Brinzolamide (Ophthalmic)

Brinzolamide is classified under medications known as carbonic anhydrase inhibitors. It works by decreasing the amount of fluid in eye, which reduces pressure inside the eye.

Overview

Brinzolamide ophthalmic is used for treating glaucoma (a condition that's characterized by increased pressure in the eye) as well as eye ailments such as ocular hypertension. Both diseases are painful and can cause a patient to lose vision if not treated early. This medicine belongs to a class of medicines called carbonic anhydrase inhibitors and works by decreasing pressure in the eye hence stopping eye pain. Brinzolamide ophthalmic can only be prescribed by the doctor and comes in the form of liquid solution (suspension).

This medication should be used in strict adherence to the doctor's instructions. Make sure you keep all appointments with your physician while taking this medication. Your doctor will run a number of tests to find out your reaction to brinzolamide ophthalmic. He or she will only change your medication if it causes allergic reaction or severe side effects.

Do not allow any other person to use this medication. Ask your doctor or physician any questions you have about using this medication.

Conditions treated

  • Glaucoma
  • Ocular hypertension

Type of medicine

  • Anhydrase inhibitors

Side effects

Brinzolamide ophthalmic is quite effective in treating glaucoma and ocular hypertension symptoms. But along with the needed effects, this medication is known to cause a number of side effects. However, not all side effects can occur on one patient; side effects vary in each and every patient. If any of these side effects occur while using this medication, talk to your doctor for help immediately.

More common side effects

  • Blurred vision

Less common side effects

  • Dry eyes
  • Discharge from the eye
  • Soreness in the eye
  • Irritation in the eye
  • Pain of the eye or eyelid
  • Skin rash
  • Redness in the eye

Rare side effects

  • Cough
  • Chest pain
  • Difficulty with swallowing
  • Dizziness
  • Crusting in the corner of the eye
  • Eye redness, irritation, or pain
  • Double vision
  • Fast heartbeat
  • Swelling, itching or other signs of eye irritation
  • Muscle stiffness
  • Hives
  • Muscle tension or tightness
  • Kidney pain
  • Puffiness around the eyes
  • Swelling on face, tongue and lips
  • Seeing double
  • Sore throat
  • Shortness of breath
  • Unusual tiredness or weakness
  • Wheezing
  • Tightness in the chest

Incidence not known

  • Chills
  • Clay-colored stools
  • Abdominal pain
  • Blistering, peeling, or loosening of the skin
  • Diarrhea
  • Fever with or without chills
  • General feeling of tiredness or weakness
  • Headache
  • Dark urine
  • Joint or muscle pain
  • Hoarseness
  • Lower back or side pain
  • Loss of appetite
  • Painful or difficult urination
  • Nausea Red or irritated eyes
  • Sores, ulcers, or white spots on the lips or in the mouth
  • Swollen or painful glands
  • Unpleasant breath odor
  • Unusual bleeding or bruising
  • Vomiting Yellow eyes or skin
  • Red skin lesions

Some unwanted effects do not necessarily need the doctor's intervention as they go away once your body adjusts to this medication. Also, your doctor may give you some tips on how to reduce or prevent some of these side effects. Talk to your physician if any of these unwanted effects get worse.

More common

  • Bitter or unusual taste

Less common

  • Burning discomfort when drug is applied
  • Feeling of something in the eye
  • Runny nose
  • Sneezing/stuffy nose
  • Dry eyes

Rare

  • Body aches or pain
  • Acid or sour stomach
  • Difficult or labored breathing
  • Dry mouth
  • Indigestion
  • Hair loss
  • Heartburn
  • Hives or welts
  • Stomach upset, pain or discomfort
  • Tender, swollen glands in the neck
  • Congestion
  • Indigestion
  • Thinning of the hair

Other unwanted effects may occur but are not listed here. If you experience any other side effects not mentioned here, notify your physician as soon as possible. You can also read the printed leaflet that comes with this medication to know all the possible side effects that may occur while using this medication. Talk to your doctor if you have any questions about some of the side effects you are likely to experience while using brinzolamide ophthalmic.

