Corticorelin Ovine Triflutate (Intravenous)

Corticorelin Ovine Triflutate is an injectable form of medication that is often utilized as part of a test that identifies Cushing syndrome.


Corticorelin Ovine Triflutate is a form of injection for testing purposes. It is part of a series of tests that help to identify Cushing syndrome in patients.

This medicine's purpose means that it is only given by, or used under the supervision of, a doctor. It is used to examine the level of cortisol within the blood, and as such can also be used by a doctor to determine why your body is producing too much of its own cortisol.

This medicine is available only through a medical professional and is injected within the same environment, as it is part of a time-sensitive test used in a controlled environment and involves multiple blood draws.

Conditions Treated

Corticorelin Ovine Triflutate is not used for the treatment of any types of blood, but is used for the informed diagnosis of the following:

Type of Medicine

  • Injectable
  • Powder for Solution

Side Effects

Along with the required diagnostic effects of this medication, this drug can also cause some additional unwanted side effects as a result of its use. Although some, or none, of these side effects, can occur, it is critical to have an informed understanding of any and all side effects that may result from Corticorelin Ovine Triflutate.

It is essential to speak with a medical professional or emergency medical services urgently if any of the listed side effects occur while taking this medication:

  • style="font-weight: 400;">Difficult/labored breathing
  • Feelings of warmth
  • 400;">Hives or welts, itching, and/or skin rash
  • Large, hive-like swellings on or around the face, eyes, lips, mouth, hands, legs, feet, or sexual organs
  • Redness on or around the face, neck, arms, or upper chest
  • Redness on the skin
  • Tightness in the chest

Corticorelin Ovine Triflutate can also cause an overdose. If the patient is experiencing any of the below symptoms, then they may have received an overdose. It is critical to request emergency medical support immediately if any of these symptoms are present:

  • Difficult and/or labored breathing
  • Severe redness on the face
  • Pain in chest

If any of the symptoms listed have occurred, or if you are concerned about any of the side effects that you have experienced that are not listed above, it is essential to discuss your concerns with your doctor. If you experience any painful or uncomfortable symptoms, contact your doctor as soon as possible to seek advice.


When testing for Cushing syndrome, the standard dosage is a single injected dose of 1 mcg/kg over 30 seconds. This is the case for all patients undergoing this test, regardless of age.

This is usually the maximum dose recommended for this medication, in order for the doctor diagnosing this syndrome to accurately differentiate pituitary and ectopic production of ACTH in the body.

In combination with multiple blood draws, this medication is used as a test of the level of cortisol in the blood under specific circumstances in order to diagnose Cushing syndrome.


Although certain medications shouldn't be used together, in some cases two different drugs that are otherwise incompatible may be used together if the positives outweigh the risks.

It is essential the patient discusses all of their medication with their doctor, as they may wish to change the dosage or offer other precautions. When taking this medication, it is especially crucial that your doctor or medical professional is aware if you are prescribed or have taken any of the medicines listed below or have taken them recently.

If you do not inform your doctor of all your current medications, including but not limited to herbal supplements, vitamins, and vaccinations, as well as over-the-counter drugs, there is a higher possibility that interactions will occur, as this medication may otherwise not have been prescribed.

Using Corticorelin Ovine Triflutate with any of the below drugs is more likely to result in various adverse interactions and conditions, and, as such, it is highly recommended you talk to your doctor prior to taking this medication for diagnostic purposes, as side effects of taking these medications together could cause serious complications:

  • Adalimumab
  • Bupropion
  • Certolizumab
  • Desirudin
  • Etanercept
  • Fingolimod
  • Golimumab
  • Golimumab
  • Infliximab
  • Mifepristone
  • Natalizumab
  • 400;">Smallpox vaccine
  • Teriflunomide
  • Tofacitinib

Interactions with Food/Tobacco/Alcohol

Certain medications should not be used at/around the same time of eating food, as certain types of food can cause interactions to happen. Also, using alcohol or tobacco with certain drugs can cause interactions to occur.

