Chlordiazepoxide and Clidinium (Oral)

Chlordiazepoxide and Clidinium, which is also known by its brand name Librax, is a blended oral medication that is used to treat some stomach and bowel disorders.

Overview

This medication is a combination of two medications: Chlordiazepoxide, which belongs to a class of benzodiazepines, and Clidinium, which belongs to a class of drugs known as antispasmodics. The combination works to relax muscles in the stomach and intestines, thus slowing the natural movements of the gut. This helps to relieve symptoms in various bowel and stomach disorders. This medication alone is not normally used to treat the conditions it is indicated for; normally, it will be given as an additive to further help relieve symptoms and aid in ongoing treatments. It might not be effective in all patients, so it is important to have communication with your doctor while you are taking this medication to make sure it is working for you.

Condition Treated

  • style="font-weight: 400;">Ulcers
  • 400;">Irritable Bowel Syndrome
  • Bowel infections
  • Certain types of bowel swelling disorders
  • Other stomach and bowel disorders
  • Type of Medicine

Symptom relief

Side Effects

Some common side effects of this medication can include:

  • 400;">Dizziness
  • Drowsiness
  • Vision problems, blurriness of vision
  • 400;">Dry eyes or mouth
  • Weakness
  • Nausea
  • 400;">Constipation
  • 400;">Abdominal bloating
  • Confusion

The following side effects are more serious but are more unlikely to occur while taking this medication. If you experience any of the following, please talk to your doctor right away:

  • Decreased sweating
  • Skin that appears hot or feels flushed
  • Heartbeat that is fast or irregular
  • Loss of coordination, falling, or fainting
  • Slurred speech
  • Abnormal mental or mood changes
  • Difficulty urinating
  • Decreased sexual ability

While rare, if any signs of infection occur, please contact your doctor right away. Some of the signs of infection include:

While rare, if any signs of liver problems occur please contact your doctor right away. Some of the serious signs of liver problems can include:

  • Dark urine
  • Persistent nausea, vomiting, and/or abdominal pain
  • Yellowing of the skin or eyes
  • Unusual tiredness

Seek medical attention immediately if you experience any of the following very serious side effects:

  • Eye pain, swelling, or redness
  • Vision changes such as seeing rainbows around light

While allergic reactions to this medication are rare, they have been known to occur. Seek medical attention immediately if you are experiencing any of the signs of a very serious allergic reaction, which can include:

  • Swelling or itching of the throat, tongue, or face area.
  • Severe dizziness
  • Trouble breathing
  • Rash

This medication has been known to cause addiction. While it is not common, the chances of developing an addiction may increase if the patient has other substance abuse disorders. It is important to take the medication exactly as it is prescribed in order to lower the chances of developing an addiction. The medication can also have withdrawal effects, especially if used in higher doses than prescribed, more than prescribed, and for a long time. Talk to your doctor if you feel you may be addicted or have been using the medication incorrectly for a long period of time. Some of the side effects of withdrawal for this medication if the medication is stopped suddenly can include:

  • Shakiness
  • Sweating
  • Nausea
  • Seizures

Dosage

Dosage is based on the patient's age, medical history, the seriousness of the disease, and response to treatments. It is normal to start the patient off with a lower dose to reduce the risk of side effects and move the dosage up if needed. Normally the dosage will start at only one to two capsules per day and increase as the individual builds up a tolerance. It is normally about 5 mg of Chlordiazepoxide and 2.5 mg of Clidinium for the active ingredients, with the pill containing other inactive ingredients as well. The dosage should never be increased with doctor approval, as it could increase the risk of harmful side effects. The medication is normally intended to be used over a short-term period, and using it for long amounts of time may potentially lower its effectiveness.

The medication is normally taken three to four times a day before meals and before bedtime. When taken before meals it is normally taken 30 to 60 minutes prior to the meal. If a patient is on antacids as well as this medication, take the medication as you would normally and take the antacid after you have finished your meal so the two do not interfere with each other. Talk with your doctor about the specific times that the medication should be taken.

If you miss a dose, you should take the missed dose as soon as you remember it as long as it is not time for your next dose. If it is time for your next dose, do not take two doses to make up for the missed dose. Doing so can increase your potential for overdose and experiencing harmful side effects. If you miss a dose and it is time for your next dose, simply skip the missed dose and continue taking your medication as normal.

Interactions

Before beginning any medication it is important to talk to your doctor about all the prescribed medications, over the counter medications, and supplements including vitamins that you may take on a daily basis.

Some drugs that may affect how this drug works and decrease its effectiveness can include:

  • Potassium tablets or capsules
  • Sodium oxybate
  • Pramlintide or similar drugs
  • Cimetidine
  • Disulfiram
  • Blood thinners such as warfarin
  • Some psychiatric drugs
  • Drugs similar to the ones that have been listed

This drug may affect the effectiveness of some antifungal drugs such as ketoconazole. If you are taking this drug or a similar one, be sure to take it at least two hours before taking Chlordiazepoxide and Clidinium.

This medication may interfere with some laboratory tests and cause a false positive. Talk with your laboratory technician or your pharmacist before taking any laboratory tests to make sure that this medication will not interfere.

Smoking cigarettes decreases the effectiveness of this drug by decreasing Chlordiazepoxide levels in the blood. Talk to your doctor if you smoke or have recently stopped smoking.

There are many drugs that cause dry mouth or constipation that can interact with antispasmodics such as Clidinium, causing these symptoms to worsen. Talk to your doctor if you are currently on any of the following medications, as they may make these symptoms worse:

  • Amantadine
  • Other antispasmodic/anticholinergic drugs such as atropine, dicyclomine, propantholine, or scopolamine
  • Belladonna alkaloids
  • Benztropine
  • Quinidine
  • Disopyramide
  • MAO inhibitors such as isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, or selegiline
  • Chlorpromazine
  • Trycyclic antidepressants

Serious but rare side effects such as shallow breathing or severe drowsiness and dizziness can be increased if this medication is taken alongside other medications that also cause breathing problems or drowsiness/dizziness. Talk to your doctor or pharmacist if you take any of the following medications or other drugs:

  • Alcohol
  • Marijuana
  • Opioids such as codeine, oxycodone, or morphine
  • Drugs for sleeping or anxiety such as alprazolam or lorazepam
  • Muscle relaxants such as carisoprodol
  • Antihistemines such as cetirizine

Warnings

Taking this medication with opioids such as codeine, oxycodone, morphine, or other related drugs can greatly increase the potential for very serious side effects to occur. These serious side effects include intense sedation, respiratory depression, coma, and even death. Talk to your doctor about all of your present medications so that they can prescribe the best dose possible for you. If you are taking both opioids and this medication and begin to experience any serious side effects, seek medical help immediately.

Before taking this medication, talk to your doctor about any existing allergies, especially if you are allergic to this medication or any similar medications. The medicine may also contain ingredients that can cause allergic reactions.

Before beginning this medication, it is important to talk to your doctor about your entire medical history, including any current or past problems involving any of the following

Common side effects of this drug include dizziness and blurred vision. Do not drive, operate machinery, or do other activities that require full alertness while taking this medication. Do not drink alcohol while on this medication as it can worsen these effects.

This medication can make you sweat less, making you more susceptible to com/health/heat-stroke/">heat stroke. Avoid excessive exercise or other hard work that might cause you to overheat. Avoid going outside for long periods of time if it is excessively hot. Avoid other areas that might cause you to overheat, such as a hot tub. If you begin to experience any symptoms of heat stroke, such as mental/mood changes, fever, headache, or dizziness, please seek medical attention immediately.

Elderly adults or young children may be more susceptible to experiencing serious side effects or worse common side effects. Consult with your doctor before beginning this medication if you are over the age of 60 or under the age of 18. The elderly may be more prone to falling while on this medication to increased dizziness, or experiencing other unwanted side effects such as stomach issues. The elderly are also much more prone to having issues with increased sedation due to the negative side effects of this drug. The elderly can still take this drug, though it would normally be in smaller doses for a shorter amount of time to prevent serious side effects. Young children are at risk to develop mood disorders while taking the drug or having a negative reaction.

It is not recommended for mothers who are pregnant or might become pregnant while on this medication to take this medication. It is not recommended for mothers who are breastfeeding to take this medication, as the medication can pass through the breast milk, and the medication can inhibit proper lactation. This medication can have undesirable effects on an infant and may even harm an unborn baby, especially when taken for long periods of time. An unborn baby could potentially have malformations if the mother takes the medication while they are in the womb. Because the drug is not necessary and only acts as symptom relief, it should never be taken by a pregnant woman because of the severe risks it poses to a child.

It is possible to overdose on this drug. It is important to take the drug exactly as it is prescribed to you by your doctor to decrease your risk of overdose. Some minimal side effects of Chlordiazepoxide overdose include somnolence, confusion, coma, and diminished reflexes. Usually, the signs of a Clidinium overdose will be more present in someone who overdoses on this medication. The signs of a Clidinium overdose include excessive dry mouth, constipation, inability to urinate, and blurring of vision. If you suspect someone taking this medication has overdosed, seek medical attention immediately. The patient who has overdosed should have the drug removed from their system as soon as possible to prevent any long-lasting or serious effects.

To prevent overdoses or addiction, it is important to keep count of your drug and not to share your drug with anyone else on top of taking it exactly as directed.

Storage

Pills are normally stored in pill bottles containing 100 capsules. The bottle is to be stored at room temperature and kept out of reach of children. It should be stored away from sources of moisture and heat; do not store it in the bathroom. Talk to your doctor about the proper way to dispose of unused or expired medication.

Summary

Chlordiazepoxide and Clidinium is a combined drug indicated to treat bowel and stomach disorders such as ulcers and irritable bowel disease, or other disorders that are similar. Chlordiazepoxide is a drug that is normally indicated to help with anxiety and is in a class of drugs called benzodiazepines. Clidinium is an antispasmodic drug used to help relax muscles. The combination helps to relax gut muscles and aid in symptoms relief for the disorders it helps to treat.

There is an extensive list of side effects, both common and serious, and drugs that can potentially worsen these side effects. Some of the most common side effects are dizziness, drowsiness, blurred vision, constipation, dry eyes, dry mouth, nausea, and vomiting. Some of the more serious side effects can include fainting, irregular heartbeat, loss of coordination, mental mood changes, uncontrollable muscle movements, or decreased sweating. There are several drugs that can increase these side effects when taken alongside this medication, especially the side effects of dry mouth, constipation, dizziness, and drowsiness. This drug should never be taken with opioid medications, as the combination can cause severe sedation that can lead to coma or even death.

The elderly are also at increased risk for having serious side effects, as well as young children, pregnant women, and mothers who are breastfeeding. Talk to your doctor if you belong in any of these categories.

This drug will negatively affect some people with certain medical histories, most notably enlarged prostate, glaucoma, or urinary problems. Read the full list and talk to your doctor about your entire medical history before beginning this medication.

This medication is a risk for overdosing and addiction. To prevent the risk of overdose and addiction, take the medication exactly as it is prescribed to you by your doctor. Patients who have a history of other substance abuse are at a higher risk for addiction or overdose. Patients who are addicted or take this drug for a long time can also experience withdrawal symptoms. Seek medical attention immediately if you are experiencing overdose symptoms.