Danaparoid (Injection, Subcutaneous)

Danaparoid is used in the prevention of a condition called deep vein thrombosis, a potentially life-threatening condition.

Overview

Danaparoid is a drug that is used to prevent a condition called deep vein thrombosis (DVT). Deep vein thrombosis is a condition where blood clots develop in the veins of the legs, from where they can easily move to the heart, brain or lungs, blocking the veins and causing an embolism. Embolisms cut off the blood supply to the affected organ, often proving fatal.

Danaparoid is typically used to treat patients in the immediate few days following certain types of surgery, where the person is immobile and confined to a bed or wheelchair. This period is the most dangerous, as it is this lack of activity that provides the ideal environment for blood clots to form. This medication may also be a treatment option for other medical conditions if considered appropriate by your GP.

This medication cannot cure a deep vein thrombosis or an embolism that has already formed; it is purely used for preventative purposes. In the event that a clot forms in the patient's vein, other medication will be used to disperse it.

Danaparoid is administered via subcutaneous injection (under the patient's skin).

In the US, danaparoid is sold under the brand name Orgaran. You cannot buy danaparoid over the counter; it can only be obtained on prescription from a medical professional.

Conditions treated

  • prevention of deep vein thrombosis

Type of medicine

  • anti-clotting agent

Side effects

Together with the beneficial effects it is designed to have, danaparoid can cause unwanted side effects. Not everyone notices all these effects, but if you are affected, you may need to seek further medical treatment.

If you experience any of the effects in the list below, you should discontinue the medication immediately and summon emergency medical help.

  • weakness
  • vomiting of coffee ground-like material or blood
  • vaginal bleeding or increased menstrual flow
  • unusual bruising
  • unexplained pain, discomfort, or swelling, especially in the abdomen, chest, joints, or muscles
  • tingling, burning, tickling, or pricking sensation
  • skin rash
  • shortness of breath
  • red or dark brown urine
  • prolonged bleeding from cuts
  • problems with breathing or swallowing
  • problems with bladder or bowel function
  • paralysis
  • numbness
  • nosebleeds
  • leg weakness
  • headaches
  • fever
  • dizziness
  • coughing up blood
  • bleeding gums
  • black or red, tarry stools
  • back pain

You may notice some side effects that do not generally require any further medical assistance. These effects usually resolve themselves once your body had adjusted to the drug. Your GP may also suggest ways in which you can prevent or combat some of these effects. However, if any of the side effects prove to be especially problematic or if you have any questions about your treatment, have a chat with your GP or specialist.

Common side effects of danaparoid that usually resolve by themselves include pain at the injection site, nausea, and constipation.

If you experience any side effects that are not mentioned here, ask your treating physician for advice.

Dosage

Danaparoid is administered via an injection under your skin. If you have been told to use this drug at home, your treating physician will show you how to carry out the injections on yourself. Follow the instructions that you are given, and ask your health care professional for help if you are not confident in giving the injections.

Note that any used syringes should be placed in the sharps bin that you will be provided with. When the bin is full, you should take it to your GP surgery or pharmacist for safe disposal.

The dose of danaparoid that you are prescribed will not be the same for every patient. You should follow the instructions for dosage that are shown on the product label or take the drug as directed by your GP. The dosage information shown below is based on the average for this medication. Do not change the dose if what you have been prescribed is different, unless you are told to do so by your treating physician.

The dose of danaparoid that you are told to take will depend on the potency of the preparation. The health condition for which you are using the drug will determine the number of daily doses that you take, how often you need to take them, and the length of your course of treatment.

For the prevention of deep vein thrombosis and clot formation:

  • Adults: 750 units Xa anti-factor, injected subcutaneously, twice daily for up to two weeks following surgery.
  • Children: Dose and use to be decided by your child's treating physician.

If you forget to use a dose of your prescribed danaparoid, you should try to use it as soon as possible. If it is almost time for your next scheduled dose, omit the one that you have missed and revert to your usual schedule. Do not use twice the dosage amount.

