Carbinoxamine (Oral)

Carbinoxamine is an antihistamine used to treat seasonal short-term allergies or long-term (chronic) allergies caused by medications, inhalants or foods.

Overview

Carbinoxamine helps to reduce the body's natural histamine response which causes symptoms such as itching, watery eyes, runny nose and sneezing that appear with allergies or the common cold. In some situations, as an antihistamine, it's used in combination with other medicines to relieve breathing illnesses like sinusitis and bronchitis.

The real source of allergies is our immune system, mistaking a harmless substance as an intruder, launching an attack that sets off allergic reactions. If you have one allergy, most likely, you have others - the combination can cause more severe reactions.

Your immune system releases these chemicals to help get rid of the allergen. Histamines attach to the cells in your body and they cause the cells to swell and leak fluid. Antihistamines prevent histamines from attaching to your cells, stopping the symptoms.

As children, we are more likely to develop food allergies - some we outgrow. As we mature, allergies become more permanent and are often triggered by drug interactions or sensitivity to insects (venom).

If your allergies are treated with prescription or nonprescription medications then before you use this medicine you should have a discussion with your doctor - you may be allergic to carbinoxamine.

Condition(s) Treated

  • Seasonal and perennial allergic rhinitis
  • Vasomotor rhinitis
  • Allergic conjunctivitis due to inhalants, allergens and foods
  • Mild allergic skin reactions
  • Dermatographism an extreme skin condition

Type of Medicine

  • Antihistamine

Side Effects

There are several forms of antihistamine, some like carbinoxamine are available by prescription and others are obtainable as over-the-counter medicines. Antihistamines help to reduce or block histamines, so they stop allergy symptoms - they can also cause unwanted side effects. Not all the effect will occur, nor will they all be serious unless you have an underlying condition requiring medical attention when taking this drug.

Before you take the medication, talk to your doctor, since medicines contain different active ingredients that cause harmful reactions. Your doctor can explain the side effects most likely to occur with your own health and the precautions needed when taking this medicine.

Other side effects not listed may also occur in some patients - it depends on your own health condition and lifestyle routines. If you recognize other effects, check with your doctor. Serious allergic reactions are rare, but if the effect persists - contact your doctor.

More Common

  • Burning
  • Chills
  • Confusion
  • Cough
  • Decrease in the frequency of urination
  • Difficulty with swallowing
  • Dizziness or lightheadedness
  • Double vision
  • Drowsiness
  • Dry mouth, nose, and throat
  • Fever
  • General body swelling
  • Headache
  • Hives or welts
  • Increased sensitivity of the skin to sunlight
  • Itching
  • Loss of appetite
  • Pale skin
  • Pinpoint red spots on the skin
  • Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • Rash
  • Redness of the skin
  • Severe sunburn
  • Shakiness in the legs, arms, hands, or feet
  • Skin rash
  • Sweating
  • Tiredness or weakness
  • Upset stomach
  • Weight loss
  • Yellowing of the eyes or skin

Some side effects appear at the start of treatment and fade away as your body adjusts to the medication. Your doctor may have solutions to help prevent or ease these effects for you. Be sure to share all of your health, medical and family history with your doctor - the information will help in predicting how your body reacts to this medicine.

These side effects may occur and differ in severity. If you experience any of these effects, contact your doctor. DO NOT stop taking the medication; DO NOT change the dose or frequency without your doctor's approval.

Rare

  • Anxiety
  • Back, leg, or stomach pains
  • Black, tarry stools
  • Bleeding gums
  • Blood in the urine or stools
  • Blurred vision
  • Continuing ringing or buzzing or other unexplained noise in the ears
  • Difficult or painful urination
  • Difficulty breathing
  • Difficulty having a bowel movement
  • Fast, irregular or racing heartbeat or pulse
  • Hearing loss
  • Nosebleeds
  • Restlessness
  • Seeing double
  • Seizures
  • Sores, ulcers, or white spots on the lips or in the mouth
  • Tightness in the chest
  • Trouble sleeping
  • Unusual bleeding or bruising

If you suffer or have suffered from these health disorders - you need to tell your doctor. Medications used to treat other health disorders can cause a serious side effect when taking this medicine. Even if you stopped taking the medication months ago, the drugs may linger in your bloodstream. Your doctor will make sure carbinoxamine is safe for you.

Existing Health Conditions

  • Asthma
  • Bladder obstruction or other urination problems
  • Blockage in your digestive tract
  • Enlarged prostate
  • Heart disease or high blood pressure
  • Narrow-angle com/health/coma/">glaucoma
  • Overactive thyroid
  • Stomach ulcer

Dosage

Doses vary depending on the severity of the condition, the health, age and weight of the patient. Follow the doctor's instructions, do not use more or less, and stick to the schedule.

