Cyclandelate (Oral)

As a vasodilator, Cyclandelate helps to relax veins and arteries, making it useful for the treatment of claudication, arteriosclerosis, Raynaud's and night-time leg cramps.


Cyclandelate is orally administered and helps to relax and increase the size of blood vessels and veins, allowing blood to circulate more easily. It is an effective treatment for arteriosclerosis, claudication, Raynaud's disease and leg cramps, and belongs to a group of medications known as vasodilators.

As a direct-acting muscle relaxing vasodilator, Cyclandelate is particularly effective and a popular choice among physicians around the world to treat various circulation issues, or as a preparative medicine for surgery. It can also be used to treat painful muscle spasms.

This prescription-only medicine was marketed by Wyeth-Ayerst until 1997. It may be used off-label for purposes it has not been approved for, at the discretion of a prescribing doctor. It is not currently commercially available in the United States.

Type of medicine

  • Vasodilator

Conditions treated

  • style="font-weight: 400;">Claudication
  • Raynaud's disease
  • Arteriosclerosis
  • Leg cramps

Side effects

Along with the desired effects, Cyclandelate can also cause some unwanted side effects. The most common symptoms reported by patients undergoing treatment with this medicine include the following: heartburn, belching, dizziness, flushing of the face, headache, tingling sensation, sweating, unusual tiredness or weakness.

Most patients only experience minimal side effects (if any at all) while using Cyclandelate. Many physicians agree that the benefits of alleviating the symptoms caused by constricted veins and arteries far outweigh the risk of the possibility of experiencing mild discomfort due to side effects. As the patient continues to take this medication as prescribed by a doctor or qualified healthcare professional, the side effects mentioned above should lessen.

If side effects continue over a prolonged period or appear to get worse, the patient is advised to raise the issue with their doctor as soon as possible. In many cases, a healthcare provider will be able to recommend ways to alleviate discomfort caused by certain side effects via natural or over the counter treatments.

Because this medication can potentially cause dizziness and/or headaches, patients are advised to refrain from driving or operating heavy machinery until it has been observed that these side effects do not impede on their motor skills, reaction times or vision. This is because the patient could potentially put themselves or other road users at unnecessary risk if affected by Cyclandelate.

Some side effects of Cyclandelate may not have been reported. Patients who experience side effects which are not listed are advised to contact their healthcare provider and to also relay their findings to the FDA.


As with all medicines, it is incredibly important to only take Cyclandelate as advised by a qualified physician. This means that patients must avoid taking any more of this drug than prescribed by a doctor, both in terms of frequency and dosage amount. The instructions printed on the side of the packaging the drug is shipped in may also be followed, provided they contain the patient's prescription information.

Doses may vary from patient to patient based on a number of deciding factors, including the weight, height, age and condition of the patient. Although the manufacturer provides dosage recommendations, it should be reiterated that these are merely guidelines the individual advice of the patient's doctor should always take precedence over generic instructions on how to take Cyclandelate, as factors unique to the patient will affect the way in which this medicine should be taken.

The tablet should be swallowed whole. Patients are advised against crushing or grinding tablets or dissolving them in water.

For the treatment of poor circulation, adults are advised to initially take between 1.2g to 1.6g of Cyclandelate per day. Cyclandelate should be taken with a meal and before bedtime. As the patient responds to treatment with the medication, the patient's doctor will gradually lower the dose to between 400mg to 800mg per, divided into two to four doses per day.

There are no official dosage guidelines for the treatment of children with this medicine. Children who require therapy with Cyclandelate should rely on the judgement of their doctor, who will determine the optimum dose on a patient-by-patient individual basis. The manufacturer leaves pediatric dose adjustments to the discretion of the prescribing physician.

Patients are advised against taking more of this medication than advised. If the patient misses a dose, he or she should take the following dose as soon as possible, unless it is nearer the next dose administration time. If it is nearer to the time for the next dose, the patient should skip the missed dose, take the next dose at the usual time and continue with the dosing schedule as normal.

Taking double doses could potentially result in overdose. If a patient suspects they may have overdosed or are experiencing symptoms of overdose (difficulty breathing, slow or fast heartbeat, loss of consciousness, seizures and lack of coordination) they (or their caregiver) are advised to contact their local poison control center on 1800-222-1222 or the emergency services on 911. Alternatively, patients can make their way to the local Emergency Room (ER) if it is in close enough proximity.


