Conjugated Estrogens Synthetic A (Oral)

Conjugated Estrogens Synthetic A is used to treat symptoms of menopause and low estrogen levels including hot flashes and vaginal dryness.


Conjugated Estrogens Synthetic A is used in the treatment of symptoms of menopause and low estrogen levels.

Most commonly it is used in the treatment of moderate or severe hot flashes and changes to the vaginal area of the patient that are caused by menopause. These include vaginal dryness, vaginal itching and vaginal burning.

This medication is only available when prescribed by a doctor and is prescribed in the form of a Cenestin tablet for oral consumption.

This medication is not for use in children.

This treatment, when used for a prolonged period, will significantly increase the risks of the development of certain forms of cancer. You should discuss this with your doctor before beginning treatment so that you understand the potential risk from use.

Patients should not take any other medications in addition to the use of Conjugated Estrogens Synthetic A unless they have been discussed with and approved by their doctor.

Conditions treated

  • Symptoms of menopause
  • Symptoms of low estrogen levels

Type of medicine

  • Endocrine-Metabolic agent

Side effects

In addition to the desired effects from the use of Conjugated Estrogens Synthetic A, it is also possible that some unwanted side effects can occur in the patient. Some of these side effects may require medical attention, while others may simply abate over time.

If you experience the following side effects from the use of Conjugated Estrogens Synthetic A then you should contact your doctor immediately:

Occurring commonly:

style="font-weight: 400;">Bloating or swelling experienced of the:

  • Arms
  • Face
  • Feet
  • Hands
  • Lower legs
  • Coughing
  • Cramping
  • Difficulty in swallowing
  • 400;">Dizziness
  • Heavy bleeding
  • 400;">Hives, itchiness or a skin rash
  • Increased heartbeat
  • Itchiness of the vaginal or genital region
  • Pain experienced during sexual intercourse
  • Puffy or swollen eyelids, face, lips, or tongue
  • Rapid weight gain
  • Tightness across the chest
  • Tingling experienced in the hands or feet
  • Unusual tiredness
  • Unusual weakness
  • Unusual weight gain
  • Unusual weight loss
  • Usual menstrual bleeding occurring sooner or lasting longer than expected
  • Vaginal discharge with no odor or little odor and a white appearance

Frequency of incidence unknown:

  • Acid stomach
  • Audible breathing
  • Backache
  • Belching or burping
  • Changed vaginal discharge
  • Clear or bloody discharge occurring from the nipple
  • Confusion or disorientation
  • Decreased volume of urine
  • Difficulty in speaking
  • Dimpling of the skin on the breast
  • Double vision
  • 400;">Headaches
  • 400;">Heartburn
  • Inability to speak
  • 400;">Indigestion
  • Inversion of the nipple
  • Loss of hunger
  • Lump developing in the breast or beneath the arm
  • Ongoing crusting or scaling on the nipple
  • Painful pressure felt in the pelvis
  • Slowing of speech
  • Sore patch of skin on the breast that does not heal with time
  • Sour stomach
  • Stomach discomfort or pain
  • Swelling in the arm or leg
  • Swelling of the breasts
  • Swelling of the extremities
  • Swollen abdomen or stomach
  • Troubled breathing when resting
  • Unable to move arms, legs, or facial muscles
  • Unusual or unexpected vaginal bleeding

Other side effects can occur that would not normally require the patient to seek medical attention. Oftentimes these side effects will abate as the body becomes used to the treatment being received. If the following side effects become bothersome or are ongoing then you can contact your doctor to determine how these side effects may be alleviated:

Occurring more commonly

  • Blocked nose
  • Burning or tingling feelings on the skin
  • Excess build up of air or gas within the stomach or intestines
  • Heartburn
  • Increased volume of clear or white vaginal discharge
  • Indigestion
  • Irrational fear or nervousness
  • Lack of strength
  • Loss of control of the bladder
  • Loss of strength
  • Nausea
  • Passing of gas
  • Runny nose
  • Sneezing
  • Vomiting

Occurring less commonly:

Frequency of incidence unknown:

  • Discouragement or lack of confidence
  • Enlarging of the breasts
  • Feeling of sadness or emptiness
  • Irritability or quickness to annoyance
  • Lack of hunger
  • Loss of usual pleasure or interest
  • Sleepiness
  • Swelling, pain or tenderness of the breast
  • Thinning or loss of the hair
  • Tiredness
  • Trouble with concentrating
  • Trouble with sleeping
  • Unusual drowsiness

Side effects that have not been listed herein may also occur. You should inform your doctor if you experience any other side effects that have not been listed. If you are worried about your immediate health, however, then you should seek emergency medical attention.


This medication must be used as directed by your doctor. You should never use more of it, use it more often, nor use it for longer than ordered by your doctor. Using too much of this treatment can result in unwanted side effects and increased severity of those side effects.

This medication will always be provided with a patient information booklet. Patients should read and familiarize themselves with this before beginning treatment. Discuss any questions that you have after reading with your doctor before use.

Tablets should be taken whole and should not ever be broken before swallowing. Do not chew, dissolve or break them in any way and do not take damaged tablets.

This medication will be prescribed in different doses for each patient. You should not change your dose unless directed to by a doctor. The following information is a guideline only and you should not make changes to your dosing based upon this.

To treat moderate to severe hot flashes and menopause symptoms:

Adults: 0.45mg daily. Dose can be adjusted by the doctor as required.
Children: Use would not be recommended for children.

To treat atrophic vaginitis that has been caused by menopause:

Adults: 0.3mg daily. Dose can be adjusted by the doctor as required.
Children: Use would not be recommended for children.