This medicine is available in several forms:

  • Suspension, Extended Release
  • Suspension
  • Solution
  • Tablet
  • Liquid
  • Tablet, Extended Release
  • Capsule, Extended Release

If you are using an oral liquid, use a medication measuring spoon, oral syringe or medicine cup. DO NOT use household utensils - you need to measure exact doses.

  • Do not give this medicine to a child younger than 2 years old.
  • Death can occur from the misuse of medicines in very young children.

These are average doses and your doctor may change the dose depending on the patient's age, weight and condition. Other conditions related to allergies with similar symptoms may have different doses. DO NOT share your medicine with someone else - you risk serious consequences for taking the wrong amounts of medicine.

Follow the directions given by the doctor - DO NOT change the dose.

For Allergic Reactions

Adults

  • Tablet 4 milligrams (mg)
    • orally 3 to 4 times a day. Your doctor may increase the dosage up to a maximum of 24 mg a day.
  • Solution 4-8 mg equal to .004 to .008 milliliters (mL)
    • orally 3 to 4 times a day. Your doctor may increase the dosage.

Pediatric

  • Tablet 4 mg
    • Younger than 2 years - Your doctor will decide
    • 2 to 6 years: 1 to 2 mg - orally 3 to 4 times a day. Your doctor may increase the dose as needed.
    • 6 to eleven years: 2 to 4 mg - orally 3 to 4 times a day. Your doctor may increase the dose as needed.
  • ┬áSolution 5 mL
    • Younger than 2 years - Your doctor will decide
    • 2 to 6 years: .001 to .002 mL equal to 1 to 2 mg - orally 3 to 4 times a day. Your doctor may increase the dose.
    • 6 to eleven years: .002 to .004 mL equal to 2 to 4 mg - orally 3 to 4 times a day. Your doctor may increase the dose.

Liquid medications may need to be shaken before taking - read the product instructions. Measure liquid medicine with the proper tool to prevent overdosing - your doctor or pharmacist can provide one for you.

Medication Forms

Sugar is added to liquid medicines as a motivation factor when administering medication to children. Liquid forms, chewable or dissolving tablets have made it easier to administer medicine for children and they allow for the adjustment of doses. There is a concern over children or adults with conditions like diabetes, alcohol dependence or liver disease. Ask your doctor about sugar-free and alcohol-free medicines when diets or medical conditions require a limited intake.

Overdose Symptoms

Take this medicine as directed by your doctor. Be sure to read the product package - if you have questions, ask your doctor. For whatever reason, if you find that you have taken too much of this medication, you may feel symptoms of overdose. Contact your doctor or call for emergency help.

  • Agitation
  • Convulsions
  • Diarrhea
  • Disorientation
  • Drowsiness to profound coma
  • Fixed and enlarged pupils
  • Gas
  • Lethargy
  • Nausea
  • Hallucinations
  • Stomach pain
  • Tightness of the chest
  • Trouble breathing
  • Vomiting

Missed Dose

Because carbinoxamine is used as needed - you may not be on a regular dosing schedule. If you are on a schedule, take the missed dose as soon as you remember. If you are close to the next scheduled dose, continue with the normal dose - do not double the dose. Contact your doctor.

Interactions

Certain medicines should not be used together because of the interactions - in most cases, the reaction worsens the condition. Here's a list of known medicines that react with carbinoxamine. If you are taking any of these medications, tell your doctor.

Each of these medicines has an active ingredient, although the medicine you're taking now may not be on this list - if it contains the same or similar active ingredient, it may change how your body responds to carbinoxamine.

The interaction could make it less effective or trigger a severe side effect. Your doctor may use an alternative medicine or change the dose of one or both medications.

  • Alfentanil
  • Alprazolam
  • Amobarbital
  • Anileridine
  • Bromazepam
  • Bromopride
  • Buprenorphine
  • Bupropion
  • Butabarbital
  • Butorphanol
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chlorpromazine
  • Clorazepate
  • Codeine
  • Dexmedetomidine
  • Diacetylmorphine
  • Difenoxin
  • Dihydrocodeine
  • Diphenhydramine
  • Diphenoxylate
  • Donepezil
  • Doxylamine
  • Estazolam
  • Eszopiclone
  • Ethchlorvynol
  • Ethylmorphine
  • Fentanyl
  • Flibanserin
  • Flurazepam
  • Halazepam
  • Hydrocodone
  • Hydromorphone
  • Hydroxyzine
  • Iproniazid
  • Isocarboxazid
  • Ketazolam
  • Ketobemidone
  • Levorphanol
  • Linezolid
  • Lorazepam
  • Meperidine
  • Meprobamate
  • Methadone
  • Methotrimeprazine
  • Methylene Blue
  • Morphine
  • Morphine Sulfate Liposome
  • Nalbuphine
  • Nicomorphine
  • Nitrazepam
  • Opium
  • Opium Alkaloids
  • Oxazepam
  • Oxycodone
  • Papaveretum
  • Paregoric
  • Pargyline
  • Pentazocine
  • Phenobarbital
  • Piritramide
  • Procarbazine
  • Promethazine
  • Propoxyphene
  • Quazepam
  • Rasagiline
  • Remifentanil
  • Secobarbital
  • Selegiline
  • Sodium Oxybate
  • Sufentanil
  • Tapentadol
  • Thioridazine
  • Tiotropium
  • Topiramate
  • Tramadol
  • Tranylcypromine
  • Zolpidem
  • Zopiclone

Health Factors

Foods, health supplements, herbal remedies and over-the-counter medicines can interfere with the body's ability to absorb a medication - reducing its effectiveness or inducing toxicity. Tell the doctor about your daily dietary routines.