All drugs have the potential to interact with other chemicals and medications with the human body, changing the effects of each medicine. In some instances, these interactions can make one or more medications ineffective in treating the condition they were prescribed to alleviate. In others, interactions can cause serious and potentially fatal side effects. Because of this, patients are advised to keep a fully detailed list of all medicines they are currently taking and this extends to vitamins, herbal supplements, over the counter remedies and complementary medicines as well as prescribed medications.

Below is a partial list of drugs known to interact negatively with Cyclandelate. Patients who are already receiving treatment with one or more of these medicines are advised to inform their doctor prior to beginning therapy with Cyclandelate:

  • amifostine
  • amitriptyline/perphenazine
  • amyl nitrite/sodium nitrite/sodium thiosulfate
  • apomorphine
  • apraclonidine ophthalmic
  • aripiprazole
  • asenapine
  • avanafil
  • brexpiprazole
  • brimonidine ophthalmic
  • brimonidine topical
  • brimonidine/brinzolamide ophthalmic
  • brimonidine/timolol ophthalmic
  • canagliflozin
  • canagliflozin/metformin
  • cariprazine
  • chlorpromazine
  • clozapine
  • codeine/phenylephrine/promethazine
  • empagliflozin/metformin
  • epoprostenol
  • fluoxetine/olanzapine
  • fluphenazine
  • furazolidone
  • garlic
  • haloperidol
  • iloperidone
  • iloprost
  • maraviroc
  • meperidine/promethazine
  • nefazodone
  • olanzapine
  • paliperidone
  • pentoxifylline
  • perphenazine
  • phenelzine
  • phenylephrine/promethazine
  • procarbazine
  • quetiapine
  • rasagiline
  • riociguat
  • risperidone
  • safinamide
  • selegiline
  • selexipag
  • sildenafil
  • sodium nitrite
  • sodium nitrite/sodium thiosulfate
  • tadalafil
  • thiethylperazine
  • thioridazine
  • thiothixene
  • tizanidine
  • tranylcypromine
  • treprostinil
  • trifluoperazine
  • triflupromazine
  • vardenafil
  • ziprasidone


Patients who have ever had any unusual allergic reactions to medicines or foods, preservatives or dyes are advised to inform their healthcare provider prior to beginning treatment with Cyclandelate. This is because this medication could contain inactive ingredients which can potentially cause allergic reactions.

Studies on the effects of this medication have only been undertaken in adult patients, and there is no documented evidence on how this drug will affect children or the elderly. This does not mean Cyclandelate is expected to cause any different side effects in pediatric or geriatric patients, although dose adjustments may be required in some cases.

There are no adequate studies to determine whether there is a risk for breastfeeding women to contaminate infants through breast milk. However, because the possibility for this medicine to be excreted in human breast milk exists, breastfeeding patients are advised to exercise caution and to consider stopping breastfeeding for the duration they spend on Cyclandelate.

Taking this medication could result in decreased blood supply to the heart. It is therefore recommended that patients are monitored (in a clinical setting where possible) when initially starting treatment with this medicine.


Cyclandelate should be stored in the packaging it was shipped in, at room temperature and away from light and/or moisture. It is therefore unsuitable for storage in a bathroom, and should be kept out of reach of children and pets in a dedicated medicine cabinet where possible.

If the patient needs to dispose of unwanted, unused or expired Cyclandelate, they should do so in a safe manner, in accordance with state law. Most pharmacies offer medication œtake back schemes where they will dispose of or recycle returned drugs, often free of charge.


While Cyclandelate is a beneficial treatment for alleviating symptoms of Raynaud's disease and leg cramps, it is not without its risks. Patients are advised to communicate fully with their physicians before undergoing treatment with this medicine, in order to eliminate any risk factors such as interactions or unsuitability.

When used correctly, Cyclandelate is incredibly effective at treating painful leg cramps and dilation of the veins, allowing patients to walk easier and enjoy a greater quality of life. To get the most out of this medication, patient and doctor are advised to work together to determine the optimum dosage and frequency timetables.