • Aldesleukin
  • Acemetacin
  • Aceclofenac

If patients combine clotrimazole and betamethasone with the following list of medications, it will likely trigger a heightened chance of side effects; however, implementing the use of both medications could prove to be the best treatment. In rare cases where your physician may prescribe clotrimazole and betamethasone along with any of the following medications, the dose or frequency of doses may be adjusted.

  • Trimetrexate
  • Tosufloxacin
  • Tacrolimus
  • Sparfloxacin
  • Saiboku-To
  • Rufloxacin
  • Rifapentine
  • Rifampin
  • Prulifloxacin
  • Primidone
  • Phenytoin
  • Phenobarbital
  • Pefloxacin
  • Pazufloxacin
  • Ofloxacin
  • Norgestrel
  • Norgestimate
  • Norfloxacin
  • Norethindrone
  • Norelgestromin
  • Nadifloxacin
  • Moxifloxacin
  • Metocurine
  • Mestranol
  • Medroxyprogesterone Acetate
  • Lomefloxacin
  • Licorice
  • Levonorgestrel
  • Levofloxacin
  • Hexafluorenium
  • Gemifloxacin
  • Gatifloxacin
  • Gallamine
  • Fosphenytoin
  • Flumequine
  • Fleroxacin
  • Etonogestrel
  • Ethynodiol Diacetate
  • Ethinyl Estradiol
  • Estradiol Valerate
  • Estradiol Cypionate
  • Enoxacin
  • Drospirenone
  • Dienogest
  • Desogestrel
  • Ciprofloxacin
  • Besifloxacin
  • Balofloxacin
  • Atracurium
  • Aspirin
  • Alcuronium

Other Interactions

Some prescription ointments should not be used while eating or drinking as it can increase the possibility of interactions taking place. The use of tobacco or alcohol with various medications can also trigger interactions. Be sure to consult your physician regarding your medication lotion and how the use of it relates to food, tobacco, or alcohol.

Other Medical Problems

When patients have additional medical issues, it can create complications and may even impact the effectiveness of this medication. Inform your physician of any other medical issues, including:

  • Varicella (chickenpox)
  • Vaccinia (cowpox)
  • Skin virus infections ' take caution, betamethasone can increase spread virus infections
  • Skin tuberculosis' take caution, betamethasone can cause conditions to become worse.
  • Skin infection near application
  • Skin diseases that damage circulation (stasis dermatitis)
  • Skin bacterial infections
  • Liver failure ' take caution, heightened possibility of side effects
  • Intracranial hypertension (pressure within head) ' take caution; can make side effects worse
  • Hyperglycemia (high blood sugar)
  • Herpes
  • Diaper dermatitis (diaper rash) do not use clotrimazole and betamethasone for patients with this ailment
  • Diabetes
  • Broken skin, serious skin injury, or large sores at affected area of skin
  • Adrenal gland disorder (Cushing's syndrome)


This medication must be applied to the skin only.

It is important to note infections of the skin that do not progress within a week for ringworm or jock itch and two weeks for athlete's foot. If conditions become worse, consult your physician regarding next steps.

Patients should use caution not to use too much clotrimazole and betamethasone, and should not to use it for longer than prescribed; adrenal gland issues can be increased otherwise.

Patients and young people who use clotrimazole and betamethasone over a long period of time are at a greater risk. Consult with your medical professional immediately if the patient has more than one of the following symptoms while on this medication:

  • Weakness (unusual)
  • Vision blurred
  • Dizziness
  • Fainting
  • Fast heartbeat
  • Irregular heartbeat
  • Pounding heartbeat
  • Increased urination
  • Increased thirst
  • Tiredness (unusual)

Consult your physician immediately if the skin becomes irritated, red, swells, burns, stings, or rash covered.

Avoid using skin care items, such as lotion, on the affected area.

Consider the following beneficial health habits to aid in clearing skin infections entirely.

Tips for patients using clotrimazole and betamethasone for athlete's foot:

  • Cautiously dry the area between the toes and the feet overall after showering.
  • Do not wear socks that were manufactured with synthetic or wool materials, such as nylon or rayon. In its place, put on fresh, cotton socks and be sure to change the socks every day or even more frequently if you experience greater sweating.
  • Well-ventilated shoes should be worn; this includes sandals or shoes with holes.
  • An antifungal powder or an absorbent powder (such as talcum powder) should be applied to the feet, in between the toes, and in shoes and socks one to two times daily.
  • It is important to use the powder only after lotion has been applied and has been absorbed into the skin. Do not rely on the powder as the only form of healing.

Tips for patients using clotrimazole and betamethasone for jock itch:

  • Cautiously dry the area around the groin after cleaning the area.
  • Do not wear underwear that is made from synthetic fibers or is too tight fitting, as these can cause irritation. Alternately, cotton loose-fitting underwear should be worn.
  • An antifungal powder or an absorbent powder such as talcum powder should be applied one to two times daily. Ensure the powder is used after clotrimazole and betamethasone cream has been applied and has been absorbed into the skin. Never consider the powder as the main form of treatment for a lung infection.

Tips for patients using clotrimazole and betamethasone for body ringworm:

  • Cautiously dry yourself once finished showering.
  • Do not spend much time around humidity and heat, if possible. Attempt to stay far from moisture becoming built upon impacted area of the skin.
  • Ensure clothing is always well-ventilated.
  • Be sure to use an antifungal powder or an absorbent powder, such as talcum powder one to two times daily. Apply the powder after clotrimazole and betamethasone lotion is applied and has been absorbed into the skin.
  • Never use the powder as the main form of treatment for a fungus infection.

If patients have questions or concerns regarding clotrimazole and betamethasone, they should consult their physician.


Ensure this medication is kept in a sealed container at a comfortable room temperature. Keep the container far from moisture, heat, and direct light. Do not keep medication near freezing temperatures.

Do not store clotrimazole and betamethasone in a location where children can reach it.

Medication or lotion that is past its expiration date should not be kept. Consult your physician regarding how to properly dispose of unused medication.


Clotrimazole and betamethasone is a prescription ointment that can improve fungus infections. It is a topical combination cream that hinders the advancement of the fungus. Betamethasone helps with improving itching, swelling, redness, and additional uneasiness of fungus illnesses. Betamethasone is a steroid, also known as a corticosteroid. It is a cortisone-like medication. If extreme skin irritation and redness occur, patients must seek medical attention immediately as there are various side effects of this medication.

There are also several medications that can cause interactions with clotrimazole and betamethasone, which is why it is important to consult your physician prior to combining the use of any prescription medications. Any prescription drug should be taken for the entire prescribed period, as the medication may require the entire time to work and begin correcting redness and irritation issues. Patients who currently have, or have had ringworms in the past should read through the warnings section of this article. Other medical issues that are preexisting can also impact the effects of this medication. Talk to your physician to find out how this prescription may interact with preexisting medical issues. Adrenal gland issues can take place if patients apply this medication for a longer period of time than prescribed. Always use caution and apply this medication in accordance with instructions from your physician.

Last Reviewed:
December 25, 2017
Last Updated:
April 05, 2018
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