  • Teas are healthy and most of us enjoy a cup or two - depending on the tea, they contain a powerful inhibitory trait interfering with the drug's chemical reaction.
  • Alcohol and tobacco contain active ingredients that slow down the metabolism of this drug - depending on your health, it can increase the side effect or trigger other health disorders.

Existing Conditions and Medicines

Medicines are prescribed to help restore our health, yet when interacting with each other they can cause harmful effects. If you are taking these medicines, tell your doctor.

  • Antihistamines applied to the skin in the form of creams, ointments or spray
  • Beta-blockers - manage abnormal heart rhythms
  • Calcium channel blockers - heart conditions
  • Cough relievers
  • Marijuana
  • Monoamine oxidase inhibitor (MAO) - antidepressants
  • Muscle relaxants
  • Opioid pain relief

There are methods to reduce the risk of drug interactions without eliminating the drug. Your doctor will review your health status and ask for tests before prescribing this medicine. If you've been taking the same drug for a long time, one solution is a more current drug that's compatible to help manage the effectiveness of both drugs. Or it could be a different time schedule for taking each medicine, allowing your body time to absorb the medicine and ease the interaction.

In all cases, your doctor will monitor you closely - unless a severe problem is discovered, the risk of taking you off a medication or even changing the dose could worsen the interactions.

Learn about the medications you're taking now and ask your doctor what symptoms you should watch for when taking carbinoxamine. Understanding what could happen can help manage your health and reduce the risks associated with this medication.

Warnings

The term population health is used to categorize the potential effects during treatment and the outcomes for different age groups. U.S. Food and Drug Administration (FDA) posts information essential for patients and professionals - the purpose is to select the medication that works best for the patient and the condition.

  • FDA noted three specific groups, where precautions are necessary when taking this medication.

When deciding to use this medicine, you need to understand the risks and the benefits associated with a drug and the potential effects, your own health may contribute to these effects. Before taking this medicine, make sure your doctor knows about any medical conditions, allergies and all of your medications- both nonprescription and prescription.

Group Warnings

Pediatric Patients

Carbinoxamine should not be used to treat newborn or premature infants. Children less than 2 years of age have died from taking antihistamines - including carbinoxamine - or drugs sharing active ingredients.

  • Children are more sensitive to the side effects of this drug.
  • Carbinoxamine may diminish mental alertness or produce sedation in children.

Pregnancy and Lactation

FDA assigned Pregnancy Category C to this medicine - in some cases, this medicine is prescribed to a pregnant woman only if no other alternative is available. Your doctor will watch your vitals through the pregnancy. At this time there is no evidence to show significant harm to the fetus, but precautions are necessary. If you become pregnant while taking this medicine, tell your doctor immediately.

  • Carbinoxamine should not be prescribed to women who are or may become pregnant.
  • This medication may pass on to the infant through breastfeeding. The effects are not known - talk to your doctor.

Geriatrics

Older adults are more susceptible to the side effects of this drug - dizziness, drowsiness, confusion, irregular heartbeat and insomnia or bladder problems. The side effects cause concerns for existing health conditions, and they also add precautions to new health injuries like the increased risk of falling caused by disorientation.

Storage

Store this medicine in a closed container at room temperature, away from heat, moisture and direct light. Keep this and all medicines out of reach of children and pets.

  • Do not freeze liquid forms of this medicine.
  • Do not keep outdated or unused medicine longer than needed.
  • Do not flush medications or dispose of them in household trash containers.
  • Ask your healthcare or pharmacist how you should dispose of any medicine you do not use.
  • There are take-back programs for disposing of unused medicine and supplies.

Summary

Carbinoxamine is an oral antihistamine used to treat common symptoms of an allergic reaction such as a runny nose, watery eyes, and sneezing. It has been tolerated in adults using maximum doses that do not exceed 24 mg daily over prolonged durations. In most cases, patients respond to an average daily dose of 4 mg daily.

There are several precautions when using this medicine as it reacts with many drugs treating existing health conditions for cardiovascular disease, hypertension, hyperthyroidism and intraocular pressure. Adverse reactions affect the body, more specifically conditions associated with cardiovascular, hematologic, central nervous system and gastrointestinal functions.

Resources
Last Reviewed:
December 25, 2017
Last Updated:
April 04, 2018
Content Source: