Danazol (Oral)

Danazol is prescribed to treat hereditary angioedema, fibrocystic breast disease and endometriosis.

Overview

Danazol is an effective treatment for endometriosis and other medical conditions. Endometriosis causes endometrial tissue to grow in other areas of the body usually in the pelvis, initiating pain, bleeding, pain during sexual intercourse and can result in infertility. Endometriosis is a gynecologic illness.

This medication is manufactured under the US brand name of Danocrine and can be obtained in capsule form. Danazol requires a prescription by a physician.

This medication assists in reducing inflammation or endometrial tissue swelling in areas other than the uterus. Patients experiencing fibrocystic breast disease (but is noncancerous) may also experience breast tissue to grow into inflamed growths. Danazol steps in during this process and aids by lowering the number of hormones that the ovaries produce which lead the noncancerous growths to develop. Danazol also aids in the reduction of certain signs of hereditary angioedema (wherein the airways, intestinal tract, face, and limbs could potentially turn reddened or swollen). This medication is prescribed for a variety of medical issues.

Conditions treated

  • style="font-weight: 400;">Cysts in the breast (fibrocystic breast disease)
  • Endometriosis
  • Genetic angioedema (swelling of the skin, sexual organs, throat, legs, arms, stomach, or abdomen)

Type of medicine

  • Hormones

Side effects

Medications can occasionally prompt undesired side effects along with the necessary benefits of the drug. Medical attention may be required if these side effects take place, however not every one of the following side effects will take place. Consult your physician right away if you experience one or more of the subsequent side effects:

Less Common Side Effects (Male and Female) Medical Care Required

  • Weight gain (sudden and rapid)
  • Weakness or tiredness (unusual)
  • Urine appearing darker than usual
  • Swelling of lower legs or feet
  • Oiliness of skin or hair (increased)
  • Muscle spasms or cramps
  • 400;">Acne

Rare Side Effects (Male and Female) Medical Care Required

  • Gums bleeding
  • Stomach or abdomen tenderness, pain, or bloating
  • Blood within urine
  • 400;">Chest pain
  • Vision changes
  • Chills
  • Cough
  • Blood coughing
  • 400;">Diarrhea
  • Speaking difficulty
  • Swallowing difficulty
  • Nipple discharge
  • Eye pain
  • 400;">Fever
  • Heartbeat quickened
  • 400;">Headache
  • Pain, numbness, tingling, or burning in each finger other than your pinkie (smallest) finger
  • Weakness or numbness on half of the body (partial or complete)
  • 400;">Skin rash or hives (or other types of skin rash)
  • Joint pain
  • Stool discolouration (light in colour)
  • Appetite loss (prolonged)
  • Muscle coordination loss
  • Nosebleeds occurring frequently (more than normal)
  • Muscle aches
  • Nausea
  • Spots inside the nose, mouth, or on your body (red or purple in colour is common, or other colours can occur)
  • Restlessness
  • Shortness or loss of breath
  • Throat soreness
  • Sweating
  • Weakness, numbness, or tingling sensations in the legs, potential to move up to face, trunk, or arms
  • Bleeding or bruising (unusual)
  • Weakness, tiredness, or sensations of sickness (out of the ordinary)
  • Vomiting
  • Skin or eyes yellowing

More Common Side Effects (Female Only) Medical Care Required

  • Weight gain
  • Menstrual period irregularity
  • Breast side decrease

Rare Side Effects (Female Only) Medical Care Required

  • Hair growth (unnatural)
  • Voice deepening (or hoarseness)
  • Clitoris enlarged

Rare Side Effects (Male Only) Medical Care Required

  • Semen changes
  • Testicle side reduction

Certain side effects could take place that may not necessitate medical care. These effects could diminish or disappear completely throughout the treatment as the body becomes more adjusted to the prescription. These side effects can potentially be reduced or prevented, consult with your physician to learn ways to make side effects more tolerable. If you experience one or more of the subsequent side effects, ask your doctor for more information if you have questions or if they become troublesome.

Less Common Side Effects (Male and Female) Medical Care Not Required

  • Nervousness
  • Mental shifts or mood changes
  • Skin redness or flushing

Rare Side Effects (Male and Female) Medical Care Not Required

  • Heightened sensitivity to sunlight by skin

Less Common Side Effects (Female Only) Medical Care Not Required

  • Bleeding (vaginal)
  • Itching, dryness, or burning of vagina

Additional side effects that were not noted above could also take place for certain patients. If other side effects are observed, be sure to consult with your doctor.

Contact your physician for healthcare advice regarding side effects. They can also be reported to the FDA by calling them at 1-800-FDA-1088.

Dosage

Danazol must be taken according to the directions given by the prescribing physician. Never take more than the prescribed amount. Never take danazol more frequently than prescribed. Do not take this medication for a duration that is longer than the physician ordered. Doing any of these things could trigger undesired effects.

This drug must be started during the menstrual cycle.

