Conjugated Estrogens and Bazedoxifene (Oral)

Bazedoxifene and conjugated estrogens combination is a prescription medication that treats moderate to serious hot flashes and signs of menopause in women.


Bazedoxifene and conjugated estrogens combination is a medication prescribed to treat temperate to serious hot flashes and additional signs of menopause for women who have a womb (uterus). This medication also can counteract osteoporosis (bone thinning) after menopause.

This medication can only be obtained with a recommendation from your doctor.

Bazedoxifene and conjugated estrogens combination is available in tablet dosage form and is manufactured under the US brand name Duavee.

Conditions treated

Type of medicine

  • Estrogen hormones

Side Effects

Medications can occasionally trigger undesirable side effects along with the provided benefits. Not all of these side effects will take place, however, if they do happen they could necessitate medical care.

The most common side effects are:

  • style="font-weight: 400;">Upper abdominal pain
  • Throat pain
  • 400;">Neck pain
  • Nausea
  • Muscle spasms
  • Dyspepsia
  • 400;">Dizziness
  • 400;">Diarrhea

Consult with your physician right away if any of the subsequent side effects take place:

Side Effects

  • Yellowed skin or eyes
  • Vomiting
  • Vaginal discharge change
  • Vaginal bleeding
  • Urine darkened
  • Swelling, redness, or pain in the leg or arm
  • Swelling of the stomach or abdomen
  • Stomach pain, discomfort, or upset
  • Stomach bloated, full, or pressured feeling
  • Speech slowed
  • Speaking inability
  • Speaking difficulty
  • Sour or acid stomach
  • Side, stomach, or abdomen pains (possibly moving to the back)
  • Pelvis pain or pressured feelings
  • Nipple inversion
  • Nipple discharge (bloody or clear)
  • Nipple crusting (persistent) or scaling
  • Nausea
  • Lump under an arm or within the breast
  • Lightheadedness or dizziness
  • 400;">Indigestion
  • 400;">Heartburn
  • Heartbeat quickened
  • 400;">Headache
  • 400;">Fever
  • Fainting
  • Facial muscles, legs, or arms movement inability
  • Double vision
  • Cough
  • 400;">Constipation
  • Confusion
  • Chills
  • 400;">Chest pain
  • Breathing difficulty or abrupt shortness of breath
  • Breast swelling or redness
  • Breast skin sore and not healing
  • Breast skin dimpling
  • Bloating
  • Belching
  • Backache
  • Appetite loss
  • Anxiety

Sometimes, side effects take place but do not typically require medical care. Your body will likely become more adjusted to this medication over the course of treatment. Your medical care professional will be able to inform you of additional ways to reduce or prevent certain side effects. Consult with your physician if you have questions regarding side effects, or if any of the subsequent side effects become prolonged or troublesome.

More Common Side Effects (Medical Care Not Required)

  • Throat pain
  • Stomach pain or upper abdominal
  • Muscle spasm
  • Diarrhea

Less Common Side Effects (Medical Care Not Required)

Patients may experience additional side effects that are not included here. If other side effects are noticed, please consult with your physician right away.

Contact your doctor regarding medical advice you may need regarding side effects. You can also let the FDA know about additional side effects - they can be reached by calling 1-800-FDA-1088.


It is highly imperative that you only take this medication as instructed by your physician. Never take it more than prescribed, never take it more frequently, and never take the medication for a longer duration than your doctor intended. Doing so could trigger additional undesirable side effects.

This medication is manufactured with a patient directional manual. Be sure to read and carefully follow the directions that are printed in the leaflet. Consult with your physician if you have questions or concerns.

Be sure to swallow the entire tablet whole. Never chew, break, or crush the tablet. The medication can be taken with or without a meal.

Your physician may request for you to take calcium and vitamin D supplements while taking the bazedoxifene and conjugated estrogens combination.

Different patients may require different doses of this medication. Always follow the instructions of your doctor or the instructions on the medication label. The information listed below covers only the average doses of the medication. If you have a dose that varies, do not adjust it unless already approved by your doctor.

The strength of the medication determines how much bazedoxifene and conjugated estrogens combination is prescribed to you. In addition, the allotted time between doses, the total count of doses taken per day, and the total duration for how long you take the medication will impact your dose.

