Carisoprodol and Aspirin


Carisoprodol and aspirin combination is used in the treatment of certain acute bone or muscle conditions. The medication is a skeletal muscle relaxant that is most effective when used together with remedial therapy in the form of rest, physiotherapy, controlled exercise, and certain other treatments, as recommended by your doctor.

Carisoprodol works by acting on the body’s central nervous system in order to relax the muscles. Aspirin is an anti-inflammatory agent that is often used to relieve the symptoms of pain and swelling.

Carisoprodol and aspirin oral combination is only available on prescription from your doctor and comes in tablet form.

Conditions treated

  • muscle and bone conditions

Type of medicine

  • anti-inflammatory
  • tablet


The use of carisoprodol and aspirin oral combination is intended to control the symptoms of bone and muscle inflammation. It is possible that you may suffer a few unwanted side-effects while you are taking it. Before you begin using carisoprodol and aspirin oral combination, you should tell your doctor about any allergic reactions that you have experienced while taking any other form of medicines. You should also mention any health conditions or bad reactions that you have noted when taking non-prescription products, including herbal preparations or vitamin supplements.

Some drugs may contain animal products, preservatives or dyes, and you must tell your doctor if you are aware of any allergies that you may have to any of these.

The side-effects that are outlined below are known to sometimes occur in patients taking carisoprodol and aspirin oral combination. However, it is important to note that this list is not all-inclusive. If you notice any other effects or if you begin to feel ill while taking this drug, you must tell your doctor straight away.

Tell your doctor if you begin to notice a burning feeling in your stomach or chest, if you have an upset stomach, indigestion, or if you develop a feeling of tenderness in the area around your stomach.

Other less common side-effects that have been reported by people taking this medication include:

  • wheezing
  • unusually warm skin
  • unusual tiredness or weakness
  • unusual bleeding or bruising
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • tightness of the chest
  • swollen glands
  • sores, white spots, or ulcers on the lips or in the mouth
  • sore throat
  • skin rash
  • shakiness and unsteady walk
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • painful or difficult urination
  • noisy breathing
  • large swellings on the face, tongue, throat, eyelids, lips, hands, legs, feet, or genitals
  • itching
  • hives
  • hearing loss
  • flushing or redness of the skin
  • fast, pounding, or irregular heartbeat or pulse
  • dizziness, faintness, or lightheadedness, especially when standing up suddenly from a lying or seated position
  • difficulty with swallowing
  • continuing ringing or buzzing or other unexplained noise in the ears
  • confusion
  • cold sweats
  • chills
  • breathing difficulties
  • a cough

In the event of an overdose, you may notice the following symptoms:

  • wrinkled skin
  • vomiting of blood or material that looks like coffee grounds
  • vomiting
  • unusual excitement, nervousness, or restlessness
  • thirst
  • swelling in the legs and ankles
  • sweating
  • sunken eyes
  • severe sleepiness
  • pale, clammy skin
  • cyanosis
  • nausea
  • muscle pain or weakness
  • muscle cramps
  • loss of strength or energy
  • loss of consciousness
  • lethargy
  • irregular, fast or slow, or shallow breathing
  • holding false beliefs that cannot be changed by fact
  • headache
  • hallucinations
  • fast, weak pulse
  • fast or deep breathing
  • fainting
  • extremely high fever or body temperature
  • expressed fear of impending death
  • dry mouth
  • difficult, fast, or noisy breathing, sometimes with wheezing
  • diarrhea
  • depression
  • decreased urination
  • decreased awareness or responsiveness
  • coughing, sometimes producing a pink frothy sputum
  • confusion
  • cold, clammy skin
  • change in consciousness
  • bloody stools
  • black, tarry stools
  • anxiety
  • agitation or combativeness

Some of the side-effects that patients taking carisoprodol and aspirin combination report do not usually need further medical intervention. These effects often disappear during treatment, once your body has become acclimatized to the new medication. Your health professional will be able to offer advice as to how you can mitigate the worst of your side-effects. If you have any questions about the effect of your new medication, just ask your doctor or pharmacist.

