Carisoprodol, Aspirin and Codeine (Oral Route)

Carisoprodol, aspirin and codeine are used in combination for the short-term pain relief treatment of bone and muscles conditions.


The carisoprodol, aspirin and codeine combination is used in patients to relieve pain caused by acute muscle and bone conditions. The combination works by relaxing certain muscles in the body to relieve the pain.

Carisoprodol is a skeletal muscle relaxant that works by blocking pain sensations between the nerves and the brain. By acting on the central nervous system this medication can cause skeletal muscles to relax and this can relieve the pain in some conditions.

Aspirin is an anti-inflammatory drug that helps to relieve both pain and fever.

Codeine is a narcotic analgesic. This medication also acts on the central nervous system in order to relieve pain in the patient.

This medication is only available when prescribed by a doctor and is administered in the form of a tablet. This medication will always be prescribed along with other advice on how to treat your medical condition and pain. This advice will include rest, physical therapy, exercise, healthy eating and other treatments that your doctor may recommend. To prevent your discomfort over the longer term you should follow this advice closely.

This combination of medications is habit-forming and as such should only be taken as directed by your doctor. Misuse can lead to a dependency on the medication.

Conditions treated:

  • Muscle pain
  • Bone pain

Type of medicine:

  • Relaxant
  • Narcotic analgesic
  • Anti-inflammatory

Side Effects:

As well as the desired effects of this medication, it is possible that this medication can produce unwanted side effects in the body. In some cases, these side effects can be very serious and medical attention may be needed. In other cases, side effects may abate over time as the body gets used to the treatment.

If you experience any of the following side effects then you should inform your doctor immediately:

Occurring commonly:

• Burning feelings experienced in the chest and/or stomach
• Indigestion
• Stomach upset or discomfort
• Tenderness around the area of the stomach

Occurring less commonly:

• Coughing
• Difficulty or troubled breathing
• Swellings or hive-like protrusions that appear on the body in any of the following locations:

o Face, including eyelids, lips, tongue and throat

o Legs

o Hands

o Feet

o Sexual organs

• Noisy or increased audibility of breathing
• Shakiness
• Unsteadiness when walking
• Tightness in the chest
• Problems controlling muscles or coordinating movements

Frequency of incidence unknown:

• Chills
• Cold sweats
• Confusion or disorientation
• Difficulty in swallowing
• Dizziness when standing up from lying or sitting down.
• Flushing or redness of the skin
• Hearing loss
• Hearing noises that are not heard by others including continued ringing
• Hives
• Increased or irregular heartbeat
• Itchiness
• Pain or difficulty experienced during urination
• Skin rash with or without lesions
• Soreness of the throat
• Sores or ulcers
• Swelling or puffiness of face or neck
• Swollen glands
• Unusual bleeding
• Unusual bruising
• Unusual tiredness
• Unusual weakness
• Unusually warm skin
• White spots appearing on the lips or on the mouth

Other side effects may occur from the use of this combination of medicines that would not necessitate medical attention normally. In some cases, these side effects can become bothersome. If this is the case you can consult your doctor for advice on how you may be able to alleviate these side effects.

Occurring commonly:

• Drowsiness or tiredness

Occurring less commonly:

• Feeling that self or surroundings are constantly moving
• Spinning sensation

Occurring only rarely:

• Hyperventilation or heavy breathing
• Irritability or quickness to annoyance
• Shaking or involuntary muscle movements
• Troubled sleep

Frequency of incidence unknown:

• Constipation
• Constriction of the pupils
• Feeling unusually relaxed and calm

It is possible to overdose on the use of this medication. You should never take more of this medication than directed, should not share this medication with anyone else and should always keep it out of the reach of children. If you believe that you or someone else has overdosed on this medication then you must seek emergency medical assistance immediately. The following are symptoms of overdose that you should beware of:

• Aggressive coughing with occasional production of pink frothy sputum
• Agitation or unusual combativeness
• Anxiousness
• Black stools with an appearance of tar
• Blood in the stools
• Bluish tinge to the lips and fingernails
• Change in consciousness
• Cold or clammy skin
• Confusion about the time, place, or person
• Confusion or disorientation
• Decreased level of awareness or responsiveness
• Decreased volume or frequency of urination
• Depression or extreme feelings of sadness
• Diarrhea
• Difficult breathing with increased audibility
• Difficulty in sleeping
• Drowsiness to profound coma
• Dry mouth or feelings of dehydration
• Expressed fear of impending death
• Extremely high fever or body temperature
• Fainting or feeling of faintness
• Fast but weak pulse
• Fast or deep breathing
• Hallucinations or visions
• Headaches
• Holding false beliefs that cannot be altered by fact
• Irregular or changed breathing
• Lethargy or tiredness
• Loss of consciousness
• Loss of strength or energy
• Mood changes or other mental changes
• Muscle cramping
• Muscle pain
• Muscle weakness
• Nausea
• Pale or bluish lips, fingernails or skin
• Pale or clammy skin
• Pinpoint pupils
• Severe sleepiness
• Sunken eyes or appearance of extreme tiredness
• Sweating when cool
• Swelling in the legs and ankles
• Thirstiness
• Unusual excitement, nervousness, or restlessness
• Vomiting
• Vomiting of blood or substance that looks like coffee grounds
• Wrinkling of the skin

Other side effects that have not been listed herein may occur in the patient. In cases where other side effects occur you should contact your doctor for advice. If you believe yourself to be at risk then contact the emergency services.


This medication should only be used as directed by your doctor in the doses prescribed and at the frequency prescribed. Do not take any more than ordered under any circumstances. Both codeine and carisoprodol are addictive and habit-forming substances. Overuse of these medications can lead to a physical dependency to these medications.

This medication should be avoided in cases where the patient has a history of drug or alcohol abuse or dependency because of an increased risk of abuse.

The dose of this medication prescribed to each patient will be different depending on a range of factors including weight, age, the condition being treated, other medications being taken and other medical conditions that you may have. You should only ever take this medication as prescribed. The following dosing information is a guideline only and you should not alter your prescribed dose unless directed to by your doctor.

For muscle relaxation:

• Adults and teenagers above the age of 16 years.

o 1 or 2 tablets taken up to 4 times daily.

• Children below the age of 16 years.

o Use and dose must be determined by the prescribing doctor.

If a dose of this medication is missed then you should take it as soon as you are able to. If, however, you are close to your next dose then you should skip the missed dose and return to your usual schedule of dosing. Never take a double dose of this medication.


This medication can interact with a wide range of other medications. It is very important that you inform your doctor of any and all medications that you are taking before using this treatment. In some cases, medications can interact violently with one another causing serious side effects in the patient. In other cases, they can prevent other medications from working or can increase the risks of side effects. The following list of medications has been selected due to their seriousness, but this list may not be all-inclusive. You should inform your doctor of all medications that you are taking whether they are prescribed, over the counter treatments, vitamin supplements or herbal remedies.

The following medications should not be used alongside treatment with the carisoprodol, aspirin and codeine combination. If you are using any of the following then your doctor may need to change your prescription.

• Naltrexone
• Live Influenza Virus Vaccine
• Ketorolac
• Dichlorphenamide
• Defibrotide

The use of the following medications alongside the carisoprodol, aspirin and codeine combinations would not be recommended under normal circumstances. These medications can be prescribed in conjunction with one another but your doctor may wish to change the frequency of treatment or dose of treatment.