Interactions

There are some medications that should never be used together, as to do so could cause a potentially dangerous interaction. However, it may be possible and appropriate to use two or more different drugs together, even though an interaction might take place. In this case, your treating specialist might elect to alter the dose of one or more of your prescriptions or may advise you on other precautions that you can take to mitigate any interactions that could happen.

During the course of your treatment with this medicine, you must tell your health care professional if you are also taking any of the following drugs. The medicines listed here are those that could cause the most significant interactions and there may be others that are not mentioned.

  • Warfarin
  • Vortioxetine
  • Vorapaxar
  • Vilazodone
  • Venlafaxine
  • Valdecoxib
  • Urokinase
  • Treprostinil
  • Tolmetin
  • Tolfenamic acid
  • Tirofiban
  • Tinzaparin
  • Ticlopidine
  • Tiaprofenic acid
  • Tenoxicam
  • Tenecteplase
  • Tan-Shen
  • Sulindac
  • Sulfinpyrazone
  • Streptokinase
  • St John's wort
  • Sodium salicylate
  • Sertraline
  • Selexipag
  • Salsalate
  • Salicylic acid
  • Rofecoxib
  • Rivaroxaban
  • Reteplase, recombinant
  • Proquazone
  • Propyphenazone
  • Propionic acid
  • Proglumetacin
  • Prasugrel
  • Piroxicam
  • Piracetam
  • Piketoprofen
  • Phenylbutazone
  • Phenprocoumon
  • Phenindione
  • Pentosan polysulfate sodium
  • Paroxetine
  • Parecoxib
  • Papaya
  • Oxyphenbutazone
  • Oxaprozin
  • Orlistat
  • Nintedanib
  • Nimesulide beta cyclodextrin
  • Nimesulide
  • Niflumic acid
  • Nepafenac
  • Naproxen
  • Nadroparin
  • Nabumetone
  • Morniflumate
  • Milnacipran
  • Meloxicam
  • Mefenamic acid
  • Meclofenamate
  • Lumiracoxib
  • Loxoprofen
  • Lornoxicam
  • Levomilnacipran
  • Lepirudin
  • Ketorolac
  • Ketoprofen
  • Indomethacin
  • Iloprost
  • Ibuprofen lysine
  • Ibuprofen
  • Heparin
  • Ginkgo
  • Garlic
  • Fondaparinux
  • Fluvoxamine
  • Flurbiprofen
  • Fluoxetine
  • Flufenamic acid
  • Floctafenine
  • Feprazone
  • Fepradinol
  • Fenoprofen
  • Fenofibric acid
  • Fenofibrate
  • Felbinac
  • Etoricoxib
  • Etofenamate
  • Etodolac
  • Escitalopram
  • Eptifibatide
  • Epoprostenol
  • Enoxaparin
  • Edoxaban
  • Droxicam
  • Drotrecogin alfa
  • Dipyrone
  • Dipyridamole
  • Diflunisal
  • Diclofenac
  • Dexketoprofen
  • Dexibuprofen
  • Desvenlafaxine
  • Defibrotide
  • Dalteparin
  • Dabigatran etexilate
  • Collagenase clostridium histolyticum
  • Clopidogrel
  • Clonixin
  • Citalopram
  • Cilostazol
  • Choline salicylate
  • Chamomile
  • Celecoxib
  • Cangrelor
  • Bufexamac
  • Bromfenac
  • Bivalirudin
  • Bemiparin
  • Aspirin
  • Argatroban
  • Apixaban
  • Anistreplase
  • Anagrelide
  • Amtolmetin guacil
  • Alteplase, recombinant
  • Alipogene tiparvovec
  • Acenocoumarol
  • Acemetacin
  • Aceclofenac
  • Abciximab

The following medicines, when used with danaparoid, can present an increased likelihood of some side effects, although using both drugs together might be the best option in your case. In this case, your GP may decide to alter the dose or frequency of use of one or more of the drugs:

  • Vitamin A
  • Ginger
  • Dong Quai
  • Curcumin
  • Coenzyme Q10
  • Chondroitin

Some food groups, tobacco, or alcohol can also cause interactions or severe side effects when they are eaten or used at the same time as danaparoid. Discuss this aspect of your treatment regimen with your doctor, especially if you have a preference for certain foods, if you smoke, or if you drink alcohol.

