Ceftazidime and Avibactam

Used most commonly to treat a wide range of bacterial infections, the use of Ceftazidime and Avibactam discussed here comes in injection form.

Overview

Ceftazidime and Avibactam will be prescribed to you by a medical professional as a means to treat infections that can occur in various parts of your body. Ceftazidime and Avibactam is effective in treating bacterial infections by either preventing the growth of the bacteria or killing it altogether. It comes in a powdered form which can then be turned into a solution to inject into your body. Ceftazidime and Avibactam is not suitable for treating common colds or flu.

Do be aware that Ceftazidime and Avibactam, like many other drugs, can come with a number of side effects and is known to interact with various foods and other drugs. For this reason, Ceftazidime and Avibactam is not something you should take without a prescription. Instead, always go to your doctor regarding your ailments and discuss with them what the best course of treatment is. This may involve taking Ceftazidime and Avibactam, or an alternate form of medication which is better for you.

Conditions treated

A variety of bacterial infections all across the body. This includes, but is not limited to;

  • Pneumonia as a result of the bacteria Enterobacter
  • Bacterial pneumonia as a result of Haemophilus Influenzae
  • Pneumonia as a result of bacteria
  • Pneumonia as a result of Proteus bacteria
  • Cervix bacterial infections as a result of E. Coli

Type of Medicine

  • Injection

Side Effects

As with all drugs, there are a number of possible side effects you should be aware of when taking Ceftazidime and Avibactam. Be aware that side effects can tend to be very common and should not overly distress you. However, there are some rarer side effects (as listed below) which are a little more harmful or worrying. In which case you should make your doctor aware of them.

You should check immediately in with your doctor if you experience any of these side effects;

  • Rapid increase in weight
  • Seizures
  • Agitation
  • Convulsions
  • Decrease rate of urination
  • Persistent cough
  • Gums are bleeding
  • Blood in stool or urine
  • Skin changing color (blue)
  • Pains in the chest
  • Chills
  • Dropping into a coma
  • Bouts of confusion
  • Black, tarry stools
  • Dizziness
  • A fever
  • Unnecessary bouts of hostility
  • Lethargy
  • Losing your appetite
  • Sudden cramps or muscle pains
  • Twitching muscles
  • Glands are swollen
  • Tenderness
  • Bleeding or bruising in usual manner
  • Out of character weakness or tiredness
  • Vomiting or nausea
  • Tingling or numbness in feet, hands or lips
  • Difficulty urinating
  • Pinpoint red spots on your skin
  • Sore throat
  • Ulcers, white spots or sores in the mouth or on your lips
  • Stupo
  • Ankles, face, feet, legs or hands swelling
  • Persistent headaches
  • Increased thirstiness
  • Irregular heartbeat

If you experience any of the following, then again contact your doctor. However, do be aware that they are currently unrecorded in the medical industry as a result of taking Ceftazidime and Avibactam, but could occur.

  • Tightness in your chest
  • Swelling around the tongues, lips, eyes, face or eyelids.
  • Difficulty with your swallowing
  • Skin rash, hives or another itching
  • Fast heartbeat

As mentioned there are also some side effects which will not require you to necessarily seek medical attention, unless you are worried. These more common side effects include;

  • Changes in your tastes
  • Complete loss of taste
  • Stomach or abdominal pain
  • White patches covering throat, tongue or mouth
  • Diaper rash with white patches.
  • Difficult with your bowel movements
  • Diarrhea
  • Skin redness

This list of side effects from Ceftazidime and Avibactam is extensive though not necessarily comprehensive. This means that other side effects may recur as a result of you taking Ceftazidime and Avibactam. If you experience any other side effects which you think are related, then contact your nurse, doctor or medical professional right away. They will be able to advise you as to whether to stop taking Ceftazidime and Avibactam altogether, to drop your dosage or to try a different form of medication.

Dosage

As Ceftazidime and Avibactam is only available via prescription, your doctor will inform you of the correct dosage. Your exact dosage will depend on a number of factors. This includes but is not limited to age, height, weight, gender, and your physical condition.

Major Drug Interactions

As is the case with many different drugs, taking Ceftazidime and Avibactam alongside other medications can lead to unexpected side effects. Before you begin a course of Ceftazidime and Avibactam, you should always make your doctor aware of any other drugs you currently take. They can then make an informed decision as to whether Ceftazidime and Avibactam is indeed the right medication, or whether a different drug may be better suited. Alternatively, they may still prescribe you with Ceftazidime and Avibactam or alter the recommended dosage.

If you take any of the following drugs, then it is recommended you do not start taking Ceftazidime and Avibactam;

  • Cholera vaccine, Live
  • Warfarin
  • Proenecid
  • Chloramphenicol

This is not to say you will not still be prescribed the two together. Instead, it may be vital that you take both. However, you will likely have your dosage of one or the other altered to limit any potential interactions that could occur. Your personal circumstances, such as age, gender, and physical condition will also play a part, so the course of action taken will be as a result of considering you on a unique basis.