A common side-effect reported by patients taking carisoprodol and aspirin combination is drowsiness. Less commonly experienced are a spinning sensation and a feeling that you or your surroundings are continually moving.

A very few patients report the following effects:

  • unable to sleep
  • trouble sleeping
  • sleeplessness
  • shaking
  • irritability
  • hyperventilation

If you notice any other side-effects that are not included in the foregoing lists, check with your doctor or specialist.


The dosage of this medication that is recommended may vary between patients. Always take your medicine exactly as per your doctor’s direction or refer to the guidelines on the product packet.

The dosage guidelines that are included below are based on the average. The dose that your doctor prescribes for you may depend on a number of factors, including the strength of the medicine, your condition, and how your body reacts to the drug. The quantity of medication that you are instructed to take each day and the frequency of daily doses may also vary. If you are prescribed a different dose from that outlined below, do not change it unless you are told to do so by your doctor.

If you use this medication over a long period of time and in large quantities, it can become habit-forming, causing physical or mental dependence. Do not take the medication in larger doses or for a longer period than recommended by your doctor.

Carisoprodol and aspirin combination for relaxing muscles

  • Adults and children over 16 years of age: one or two tablets to be taken four times daily. One tablet contains 200 mg if carisoprodol and 325 mg of aspirin.
  • Children up to 16 years of age: Use and dose as instructed by your doctor.

You may take this medication with or without food. You should swallow the tablets in one piece. Do not chew or crush the pills.

In the event that you miss a dose of your medication, take the tablet as soon as possible. If it is almost time for your next dose, miss out the one you missed and resume your normal dosage schedule. Do not double-dose.

In the case of an overdose and the patient develops breathing difficulties or loses consciousness, you should call 911. If an overdose occurs but no serious side-effects are initially evident, consult your doctor without delay.

Major drug interactions

Although some drugs should never be used together, there are cases where it may be appropriate to use two or more different medications, even though an interaction may occur. In this case, your doctor may decide to adjust the dose or might suggest that you take other precautions.

If you are prescribed carisoprodol and aspirin combination and you are already taking another form of medication, you should inform your doctor immediately. This includes things like herbal preparations, vitamin supplements or over-the-counter medicines. In addition, some foodstuffs should be avoided when taking certain types of medication, as should consuming alcohol and tobacco when interactions may occur. Discuss with your doctor the possible implications of eating, consuming alcohol, and tobacco products with this drug before you begin taking it.

Using carisoprodol and aspirin combination with the following drugs is not usually recommended, although your doctor may deem it necessary in your case. If two medicines are prescribed together, your doctor may change the dose or frequency of dose of one or more of the drugs:

  • Ketorolac
  • Influenza Virus Vaccine, Live
  • Dichlorphenamide
  • Defibrotide
  • Zolpidem
  • Xipamide
  • Warfarin
  • Vortioxetine
  • Vilazodone
  • Venlafaxine
  • Varicella Virus Vaccine
  • Valdecoxib
  • Trimipramine
  • Trichlormethiazide
  • Triazolam
  • Triamterene
  • Treprostinil
  • Tramadol
  • Torsemide
  • Tolmetin
  • Tolfenamic Acid
  • Tolbutamide
  • Tolazamide
  • Tirofiban
  • Tiotropium
  • Ticlopidine
  • Ticagrelor
  • Tiaprofenic Acid
  • Tianeptine
  • Thiopental
  • Tenoxicam
  • Temazepam
  • Tapentadol
  • Tacrolimus
  • Sulindac
  • Sufentanil
  • Spironolactone
  • Sodium Salicylate
  • Sodium Oxybate
  • Sertraline
  • Secobarbital
  • Salsalate
  • Salicylic Acid
  • Rofecoxib
  • Rivaroxaban
  • Reteplase, Recombinant
  • Repaglinide
  • Remifentanil
  • Quazepam
  • Protriptyline
  • Protein C
  • Proquazone
  • Propyphenazone
  • Propoxyphene
  • Proglumetacin
  • Primidone
  • Prazepam
  • Prasugrel
  • Pranoprofen
  • Pralatrexate
  • Polythiazide
  • Piroxicam
  • Piracetam
  • Piketoprofen
  • Phenylbutazone
  • Phenprocoumon
  • Phenobarbital
  • Phenindione
  • Periciazine
  • Pentoxifylline
  • Pentosan Polysulfate Sodium
  • Pentobarbital
  • Pentazocine
  • Pemetrexed
  • Paroxetine
  • Parecoxib
  • Oxyphenbutazone
  • Oxymorphone
  • Oxycodone
  • Oxazepam
  • Oxaprozin
  • Opipramol
  • Nortriptyline
  • Nitrazepam
  • Nimesulide Beta Cyclodextrin
  • Nimesulide
  • Niflumic Acid
  • Nepafenac
  • Nefazodone
  • Nateglinide
  • Naproxen
  • Nabumetone
  • Morphine Sulfate Liposome
  • Morphine
  • Morniflumate
  • Milnacipran
  • Midazolam
  • Metolazone
  • Methyclothiazide
  • Methotrexate
  • Methohexital
  • Methocarbamol
  • Methadone
  • Metformin
  • Metaxalone
  • Meprobamate
  • Mephobarbital
  • Mephenesin
  • Meperidine
  • Meloxicam
  • Melitracen
  • Mefenamic Acid
  • Medazepam
  • Meclofenamate
  • Lumiracoxib
  • Loxoprofen
  • Lornoxicam
  • Lormetazepam
  • Lorazepam
  • Lofepramine
  • Lithium
  • Levorphanol
  • Levomilnacipran
  • Lepirudin
  • Ketoprofen
  • Ketazolam
  • Indomethacin
  • Indapamide
  • Imipramine
  • Ibuprofen
  • Hydromorphone
  • Hydroflumethiazide
  • Hydrocodone
  • Hydrochlorothiazide
  • Heparin
  • Halazepam
  • Gossypol
  • Glyburide
  • Glipizide
  • Glimepiride
  • Ginkgo
  • Furosemide
  • Fondaparinux
  • Fluvoxamine
  • Flurbiprofen
  • Flurazepam
  • Fluoxetine
  • Flunitrazepam
  • Flufenamic Acid
  • Floctafenine
  • Flibanserin
  • Feverfew
  • Feprazone
  • Fepradinol
  • Fentanyl
  • Fenoprofen
  • Felbinac
  • Etoricoxib
  • Etofenamate
  • Etodolac
  • Ethchlorvynol
  • Ethacrynic Acid
  • Estazolam
  • Eslicarbazepine Acetate
  • Escitalopram
  • Eptifibatide
  • Eplerenone
  • Edoxaban
  • Duloxetine
  • Droxicam
  • Doxylamine
  • Doxepin
  • Dothiepin
  • Dipyrone
  • Dihydrocodeine
  • Digoxin
  • Diflunisal
  • Dicumarol
  • Diclofenac
  • Dibenzepin
  • Diazoxide
  • Diazepam
  • Dexketoprofen
  • Dexibuprofen
  • Desvenlafaxine
  • Desirudin
  • Desipramine
  • Dantrolene
  • Danaparoid
  • Dabigatran Etexilate
  • Cyclosporine
  • Cyclopenthiazide
  • Codeine
  • Clorazepate
  • Clopidogrel
  • Clopamide
  • Clonixin
  • Clonazepam
  • Clomipramine
  • Clobazam
  • Citalopram
  • Cilostazol
  • Choline Salicylate
  • Chlorzoxazone
  • Chlorthalidone
  • Chlorpropamide
  • Chlorothiazide
  • Chlordiazepoxide
  • Chloral Hydrate
  • Celecoxib
  • Carisoprodol
  • Butorphanol
  • Butalbital
  • Butabarbital
  • Buprenorphine
  • Bumetanide
  • Bufexamac
  • Bromfenac
  • Bromazepam
  • Bivalirudin
  • Beta Glucan
  • Benzthiazide
  • Bendroflumethiazide
  • Argatroban
  • Aprobarbital
  • Apixaban
  • Anisindione
  • Anileridine
  • Anagrelide
  • Amtolmetin Guacil
  • Amoxapine
  • Amobarbital
  • Amitriptylinoxide
  • Amitriptyline
  • Amineptine
  • Amiloride
  • Alteplase, Recombinant
  • Alprazolam
  • Alipogene Tiparvovec
  • Alfentanil
  • Acemetacin
  • Aceclofenac
  • Acarbose