Some patients have reported an interaction if they eat avocado at the same time as taking danaparoid.

Warnings

Before using any medication, it is important to discuss the risk and benefits of doing so with a medical professional. You will then be in an informed position to decide whether to proceed with the treatment.

Allergies

If you know of any allergies or bad reactions that you have previously experienced to danaparoid or any other prescription drug, you must tell your GP before your treatment begins. You should also mention allergies that you may have to particular food groups, colorants, preservatives, or animal by-products.

Tell your doctor if you are already taking any non-prescription medicines, vitamins, or herbal remedies.

Pregnancy and breastfeeding

Studies have revealed no risk from danaparoid to the unborn baby. However, you should tell your GP if you think you may be expecting a baby. It may also be sensible to avoid getting pregnant while you are being treated with this drug.

No studies have been carried out to show whether danaparoid can pass into breast milk. However, you should discuss the potential risks of breastfeeding your infant while you are being treated with this drug with your GP or midwife. It may be better to choose an alternative form of nutrition for your child until your course of treatment with danaparoid has finished.

Medical history

Some existing or historical medical conditions can affect how danaparoid works. You must have a full and frank discussion about your medical history with your doctor before starting treatment with this medication.

If you have a history of the following conditions, using danaparoid could present an increased risk of bleeding:

  • stroke
  • kidney disease
  • hypertension
  • heart infection
  • bleeding problems
  • active intestinal or stomach ulcers

You must also tell your doctor if you have ever experienced a low blood platelet count (thrombocytopenia) when previously treated with danaparoid, or if any new blood clots formed during your treatment with this drug.

If you have recently undergone medical surgery, including cosmetic surgery, you must tell your treating physician. The risk of serious bleeding problems may be increased if you are also taking danaparoid.

If you are scheduled for any dental treatment, including surgical procedures or extractions, tell your dentist that you are taking danaparoid.

Any of the following side effects could indicate that you have developed an internal bleeding problem as a result of taking danaparoid. Tell your GP immediately if you notice any of these signs:

  • bleeding or bruising
  • bleeding that is very difficult to stop
  • bloody, black or tarry stools
  • feeling faint
  • pains in your back
  • sensation of pricking, tingling, burning, or tickling
  • numbness or weakness in the legs
  • paralysis
  • problems with bladder or bowel function

Storage

If you are given danaparoid subcutaneous injections for home administration, you must store your medication correctly. Keep the solution in the packaging it came in, in a closed outer container, and at room temperature. Do not place the solution close to a heat source or in a position where it could be affected by direct sunlight.

This drug is not suitable for refrigeration or freezing.

Be sure to store the solution and your supply of needles and syringes in a location that is not accessible to children or pets. If a pet does manage to consume any of your danaparoid, contact your emergency vet immediately.

Do not use any of the solution that appears to contain particulate or is discolored. Do not use any medication that has passed its use-by date or if the packaging appears to have been opened or is damaged.

Place all used syringes in the sharps bin provided. When the bin is full, seal it and return it to your GP clinic or pharmacist, together with any unused medicine.

Summary

Danaparoid is used following certain surgical procedures to prevent a condition called deep vein thrombosis (DVT). DVT causes blood clots to form in the patient's leg veins, from where they can travel to the heart, brain or lungs, potentially causing an embolism. If an embolism occurs, the blood supply to the affected organ is obstructed, often proving fatal.

Danaparoid is administered via subcutaneous injection (under the patient's skin), either in a hospital or by the patient themselves at home.

Patients who have a history of medical conditions where bleeding is a side effect should not use danaparoid, as doing so can make these conditions worse. There is a long list of drugs that should not be used concurrently with danaparoid, as interactions may occur or the side effects that these drugs cause could be made worse. For this reason, it is very important that you discuss your treatment regimen with your doctor and provide a full disclosure of the medical history.