Colistin, Neomycin, Thonzonium, and Hydrocortisone (Otic)

This is a full description of the combined drug that uses neomycin, colistin, hydrocortisone, and thonzonium to treat swimmer's ear and similar infections.


The drug mentioned here is actually a combination of four different drugs that work together. They are intended to help patients receive the antibiotic benefits of neomycin and colistin, and it contains an anti-inflammatory known as hydrocortisone. Thonzonium is used to move through the pus and dead tissue that is created by the infection, and the four work at the same time to give patients all their benefits simultaneously.

The drug itself is often known as Cortisporin-TC, and the generic style is simply called Neomycin/Colistin/Hydro Suspension - OTIC. The drug has been sold in both forms for some time, and it is simply a matter of the doctor's recommendation or the preference of the patient.

The drug is an in-ear solution that is applied to the ear from a dropper and/or on to a cotton swab. Someone who wants to rub this inside their ear may do it themselves, or they may ask a friend to do the same. It is used over the course of a few days, but it is wise to stop the treatment at 10 days, as directed by a doctor.

The medication must be stored properly, and the doctor must be consulted if there are ever any issues with the symptoms that are related to the infection.

The medication is a powerful drug that must be used often to ensure that the results given come about quickly because the medication cannot be used for long periods of time. The people who are using this medication must be given as many opportunities as possible to use this medication in short stints, and they must consult their doctor if they realize that the medication may have been used for too long.

These drugs together are meant to provide the finest quality of care, but they cannot be used for too long. Someone who chooses to use these medications for long periods of time could cause their body to be immune to treatment, and they will have more ear infections as a result. The simplest choice is to ensure that someone may be given the medication, asked to use it for only a short time, and discontinue use if they believe that the infection is not going away as it should.

Someone who has used the drug too much will find that they are hindering its effectiveness, and they must ask their doctor for assistance if there is a drop in the results seen in the patient.

Conditions That It Treats

  • These medications together treat the following things:
  • Ear infections more commonly known as swimmer's ear.
  • Possible middle ear infections.
  • Fenestration cavities caused by ear infections.

Type of medicine

  • In-ear solution.

Side Effects

The most common side effect is a stinging or burning sensation in the ear, but this is common because the medication is killing the bacteria in the ear. Serious side effects are not common with this drug, but it is possible that someone could have hearing problems or hearing loss. Using the drug for extended periods of time after the original treatment dates could cause a new bacterial infection in the ear.

It is unlikely that someone could have a more serious infection while treatment is ongoing, and a doctor must be contacted if any symptoms of a major allergic reaction are noticed. The patient could be going through a rash, itching, swelling, red ears, dizziness, and breathing problems. Other side effects may occur that the patient may not be aware of, and these must be reported to a doctor as soon as possible.


The medication is designed to be used about three or four times a day. Each person who is put on the medication must plan to use it at their doctor's discretion because their doctor will let them know how often they prefer they use it. Use must be discontinued after around 10 days, because a new infection could be created.

The patient must have a completely clean ear canal that has been dried before they start using this medication. Someone else should actually drop the medication into the ear to ensure that the right number of drops has been used. This is a delicate process, because of the strong nature of the drug. Using only the exact amount is recommended, so that it is not overused.

The container itself must be warm before the drops are used, and it can be warmed simply by holding it in the hand for a little while before administering the drops. The ear drops must be dispensed from the dropper that is provided with the medication because it will create a drop that is the right size for the patient.

The dropper must be held over the ear while the patient tilts their head. The purpose is to drop the medication into the ear without touching the dropper to the ear. This is because the dropper could be contaminated with the actual infection. To avoid contamination, the dropper must be held away from the ear canal.

The medication must be shaken before it is used because the four components have to be mixed as well as possible. Because they sit in a suspension, they may not be combined well when not shaken. The drops must be left in the ear for five minutes, and they will be swabbed out with a cotton swab. The patient may pull on their earlobe to ensure that the medication falls into their ear.

A wetted cotton swab could have all the prescribed drops on it, and it may be placed in the ear canal while the infected area is swabbed for a few minutes. The dropper cannot be rinsed, and any cotton swabs that are used to clean the ear should not be reused.

Someone may notice that the symptoms of their infection have gone away after a couple days, and they must not stop using the medication. The medication cannot be used longer than prescribed, and the doctor should be alerted if the symptoms do not go away after the prescribed length of treatment.


There are no known interactions with this medication, but all patients should alert their doctor of the medications they are taking. It is very important that doctors have a full medical history of their patients even though drug interactions are not common with this medication. Herbal and natural supplements must be reported to the doctor because they may play a part in the prescription process.


All patients must ensure that they are not allergic to neomycin, thonzonium, colistin, and/or hydrocortisone. It is also possible that someone who is allergic to gentamicin or tobramycin could have issues using this medication. Someone who is allergic to corticosteroids such as prednisone or dexamethasone may have issues with this medication, and other allergies must be considered. It is wise to tell the doctor of any allergies that are present just to ensure that all bases are covered.

This medication should not be used by someone who has a hole in their eardrum, a middle ear infection, or other ear infection. Pregnant women must consult their doctors because it is not known if the medication will cause problems while they are carrying, and they must ask their doctor if it safe to use during breastfeeding. Additionally, patients should avoid swimming while on this medication.

The medication could cause another infection if it is used for too long or in a dosage that is too high. There are many people who are of the belief that they must use as much of the medication as possible, but they must ensure that they follow the doctor's instructions to the letter.


This suspension should be stored at room temperature in a place that does not get direct heat or light. The drug should not be stored in a traditional bathroom or kitchen medicine cabinet, and it should not be stored where children or pets can access it. The drop is a suspension intended only for topical use, and it should not be ingested at any time. These drugs must be discarded properly when they are expired or finished, and a doctor or pharmacist can help the patient learn how to dispose of this medication properly. Do not flush it down the toilet or pour it down the sink.


The suspension commonly called Cortisporin is a combination of four drugs that will treat swimmer's ear, and it could be used by anyone who has an infection of their ear. The infections may cause pus or dead tissue to build up in the ear, and the medication will help kill the bacteria, reduce inflammation, and move through any of the tissue in the ear that may be infected. It is a drug that must be used at the direction of a professional, and it may be wise to have someone else help with the drops.

The medication comes in a bottle with a dropper, and the medication must be dripped into the ear or rubbed in with cotton swab. The medication is very strong, and it cannot be used past the normal treatment window. The medication should not be shared, and it could cause a secondary infection if it is used for too long. Someone who is using this medication could feel a stinging or burning sensation in their ear, and they must ensure that they have used the medication regardless of what happens. They may ask their doctor if they believe the side effects are too strong, and they may speak to their doctor if the symptoms do not go away after they have completed their course of treatment.

A partner may be helpful when using this medication, and it must be used with extreme care to prevent contamination of the tools that are used to apply the medicine. There are many different people who are using this medication for swimmer's ear, but they cannot wash their dropper or reuse their cotton swabs. There are no known drug interactions with this medication, and a doctor must be consulted if there is ever a problem or perceived problem.

The Cortisporin suspension will help anyone with an ear infection, middle ear infection, or other infections when directed by a doctor to use this medication. There are many generic suspensions, and the Cortisporin name is used as the brand name where it is sold. The combination of all four medications together helps ensure that the infection has been removed completely so that the patient may go on swimming.