Dalbavancin (Intravenous)

Dalbavancin is given intravenously in a hospital room or other clinical setting. It is also known as Dalvance.


Dalbavancin is an antibiotic used to treat acute bacterial skin and skin structure infections or ABSSSI, such as methicillin-resistant Staphylococcus aureus or MRSA and other bacterial infections. Dalbavancin works by preventing the growth of bacteria and killing bacteria in the body. It does not work for viral infections such as cold or flu.

Conditions Treated

  • style="font-weight: 400;">Acute bacterial skin and skin structure infections
  • Methicillin-resistant strains of Staphylococcus aureus
  • MRSA
  • Methicillin-resistant strains of Streptococcus pyogenes
  • Methicillin-resistant strains of Streptococcus agalactiae
  • Methicillin-resistant strains of Streptococcus anginosus
  • Methicillin-resistant strains of Streptococcus intermedius
  • Methicillin-resistant strains of Streptococcus constellatus

Type of Medicine

  • Antibiotic
  • Lipoglycopeptide antibiotic

Side Effects

Mild Side Effects

In addition to its therapeutic effects, Dalbavancin can cause unwanted side effects. Some of these side effects are just a result of your body adjusting to the medication, and do not necessarily need medical attention. These side effects should subside over the course of your treatment. Your health care professional can suggest some ways to deal with these side effects.

Some patients taking Dalbavancin may experience gastrointestinal side effects such as:

  • 400;">Diarrhea
  • Increased hunger

Some patients taking Dalbavancin may experience side effects such as:

  • Cold sweats
  • Cool, pale skin
  • Blurred vision

Some patients taking Dalbavancin may experience neurological side effects such as:

  • Anxiety
  • 400;">Depression
  • Confusion
  • Shakiness
  • Nightmares
  • Slurred speech
  • Seizures
  • 400;">Coma

If these side effects become bothersome, get worse, or do not subside, let your doctor know.

Serious Side Effects

Some patients taking Dalbavancin may experience more serious side effects. These side effects need medical attention, and can be signs of a health problem that may have been triggered or exacerbated by the Dalbavancin. If you experience any of these side effects while taking Dalbavancin, contact your doctor immediately or seek medical treatment.

Some patients may experience gastrointestinal side effects such as:

  • Tenderness or pain in the stomach or abdomen
  • Severe pain or cramps in the stomach or abdomen
  • Decreased appetite or loss of appetite
  • Diarrhea that is watery, severe, or bloody
  • Vomiting blood, or vomiting black and tarry material that may resemble coffee grounds

Some patients may experience side effects in elimination, such as:

  • Clay-colored stools
  • Black and tarry stools
  • Blood in the stools
  • Blood in the urine
  • Unusually dark urine
  • Urination that is painful or difficults

Some patients may experience respiratory side effects such as:

  • A cough
  • Difficulty swallowing
  • A sore throat
  • Tightness in the chest
  • Trouble breathing while exerting or exercising
  • 400;">Chest pain

Some patients may experience dermal side effects such as:

  • Yellow eyes or skin
  • Redness of the skin
  • Pale skin
  • 400;">Hives, welts, or pinpoint red spots on the skin
  • Itching or an unusual rash
  • Redness of the face, neck, upper chest, or arms
  • Puffiness around the eyes, face, lips, or tongue, or swelling of the eyelids
  • Swelling in the lower legs and feet

Some patients may experience side effects such as:

  • 400;">Fever
  • Chills
  • A feeling of warmth
  • 400;">Dizziness
  • 400;">Headaches
  • 400;">Back pain
  • Fast heartbeat
  • Unusual tiredness or weakness
  • Unusual bleeding or bruising
  • Swollen glands
  • A sore mouth or tongue
  • Sores, white spots, or ulcers in the mouth or on the lips
  • Bleeding gums


Dalbavancin is administered via intravenous solution. It is normally given in a hospital or other clinical setting by a trained healthcare professional. The medicine will be injected into your vein over a period of 30 minutes.

The dosage here is a standard given by the manufacturers. Your dose and the scheduling of your dose will be determined by your prescribing physician, depending on your condition and needs.

Dalbavancin is normally given as a single dose at 1500 mg, or in two doses at 1000 mg followed by 500 mg one week later. Adjustments may be required for patients with renal impairment.

Dalbavancin must be given for the full time of treatment, even if your symptoms start to subside after a few days. Dalbavancin works better with a constant amount in the bloodstream, so it should be given on a regular schedule. If you miss your scheduled dose of Dalbavancin, contact your doctor as soon as possible.


Drug interactions may increase your risk of side effects or alter how your medications work. Keep a list of the medications and supplements you take on a regular basis, whether they have been prescribed to you by a healthcare professional or taken over the counter. Your doctor, pharmacist, or other healthcare professional can identify any potential interactions with Dalbavancin.

Dalbavancin may reduce the effectiveness of hormonal birth control such as a patch, pills, or a ring. This may result in pregnancy, breakthrough bleeding, or other health issues. If you use hormonal birth control or are unsure about the method of your birth control, ask your doctor or pharmacist for more details.


Regular Check-Ups

While you are taking Dalbavancin, you will need to keep regular appointments and check-ups with your doctor. Your doctor will need to take blood tests to monitor for unwanted side effects, and will need to perform check-ups to ensure that the medication is continuing to work properly. This will allow your doctor to determine whether you should keep taking Dalbavancin.