Oral dosage form (tablet)

For prevention of osteoporosis and treatment of menopause signs:

Adults: take one tablet daily, each tablet is made up of bazedoxifene (20 milligrams) and conjugated estrogens (0.45 milligrams)
Children: not recommended for use in children.

This combination of bazedoxifene and conjugated estrogens is only permitted for a single dose per day. Women who are not at a significant risk of osteoporosis should not take this medication.

Missed Dose

If you accidentally skip a dose of this medication, it should be taken soon after recognizing that a dose was missed. No need to worry because alternatively, if it is closer to the scheduled next dose, the missed dose should remain missed and you should revert back to your normal dosing schedule. Never double doses of the bazedoxifene and conjugated estrogens combination.


Drug Interactions

While in certain instances, some medications never should be taken at the same time, on other occasions it is perfectly acceptable to take more than one medication, even if there is a slight chance that an interaction could take place. For these situations, your doctor may decide to simply adjust the dose, or they may decide to take other necessary precautions to protect you as a patient. While taking this medication, it is highly important that your medical care professionals are aware if you are currently also taking any of the following medications. The following potential interactions have been chosen due to their probable significance, and the following list is not exactly all-inclusive.

It is not usually suggested to take the bazedoxifene and conjugated estrogens combination with the medications listed below, however certain rare instances may require the combination. It is likely that your physician will change the total dosage amount for either or both medications if both are prescribed simultaneously.

  • Bupropion
  • Dasabuvir
  • Donepezil

There may be an increased chance of certain side effects if this medication is used with any of the following medicines, however, it may be the most optimal kind of treatment for you as a patient. If your physician chooses to prescribe both medications at the same time, they will likely change how frequent one or both medications are taken.

  • Tipranavir
  • St. John's Wort
  • Licorice
  • Levothyroxine
  • Ketoconazole
  • Ginseng
  • Etoricoxib
  • Clarithromycin

Other Interactions

Some medications should be avoided around mealtime or when eating particular kinds of food due to the heightened possibility of interactions. Patients who do use tobacco or alcohol along with particular medications can also cause interactions to be triggered. The following list of interactions has been chosen due to their possible significance, but it not entirely all-inclusive.

The following interactions could cause a heightened risk of some side effects, however, for certain patients this may not be able to be avoided. Your physician may choose to adjust the dosage frequency for how often you are taking this medication, or alternatively they may give you tailored instructions for proper use of tobacco, alcohol, and food.

  • Grapefruit juice

Other Medical Issues

Patients who have additional medical issues can experience impacts in the usefulness and effectiveness of the bazedoxifene and conjugated estrogens combination. Be sure your doctor is aware of any medical issues you may have, including:

  • Vaginal bleeding (atypical or unusual)
  • Underactive thyroid (hypothyroidism)
  • Tumors (suspected or known) patients who are estrogen dependent or who have tumors should not take this medication
  • Systemic lupus erythematosus; take caution, can make certain conditions worse
  • Swelling of the throat, tongue, lips, face (hereditary angioedema)
  • 400;">Stroke (or history of)
  • Seizures (epilepsy)
  • 400;">Porphyria (enzyme issue)
  • 400;">Obesity (history of)
  • Low calcium in the blood (hypocalcemia)
  • 400;">Liver tumors
  • 400;">Liver disease
  • Kidney diseas not recommended to use, there have not been any studies of this medication for patients with kidney disease
  • Jaundice (while pregnant, or from previous hormone therapy)
  • High triglycerides or fat levels within the blood (hypertriglyceridemia)
  • 400;">High cholesterol (in blood or fats) hypercholesterolemia
  • High calcium levels within the blood (hypercalcemia)
  • High blood pressure (hypertension)
  • Heart disease
  • Heart attack (history of)
  • Headaches (severe, migraine)
  • 400;">Gallbladder disease
  • Extended periods of being immobilized take caution; conditions can cause heightened risk of severe side effects
  • 400;">Endometriosis
  • Edema (swelling of the body or retaining fluid)
  • Diabetes
  • 400;">Breast cancer (suspected or known, or history of)
  • Blood clotting disorders (protein S or protein C)
  • Blood clots (pulmonary embolism or deep vein thrombosis) history of or active
  • 400;">Asthma


It is highly imperative that you visit your doctor regularly and that your physician regularly monitors your progress to be sure that the bazedoxifene and conjugated estrogens combination is working appropriately and does not trigger any disadvantageous side effects. Your physician may require you to have pelvic area exams, breast preventative exams, and/or mammograms (breast preventative x-ray) to monitor for negative side effects. Ensure that you make it to every appointment, or reschedule if you run into scheduling complications.