Dosage

This medication comes as a liquid suspension and is applied right into your eye in the form of drops. You should wash your hands prior to using this medication to prevent any chance of contamination.

Adult dose for Glaucoma

Apply one drop in each eye three times a day. If you are using other medication, don't apply both medications at the same period. Space them apart for 10 minutes or more.

Adult dose for ocular hypertension

Apply one drop on each eye three times per day. If you are using other eye medications, ensure that you apply one medication at a time. Wait at least 10 minutes before applying the next medication.

If you miss a dose, take one immediately once you remember. However, if you are nearing your next dose, just skip the missed dose and continue with your normal dosing schedule. Don't take extra medicine to compensate for the missed dose.

Seek attention immediately if you've applied too much of this medicine. An overdose of this medication may not produce life threatening symptoms. However, this doesn't mean that you shouldn't seek quick medical intervention if certain side effects become unbearable.

Use brinzolamide ophthalmic according to the instructions provided by your doctor. Do not use this medication in large or lesser amounts than what's recommended by the doctor. You can check out more information regarding this medication online or on the printed prescription label. Ask your doctor or pharmacist if you don't understand some of the information provided on using this drug safely. You can also do a bit of research online just to make sure that you are using this medication as instructed.

Brinzolamide ophthalmic has been found to be effective in controlling the symptoms of glaucoma. However, this medication may not completely cure such symptoms. Continue using this medication even if you feel relief in your eyes. Do stop applying this medication unless the doctor permits you to do so. If you stop using this medication without the permission of your doctor, your eye infection may not go away completely.

Drug Interactions

Prior to using brinzolamide ophthalmic, you should inform the doctor about any other medication you are using or plan to start taking. When certain drugs are used together interactions may occur. As such, you ought to know what drugs interact with brinzolamide ophthalmic. In some special cases, drugs that interact with each other may be used in combination for your own benefit.

Maintain a list of all drugs that interact with brinzolamide ophthalmic. This list should have both prescription as well as over-the-counter medications that you buy without prescription. Herbal supplements, vitamins and minerals should also be added to the list. The following is a list of medications that interact with brinzolamide ophthalmic. Do not start using any of these drugs without the permission of the doctor:

Common drugs that interact with brinzolamide ophthalmic

  • Acetylsalicylic Acid (aspirin)
  • Aspirin Aspir 81 (aspirin)
  • Low Strength (aspirin)
  • Crestor (rosuvastatin)
  • Humalog (insulin Lovenox (enoxaparin)
  • Lumigan (bimatoprost ophthalmic)
  • Paracetamol (acetaminophen)
  • Nitrolingual Pumpspray (nitroglycerin)
  • Travatan Z (travoprost ophthalmic)
  • Tylenol (acetaminophen)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • Vitamin B Complex 100 (multivitamin)
  • Vitamin C (ascorbic acid)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin D2 (ergocalciferol)
  • Vitamin D3 (cholecalciferol)
  • Xalatan (latanoprost ophthalmic)
  • Vitamin K (phytonadione)
  • Vitamin B6 (pyridoxine)

If you have other medical problems, it's good to inform your doctor as this medication may interact with them. This medication may cause serious side effects or worsen some of your symptoms if you are suffering from other medical conditions.

Your doctor may change the dosage amount or instruct you not to use this medication if it worsens your symptoms. Brinzolamide ophthalmic is known to interact with the following diseases:

  • Hematologic Toxicity
  • Porphyria
  • Hypersensitivity Reactions
  • Liver Disease
  • Crystalluria
  • Renal Dysfunction
  • Urinary Obstruction

Warnings

Stop using this medication immediately if you are allergic to brinzolamide ophthalmic. Some of the common symptoms of an allergic reaction are itching or swelling of the eye. Speak with your doctor as soon as possible if you are allergic to this medication.