• Zotepine
• Zopiclone
• Zolpidem
• Ziprasidone
• Zaleplon
• Xipamide
• Warfarin
• Vortioxetine
• Vilazodone
• Venlafaxine
• Varicella Virus Vaccine
• Valdecoxib
• Trimipramine
• Trimeprazine
• Triflupromazine
• Trifluperidol
• Trifluoperazine
• Trichlormethiazide
• Triazolam
• Triamterene
• Treprostinil
• Tramadol
• Torsemide
• Topiramate
• Tolonium Chloride
• Tolmetin
• Tolfenamic Acid
• Tolbutamide
• Tolazamide
• Tizanidine
• Tirofiban
• Tiotropium
• Tilidine
• Ticlopidine
• Ticagrelor
• Tiaprofenic Acid
• Tianeptine
• Thiothixene
• Thioridazine
• Thiopropazate
• Thiopental
• Thiethylperazine
• Tenoxicam
• Temazepam
• Tapentadol
• Tacrolimus
• Suvorexant
• Sulpiride
• Sulindac
• Sufentanil
• Spironolactone
• Sodium Salicylate
• Sodium Oxybate
• Sertraline
• Sertindole
• Secobarbital
• Salsalate
• Salicylic Acid
• Rofecoxib
• Rivaroxaban
• Risperidone
• Reteplase, Recombinant
• Repaglinide
• Remoxipride
• Remifentanil
• Ramelteon
• Quetiapine
• Quazepam
• Protriptyline
• Protein C
• Proquazone
• Propyphenazone
• Propoxyphene
• Propofol
• Promethazine
• Promazine
• Proglumetacin
• Prochlorperazine
• Primidone
• Prazepam
• Prasugrel
• Pranoprofen
• Pralatrexate
• Polythiazide
• Piroxicam
• Piritramide
• Piracetam
• Pipotiazine
• Piperacetazine
• Pimozide
• Pimavanserin
• Piketoprofen
• Phenylbutazone
• Phenprocoumon
• Phenobarbital
• Phenindione
• Perphenazine
• Periciazine
• Perazine
• Perampanel
• Pentoxifylline
• Pentosan Polysulfate Sodium
• Pentobarbital
• Pentazocine
• Pemetrexed
• Paroxetine
• Paregoric
• Parecoxib
• Papaveretum
• Paliperidone
• Oxyphenbutazone
• Oxymorphone
• Oxycodone
• Oxazepam
• Oxaprozin
• Orphenadrine
• Opium Alkaloids
• Opium
• Opipramol
• Olanzapine
• Nortriptyline
• Nitrous Oxide
• Nitrazepam
• Nimesulide Beta Cyclodextrin
• Nimesulide
• Niflumic Acid
• Nicomorphine
• Nepafenac
• Nefazodone
• Nateglinide
• Naproxen
• Nalbuphine
• Nabumetone
• Morphine Sulfate Liposome
• Morphine
• Morniflumate
• Moricizine
• Molindone
• Milnacipran
• Midazolam
• Metolazone
• Methylene Blue
• Methyclothiazide
• Methotrimeprazine
• Methotrexate
• Methohexital
• Methocarbamol
• Methdilazine
• Methadone
• Metformin
• Metaxalone
• Mesoridazine
• Meptazinol
• Meprobamate
• Mephobarbital
• Mephenesin
• Meperidine
• Melperone
• Meloxicam
• Melitracen
• Mefenamic Acid
• Medazepam
• Meclofenamate
• Meclizine
• Lurasidone
• Lumiracoxib
• Loxoprofen
• Lornoxicam
• Lormetazepam
• Lorazepam
• Lofepramine
• Lithium
• Levorphanol
• Levomilnacipran
• Lepirudin
• Ketoprofen
• Ketobemidone
• Ketazolam
• Ketamine
• Isoflurane
• Indomethacin
• Indapamide
• Imipramine
• Iloperidone
• Ibuprofen
• Hydroxyzine
• Hydromorphone
• Hydroflumethiazide
• Hydrocodone
• Hydrochlorothiazide
• Hexobarbital
• Heparin
• Halothane
• Haloperidol
• Halazepam
• Gossypol
• Glyburide
• Glipizide
• Glimepiride
• Ginkgo
• Furosemide
• Fospropofol
• Fondaparinux
• Fluvoxamine
• Flurbiprofen
• Flurazepam
• Fluphenazine
• Fluoxetine
• Flunitrazepam
• Flufenamic Acid
• Floctafenine
• Flibanserin
• Feverfew
• Feprazone
• Fepradinol
• Fentanyl
• Fenoprofen
• Felbinac
• Etoricoxib
• Etofenamate
• Etodolac
• Ethylmorphine
• Ethopropazine
• Ethchlorvynol
• Ethacrynic Acid
• Eszopiclone
• Estazolam
• Eslicarbazepine Acetate
• Escitalopram
• Eptifibatide
• Eplerenone
• Enflurane
• Edoxaban
• Duloxetine
• Droxicam
• Droperidol
• Doxylamine
• Doxepin
• Dothiepin
• Donepezil
• Dipyrone
• Diphenoxylate
• Diphenhydramine
• Dihydrocodeine
• Digoxin
• Diflunisal
• Difenoxin
• Dicumarol
• Diclofenac
• Dichloralphenazone
• Dibenzepin
• Diazoxide
• Diazepam
• Diacetylmorphine
• Dezocine
• Dexketoprofen
• Dexibuprofen
• Desvenlafaxine
• Desirudin
• Desipramine
• Darunavir
• Dantrolene
• Danaparoid
• Dabigatran Etexilate
• Cyclosporine
• Cyclopenthiazide
• Cyclobenzaprine
• Conivaptan
• Codeine
• Clorazepate
• Clopidogrel
• Clopamide
• Clonixin
• Clonazepam
• Clomipramine
• Clobazam
• Citalopram
• Cilostazol
• Choline Salicylate
• Chlorzoxazone
• Chlorthalidone
• Chlorpropamide
• Chlorpromazine
• Chlorothiazide
• Chlordiazepoxide
• Chloral Hydrate
• Celecoxib
• Carphenazine
• Carisoprodol
• Cariprazine
• Carbinoxamine
• Butorphanol
• Butalbital
• Butabarbital
• Buspirone
• Bupropion
• Buprenorphine
• Bumetanide
• Bufexamac
• Bromopride
• Bromfenac
• Bromazepam
• Bivalirudin
• Beta Glucan
• Benzthiazide
• Benperidol
• Bendroflumethiazide
• Baclofen
• Asenapine
• Aripiprazole
• Argatroban
• Aprobarbital
• Apixaban
• Anisindione
• Anileridine
• Anagrelide
• Amtolmetin Guacil
• Amoxapine
• Amobarbital
• Amitriptylinoxide
• Amitriptyline
• Amisulpride
• Amineptine
• Amiloride
• Alteplase, Recombinant
• Alprazolam
• Alipogene Tiparvovec
• Alfentanil
• Acepromazine
• Acemetacin
• Aceclofenac
• Acarbose

The use of the following medications in conjunction with the use of the carisoprodol, aspirin and codeine combination can increase the risk of the patient experiencing certain side effects. Your doctor may still treat you with both medications, but may wish to adjust the frequency of use, or the dose prescribed.

• Valproic Acid
• Triamcinolone
• Timolol
• Tenecteplase
• Temocapril
• Tamarind
• Streptokinase
• Sotalol
• Propranolol
• Probenecid
• Prednisone
• Prednisolone
• Practolol
• Pindolol
• Penbutolol
• Paramethasone
• Oxprenolol
• Nitroglycerin
• Nebivolol
• Nadolol
• Metoprolol
• Metipranolol
• Methylprednisolone
• Lisinopril
• Levobunolol
• Labetalol
• Imidapril
• Esmolol
• Enalaprilat
• Enalapril Maleate
• Dexamethasone
• Delapril
• Cortisone
• Celiprolol
• Carvedilol
• Carteolol
• Captopril
• Bisoprolol
• Betaxolol
• Betamethasone
• Atenolol
• Acebutolol

This medication can also interact with ethanol. Your doctor may give you special instructions about the consumption of alcohol in conjunction with the use of this medication. Ensure that you follow these instructions and inform your doctor before receiving this treatment if you have any dependency on alcohol or a history of dependency on alcohol.

Other medical conditions can also impact the use of medications. In some cases, conditions other than the one being treated can be worsened by the use of other medications. You should inform your doctor of all medical conditions from which you suffer or from which you have suffered previously before accepting this treatment. This is particularly important if you suffer from any of the following conditions:

This treatment should not be prescribed to patients who suffer from the following:

• A history of aspirin-induced asthma
• A history of bleeding disorders
• A history of porphyria
• A history of stomach or bowel problems
• For the treatment of pain in children after surgery

Use in patients who suffer from the following conditions will be at greater risk of respiratory depression:

• Lung disease
• Breathing problems
• Brain tumor
• History of head injury

Patients who have suffered from the following will be at increased risk of developing a dependency on carisoprodol or codeine:

• A history of drug or alcohol abuse or dependence

The following conditions may be worsened by use of this treatment:

• Gastritis
• Hypotension
• Pancreatitis
• A history of seizures
• Acute history of stomach ulcers

Side effects and effects of medication can be increased because of slower removal of medication from the body in patients who suffer from the following conditions:

• Kidney disease
• Liver disease


Before taking this medication you should consider the risks and potential side effects in relation to the benefits of use. You should make this decision with your doctor having given appropriate consideration to all of the following factors and taking into account your medical history and current medication use:

Allergies – Inform your doctor of any allergies from which you suffer. This is especially important where you have suffered an allergic reaction to any medication in the past.

Pediatric – Safety and efficiency have not be tested below the age of 16. Discuss with your doctor if you are concerned about receiving a prescription. Codeine should not be used following surgery to remove tonsils and/or adenoids in children. Serious problems have been reported in the use previously.

Geriatric – There are no known limitations to use in elderly patients.

Pregnancy – Do not take this medication when pregnant. If you are pregnant then inform your doctor and an alternative medication will be found for treatment. Harmful effects have been demonstrated to occur in a fetus through use of this medication during gestation. Avoid becoming pregnant during use of this medication and take appropriate contraceptive steps to ensure this. Inform your doctor immediately if you believe you have been impregnated during use of this medication.

