Clioquinol and Hydrocortisone (Topical)

Clioquinol and Hydrocortisone is a cream or ointment used in the treatment of skin infections to provide relief.


Clioquinol and Hydrocortisone is a combination treatment that comes in the form of creams or ointments. It is used to treat infections of the skin and to provide relief for common symptoms of infections including itchiness, redness and discomfort.

Clioquinol is an antibiotic treatment that helps to prevent the growth of fungus and bacteria in the wound, allowing these to be killed off. Hydrocortisone is a corticosteroid that aids in the reduction of swelling, redness, and itchiness of the infected area.

This medication is only available with a doctor's prescription and is provided in the form of a cream or ointment.

This treatment is safe for use on children over the age of two and in adults. Do not use on infants below the age of two and avoid use when pregnant.

Condition treated

  • Infection, of the skin

Type of medicine

  • Clioquinol¬†' antibiotic
  • Hydrocortisone¬†' corticosteroid

Side Effects

The use of this treatment can result in unwanted side effects, in addition to the desired effects of use. Some of these side effects can be serious and will require you to seek medical attention. In other cases, the side effects may be mild and will abate over time.

You should check in with your doctor immediately if you experience any of the following side effects, which may require you to receive medical attention:

  • style="font-weight: 400;">Burning of the skin with the presence of pinhead-sized red blisters
  • Darkening of the skin where applied
  • Depression or extreme sadness
  • Diarrhea
  • Dizziness
  • Drying of the skin resulting in blistering, flaking, burning or crusting.
  • Dryness
  • Easier bruising
  • Faintness or fainting
  • Fever
  • Hives
  • Hoarseness of the voice
  • Irritation
  • Itchiness
  • Joint stiffness, pain or swelling
  • Loss of feelings of hunger
  • Nausea
  • Pus appearing in hair follicles around the applied area
  • Rash
  • Red or purple lines appearing on the body
  • Redness and/or scaling around the mouth
  • Scaling, redness, soreness or swelling of the skin
  • Softer feeling of skin
  • Swelling of face or hands and feet
  • Thinning of skin
  • Tightness in the chest
  • Troubled breathing
  • Troubled swallowing
  • Unusual tiredness
  • Unusual weakness
  • Vomiting

Side effects can also occur that would not usually necessitate that you visit a doctor. If they become bothersome or are ongoing, however, you can seek advice from your doctor on how to alleviate these side effects. These can include:

  • 400;">Acne
  • Increased growth of hair on arms, legs, forehead, and back
  • Lightened skin color around area of application
  • Lightening of dark areas of skin
  • Pimples

Other side effects that have not been listed herein may also occur from the use of this treatment. If you experience other side effects from use, you should inform your doctor. If you believe that your health is at immediate risk, however, then you should always contact emergency services.


This medication should only ever be used as directed by your doctor. Failing to use this medication properly can lead to more significant side effects and can cause unwanted skin irritation. Ensure that you use the cream as your doctor directs and do not use it for longer than prescribed.

Do not use this medication on the nose, mouth eyes or vagina. This is not for use on any body part other than the skin. If you do get this medication on any of the listed areas then you should wash it off immediately with warm water.

This medication must be used for the full course of treatment. It may appear that the infection is gone before this, but it is possible that the infection still remains. If you fail to destroy the infection completely then it can return and may be resistant to treatment, so it is vital that you finish the full course and do not miss any doses of treatment.

This treatment should only be used for the infection or irritation it has been prescribed for. This treatment can actually make some skin conditions worse, so you should always check with your doctor before using it on any condition for which it was not originally prescribed.

This treatment should not be used for cuts, scrapes or burns. This will be painful and should be avoided.

To use this treatment follow the following steps:

  • Ensure that your hands and the area being treated are thoroughly cleaned and then dried.
  • Apply a thin layer of medication to the affected area of skin.
  • Gently rub the medication into the affected area
  • Do not cover or wrap the treated area unless your doctor has directed you to.

This medication will be used differently for different patients. You should follow the directions as given by your doctor and follow the instructions on the packaging. The following dosing information is an average only and does not take into account the specifics of your condition, your weight or the variable strength of different treatments. Do not make changes to the dosage instructions that were given to you by your doctor.

For treatment with cream, lotion or ointments for use on bacterial and fungal infections of the skin:

  • Adults and children aged over two: Apply to the affected area as directed two to four times daily.
  • Children under the age of two: Treatment to be determined by the doctor.

If you miss a dose of this treatment then you should ensure that it is applied as soon as possible.

Do not use double doses of this treatment.


Before using any medication you should discuss potential interactions with other medications that you are taking with your doctor. Inform them of all of the treatments you are taking before use. This is important because medications can interact with one another to cause severe side effects, stop one another from working, or to expose you to greater risk of unwanted side effects. With this treatment you should be especially careful to inform your doctor before use if you are taking any of the following medications:

The following treatment would not be recommended for use in addition to Clioquinol and Hydrocortisone. Your doctor may change the prescription you are given:

In normal cases, the use of the following treatments in conjunction with Clioquinol and Hydrocortisone would not be recommended. In some cases, both may be prescribed but your doctor may wish to change the dose of one or more of the treatments you are taking:

  • Valdecoxib
  • Tolmetin
  • Tolfenamic Acid
  • Tiaprofenic Acid
  • Tenoxicam
  • Sulindac
  • Sodium Salicylate
  • Salsalate
  • Salicylic Acid
  • Rofecoxib
  • Proquazone
  • Propyphenazone
  • Proglumetacin
  • Pranoprofen
  • Pixantrone
  • Piroxicam
  • Piketoprofen
  • Phenylbutazone
  • Parecoxib
  • Oxyphenbutazone
  • Oxaprozin
  • Nimesulide Beta-Cyclodextrin
  • Nimesulide
  • Niflumic Acid
  • Nepafenac
  • Naproxen
  • Nadroparin
  • Nabumetone
  • Morniflumate
  • Meloxicam
  • Mefenamic Acid
  • Meclofenamate
  • Lumiracoxib
  • Loxoprofen
  • Lornoxicam
  • Ketorolac
  • Ketoprofen
  • Indomethacin
  • Ibuprofen
  • Flurbiprofen
  • Flufenamic Acid
  • Floctafenine
  • Feprazone
  • Fepradinol
  • Fenoprofen
  • Felbinac
  • Etoricoxib
  • Etofenamate
  • Etodolac
  • Droxicam
  • Dipyrone
  • Diflunisal
  • Diclofenac
  • Dexketoprofen
  • Dexibuprofen
  • Conivaptan
  • Clonixin
  • Choline Salicylate
  • Celecoxib
  • Bupropion
  • Bufexamac
  • Bromfenac
  • Bemiparin
  • Amtolmetin Guacil
  • Aldesleukin
  • Acemetacin
  • Aceclofenac

The use of the following medications in conjunction with Clioquinol and Hydrocortisone may increase your risk of exposure to certain side effects. This combination may still be the best treatment for you, however. To reduce this risk your doctor may wish to change the dose or frequency of use of one or more medication:

  • Tosufloxacin
  • Sparfloxacin
  • Saiboku-To
  • Rufloxacin
  • Rifapentine
  • Prulifloxacin
  • Primidone
  • Pefloxacin
  • Pazufloxacin
  • Ofloxacin
  • Norfloxacin
  • Nadifloxacin
  • Moxifloxacin
  • Metocurine
  • Lomefloxacin
  • Licorice
  • Levofloxacin
  • Hexafluorenium
  • Gemifloxacin
  • Gatifloxacin
  • Gallamine
  • Flumequine
  • Fleroxacin
  • Enoxacin
  • Colestipol
  • Ciprofloxacin
  • Besifloxacin
  • Balofloxacin
  • Atracurium
  • Alcuronium

Other interactions that have not been listed herein may also occur when used alongside Clioquinol and Hydrocortisone. To ensure that you are not putting yourself at risk through the use of medications that interact with one another you should ensure that you have informed your doctor of all medications you are taking, including any over the counter treatments that you use.

Other medical problems that are not being treated with this medication may still be affected by it or may affect the use of it. You should ensure that your doctor has been informed of all medical conditions from which you suffer before beginning the use of this treatment. This is especially important if you suffer from any of the following conditions:

The following conditions may be worsened by use of Clioquinol and Hydrocortisone:

Should not be used for the treatment of:

Side effects from the use of Clioquinol and Hydrocortisone may be increased in patients suffering from the following:

  • Infection of the skin near the point of application.
  • Sores or broken skin at the site of application.


Before beginning use of this treatment, you should consider the risks of use in relation to the benefits. You should make the decision to use this medication in line with your doctor. Before using Clioquinol and Hydrocortisone ensure that you have considered all of the following factors:

Allergies: You must inform your doctor if you have every reacted unusually to any medications that you have taken in the past. Ensure that they are also aware of any allergies you have to foods, dyes, preservatives, animals or other substances.

Pediatric: This medication has not demonstrated risk in children over the age of two. However, caution should be used as the treatment has a level of toxicity that could put them at risk. Children absorb more of the medication through the skin than adults do, so it is important to dose correctly. Ensure that you follow the instructions of your doctor closely and do not exceed dose or use. Use in children under the age of two would not be recommended. Alternative treatments should be identified.

Geriatric: No limitations for use in elderly patients have been identified with this treatment.

Pregnancy: This medication can pose a risk to the child. It should only be used during pregnancy where the treatment is obviously needed. Inform your doctor if you are pregnant before use and an alternative treatment may be determined.

Breastfeeding: It is unknown if this medication can affect the production or constitution of milk. Discuss the risks and benefits with your medical professional before use when nursing.

Your doctor will need to check up on your progress during use of this treatment to ensure the infection is decreasing. If your symptoms have not improved within one to two weeks, or if they worsen at any point then you should visit your doctor for a check-up.

This medication can stain items that it comes into contact with. This includes, skin, clothing, furniture, hair, and nails. Use caution when applying this treatment and avoid application to anything other than the affected area.

This medication can increase the risk of the development of problems with the adrenal gland. Limit this risk by using the treatment only as directed by your doctor and be aware of the following symptoms. These symptoms of adrenal gland problems should be shared with a doctor immediately:

  • Blurring of vision
  • Dizziness
  • Fainting
  • Increased thirst
  • Increased volume of urination
  • Irregularity of heartbeat
  • Irritability or quickness to annoyance
  • Unusual tiredness
  • Unusual weakness

Use of this treatment can make you temporarily more sensitive to light, which can lead to severe sunburn. Wear suncream whenever you are in direct light. Avoid tanning beds and UV lights during treatment.

If the cream is being applied to the diaper area of your child then you should avoid the use of tight-fitting diapers and plastic underwear. These can increase the rate of absorption and in doing so increase the risk of toxicity in the child.

Do not use any other products including skin care treatments and makeup on the affected areas.


  • You should store this medication in the original packaging at room temperature.
  • Store away from heat, moisture, and direct light.
  • Prevent from freezing.
  • Do not store outdated medication for a longer period than required.
  • Ask your healthcare professional or pharmacist how best to dispose of any unwanted or unused medication.


Clioquinol and Hydrocortisone is a combination of medications in the form of a cream, ointment or lotion that can be used for the treatment of fungal or bacterial skin infections in patients.

Clioquinol is an antibiotic that works to kill and destroy the bacteria or fungus so that the wound can heal. As an antibiotic, it is important that the patient uses the full course of this treatment to ensure that all of the bacteria is in fact dead. While the wound may appear healed before this, there is a chance of recurrence if you stop use too early and the treatment would then be ineffectual against it.

Hydrocortisone is a corticosteroid that provides relief from the symptoms of the infection. This treatment will help to reduce redness, itching and swelling around the affected area.

This treatment is not effective against any viral infections that may occur and should not be used for their treatment.

Clioquinol and Hydrocortisone can be used in the treatment of children aged 2+ and adults. Caution should be carried out in the treatment of children as there is a higher risk of toxicity occurring if too much is used. Children under the age of 2 should not be treated and pregnant women should avoid use where possible.

When using this treatment apply as instructed and avoid contact of affected and treated area with clothing and furniture. Do not cover the affected area as this can increase the rate of absorption and result in toxicity being experienced by the patient.