Cefuroxime (injection)

Studies have shown cefuroxime to be more effective in combatting Lyme disease, Neisseria gonorrhea and haemophilus influenza.

Overview

First marketed in 1978, cefuroxime is a second-generation antibiotic of the cephalosporin family of drugs. It is regularly prescribed for the treatment of bacterial infections, being most effective in clearing up these particular ailments.

Studies indicate a particular efficacy of this drug in the treatment of Lyme disease, haemophilus influenzae, and neisseria gonorrhoeae. Likewise, there is compelling evidence that an injection of cefuroxime immediately following catarct surgery often lowers the risk of the patient subsequeently developing endophthalmitis.

Cefuroxime is only available under a prescription from your doctor.

Cefuroxime is available as the following dosage forms:

  • powder for solution
  • solution

Conditions Treated

  • bacterial infections
  • Lyme disease
  • neisseria gonorrhoea
  • haemophilus influenza
  • post-surgery endophthalmitis in cataract patients

Type of Medicine

  • cephalosporin antibiotic

Side Effects

Alongside its expected and desired effects, any medication might result in some less desirable effects. While it is by no means certain that all (or any) of the following side effects will occur, should you happen to exhibit any of them, it might be necessary to seek medical attention.

Should any of these side effects listed exhibit themselves during your course of treatment with Cefuroxime, you should consult your doctor as a matter of urgency.

  • tarry, black stools
  • unusual loss of weight
  • unusual weakness or tiredness
  • unusual bruising or bleeding
  • tightness around the chest
  • tenderness
  • swollen glands
  • swelling of leg or foot
  • swelling to tongue, throat or face
  • sudden blackout, or losing consciousness
  • white spots, ulcers, or sort in the patient’s mouth, or on the patient’s lips
  • sore throat
  • peeling, burning, itching, tenderness, or redenning of skin
  • skin lesions, usually red and exhibiting a purple center
  • irritated or red eyes
  • general puffiness to the tongue, lips, face, eyes, or eyelids
  • difficult or painful urination
  • pain
  • vomiting and nausea
  • spasms or jerking of muscles and extremities
  • muscle or joint pain
  • increased thirst
  • welts or hives
  • moderate or mild hearing loss
  • large decrease in amount of urine expelled during urination, or the frequency of same
  • fever
  • fast heartbeat
  • dizziness
  • unable to catch breath, wheezing, difficulty in swallowing or breathing
  • watery, severe, and possibly bloody diarrhea
  • cough
  • chills
  • chest pain
  • changes to color of skin, especially to a bluish color
  • cloudy or bloody urine
  • bloating
  • loosening, peeling, or blistering of skin
  • stomach or abdominal pain or tenderness
  • stomach or abdominal cramps

The effects listed above might require the attention of a medical expert. However, other side effects might also present themselves, which do not require medical attention. Many of the negative will likely disappear during your treatment, as you become acclimatized to it. Further, your doctor might recommend ways to prevent or reduce some of these negative impacts. If any of these listed side effects continue to affect you during your treatment, or if any of them become bothersome, be sure to consult your doctor.

  • lacking in appetite
  • gas

The effects listed above are not exhaustive, and there might be other negative impacts that present themselves as a result of taking Cefuroxime. If you become aware of any negative effects during your course of treatment with Cefuroxime, be sure to speak with your doctor.

Dosage

The dosage recommended of Cefuroxime differs from one patient to the next. You should always follow your prescribing doctor’s directions, or the instructions on the label. The information listed below indicates the average dosages of Cefuroxime, and should not be taken as medical advice. Should you be prescribed a different dosage from those listed below, do not alter it unless your examining doctor advises you to do so.

The amount of Cefuroxime you take will depend upon how strong the medicine is. Additionally, the time you should allow to elapse between doses, the amount of doses that you take every day, and how long your course of Cefuroxime lasts will depend upon the nature of your illness, for which your doctor has prescribed it.

For injection dosage:

Adults and teenagers: 750 milligrams (mg) to 3 grams (g) each six to eight hours, over a period normally lasting between five and fourteen days. The solution ought to be injected directly into a vein or muscle. Gonorrhea is typically treated via a single dosage of cefuroxime of around 1.5 g, injected directly into a muscle. This 1.5 g dosage is split into two injections, both to be administered intramuscularly at two different injection sites upon the body, alongside an oral 1 gram dosage of probenecid.

Infants or children over the age of one month: 12.5 milligrams (mg) to 150 mg per kilogram (kg) (or 5.68 mg to 68 mg per pound (lb)) of the child’s body weight each six to eight hours, to be injected directly into the vein or muscle.

Newborns: 30 milligrams (mg) to 100 mg per kilogram (kg) (or 13.6 mg to 45.5 mg per pound (lb)) of the baby’s body weight, each eight to twelve hours, to be injected directly into the vein.

If you happen to miss a dosage of Cefuroxime, you should take it at the earliest opportunity. If it is almost time for your next dosage, you should skip the missed dose and go back to your regular dosing schedule. Under no circumstances should you double the dose.