Other Medical Problems

The presence of pre-existing or historically occurring medical problems may affect the use of Corticorelin Ovine Triflutate and the effectiveness of the medication. Ensure that you inform your doctor if any of the following medical conditions apply to you, especially:

  • Adrenal Insufficiency
  • 400;">Cirrhosis
  • 400;">Depression/Psychoses
  • Diabetes
  • Electrolyte Imbalance
  • Elevated IOP
  • Fluid Retention
  • Gi Perforation
  • Hyperadrenocorticism
  • 400;">Hypothyroidism
  • Infections
  • 400;">Myasthenia Gravis
  • Myopathy
  • Ocular Herpes Simplex
  • 400;">Osteoporosis
  • Pud
  • 400;">Scleroderma
  • Thromboembolism


It is important to know that diagnostic testing using this medication may take an hour or more to complete. As part of diagnostics, Corticorelin Ovine Triflutate is given as a single injection for a Corticorelin test. After this initial injection, your blood will be drawn at least five times in order to compile an accurate and reliable baseline.

In the majority of cases, the blood is tested 15 minutes before and then right before you receive the injection to get the best overview of differences in the blood. After this, your blood will be drawn at 30 minutes and 60 minutes, in order to get a better overview of your condition.

The timing of these blood tests before and after the injection is vital in assuring the most accurate results from a Corticorelin test. If you have a fear of needles or feel unable to take part in this diagnosis process, talk to your doctor beforehand for alternatives or coping methods to use.

This medication is listed as FDA pregnancy category C. This means it is unknown whether Corticorelin Ovine Triflutate can cause harm to an unborn baby. As such, it's important to discuss in detail with your doctor the risks and benefits of this diagnostic test during pregnancy. If you are planning to fall pregnant or fall pregnant before taking this medication as part of a diagnostic test, it's important to inform a medical professional so all the correct precautions can be taken.

It is not known if Corticorelin Ovine Triflutate can pass into breast milk, nor is it known if it could harm a nursing baby. If you are currently breastfeeding, it is important to discuss this with your doctor prior to undergoing diagnostic testing.

For this medication, appropriate studies performed to date have not demonstrated geriatric or pediatric-specific problems that could limit the usefulness of Corticorelin Ovine Triflutate.

This suggests it could also be an effective and consistent tool for diagnostic treatment in both parties without additional adverse symptoms or issues. It is key that the patient, or caregiver of the patient, is fully informed of this diagnostic test before it taking place, along with all the potential risks and interactions.

This medication may prompt an allergic reaction, and also can interact with a variety of different medications that the patient may already be taking to cause a reaction. It is important that all parties involved in diagnostics, including all medical professionals, are informed prior to the patient undergoing treatment with this form of medication, to avoid any issues of allergic reactions.

If any of the following symptoms occur, or any other signs of allergic reaction that the patient has previously experienced, it is important to contact emergency medical support as soon as possible:

  • Hives
  • Problems with breathing
  • Swelling


As this medication is used in a medical, controlled environment, there is no requirement for Corticorelin Ovine Triflutate to be stored at home.

When stored in a controlled facility, this medication should be protected from light. The sachet form of this medication should be kept in a dry, non-humid environment to avoid contamination.

The reconstituted unused product should be stored in a refrigerator at between 2C-8C (36-46F) and used within eight hours of constituting. The unreconstituted product should also be stored in a refrigerated environment.


Corticorelin Ovine Triflutate is an injected medication that is used for specific testing purposes, as part of a series of tests that can help in the identification of Cushing syndrome.

The purpose of this medication means that it is only used in highly controlled environments, as multiple blood draws are required during diagnosis. As such, Corticorelin Ovine Triflutate is just given by or used under the supervision of a doctor.

This medication and diagnostic tests are used to examine an increased level of cortisol in the blood, and as such can also be used by a doctor to monitor why your body is producing too much cortisol for multiple conditions.