As well as interacting with other drugs, Ceftazidime and Avibactam can react with other elements of your lifestyle like what you eat, drink and smoke. So again, be sure to make your doctor fully aware of your dietary intake. If you are unable to change your tobacco intake or intake of other foods, then Ceftazidime and Avibactam may not be the best drug for you. However, this will be up to your doctor to decide and you should not make this judgment yourself.

When discussing your exact situation with your doctor, be sure to reveal all medical problems you suffer from. Below is a list of medical problems that are more likely to react badly to Ceftazidime and Avibactam and should be properly brought to light.

  • Brain disease, such as encephalopathy
  • Myoclonus
  • An allergy to penicillin, or a history of having this allergy
  • A severe history of diarrhea
  • Kidney problems or disease
  • Known history of seizures

Warnings

Throughout your course of Ceftazidime and Avibactam, it is wise to maintain frequent check-ups with your doctor. They can check for any of the aforementioned interactions and side effects to ensure it is progressing properly.

It is possible that taking Ceftazidime and Avibactam can lead to some more serious allergic reactions. This includes anaphylaxis which is both life-threatening and requires you to get emergency medical attention. To spot the signs of this, look for trouble swallowing, swelling on your face, hands or mouth, severe itching or rashes forming.

There are other skin reactions that can occur as a result of Ceftazidime and Avibactam. Look for signs of loose skin, peeling, lesions, rashes, severe acne, ulcers, blistering, chills or fever. Again, under such a circumstance there is treatment you should follow and so you should contact your doctor right away.

As mentioned earlier, diarrhea is a known side effect of taking Ceftazidime and Avibactam, and this shouldn't necessarily worry you. Do be aware that diarrhea can occur up to two months after you stop taking Ceftazidime and Avibactam. However, if your case of diarrhea does get particularly severe then you should seek assistance. Do not take any medication to counter the effects, instead, ask your doctor for a suitable course of treatment.

Any other tests you perform whilst under a course of Ceftazidime and Avibactam may be affected as a result. For this reason, make nurses and doctors aware that you are taking Ceftazidime and Avibactam and that tests may be affected because of this.

You should properly inform your doctor of any allergies you have. It doesn't matter how innocuous or irrelevant you think these allergies may be, as they could be significantly worsened as a result of Ceftazidime and Avibactam. Allergies and reactions that should be named include reactions to food, animals, dyes, and drugs.

As of writing, there have been no formal studies conducted into the effects of Ceftazidime and Avibactam of pediatric patients. Your doctor is best informed to give pediatric patients an appropriate dose. Any reactions or worrying side effects on younger patients should be immediately reported to the prescribing doctor.

Any studies involving Ceftazidime and Avibactam and geriatric patients have not detected any underlying issues or reasons they shouldn't take it. However, elderly patients are known to suffer from a greater occurrence of kidney problems. If you are elderly and suffer from kidney problems, do make your doctor fully aware. They may well limit your dosage of Ceftazidime and Avibactam.

Some studies have been performed on both pregnant women and pregnant animals regarding how safe Ceftazidime and Avibactam is. No major issues have been brought to light regarding risk to the fetus. However, studies have not been fully comprehensive. Therefore, if any worrying signs to crop up, be sure to make your doctor fully aware of them and stop taking Ceftazidime and Avibactam.

A similar story is relevant towards breastfeeding women, whereby there have been no formal tests that have demonstrated an increased risk. Instead, you should make your doctor fully aware of your situation and together you can weigh any potential risks to decide whether Ceftazidime and Avibactam is indeed the best course of treatment.

Storage

Ceftazidime and Avibactam is usually supplied via a trained nurse in a medical environment, in which case you will not have to worry about storage. However, some patients are permitted to inject Ceftazidime and Avibactam directly from home. In such cases, refer to the prescription and thorough storage guidance by the nurse or doctor. Keep it in a cool dry place and away from direct sunlight. Unless otherwise instructed, do not allow Ceftazidime and Avibactam to be frozen. Keep it out of sight and out of reach of young children as it can be potentially harmful.

Summary

Ceftazidime and Avibactam is a very useful drug to take, as it is applicable in treating a very wide range of bacterial infections. For this reason, it is relatively common, but should only ever be taken if prescribed by a doctor. As it is known to react to a wide range of drugs and to be affected by a variety of pre-existing medical conditions, you should first openly discuss your situation with a doctor. Once you have finished your course of Ceftazidime and Avibactam be sure to dispose of the remaining medication safely and sensibly, as instructed by your doctor.

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Last Reviewed:
December 23, 2017
Last Updated:
February 09, 2018
Content Source: