Budesonide (Rectal)

Budesonide rectal foam is a prescription medication used to treat mild to moderate ulcerative colitis that generally extends from the rectum to the sigmoid colon up to 40 cm from the anal verge.
--or get it under control (induce remission). Certain medications can interact with budesonide, therefore, patients should be cautious when taking more than one prescription or nonprescription (over-the-counter) medication. Budesonide rectal foam helps relieve symptoms associated with the condition, such as diarrhea mixed with blood and abdominal pain.

Budesonide rectal foam is also known by its brand name, Uceris. Patients with certain medical conditions should not take budesonide, such as cataracts (eye disease), infection (such as fungus, virus, or bacteria), tuberculosis, a stomach ulcer, eczema, diabetes, com/health/coma/">glaucoma, rhinitis, osteoporosis, a weakened immune system, tuberculosis, infection, or hypertension (high blood pressure).


Budesonide rectal foam is a prescription medication used to treat mild to moderate ulcerative colitis that generally extends from the rectum to the sigmoid colon--or get it under control (induce remission). Budesonide is a steroid (cortisone-like) medication that's also available in oral or inhalation forms.

Condition(s) Treated

  • Mild to Moderate Ulcerative Colitis

Type of Medicine

  • Steroid

Side Effects

Some medications can cause unwanted side effects during the course of treatment. Some side effects might not occur, but if you do notice some developing, contact your physician, as it may require medical attention. Some less common side effects of this nature include:

  • Nausea
  • Diarrhea
  • Skin rash
  • Vomiting
  • Darkening of the skin
  • Unusual weakness or tiredness
  • Fainting
  • Mental depression
  • Dizziness
  • Loss of appetite

There are some side effects for which the incidence is unknown. Side effects of this nature include:

  • Burning, dryness, blistering, crusting, or flaking of the skin
  • Side or lower back pain
  • Blurred vision
  • Headache
  • Swelling or puffiness of the eyelids or around the eyes, lips, face or tongue
  • Cough or hoarseness
  • Difficulty swallowing
  • Slow or fast heartbeat
  • Itching or hives
  • Chills or fever
  • Tightness in the chest
  • Scaling, itching, soreness, redness, or swelling of the skin
  • Difficult or painful urination
  • Pounding in the ears

Some rare side effects of this nature include:

  • Trouble sleeping
  • Pimples
  • Other blemishes on the skin

Some side effects are not listed here. If you begin to develop any other side effects, contact your doctor. He or she can help you report your side effects to the FDA (Food and Drug Administration), if necessary.


Be sure to use this medication properly--meaning exactly as your doctor directed you to. Avoid using budesonide more frequently or less frequently than your doctor instructed, and avoid using budesonide for a lengthier time period than your physician recommends. Typically, budesonide is accompanied by some patient information in the form of a leaflet; be sure to read it carefully and ask your physician if any concerns arise.

Prior to using this medication, use the bathroom and try to clean out your bowels. This medication is intended to be smeared directly onto the anus--not to be taken orally.

Fasten the applicator that comes with the medication to the can. Every applicator comes coated with an emollient, however, if you need more lubrication, petroleum jelly or petrolatum is recommended. Warm up the foam in the canister; accomplish this by shaking it for ten to fifteen seconds in your hands.

When ready to insert, get into a standing, sitting, or lying position--whichever is easiest for you. Many patients find it easier to apply the medication on the toilet. Before using the foam for the first time, take off the plastic safety lock from under the pump dome. Then, twist the dome until the small notch on the underneath of it is in line with the nozzle. Turn the spray upside down and insert the applicator into your back passage as far you comfortably can. Then, push down the pump dome on the container one time before releasing it slowly. Wait about 10 to 15 seconds before you withdraw the applicator. Then remove it and put it in a plastic bag.

Apply the foam every morning and night for the first two weeks. When using it at night, using it before it's time for bed is recommended.

The dosage of budesonide will vary from patient to patient. Follow the instructions given by your doctor or the label on the packaging. The succeeding knowledge is for general purposes and it not intended to replace the instructions given by your doctor, or the instructions on the medication. If the dose you're prescribed deviates from the information given here, avoid altering your dosage--unless your general practitioner (GP) tells you it's okay.