Breastfeeding – Milk production and composition may be altered by the use of this medication. Discuss breastfeeding with your doctor before using this treatment as a nursing mother. Nursing mothers who choose to breastfeed during the use of this treatment will need to monitor their infant closely for any adverse side effects.

This medication should not be used for more than 21 days at the maximum. If your condition is not improving or is becoming worse then you should consult your doctor.

This medication may make you dizzy or disorientated. Ensure that you know how it affects you before driving or operating any machinery. Do not do anything that puts you or others around you at risk unless you are safe and alert.

During use, you should rise from sitting and lying positions slowly so as to avoid dizziness and fainting.

This medication can increase the effects of alcohol and other medications that make you drowsy. You should inform your doctor of any other such medications you are taking. You should also inform any doctor or dentist that you are taking this medication before you undergo any other treatment or procedure.

This medication can interact with alcohol in the body. Your risk of bleeding problems will be significantly increased if you drink three or more alcoholic beverages per day during treatment. If you have an alcohol dependency then you should discuss this with your doctor before beginning the treatment.

Do not stop the use of this medication suddenly. You should cease use gradually to prevent the occurrence of withdrawal symptoms. If you wish to stop treatment then you should discuss this with your doctor and continue as usual until you have done so.

This medication is habit-forming and you should never take more than prescribed. If you believe it is not working then you should contact your doctor.

Anaphylaxis can occur from the use of this medication. If it occurs then you will need to seek emergency medical attention. The following are symptoms of anaphylaxis:

• Changes in skin coloration
• Fainting
• Gasping for breath
• Hive-like swellings
• Increased heart rate
• Irregular breathing
• Irregular heartbeat
• Swelling around the eyes
• Wheezing

Codeine is changed into morphine in the body. In very rare cases some people convert codeine into morphine much faster than normal. These ‘ultra-rapid metabolizers of codeine’ will be at increased risk of the effects of morphine from use. You should call your doctor immediately if you experience the following symptoms:

• Extreme sleepiness
• Confusion or disorientation
• Shallow breathing

If a nursing mother were to be an ‘ultra-rapid metabolizer of codeine’ then this would put a nursing child at serious risk of morphine overdose.


Medications should always be stored well out of the reach of children. Store this medication away from anyone with a history of drug or alcohol dependency. Medication should be stored in a sealed container at room temperature. Keep the medication away from light, heat and moisture. Prevent from freezing.

Do not keep this medication for any longer than required. You should dispose of unused and outdated medication as soon as possible and in a safe manner. Ask your healthcare professional how you can safely dispose of this medication.

The use of narcotics for a long period of time can cause very severe constipation. Your doctor may prescribe laxatives if you experience this but you can help to prevent this by eating lots of fiber and drinking an increased quantity of water.

Do not take any other medications in conjunction with this medication without first discussing it with your doctor.


The combination of carisoprodol, aspirin and codeine is used in the treatment of acute skeletal and muscle problems. This treatment is used for the relief of symptoms and is not a cure for these conditions. In addition to a prescription for carisoprodol, aspirin and codeine, you will also receive advice on how to relieve the pain that you are experiencing. Following this advice will enable you to find a longer-term solution to the problem.

This medication should not be taken for any more than a maximum 21 days and should only be taken as prescribed by your doctor.

This is a habit-forming medication that can lead to dependency if it is abused or overused. You should not take an increased dose under any circumstances and if you believe that you need to change the dose then you should consult your doctor first. When ceasing use of this treatment you should also reduce the dose slowly as directed by your doctor. This will prevent you from experiencing withdrawal symptoms, which can be dangerous and increase the risk of developing substance dependency.

You should not use this treatment if you have a history of alcohol or drug abuse or dependency as you will be at a heightened risk of developing a dependency. This medication can cause anaphylaxis in patients. You should inform yourself of the symptoms of anaphylaxis before taking this medication and should contact the emergency services immediately if you experience these symptoms.

This medication combination should not be used when pregnant. There has been demonstrated harm caused in fetus development and this is particularly pronounced in the late stages of pregnancy. Breastfeeding may also be impacted by the use of this treatment. There has been a demonstrated change in the production and composition of milk in nursing mothers. You should discuss breastfeeding with your doctor before you begin this treatment. Nursing infants will need to be monitored while you are receiving this treatment to ensure that they are not suffering any side effects.

This medication combination interacts with a wide range of other medications and you should be sure to inform your doctor of all medications and substances that you are taking before you begin use of this treatment. This medication combination should also not be used in patients with a range of medical conditions. Share your medical history with your doctor so that you can make an informed decision about the use of this treatment together.