Caffeine and Sodium Benzoate (Injection)

The Caffeine and Sodium Benzoate injection is used following an overdose of narcotic pain medicines or alcohol to treat respiratory depression.


Caffeine and Sodium Benzoate is an injection given to patients suffering from respiratory depression following an excessive dose of narcotic pain medication or alcohol. The respiratory stimulant is used to promote an increase in breathing rate to encourage the patient to circulate more oxygen around their body and return them to consciousness.

The injection can only be used under the supervision of a doctor and is injected either into a muscle or a vein. The medication is used only in conjunction with other supportive therapies in a hospital.

This medication can make other medical conditions worse. Use should be avoided in patients who have heart disease or other conditions of the heart.

Use in pregnant women should also be avoided where it is possible to identify this before use.

Once the treatment has been given the patient will need close monitoring. Symptoms of overdose from Caffeine and Sodium Benzoate should trigger an emergency medical response.

Condition treated

  • Respiratory depression

Type of medicine

  • Respiratory stimulant

Side Effects

Along with the desired effects of increasing the rate of breathing through use of this medication, the use of this medicine may also cause unwanted side effects in the patient. Some of these side effects may require medial attention if they occur, others may not necessitate a medical response.

If any of the following side effects are experienced then you should seek immediate medical attention.

  • Extra heartbeats
  • Irregular heartbeat
  • Irregular pulse
  • Trembling or shaking of the hands or feet

It is possible to overdose on this medication once it has been administered. If you experience any symptoms of overdose from this medication then you should seek emergency medical help right away. The following are symptoms of overdose to look out for in a patient:

  • Chest pain
  • Discomfort across the chest
  • Confusion
  • Disorientation or failure to understand where you are
  • Decrease in volume of urine
  • Dizziness
  • Dry mouth
  • Faintness
  • Fainting
  • Fever
  • Hallucination or seeing lights that aren't there
  • Holding false beliefs and refusing to be swayed by fact
  • Increased heartrate
  • Lightheadedness
  • Pounding heart
  • Rapid pulse
  • Increased rate of breathing to a faster rate than usual
  • Sleeplessness
  • Slow heartrate
  • Sunken eyes or appearance of extreme tiredness
  • Thirstiness
  • Inability to sleep
  • Disturbed sleep
  • Unusual excitement
  • Unusual nervousness
  • Unusual restlessness
  • Unusual tiredness
  • Unusual weakness
  • Wrinkled skin

Other side effects can occur that will not need any medical attention. These side effects may go away as the body gets used to the treatment. In some cases the healthcare professional may be able to help you to alleviate some of the following symptoms. If they are ongoing or bothersome then inform your healthcare professional and they may be able to help. In most cases the following side effects should not be a cause for concern.

  • Anxiousness
  • Ringing or buzzing heard without any source
  • Headaches
  • Loss of hearing
  • Hyperventilation
  • Increased sensitivity of the skin to both pain and touch
  • Irritability or quickness to anger
  • Increased rate of annoyance
  • Restlessness
  • Feeling of being out of breath
  • Quickness to lose energy when trying to move
  • Tingling in the extremities
  • Troubled sleep

Other side effects not listed herein may also occur. If you experience other side effects then inform your doctor and they will be able to assess you. They may also be able to help you to alleviate the discomfort caused by some side effects.


This medication should only be administered by a trained medical professional in a hospital where other supportive therapies are available.

This medication is given as an injection either into a vein or directly into the muscle.


Some medications should not be used together at all. This is because medicines can stop one another from working or can react violently in the body to cause severe side effects. In other cases certain medications can make the side effects of the other medication worse. When taking this medication it is important that the healthcare professional knows of any medical conditions that you might have.

The use of the following medication alongside Caffeine and Sodium Benzoate is not recommended. Your doctor may wish to use a different medication if you are taking the following:

  • Riociguat

The use of Caffeine and Sodium Benzoate treatment is also not recommended alongside the following medications. Your doctor can, however, decide to prescribe both at the same time. They may wish to amend the dose of one of the medications in cases where both are prescribed.

  • Peginterferon Alfa-2b
  • Pixantrone
  • Regadenoson

Interactions with other medications may occur and this list may not be all-inclusive. Inform your doctor of all medication that you are taking where it is possible to do so before receiving this treatment.

Medications can also make other medical conditions worse. This medication should not be used with certain medical conditions as it may make them worse. The following conditions would indicate that this medication should not be used:

  • Heart disease
  • History of heart attacks
  • Irregular heartrate or arrhythmia


When receiving this medication you should be closely monitored by a doctor in a hospital environment. You should also be receiving additional supportive therapies alongside this medication.

Large doses of this medication can cause unwanted side effects and overdose can occur after or during treatment. If you experience any symptoms of overdose then you should inform your doctor straight away or seek emergency medical attention. These symptoms include but are not limited to: headaches, anxiousness, irregular heartbeat, ringing of the ears and tingling of the hands and feet.

Medical tests may be affected by the use of this medication. If you have received this treatment then you should inform a doctor before any further tests are carried out. You will need to remain in hospital until the effects have worn off and the body has stabilized. You may also be kept in hospital for a longer period and then referred on for further specialized treatment after receiving this treatment.

You should not take any other medications in conjunction with this medication. This includes over the counter medications, herbal remedies and vitamin supplements.

This medication can react with tobacco and alcohol. You should not use tobacco products or drink alcohol after receiving this treatment. Inform your doctor of any tobacco and alcohol that you have consumed before receiving this treatment. If you have a dependency on either substance then you should inform your doctor of this honestly so that they can get you the right treatment.

If you have ever experienced any unusual reactions to medications in the past then you should inform your doctor before receiving this treatment. Inform them of any other allergies you may have too. These can include allergies to animals, dyes, preservatives and other substances.

Inform your doctor if you are pregnant when receiving this treatment. Studies have shown this treatment to be harmful to the fetus in animals. There are significant risks to using this treatment when pregnant and this should be discussed with your doctor. The treatment of life-threatening conditions can in some cases outweigh the risk to exposure of the fetus.

The risks of breastfeeding whilst using this medication are unknown. You should discuss this with your doctor before breastfeeding.


This medication will be stored and administered by the doctor in the hospital.

Do not pour this medication down drains. Dispose of unwanted or unused medications appropriately.


Caffeine and Sodium Benzoate is a medication for use in extreme cases of respiratory depression that has been caused by an overdose of narcotic pain relief or alcohol. The medication can only be used in a hospital by a trained medical professional and should be injected directly into a vein or into the muscle of the patient.

The medication will work to speed up the respiration of the patient, allowing them to regain consciousness and circulate enough oxygen through the body through their own breathing. Assisted breathing equipment may still be required.

This medication is only for use in extreme circumstances and must be administered by a doctor. There are severe side effects that can occur through the use of this medication and it should not be used in patients who suffer from heart disease or in pregnant women where it is possible to identify these conditions beforehand.

This medication should be used in conjunction with other supportive therapies acting on the patient. The patient should then also be monitored for signs of overdose from the use of Caffeine and Sodium Benzoate.

The patient should receive further treatment after undergoing treatment with this stabilizing medication.