Serious allergic reactions can occur while using this medication. Stop using this drug immediately and check with your doctor if you notice any of these signs: black or tarry stools, peeling of skin, blistering of your skin, dark urine, muscle pain, joint pain, rash, ulcers or sores in the mouth and lips, unusual bleeding, bruising, unusual fatigue, yellowing of skin and eyes.

Don't use this drug if you are wearing your contact lenses. Brinzolamide ophthalmic may contain preservatives that can be easily absorbed by soft contact lenses. Also, once you apply the eye drops, give yourself an allowance of 15 minutes before you put your contact lenses back in.

Ensure that your eye dropper doesn't touch any surface including your hands or eyes. The dropper can easily be contaminated if it comes into contact with any surface. A contaminated dropper can cause severe eye infection or disease.

Do not use any other eye medication while using brinzolamide ophthalmic unless the doctor gives you permission. There are some cases where the doctor may allow you to use two medications at the same time.

Brinzolamide ophthalmic may cause blurred vision. Be very careful when driving or using machinery. Also, do not take part in any activity that may require you to see clearly. This is a side effect that may ease after your body adjusts to the medication. Speak with your doctor if you continue to experience blurred vision while using this medication. Your doctor may change your dosage or command you to stop this medication altogether.

Talk to your doctor immediately if you have an eye infection, hurt your eye or need surgery. Your doctor may use a new bottle (eye drops) just to prevent any further infection.

Stop using other medications (prescription and non-prescription) while using this medication unless your doctor allows you to do so. Don't also use herbal supplements, vitamins or minerals without the permission of your physician.

This medication can harm your unborn baby according to the FDA. Inform your doctor if you are pregnant or planning to conceive while using this medication. It has not been established if using brinzolamide ophthalmic affects breast milk. As such, do not use this medication unless you are given permission by your doctor if you are breastfeeding.

Do not use more or less of this drug - follow the dosage instructions of the doctor at all times. Also, do not stop using this medication unless your doctor tells you to do so.

Storage

Keep this medication in a safe location where children cannot reach it. Also, store it at room temperature. Do not store this medication in the bathroom as such a place may have excess heat or moisture. Unwanted medication should be disposed of safely. Your local take-back program is the best option for disposing of unneeded medications. Ask your pharmacist or garbage collector to recommend a safe option for disposing your unneeded medication if you can't find one. You can also do a bit of research online to find other smart ways of disposing unneeded drugs.

Summary

Brinzolamide ophthalmic is a medication used for treating eye diseases such as glaucoma and ocular hypertension. Glaucoma is a condition characterized by increased pressure in the eye. The disease causes unbearable pain and may cause patients to lose their vision. Brinzolamide ophthalmic is grouped in a class of medications known as carbonic anhydrase inhibitors. It works by reducing the pressure in the eye thus stopping eye pain.

Brinzolamide ophthalmic comes in the form of a liquid suspension and is applied directly into the eye. Glaucoma or ocular hypertension patients should apply one drop in each eye three times per day. You should wash your hands before using the dropper. The dropper should not come into contact with any surface as this can cause contamination.

Taking brinzolamide ophthalmic can cause certain side effects. Some side effects may go away once this medication adjusts to your body, while other unwanted effects may require urgent medical attention from the doctor. Some of the common side effects to expect while taking this medication include: blurred vision, dry eyes, headache, runny nose, feeling that things are in your eye, bitter taste, sour or unusual taste.

Also, this medication should not be applied if you are already using other drugs as interactions can occur. Tell your doctor about all the medications you are currently using or intend to use. Some of the common drugs that may interact with brinzolamide ophthalmic include, but are not limited to: Acetylsalicylic Acid (aspirin), low Strength (aspirin), Lumigan (bimatoprost ophthalmic), Travatan, and vitamin B complex 100 (multivitamin).

Stop using this medication immediately if you are allergic to brinzolamide ophthalmic. In addition, applying this medication into your eyes may cause blurred vision. As such, do not drive, operate machinery or perform complicated activities, especially if you cannot see clearly.

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Last Reviewed:
December 23, 2017
Last Updated:
April 04, 2018
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