If you miss a dose of this medication then you should take it as soon as possible. If you are close to your next dose being due, however, then you should skip this dose entirely and return to your usual schedule. Never take a double dose of this treatment.


Medications can interact with one another so it is vitally important that you inform your doctor of all medications that you take before beginning treatment with this medication. In some cases medications can prevent one another from working and in other cases it is possible that medications will react aggressively to one another causing serious side effects in the patient. You should inform your prescribing healthcare professional of all medications that you are taking including: medications available for purchase over the counter, herbal remedy treatments, prescription medications and vitamin tablets.

Other medical conditions from which you suffer can also affect your ability to use this treatment. It is possible that the medication for one condition may worsen other problems from which you might suffer. It is very important that you inform your doctor of your full medical history including all present and past conditions. This is especially important if you suffer from any of the following conditions:

  • Do not use in patients suffering from the following:
  • Abnormal vaginal bleeding
  • Blood clots or a history of blood clots
  • History of breast cancer
  • History of heart attacks
  • 400;">Liver disease
  • Blood clotting disorders
  • History of stroke
  • Surgery that has left the patient inactive for a long period
  • Tumors that are estrogen dependent

The following conditions may be worsened by the use of Conjugated Estrogens Synthetic A. Caution should be exercised in relation to patients with the following conditions:

  • 400;">Asthma
  • History of cancer
  • Diabetes
  • 400;">Edema
  • 400;">Endometriosis
  • 400;">Epilepsy
  • 400;">Gallbladder disease
  • Hereditary angioedema
  • Hypercalcemia
  • 400;">Hypertension
  • Hypertriglycerdemia
  • Hypoglycemia
  • 400;">Hyperthyroidism
  • History of jaundice caused by pregnancy or hormone therapy
  • Tumor of the liver
  • 400;">Migraine headaches
  • 400;">Porphyria
  • Systemic lupus erythematosus

Other medical conditions may affect the use of this treatment. Inform your doctor of all conditions you have suffered from, past and present.


Before using any medication you should consider the positives of doing so in relation to the risks that it may expose you to. For Conjugated Estrogens Synthetic A you should consider this with your doctor and ensure that you have taken all of the following into account:

Allergies: Allergies to medications, dyes, foods, preservatives, animals and other substances can put you at risk when using medications. Inform your doctor of all allergies that you have.

Pediatric: Do not use on children and always keep out of reach of children.

Geriatric: There are no known additional risks to use of this treatment in elderly patients. Be cautious of the increased risk of the presence of other medical conditions that can limits use. These include an increased risk of breast cancer, dementia, heart attack, liver disease and stroke, which will require additional caution to be taken.

You will need to visit your doctor regularly for check ups when using this medication. Your doctor may need to carry out regular pelvic exams and mammograms to ensure there are no unwanted side effects from use. You should ensure that you keep all appointments with your doctor.

While it is unlikely that postmenopausal women will become pregnant, it is important to understand that this treatment will put an unborn baby at risk. If you believe you have become pregnant during use of this treatment then you should inform your doctor immediately.

Use of this medication for a long period of time will expose you to an increased risk of numerous types of cancer. You should discuss this with your doctor before beginning use.

This medication can increase the risk of the onset of dementia, particularly in women over the age of 65.

Use of this treatment will increase the risk of blood clots, which can lead to serious medical conditions including stroke and heart attack. If you have high blood pressure, high levels of cholesterol or are a smoker then this risk will be increased even further. If you experience any of the following symptoms then you should seek emergency medical care:

  • 400;">Chest pain
  • Confusion or disorientation
  • Difficulty in speaking
  • Double vision
  • Headaches
  • Inability to move arms, legs or muscles in the face.
  • Inability to speak

Inform any doctors or dentists that you are receiving treatment from that you are taking this medication. The use of this treatment will change the results of medical tests that they may need to carry out and can prohibit certain procedures too.

Grapefruit and grapefruit juice consumption may alter the volume of this medication that is absorbed into the body. You should avoid these foods whilst undergoing this treatment.

Do not take any other medications in addition to Conjugated Estrogens Synthetic A without first discussing them with your doctor. This includes over the counter treatments, herbal remedies and vitamin supplements, which can all affect the use of this treatment.


This medication should be stored in its original packaging until ready for use. Keep the medication at room temperature away from heat, light and moisture and prevent from freezing at all times.

All medication should be stored well out of reach of children at all times.

Outdated medication should be disposed of properly as your doctor directs you to.


Conjugated Estrogens Synthetic A is used to treat some of the symptoms that can be experienced during menopause or a low level of estrogen in the body. These symptoms treated can include hot flashes and vaginal irritation.

This medication is administered only in a tablet form when prescribed by the doctor. These tablets need to be taken whole and should not be broken, crushed or otherwise damaged before swallowing.

The use of this medication can increase the risk of serious medical conditions in patients and prolonged use will increase these risks further. Patients will be exposed to increased risks of cancers, stroke and heart attack and patients should seriously consider these risks in relation to the benefits of use before beginning this treatment.

This medication can interact with a range of medications and existing medical conditions from which the patient may suffer. To avoid increased risk of exposure it is vital that the patient informs their doctor of all treatments they are taking and of all medical conditions from which they have suffered in the past or are currently suffering. This is particularly important with the medical conditions listed herein.

The absorption of this medication can be affected by the consumption of grapefruit or grapefruit juice. Patients should avoid the consumption of this foodstuff during treatment with this medication.

The medication should be stored in the original packaging well out of reach of children until use.

While pregnancy is unlikely in postmenopausal women, it is important to note that this treatment will put an unborn child at risk. If you believe you have become pregnant during use then you should contact your doctor immediately.