Ceftaroline (Intravenous)

Ceftaroline, which is also known as Teflaro, is an antibiotic that is used to treat a variety of bacterial infections.

Overview

Ceftaroline is a type of antibiotic that is known as a cephalosporin antibiotic. It prevents bacterial infections by working to stop the growth of harmful bacteria. It is important to note that this medication is not used to treat any viral infections such as the cold or flu, but is only used in the treatment of bacterial infections. It is only available when prescribed by a doctor.

Condition Treated

  • Bacterial infections
  • Some bacterial skin infections, including MRSA
  • Some bacterial pneumonia infections

Type of Medicine

  • Antibiotic

Side Effects

Common side effects of Ceftaroline given through an intravenous route can include:

Some rarer and more serious side effects may occur. This antibiotic is associated with a rare but serious intestinal disease that can develop while on the medication. This disease comes from an antibiotic resistant bacteria known as Clostridium difficile. The seriousness of this disease can be minimal but it can also be fatal. The disease can still appear several weeks even after you have completed your treatment. It can also exasperate or appear more frequently in people with other intestinal diseases such as inflammatory bowel disease, GI disease, diarrhea, or ulcerative colitis. If you experience any of the side effects associated with intestinal disorders contact your doctor right away. Do not take any anti-diarrhea medicine to help this because it can make the condition worse. The symptoms can include the following:

  • Persistent diarrhea
  • Abdominal or stomach pain
  • Blood in the stool

There are other potential severe side effects that may occur while taking Ceftaroline, though they are rare. Contact your doctor immediately if you begin to experience any of the following symptoms while taking this medication. These could potentially include the following:

  • Sudden fever or flu like symptoms
  • Mouth sores
  • Little or no urination
  • Constipation
  • Muscle weakness or cramping
  • Indications of a blood cell disorder: dark colored urine, jaundice, easily bruised or bleeding, skin rash, or severe numbness

While allergic reactions are rare, it is possible they can occur. Seek medical help immediately if you start experiencing any of the following symptoms of an allergic reaction:

  • Rash
  • Itching or swelling, especially of the tongue, face, and throat
  • Severe dizziness
  • Trouble breathing

Dosage

Ceftaroline is an intravenous medication that is normally administered through injection by a doctor. The medicine is normally administered in 600 mg doses every eight to twelve hours. The medication is normally given over a period of several minutes to an hour intravenously. The patient is normally hooked up to a IV machine and the solution will be administered through an infusion bag. Antibiotics are most effective when given in evenly spaced intervals, so it will most likely be administered at the same time every day. Actual dosage amount varies depending on the type of condition being treated. In some patients weight and age may also play a factor in the amount of medicine used.

This medicine can be used at home. If it is going to be used at home, be sure to follow all instructions given by your doctor. If there is any doubt about how to administer the medication at home, the patient should not take the medication and should have it administered by a medical professional.

Interactions

Most antibiotics are not likely to affect hormonal forms of birth control, but some are known to decrease its effectiveness. Decreased effectiveness of birth control can result in unplanned pregnancy. Talk to your doctor if you are on a form of hormonal birth control before beginning treatment of Ceftaroline.

This medication may interfere with certain laboratory tests, causing them to appear to fail when they would normally pass. Talk to your doctor or laboratory test manager about your use of Ceftaroline before taking any laboratory tests.

There are no serious drug interactions recorded with Ceftaroline. It is assumed it may have minimal interactions with most drugs and will not normally interfere with other medications being taken. It is still important to tell your doctor a list of all medications, supplements, and vitamins you may be taking before starting Ceftaroline, as there are some drugs the medication has minor interactions with. Your doctor will likely want to monitor you while you are taking this medication to make sure there are no bad drug interactions or other unwanted or serious side effects.

Talk to your doctor if you are on any medications that may affect kidney function. This medication has the potential to make kidney problems worse, and may have minimal interactions with other drugs that also affect kidney function. Your doctor will decide if this medication is right for you.

Because bacteria can become resistant to antibiotics when overexposed to them, Ceftaroline should only be used to treat the specific diseases it is indicated for. Your doctor should examine the bacteria to ensure they are the appropriate type. If Ceftaroline is used inappropriately, the patient may develop a tolerance to the antibiotic and it may not work as effectively in the future.

