Colistimethate medicinal solution is injected into a vein (IV) or into a muscle (IM), usually on the buttocks or thigh, when treating patients with certain bacterial infections. In some cases, the medicine is given as a constant infusion through a vein, for a duration of time. It is usually given by a nurse or trained healthcare professional at a hospital or medical center.
The antibiotic works by killing and preventing further growth of the infectious bacteria. Like other antibiotics, Colistimethate works best when it is kept at the desired level in the body. Patients should take their treatment exactly as directed to prevent the condition from getting worse or becoming resistant to antibiotics.
One of the important benefits of this antibiotic medication is its safety and efficacy in treating neonatal infections caused by multidrug-resistant gram-negative bacteria.
The use of this injection is limited in patients with certain medical problems and who are using other medications that may cause an adverse interaction. Any decision to treat them should be done with due caution.
Colistimethate is available in the US under the brand names, Coly-Mycin M and Coly-Mycin M Parenteral. It is recommended for treating only certain bacterial infections and will not work if used to treat colds, flu or other viral infections.
You should consider the potential benefits and risks of using Colistimethate. Your doctor may help you decide if it is safe for you.
Tell your doctor if you are allergic to the medicine, or have had an unusual reaction to it. Some patients may also be allergic to inactive ingredients in the medication. In discussing allergies, tell your doctor of any allergy you may have to foods, preservatives, dyes or animals.
Certain medications or medical conditions may affect the way the injection should work. Tell your doctor about all medications you are taking or plan to take. These include prescription and over-the-counter medicines (OTCs), vitamins, nutritional supplements, and herbal products.
Patients with kidney disease, severe liver disease, or diarrhea should not take this medication. If it cannot be avoided, then the medicine should be taken with caution, as determined by a doctor.
Call your nurse or doctor right away if you experience any of the following symptoms. They may be signs of a serious side effect.
The following other side effects may occur, but their incidence is not known. Call your doctor right away if you experience any of them.
Some side effects that occur go away on their own. They generally do not require medical attention. If they become worse, bothersome or do not go away, tell your doctor. Some of these effects include the following:
Other side effects not mentioned in this guide may occur. Talk to your doctor or healthcare professional if you experience any unusual symptom that becomes bothersome or gets worse. You may call the FDA at 1-800-FDA-1088 to report side effects.
Colistimethate injection is made from a powder that is mixed with a liquid to form a solution.
Patients allergic to this medicine should not be treated with it. Your doctor should immediately stop treating you with this drug if you develop an allergic reaction to it.
Your dose may be different from another patient. The strength of each dose, how often you take it, the time between each dose, and the entire duration of your treatment may be based on your age, type of infection being treated, the presence of other medical problems, and your body's response to the first dose.
Adults: The injection may not be prescribed for you to take at home. It is given into one of your veins or into a muscle by a nurse or healthcare professional, usually at a hospital or clinic. The medicine may also be given as a constant infusion through a vein.
Geriatrics: The safety and efficacy of the drug are established for use in elderly patients. However, these patients are more likely to have age-related kidney problems when treated with this drug. Dose may vary based on age, as determined by your doctor.
Pregnant or breastfeeding women: Tell your doctor if you are pregnant or breastfeeding. To avoid any risk of harm to an unborn baby or breastfeeding infant, use and dose must be determined by your doctor.
If you miss a scheduled dose of the injection, speak with your doctor or healthcare professional immediately so you can set up a new dosing schedule.
Get emergency help right away if you experience any of the following symptoms of an overdose:
Certain drugs are not recommended to be used while taking Colistimethate. This is because they can adversely interact and increase the risk of certain side effects. In cases where it is necessary to use them, precaution must be taken by your doctor to ensure all your medications are taken safely.
The antibiotic injection is usually not recommended for use with the following medicines. If it necessary to use any of them during treatment for continued health, your doctor may change the dose or how often you use any of your medicines.
There is a possibility for an increased risk of certain side effects if any of the following other drugs are used during your treatment. If their use during your antibiotic therapy is best for your health, your doctor may change the dose or how often you use any of your medications.
Other drugs that may cause adverse interaction are as follows. Your doctor should use them with caution while treating you for bacterial infection. This may include changing the dose or how often you use any of them.
You may ask your doctor about restrictions on your use of certain foods, alcohol or tobacco during treatment. Foods and other substances may affect the way a drug is intended to work or can increase the risk of side effects. Additionally, certain medicines are required to be taken with or without food.
The existence of other medical problems is known to cause interaction with Colistimethate. You must tell your doctor if you have any other medical conditions. The antibiotic may make the following conditions worse:
The medication should be used with caution in patients with the following condition. This is because it slows the removal of the medicine from the body and increases the chance for side effects.
The benefit of prolonged treatment with this drug should be balanced against the potential risk of renal failure in patients with kidney disease.
Other medicines not mentioned here may also interact with the injection when used together during treatment.
This injectable solution is usually stored by a healthcare professional at a hospital or medical center.
Colistimethate injectable medicine is safe and effective for use in adults and children. It is even safe for use in newborn babies with neonatal infections caused by multidrug-resistant gram-negative bacteria.
For the drug to be fully effective, patients are required to take all their doses strictly as scheduled, until the treatment is complete. This ensures the infectious bacteria is killed and reduces the chance of the infection coming back.
Prolong use of the medicine in patients with kidney disease can lead to kidney failure. Therefore, the potential benefits should be carefully weighed against the potential risks of using it.
The known side effects caused by the medicine are not many when compared to other drugs. However, some of the side effects can be serious and may require medical attention. Despite the antibiotic may interact with other medicines or existing medical problems, it can be safely used as determined by a doctor.