Taking carisoprodol and aspirin with any of the following medications sometimes causes an increase in some side-effects. However, using both drugs might be the most appropriate treatment in your case. Note that your doctor may change the dose or frequency of use of one or both of these medications, depending on any interactions that are noted:

  • Valproic Acid
  • Triamcinolone
  • Timolol
  • Tenecteplase
  • Temocapril
  • Tamarind
  • Streptokinase
  • Sotalol
  • Propranolol
  • Probenecid
  • Prednisone
  • Prednisolone
  • Practolol
  • Pindolol
  • Penbutolol
  • Paramethasone
  • Oxprenolol
  • Nitroglycerin
  • Nebivolol
  • Nadolol
  • Metoprolol
  • Metipranolol
  • Methylprednisolone
  • Lisinopril
  • Levobunolol
  • Labetalol
  • Imidapril
  • Esmolol
  • Enalaprilat
  • Enalapril Maleate
  • Dexamethasone
  • Delapril
  • Cortisone
  • Celiprolol
  • Carvedilol
  • Carteolol
  • Captopril
  • Bisoprolol
  • Betaxolol
  • Betamethasone
  • Atenolol
  • Acebutolol
  • ethanol


Take this medication as instructed by your doctor. Do not intentionally take more than you are prescribed or take it more frequently than you have been instructed to. If you take too much of the medication, the side-effects it has may be increased.

In addition to discussing any allergies and other drugs that you are taking, it is important that you also mention to your doctor any existing health conditions that you have, before you start taking carisoprodol and aspirin combination. Using tobacco or alcohol with certain drugs can also cause unwanted interactions to take place. Tell your doctor if you habitually use tobacco or alcohol or if you eat a lot of a particular type of food.

Some existing medical conditions can affect the use of this medication. Be sure to tell your doctor if you suffer from any health problems or if you have a history of them.

Carisoprodol and aspirin combination should not be used in patients with the following conditions as to do so could make the problem worse:

  • stomach or bowel problems
  • porphyria
  • bleeding disorders
  • aspirin-induced asthma

Use carisoprodol and aspirin combination with caution in patients who have a history of drug use or drug dependence; dependency on carisoprodol may develop.

Using carisoprodol and aspirin combination in patients with the following health problems is known to make these conditions worse:

  • gastritis
  • seizures
  • stomach ulcers

Use carisoprodol and aspirin combination with caution in patients who have a history of kidney or liver disease; the effects of the drug may be increased because of slower removal of the medication from the body.

Caution should be exercised when prescribing this medication to elderly patients who are more likely to have kidney or liver problems.

Studies have shown that using carisoprodol and aspirin combination in pregnant women can cause a risk to the fetus. Tell your doctor immediately if you are pregnant and if you think that you may have become pregnant during the course of your treatment. While you are taking carisoprodol and aspirin combination, you should be sure to use an effective form of contraception to avoid unwanted pregnancy. Allow at least two weeks following your treatment before attempting to become pregnant.

Carisoprodol and aspirin combination can be passed into breast milk. The medication can also hinder or alter milk production or its composition. You should, therefore, monitor your infant for side-effects and sufficient milk intake. Alternatively, you may wish to discontinue breastfeeding for the duration of your treatment and for two weeks immediately following cessation. During this time, you should use a suitable baby formula, and your midwife will advise you further on this. Do not express breast milk for storage and future use.