Women who have renal damage or hepatic impairment should not take this medication.

Women who are postmenopausal are not likely to become pregnant. However, it is important to know that this medication (if taken while pregnant) could cause harm to the baby. Alert your doctor immediately if you suspect that you have become pregnant while taking the bazedoxifene and conjugated estrogens combination.

This medication could possibly raise the risk of patients having heart attacks, strokes, or blood clots. It is important to understand that these risks could persist even after you've quit taking the medication. Patients with high cholesterol in their blood, high blood pressure, are overweight, smoke cigarettes, or have diabetes have a higher risk for these side effects. If you have any experiences of confusion, double vision, inability to move limbs (arms or legs), inability to move the face, chest pain, headaches, difficulty or an inability speaking.

Taking the bazedoxifene and conjugated estrogens combination could potentially raise your risk of uterine cancer, breast cancer, or endometrial cancer. Discuss this potential risk with your physician. Consult with your physician right away if vaginal bleeding takes place that is unusual.

This medication could raise the possibility of dementia taking place, especially for ladies 65 years or older.

Consult with your physician right away if serious headaches take place or you experience abrupt vision loss or other shifts in vision takes place while you are taking this medication. Your physician may be inclined to have a specialist examine your eyes, such as an ophthalmologist (an eye doctor).

Ensure any visiting physicians or dentists are aware that you are taking the bazedoxifene and conjugated estrogens combination. Patients may need to quit taking this medication prior to having surgery, or if you are on bedrest for a prolonged period of time. This medication can have impacts on the results of some medical exams.

While on this medication, grapefruit and grapefruit juice should be avoided. These can change the absorption rate of the medication by your body.

Never take additional medications unless your physician has approved them previously. This refers to both over-the-counter (nonprescription), herbal remedies or vitamin supplements (for instance, St. John's wort), and prescription medicines.

Patients must always compare the potential dangers of taking a medication against the benefits that it may provide. Make this decision carefully with your doctor. Consider the following potential risks prior to taking this medication.


Let your physician know if you have ever encountered an allergic or unusual reaction after taking any type of medication. Also inform your medical care professional if you have specific kinds of allergies, including to dyes, animals, foods, or preservatives. For products that are over-the-counter or non-prescription, carefully read the label or ingredients information on the package completely.

Specific Demographic Use

Patients must take additional caution if they identify with any of the following demographic categories.


Children should not take the bazedoxifene and conjugated estrogens combination.


It is not suggested for women over the age of 75 to take this medication. However, suitable studies have not outlined any potential issues that are specific to the geriatric population that could inhibit the effectiveness of the bazedoxifene and conjugated estrogens combination for the elderly. Elderly patients typically have a higher likelihood that undesirable side effects could take place (such as dementia), and this could require geriatric patients to take additional caution when taking this medication.


There have been dangerous effects demonstrated to the fetus which have caused fetal abnormalities in animal or human studies. Women who are currently pregnant, or who have future plans to become pregnant should not take this medication as there is a clear danger that is more alarming than any benefits the medication could provide.


There have been dangerous effects to infants after studying the impacts on the baby while the mother is breastfeeding. Mothers who are breastfeeding should seek to find an alternative prescription that their doctor will recommend, or breastfeeding should stop completely while on this medication.


Always keep this medication far from the available reach of children. Medication that is outdated, expired, or no longer required by the patient should be disposed of. Consult with your medical care professional to find out the proper disposal method for unused medication.

Bazedoxifene and conjugated estrogens combination should always be stored a room temperature far from heat or freezing sources. The medication container should also be kept away from direct light and moisture. Keep this medication in the package that it came in until it is time to take it. Never transfer the medication into pill organizers or boxes. The medication should be finished or disposed of within 60 days of opening the foil pouch.


Bazedoxifene and conjugated estrogens combination treats temperate to severe hot flashes and other signs of menopause in women. This medication also can improve effects of osteoporosis (bone thinning) after menopause. Ensure you are familiar with all side effects prior to taking the bazedoxifene and conjugated estrogens combination.