The quantity of medication you'll take will depend on the power of it and the quantity of doses you take, as well as the length of time amid doses and the period of time in which you use the medication will be contingent upon the condition you're treating.

For initiation of remission moderate to mild distal ulcerative colitis, adults should take one metered dose (which contains two milligrams) twice per day at dawn and at night for at least two weeks. Once two weeks pass, apply it only once daily at night, preferably before you go to bed for approximately four weeks. Children should have their dosage determined by their doctors.

If you miss one of your doses, take that missed dose as soon as you remember--unless it's nearly time for your next dose. In that case, skip your missed dose and resume your normal dosing schedule. Never double up on doses to make up for a missed dose.

Major Drug Interactions

Budesonide rectal foam may cause interactions when taken with certain other medications. You and your physician must decide whether the medication is worth taking, based on the information provided. Consider the following information before using budesonide rectal foam.

Certain medications should not be used together, even if there's a chance an interaction might occur. Your doctor might want to change your dosage, or take other necessary precautions. Let your physician know if you're taking any of the following medications. Use of these medications is typically not recommended while using budesonide rectal foam, however, it may be necessary as part of your treatment.

  • Aceclofenac
  • Acemetacin
  • Feprazone
  • Nimesulide
  • Pixantrone
  • Etodolac
  • Cobicistat
  • Floctafenine
  • Amtolmetin Guacil
  • Droxicam
  • Conivaptan
  • Mefenamic Acid
  • Sulindac
  • Bemiparin
  • Pranoprofen
  • Flufenamic Acid
  • Piroxicam
  • Niflumic Acid
  • Darunavir
  • Boceprevir
  • proglumetacin
  • Etofenamate
  • Sodium Salicylate
  • Nimesulide Beta Cyclodextrin
  • Dexibuprofen
  • Bromfenac
  • Flurbiprofen
  • Dexketoprofen
  • Etoricoxib
  • Lumiracoxib
  • Bufexamac
  • Meclofenamate
  • Telaprevir
  • Oxaprozin
  • Diclofenac
  • Propyphenazone
  • Ibuprofen
  • Bupropion
  • Salsalate
  • Diflunisal
  • Meloxicam
  • Felbinac
  • Tenoxicam
  • Loxoprofen
  • Nepafenac
  • Oxyphenbutazone
  • Idelalisib
  • Celecoxib
  • Dipyrone
  • Tiaprofenic Acid
  • Fenoprofen
  • Proquazone
  • Ceritinib
  • Ritonavir
  • Choline Salicylate
  • Rofecoxib
  • Morniflumate
  • Clonixin
  • Fepradinol
  • Tolfenamic Acid
  • Parecoxib
  • Indomethacin
  • Nabumetone
  • Lumacaftor
  • Ketoprofen
  • Nadroparin
  • Ketorolac
  • Phenylbutazone
  • Lornoxicam
  • Tolmetin
  • Naproxen
  • Piketoprofen
  • Valdecoxib
  • Salicylic Acid

The following medications can cause an increased risk of side effects, but in some cases, it may be the best course of treatment to take both medications. If your physician prescribes both medications simultaneously, your dosage may be adjusted.

  • Balofloxacin
  • Levofloxacin
  • Prulifloxacin
  • Fleroxacin
  • Moxifloxacin
  • Rufloxacin
  • Besifloxacin
  • Nadifloxacin
  • Flumequine
  • Norfloxacin
  • Ciprofloxacin
  • Sparfloxacin
  • Gatifloxacin
  • Ofloxacin
  • Enoxacin
  • Tosufloxacin
  • Gemifloxacin
  • Pazufloxacin
  • Erythromycin
  • Ketoconazole
  • Pefloxacin

Some medications should not be taken around the same time you eat certain foods, as an interaction could occur. Drinking alcohol or using tobacco while taking this medication can also cause an interaction. Talk to your doctor about taking your medication with food, alcohol, or tobacco. Some pre-existing medical conditions can also cause interactions. These include:

  • Liver disease
  • Cataracts (eye disease)
  • Weakened immune system
  • Eczema (skin disease)
  • Tuberculosis (current or history of)
  • Glaucoma
  • Stomach ulcer
  • Hypertension (high blood pressure)
  • Rhinitis (inflammation inside the nose)
  • Infection (such as fungus, bacteria, or virus)
  • Osteoporosis (thin bones)


Your doctor may monitor your improvement regularly while taking budesonide rectal foam to monitor any unwanted side effects, or other problems that could be triggered by budesonide. If you condition becomes worse or fails to improve, check with your physician.