You must attend your doctor for regular updates and checkups during the course of your treatment with this drug. These visits will allow your doctor to ensure that the medication is working properly and will also give you the chance to voice any concerns you may have about side-effects that you may be experiencing.

This medication can sometimes make people feel dizzy, less alert than usual, or drowsy. If the drug affects you in this way, you should avoid driving or operating machinery, until this effect has passed.

Carisoprodol and aspirin combination can add to the effects of central nervous system depressants and alcohol, potentially making you feel drowsy or less alert than usual. While you are taking this drug, you should avoid using any of the following over-the-counter medicines:

  • antihistamines
  • hay fever medication
  • cold medication
  • sedatives
  • tranquilizers
  • sleeping medicine
  • prescription pain medicine
  • narcotics
  • medicine for seizures
  • barbiturates
  • anesthetics, including some dental anesthetics

Be sure to mention to your doctor or dentist before taking any of the above while you are taking carisoprodol and aspirin combination.

Never stop taking carisoprodol and aspirin combination suddenly without first consulting your doctor. It may be necessary to steadily decrease your dosage before you stop taking the drug completely.

This medication can sometimes cause intestinal bleeding, often without warning. You are more likely to suffer this side-effect if you are over 60 years of age, have ever had a stomach ulcer, are a regular alcohol drinker, are in poor health, or if you are using other medications, including blood thinners or non-steroidal anti-inflammatories.

In some rare cases, this medication can cause a serious allergic reaction called anaphylaxis. This reaction is more common in people who have an allergy to aspirin or any of the family of non-steroidal anti-inflammatories. Anaphylaxis is potentially life-threatening and always demands immediate medical attention. Signs of a serious allergic reaction include:

  • fast or irregular breathing
  • gasping for breath
  • wheezing
  • fainting
  • changes in facial color
  • rapid, irregular heartbeat or pulse
  • hive-like swellings on the skin
  • puffiness of the eyelids or around the eyes.

If you notice any of these effects within a few minute of taking the medication, call 911 immediately.

If you notice no improvement in your condition within a few weeks of commencing treatment with this medication, you should consult your doctor. Do not use this drug for more than three weeks to treat pain, unless instructed to do so by your doctor.


Always keep carisoprodol and aspirin combination in a sealed, airtight container. Do not freeze this medication.

Do not leave this medication where it will be exposed to direct sunlight, heat or moisture.

Keep your supply of carisoprodol and aspirin combination well away from children and pets. In the event that a pet consumes your medication, you must seek veterinary advice immediately.

Do not use carisoprodol and aspirin combination that has passed its use-by date or if the packaging appears to be damaged.

If you are unsure of what to do, ask your doctor or pharmacist for advice on how to dispose of any out-of-date medication. Do not flush the leftover tablets down the toilet, throw them down the drain, or put them out with your trash where they could be mistaken for candy and eaten by children or animals.


Carisoprodol and aspirin combination is used to manage the symptoms of certain acute bone or muscle conditions. This combination medication is a skeletal muscle relaxant that is most effective when used together with rest, physiotherapy, controlled exercise, and certain other remedial therapies, as recommended by your doctor.

Carisoprodol works by acting on the body’s central nervous system in order to relax the muscles. Aspirin is an anti-inflammatory agent that is often used to relieve the symptoms of pain and swelling.

Carisoprodol and aspirin combination is highly effective and beneficial to patients. However, it is vital that you communicate fully with your doctor during the course of your treatment. This drug should not be used with a wide variety of existing or historical health conditions, prescription, and over-the-counter drugs. Therefore, to gain the most benefit from your course of treatment with this medication, it is important that you work closely with your doctor to find the appropriate dose and frequency of use.

Last Reviewed:
December 24, 2017
Last Updated:
December 22, 2017