Major Drug Interactions

Whilst some medicines ought never to be taken alongside each other under any circumstances, there might be times when a pair of drugs should be taken at the same time, even though interactions are known to occur. In a situation like this, your doctor will likely want to amend the dosage, or offer other precautions. Whilst taking Cefuroxime, it is vital that you make your examining doctor aware if you are taking any other drugs at the same time, especially if it appears on the following list. These interactions are listed here based on the likelihood of their occurrence and potential significance. This list is not necessarily exhaustive.

Using Cefuroxime alongside the following drugs is normally not recommended. However, it might be necessary in some circumstances. Should both medications be prescribed at the same time, your prescribing doctor might amend the dosage or the frequency with which either drug ought to be taken.

  • live cholera vaccine

Some drugs shouldn’t be taken about the same time as eating food, or eating certain foodstuffs, as there is a known risk of negative interactions occurring. Using tobacco or alcohol alongside certain drugs can also result in certain interactions occurring. If concerned about your used of tobacco, alcohol, or food during your course of treatment with Cefuroxime, consult your prescribing doctor.

Warnings

Whenever taking any sort of drug, the risk must be weighed against the good it is likely to do. Such a decision needs to be reached after a thorough consultation with your examining doctor. When prescribed Cefuroxime you ought to consider the following:

Inform your prescribing doctor, should you have suffered an allergic, or any other kind of unusual reaction to Cefuroxime, or indeed to any other medication. You should make your prescribing doctor aware if you are suffering from negative or allergic reactions to anything else, such as animals, dyes, preservatives, and foods.

There have been no appropriate studies conducted to determine the relationship between age and the impact of Cefuroxime among the pediatric population. Your prescribing doctor will decide if Cefuroxime is an appropriate medication for a younger patient.

Whilst studies have not shown any problems specific to the geriatric population that would preclude or limit the use of Cefuroxime among the elderly, there is evidence that more elderly patients have and increased chance of developing kidney problems as a consequence of their age. This could necessitate extra caution, or might require the prescribing doctor to adjust the dosage of Cefuroxime for elderly patients.

No studies have been conducted among women that have demonstrated a risk in the use of Cefuroxime to the fetus during pregnancy.

Studies conducted among women to determine risk to the nursing infant whilst using Cefuroxime during breastfeeding have shown only a minimal risk. You must always weigh the possible benefits of the medication against its possible risks to your child before deciding to take Cefuroxime whilst breastfeeding.

Take Cefuroxime precisely as your prescribing doctor recommends. Do not take larger, or more frequent doses, and do not extend the length of your treatment.

Cefuroxime ought to come with a leaflet providing patient information. Be sure that you read these instructions and that you follow them carefully. Should you have any concerns or questions, be sure to consult your doctor.

If the symptoms of your condition fail to improve over the first few days of your course of treatment with cefuroxime, or should they become worse in that same time period, be sure to consult your prescribing doctor.

You should only use the specific brand of Cefuroxime that has been prescribed by your doctor. A different brand might not have the same effect on your condition.

Do not stop taking or interrupt your course of Cefuroxime before consulting your doctor.

Certain medical conditions can have an impact on the efficacy of Cefuroxime. Ensure that your examining doctor knows about any other medical conditions that are currently affecting you, especially any listed below.

Cefuroxime should be used with caution along these medical conditions, as it can make the condition worse.

  • history of colitis
  • history of gastrointestinal disease

Cefuroxime should be used with caution along these medical conditions as, not only can it make the condition worse, it might also require the taking of Vitamin K supplements.

  • liver disease
  • kidney disease
  • history of poor nutrition

The effects of Cefuroxime might be increased among patients suffering from the following conditions, owing to the reduced rate at which it is removed from the body.

  • kidney problems

Storage

Consult your prescribing doctor about the correct way you ought to store your cefuroxime, as it can differ from one preparation to another.

Cefuroxime should always be kept beyond the reach of children.

If you no longer require your Cefuroxime solution, or if it should become outdated, you should not keep it.

Be sure to consult your medical professional before disposing of any unwanted or outdated Cefuroxime.

Summary

Cefuroxime is a cephalosporin antibiotic used primarily to treat infections caused by bacteria, often as a preventative measure, following surgery. A second-generation cephalosporin antibiotic drug, first marketed in 1978, it is regularly prescribed for the treatment of Lyme disease, Neisseria gonorrhea and haemophilus influenza, for which it has proven particularly effective. It works by killing off the bacteria responsible for the infections it has been employed to defeat, and preventing regrowth of the bacteria.
Studies have provided compelling evidence for the efficacy of cefuroxime in the post-operative care of patients who have recently undergone cataract surgery. It has been shown that an injection of the drug, immediately after the surgical operation, can provoke a noticeably lower risk for the eye patient contracting endophthalmitis (an inflammation of the eye, which is a common side effect of any intraocular surgery, and which can lead to loss of vision if not correctly treated).