Conjugated Estrogen Synthetic B (Oral)

Conjugated Estrogen Synthetic B is more commonly known as Enjuvia, and it has a blend of 10 estrogenic compounds used to help with several vaginal issues.

Overview

Conjugated Estrogen synthetic B is more commonly known as Enjuvia, and is a medication used to treat women going through menopause. There are women in the midst of menopause or post-menopause who need this medication, and it helps them with vaginal dryness and irritation. It helps them even out their hormones, and it is prescribed by doctors in a number of forms.

The medication route here is an oral tablet, and it is produced in a number of styles. These styles are all indicated by their color and markings, and they are used to increase and decrease the dosage as needed. This is something that is used with women who need to balance their hormones as much as possible. They will use the tablets as directed by their doctor, and they will continue to use it until they must stop.

Certain women must discontinue use of this medication simply because they are unable to continue. Some doctors wish for women to stop use because they are so far post-menopause that they need not continue. The medication has a number of potential side effects and risk factors. Women must be aware of the risks involved in using this medication, and they must read up on the side effects to ensure that they know what could happen while they are using the medication. Their diligence will help them ensure that they are safe while in treatment.

Condition(s) treated

  • Vaginal dryness
  • Vaginal irritation
  • Hormonal imbalance in menopausal and post-menopausal women.

Type of Medicine

  • Oral tablet

Side Effects

Adverse reactions to this medication are important to consider and doctors must help explain to their patients what could happen. There are many people who must read about these side effects before they take the medication.

People with cardiovascular disorders and malignant neoplasms must be given a wide range of warnings to ensure that they are safe when taking these medications. Side effects include a number of things such as:

  • Abdominal pain
  • Accidental injury
  • Asthenia
  • Chest pain
  • Chills
  • Flu syndrome
  • Headache
  • General pains
  • Constipation
  • Diarrhea
  • Flatulence
  • Nausea
  • Peripheral edema
  • Depression
  • Dizziness
  • Emotional liability
  • Parenthesis
  • Bronchitis
  • Cough
  • Pharyngitis
  • Rhinitis
  • Sinusitis
  • Acne
  • Fungaldermatitis
  • Pruritus
  • Breast tenderness and pain
  • Dysmenorrhea
  • Vaginitis

Other side effects may occur in extreme circumstances. Women who experience these side effects may be found to be on the improper dosage of this medication, and they must ensure that they have spoken to a doctor about what the proper dosage is. These side effects are different from the others because they occur in overuse more often than they do otherwise.

  • Upper respiratory tract infection
  • Sinusitis
  • Breast tenderness
  • Back pain

People have been found to have other side effects on this medication after it was marketed, and these should all be reported to a doctor. The doctor will either diagnose a condition or find that the problems are related to the medication.

  • Stomach discomfort
  • Distended stomach
  • Anaphylaxis
  • Hypersensitivity
  • Muscle spasms
  • Alopecia
  • Rest
  • Urticaria
  • Deep vein thrombosis
  • Thrombosis

These side effects happened over a number of different studies, and it is quite important for someone to ensure that they have called their doctor any time they have problems. All side effects are not isolated to the medication itself because they may be contraindications of some other disorder. A patient who feels any trouble at all must say something to their doctor to ensure that they have covered all options for their medical care.

Dosage

The dosages change from one person to another, and there are many forms of this product that provide a different dosage depending on what the doctor feels is necessary. The dosages may be changed at any time as the generic and brand new bottles come in many different sizes depending on the dosage the doctor prefers to give. All doctors must choose the appropriate pill size so that they may track patient progress.

Dosage for all women is added to a dose of progestin that is intended to lower the risk of endometrial cancer. Women who do not have a uterus are not in need of a dose of progestin, but a woman who has a history of endometriosis should ensure that she gets progestin because she needs to be sure that she has something that will help control her risk of cancer.

The lowest effective dose must be chosen for the shortest amount of time because that is the best way to keep a woman safe and give her the care that she needs. Postmenopausal women need to have checkups with the doctor often because they need to know if there is any progress. Treatment may not be necessary, but it may need to be altered from time to time.

Enjuvia tablets are offered in tablets that begin at .3 mg, .45 mg, .625 mg, .9 mg, and 1.25 mg.

  • .3. White oval tablet with an E on one side and 1 on the other
  • .45. Mauve oval with E and 2 printed
  • .625 pink oval tablet with E and 3 printed
  • .9 light blue oval with E and 5 printed
  • 1.25 yellow oval tablets with E and 4 printed

Interactions

There are no known or proven drug interactions, but it is still possible that someone who is using a number of different medications will have issues on this treatment. These items may be problematic for the person who is on this treatment, and the list below includes medications that may be difficult or interactive.