Hypersensitive Reactions

Some patients may experience serious allergic reactions to Dalbavancin. Symptoms of allergic reactions include skin problems such as red or flushed skin, itchy skin, or a rash. You may also experience an anaphylactic reaction, which is life-threatening and requires immediate medical attention. Anaphylactic reactions include symptoms such as itching, hives, a skin rash, trouble breathing, trouble swallowing, swelling in your hands or face, a fever or chills, or a feeling of warmth or redness in your upper body. These symptoms will appear while you are taking the medication. Tell your doctor or other attending physician if you experience any of these symptoms while receiving Dalbavancin.

Before taking Dalbavancin, let your doctor know if you have an allergy to this medication or to any other medications. Dalbavancin may contain inactive ingredients which can cause allergic reactions in some patients.

Infusion-Related Reactions

Dalbavancin is administered slowly to minimize the risk of an infusion-related reaction, but some patients may still experience infusion-related reactions. These reactions are life-threatening and require immediate medical treatment. Symptoms of an infusion-related reaction include a cough, difficulty with swallowing, trouble breathing or labored breathing, a fast heartbeat, dizziness, swelling in your face or hands, fever or chills, hives, or itching, or a feeling of warmth or redness on your upper body while you are receiving Dalbavancin. If you experience any of these symptoms while receiving the infusion, inform your doctor or attending health care professional immediately.

Liver Problems

Dalbavancin can cause serious liver problems in some patients. Regular blood checks can help your doctor screen for early symptoms such as post-baseline alanine aminotransferase elevation over 3 times the upper normal limit or other abnormalities in liver tests. Symptoms of a liver problem that may be caused by Dalbavancin include pain or tenderness in the upper stomach, a loss of appetite, nausea, vomiting, pale stools, dark urine, or yellow skin or eyes i.e. jaundice. If you experience any of these symptoms during a treatment regimen of Dalbavancin, contact your doctor immediately. You may need to stop taking Dalbavancin if this occurs.


Dalbavancin may cause severe diarrhea in some patients, which may occur up to 2 months or more after you stop receiving Dalbavancin. If you experience diarrhea that is severe or chronic, particularly watery, or has blood in the stool, contact your doctor immediately. Do not take any medicine to treat your diarrhea until you check with your doctor to ensure it is safe for you. If you experience mild diarrhea that gets worse, check with your doctor as soon as possible.

Dalbavancin and other systemic antibacterial drugs may cause diarrhea associated with the bacteria Clostridium difficile. This is because antibacterial drugs can alter the normal gut flora that live in the colon, making the environment a hospitable environment for Clostridium difficile. The severity of this infection can range from a mild case of diarrhea to colitis that may prove fatal. This infection can occur over two months after Dalbavancin has been discontinued. Strains of this bacteria can produce hypertoxins, which can cause increased mortality or morbidity i.e. death. Patients who experience diarrhea during or after use of Dalbavancin should be monitored closely.

Kidney Disease

Before you start using Dalbavancin, tell your doctor or pharmacist if you have any kidney disease in your medical history.


Dalbavancin may cause some live bacterial vaccines, such as the typhoid vaccine, to not work as well. Check with your doctor before you get any vaccinations or immunizations while taking Dalbavancin.


Dalbavancin may cause delayed fetal maturation if taken by a patient who is pregnant. Dalbavancin should not be used by patients who are pregnant or who may become pregnant unless the benefits of Dalbavancin outweigh risks to the fetus. If you are pregnant or suspect you may be pregnant, tell your doctor before you start a regimen of Dalbavancin. Tell your doctor as soon as possible if you think you may be pregnant or if you become pregnant while you are taking Dalbavancin.


Dalbavancin is supplied in clear glass vials which contain sterile Dalbavancin powder equivalent to 500 mg, and should be rehydrated by a lab technician. The unreconstituted Dalbavancin should be stored at room temperature at roughly 77°F, no colder than 59°F and no warmer than 86°F.


Dalbavancin is an intravenous antibiotic used to treat acute bacterial skin and skin structure infections such as MRSA. It prevents the growth of bacteria and kills bacteria within the body, and does not work for viral infections such as flu or colds. Dalbavancin is given as an intravenous injection over a 30-minute period in a hospital room or other clinical setting.

Dalbavancin can produce mild side effects in some patients such as diarrhea, increased hunger, cold sweats or pale skin, blurred vision, anxiety, depression, confusion, shakiness, slurred speech, seizures, nightmares, or a coma. This is a result of your body adjusting to the medication. Tell your doctor if these symptoms are bothersome.
Dalbavancin can cause Clostridium difficile infections in some patients, which can cause watery, bloody, or severe diarrhea up to two months or more after the medication has been discontinued. Tell your doctor if you experience these symptoms.

Dalbavancin may cause liver problems in some patients. Symptoms of liver problems include clay colored stools, black and tarry stools, blood in the stools or urine, unusually dark urine or difficult or painful urination, or yellow eyes or skin. Seek medical attention immediately if you experience these symptoms.

Dalbavancin can induce allergic reactions in some patients. If you experience a rash, swelling in the face or lower legs, tightness in the chest or trouble breathing, fever or chills, a feeling of warmth or a red and flushed chest, dizziness, headaches or back pain, or itching, seek medical attention immediately.