Tell your doctor if you've ever had a heart attack (or if you've got a heart condition); if you've got liver function problems, or if you've got kidney function problems; if you've got sugar diabetes, if you've got glaucoma, or if a close family member has either of these conditions; if you are pregnant or breastfeeding; if you have any kind of infection (like tuberculosis), or have had an infection; if you've had a heart attack, or you've got a heart condition; if you've ever had an allergic reaction to any medications, or if you've developed muscle pain after taking steroids. Local irritation may occur when taking budesonide rectal foam, but it generally eases. If it continues, contact your doctor. You may also feeling a little sick, but sticking to bland or simple foods can help ease this feeling. Be sure to avoid spicy or fatty foods also.

Also tell your doctor if you've ever had any of the following conditions: a stomach ulcer, a blood clot in a blood vessel, or a mental health problem like psychosis or depression; diverticulitis, 'thinning' of the bones (osteoporosis), high blood pressure, cataracts, epilepsy, or myasthenia gravis (a condition that causes severe muscle weakness).

Taking too much budesonide rectal foam can cause problems with your adrenal gland. Using this medication for extended periods of time can cause the same problem. Consult your doctor if you experience one or more of the following symptoms: diarrhea, nausea, fainting, unusual weakness or tiredness, darkening of the skin, skin rash, dizziness, limited appetite (or complete loss), vomiting, or mental depression.

Budesonide rectal foam may cause patients to have a decreased ability to fight infection. Therefore, it's best to avoid people with infections, or sick people. Talk to your doctor immediately if you were exposed to anyone fighting off measles or chickenpox.

Tell your physician or dentist that you're using budesonide. You might have to cease taking this medication several days prior to any scheduled surgeries or laboratory tests. Avoid taking any other medications unless you've discussed them with your general practitioner, including prescription and nonprescription (over-the-counter) medications, as well as vitamin or herbal supplements. Discontinue using budesonide rectal foam prior to having bowel preparation for a colonoscopy.

Avoid getting vaccinated while taking this medication, as some vaccines may not be suitable to take with budesonide rectal foam. If you need any immunizations, tell the person giving you the vaccine that you're currently taking a steroid medication.

If you're taking another steroid medication and you want to switch to budesonide, consult your doctor first, as this can increase your risk of having steroid withdrawal side effects, including diminished appetite (or complete loss of), headache, change in the ability to see colors (especially yellow or blue), headache, vomiting, and blurred vision.

Avoid grapefruit and grapefruit juice while taking or using budesonide, as the fruit contains a chemical that increases the amount of budesonide in your bloodstream, potentially increasing your risk of side effects.


Store budesonide rectal foam at room temperature and keep it away from direct light and heat. Avoid storing this medication in a car where it may be exposed to extreme heat. Avoid poking holes in the canister or throwing it into a fire--even if the can is empty, as the contents (or remnants) may be under pressure and highly flammable.

Store budesonide rectal foam in a closed container at room temperature, away from moisture, heat and light. Avoid freezing this medication.

If you have any unused medication, do not keep it. Dispose of it immediately so that children and pets cannot gain access to it accidentally. Ask your healthcare provider or pharmacist about ways to properly dispose of any expired or unused medication. They can refer you to a community medicine take-back program that takes unused and expired prescription medications.


While budesonide rectal foam is a greatly beneficial drug, it can also pose a risk to patients who fail to communicate fully with their doctors. For this reason, it's important that patients discuss with their doctor their family medical history, as well as any medications you may be taking that could cause serious interactions. There are several medications that can cause these reactions and several medical conditions as well. That's why it's in the patient's best interest to be honest and forthcoming with their physicians.

As a steroid treatment designed to help treat mild to moderate active ulcerative colitis that extends to the rectum to the sigmoid colon under control, budesonide rectal foam helps relieve symptoms associated with the condition, such as diarrhea mixed with blood and abdominal pain. This medication helps to reduce inflammation and improves overall quality of life for patients. You and your doctor can work together to determine the right dosage for you.

Last Reviewed:
December 23, 2017
Last Updated:
April 02, 2018