Warnings

It is important to never stop an antibiotic until the condition is completely treated, even if you are beginning to feel better early in the treatment. Stopping an antibiotic before the treatment is finished can cause the infection to come back or possibly worsen. Follow all directions given by your doctor exactly when taking this medication.

Be sure to talk to your doctor about any past allergic reactions you may have had to this medication, or to another cephalosporin antibiotic, or to penicillin, as well as any other known allergies. While allergic reactions are rare, they are known to occur in similar antibiotics. If you are experiencing the symptoms of an allergic reaction, stop use of the medication immediately and seek medical attention.

Before using this medicine, talk to your doctor if you have a history of kidney disease. Persons who have kidney disease, renal failure, or are on certain types of dialysis may have a different reaction to this drug. They may also require a different dosage than normal.

Be sure to share your entire medical history with your doctor. It is also important to talk to your doctor about any kind of medication you are taking, including herbal supplements, vitamins, or over the counter drugs.

Talk to your doctor if you are pregnant or breastfeeding before using this medication. It is unknown if the medication will pass to the baby through breast milk, but your doctor can determine if it is safe for you to have the injection. It is also unknown whether or not the medication affects the fetus, though there have not been any effects noticed in pregnant women taking the medication. The medication is recommended for adults of 18 or older, but talk to your doctor about your child's potential interactions with the medication. It is unknown how this drug interacts with children who are under the age of 18. However, if it were to be used in children, it is likely the dosage would be greatly altered or changed.

Ceftaroline may interfere with the effectiveness of some live bacterial vaccines such as the typhoid vaccine or the cholera vaccine. Ceftaroline can cause these vaccines to not work or not work as well as they might while not on the antibiotic medication, potentially resulting in a serious disease. Talk to your doctor before getting a vaccine while on this medication. It is best to avoid getting a vaccine or immunization while taking Ceftaroline.

It is important to remember that your doctor is prescribing this medication because the benefits outweigh the potential risks. Again, for this reason it is important to be completely honest with your doctor about your medical history and your medications.

Storage

Once Ceftaroline is made into a solution, it should be used within six hours if it is left at room temperature and within 24 hours if it is refrigerated under eight degrees Celsius. Ceftaroline powder is normally stored in single use vials before it is made into a solution. As a powder it is normally stored at room temperature. It can be kept as a solution in the infusion bag or in storage bags specifically made for intravenous solutions. Both the solution and the powder vial should be stored away from sources of moisture and heat.

The solution is prepared by mixing a diluent with the powder solution. The diluent should be a clear color or a light yellow. If it is any other color or has particles in it, the mixture should not be used and the pharmacist should be contacted. The solution should never be mixed with a solution containing another drug.

Summary

Ceftaroline is a cephalosporin type antibiotic that works by stopping the growth of harmful bacteria. It treats certain types of skin infections, including MRSA, as well as pneumonia caused by bacteria. It is available only as a prescription from a doctor, and is generally administered by a doctor over a period of an hour once every eight to twelve hours. It is administered intravenously by making a diluent solution.

There are several potential side effects. Common side effects include nausea, vomiting, diarrhea, constipation, rash, headache, or dizziness. Vaginal yeast infections and oral thrush can also develop while on this medication. Patients who have a medical history of kidney failure or other kidney problems such as dialysis should also consult with their doctor before taking this medication, as dosage changes may be needed. There are some other potentially harmful but rare side effects; read the full list to be aware of all the potential problems that can occur.

While Ceftaroline has no serious drug interactions, it can have some minimal interactions with other things. This drug can affect some laboratory tests and cause a false positive. It can also have minimal interactions with some drugs and decrease their effectiveness. It is important to completely take an antibiotic until it is finished. Stopping an antibiotic early even if you feel better can cause symptoms to come back or worsen.

Allergic reactions to Ceftaroline are rare, but they may occur if you have known allergies to similar antibiotics or to ingredients in the solution. Talk to your doctor before you begin this medication.

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Last Reviewed:
December 24, 2017
Last Updated:
April 04, 2018
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