Inducers and inhibitors of CYP3A4 such as St. John's Wort, phenobarbital, carbamazepine, rifampin, erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir, and grapefruit extract

This list of substances and medications shows that there are a few things to be careful of, and women must be diligent that they do not use any of these inhibitors so that they may continue to use the pills without feeling as though they are constantly losing their progress.

Warnings

Warning issued with this drug are quite important because they explain what could happen when this drug is used. Anyone who is using this drug must reveal their full medical history to their doctor, and they must ensure that they understand these warnings before they begin using the medication.

There is an increased risk of stroke and DVT and/or deep vein thrombosis on this medication, and there are people who have reported that they are at higher risk when using the corresponding progestin. The doctor will ensure that the medication is discontinued when they are experiencing these symptoms.

Vascular disease risks will rise, and these risk factors all come together with the medication to potentially cause even greater risk. Hypertension, obesity, diabetes, tobacco, and hypercholesterolemia. A family history of vein troubles and lupus will increase these risk, too.

An increased risk of stroke has been noted in women from ages 50 to 79, and doctors will stop treatment when they know that the risk of stroke is rising. There are many therapies that may be used instead.

Coronary heart disease has been indicated as a risk when using this medication, and the women who were using estrogen alone without the progestin were found to have a much higher risk as compared to others.

There is no known cardiovascular benefit in this medication, and there is a risk of WTE which is also known as venous thromboembolism. Anyone who has surgery based on these problems must stop using these medications a few weeks before surgery because their bodies need to be prepared for the surgery.

There has been an increased risk of endometrial cancer, and it is significantly greater than anyone would have suspected after studies were conducted. The risk for prolonged use could be as much as 24 times more than that of a woman who is not using this medication. Malignancy of neoplasms may be judged when a woman is on this medication, but all doctors must be quite thorough when they are completing their diagnostic profiling.

Progestin helps reduce the risks in many women over a range of disorders, and it will reduce the risk of having endometrial hyperplasia which could lead to endometrial cancer.

There is no significant risk of breast cancer associated with this medication. If the use of the medication is prolonged for years, the risk of breast cancer will go up. There was no large increase in risk for ovarian concern, but there are instances in which women's risks of ovarian cancer rise because of their use of these drugs.

The probability of dementia increases with this medication, and there wears a study where 19 women were found to have probable dementia after using this medication. A risk of an increase in gallbladder disease was found in certain patients, and the same is true of Hypercalcemia.

Medication should not be used if there is a loss of vision or migraine. This could be a sign that vascular lesions have formed.

Adding progestin in most cases helps with the risks of disease and disorder. Blood pressure went up in a few women in these studies, and a rise in plasma triglycerides is possible with this medication. This could lead to pancreatitis which could lead to even more disorders. Someone who experiences jaundice should stop using the medication and see their doctor. It is possible that estrogens are not being metabolized correctly, and this could learn to serious illness.

Women who need thyroid medication may find that it is not as effective as it was before, and estrogens may cause women to retain water or feel bloated. Hypocalcemia may occur, and hereditary angiodema may be worsened because of this medication.

Women may find that conditions such as asthma, diabetes, mellitus, epilepsy, migraine, porphyria, lupus, and hepatic hemangiomas become worse. They must be quite careful while using their medications for these problems, and they must report any side effects or problems to their doctors.

Vaginal bleeding should be handled with care, and women who are having other symptoms that are associated with vaginal bleeding must consult their doctor.

Pregnant and breastfeeding mothers must use these medications with care, and a doctor must be consulted. Anyone who is breastfeeding should not use this medication, and the mother must consult other forms of treatment with her doctor. This medication is not to be used in children, and it has not yet been studied in women over 65.

Renal impairment has not been studied, and hepatic impairment has not been studied.

Storage

Synthetic estrogens must be stored at room temperature, and and they may be stored a bit outside that range in certain circumstances. The drug should be kept out of the reach of children and pets. The container should be kept completely tight, and it should be a childproof bottle. The medication is to be dispenses into a bottle that is easy to clock up tight, and it must be kept in that bottle because those bottles were made to protect pills such as this and their special coating.

Summary

Enjuvia is a compound of conjugated synthetic estrogens that are given through a series of tablets that have been made for women who are in menopause or post-menopause. There are many different people who will find that they may use this medication if it has been prescribed by a doctor. There are many people who will find that they may use the medication when they have simple hormonal imbalances that have come about due to menopause. These women are asked to use this medication under the direction of a doctor, and they are given a dosage that the doctor believes falls in line with what they need.

The conjugated estrogens in this compound represent ten different kinds of estrogen, and they have been tested time and again to show what their side effects are. There are many warnings that come with this drug to ensure that all users know what they are getting into when they begin to use it, and there are warnings that show what must be considered when it is prescribed to every woman. There are many ladies who will find that they must report side effects and other issues to their doctor so that they may have their dosage changed or discontinued. Some women must stop using this medication because the side effects are simply too strong, and there are others who must use something that is not as strong while they stay on the medication.