To receive as much relief as possible from danazol, it should be taken consistently over the entire course of treatment, according to your physician's orders.

Patients may receive varied doses of danazol depending on their personal health history and requirements. Ensure to carefully follow the label instructions or your physician's orders. The summary below will describe only typical doses of danazol. Never adjust your dosage (even if different from what is listed here) unless instructed otherwise by your physician.

The dose that you are prescribed directly depends on how strong the medication is. In addition, the amount of doses taken per day, the total time given in between each dose, and the total duration of time that you take this drug is dependent on the medical issue you take this medication for.

Oral Dose Capsule Form

Treatment for Mild Cases of Endometriosis

Adults : Initially, 200, 400 milligrams should be taken in two separate amounts, for a period of 3-6 months to begin and use should be continued for no more than 9 months. Your physician may slightly adjust your prescribed dose as your need and tolerance for the medication may fluctuate.
Children: Physician must set the dose.

Treatment for Moderate through Severe Cases of Endometriosis

Adults: Initially, 800 milligrams should be taken in two separate amounts, for a period of 3-6 months to begin and use should be continued for no more than 9 months. Your doctor may change your dose as your need and tolerance for the medication varies.
Children: Your doctor must determine dose.

Treatment for Fibrocystic Breast Disease

Adults - Initially, the patient should take 100, 400 milligrams in two separate amounts. Your physician may be inclined to adjust your prescribed dose as your need and tolerance for the medication can vary over time.
Children, Physician will specify dosage information.

Genetic Angioedema Prevention

Initially, 200 milligrams should be taken in two or three separate amounts. Your doctor may wish to adjust your dose as your need and tolerance for the medication may change.
Children: Physician should always provide dosage instructions.

Missed Dose

If a dose of danazol is missed, it must be taken right when you remember that it had been skipped. However, in circumstances when the scheduled next dose is closer, you may disregard the skipped dose and simply wait for the next scheduled dose. Never double doses of danazol.

Interactions

Some medications should never be taken at the same time, but other circumstances may warrant the use of several medications prescribed simultaneously, despite the likelihood that an interaction may take place. For these patients, their physicians may simply change their prescribed amount, or they may choose to take additional precautions. When taking danazol, your doctor must be informed if you are already taking any of the subsequent medications that are noted below. These medications were chosen depending on how significant the interaction could be, but the list is not all-inclusive.

Drug Interactions

Doctors do not suggest patients take danazol with one or more of the subsequent medications. Your physician could choose not to prescribe this medicine to you, or they could simply adjust the dosage for other medications may also be taking.
Simvastatin

Doctors do not typically suggest patients take danazol with one or more of the subsequent medications, but certain circumstances may require it. One or both of the medications you are taking may have their dosages adjusted by the doctor for your safety.

  • Phenprocoumon
  • Lovastatin
  • Fluvastatin
  • Dicumarol
  • Bupropion
  • Atorvastatin
  • Anisindione

Patients may experience a heightened chance of some side effects if they take the subsequent medications at the same time as they are taking danazol, however, both medications could be the most optimal form of treatment. If your physician chooses to prescribe both medications at the same time, they may reduce or change the dosage for either medication for your safety.

  • Warfarin
  • Tacrolimus
  • Cyclosporine
  • Carbamazepine

Additional Interactions

Some medications should not be taken while eating as the likelihood of interactions taking place is much higher. The use of tobacco or alcohol with some medications can also influence the occurrence of interactions. Converse with your medical professional how your tobacco, food, or alcohol habits may impact the use of this medication.

Interactions with Other Medical Issues

If you have other medical issues, this can impact the effectiveness of this medication for you. Be sure to inform your physician if you also have other medical issues, including:

  • Blood clots (history of or active)
  • Vaginal bleeding (atypical or abnormal)
  • Heart disease
  • Kidney disease
  • 400;">Liver disease
  • 400;">Porphyria (enzyme issue)
  • Tumor triggered by excess in male hormones (androgen) do not take danazol
  • Diabetes
  • 400;">Epilepsy
  • Swelling of the body (edema) or fluid retention
  • 400;">Heart failure
  • High blood pressure (hypertension)
  • Kidney failure
  • Migrane headaches
  • Blood diseases (polycythemia): conditions could become worsened by retaining fluid (too much water in the body) that this medication can cause

Warnings

It is imperative that your physician monitor how your body is adjusting and progressing on the medication at regular appointments to ensure this drug will not trigger undesired side effects. Patients may also require blood tests to watch for undesired side effects.

Pregnant women who are taking danazol could endanger their fetus. Doctors are highly careful in regards to this women who are of child-bearing age are typically given a pregnancy test prior to beginning use of this medication to ensure you have not become pregnant without realizing it.

Patients may discover that their birth control medications do not tend to work as well when they are taking danazol. Always use a back-up form while on this medication, such as a diaphragm, condom, or spermicide. Inform your physician immediately if you suspect that you are pregnant after taking danazol.

Danazol can also cause period irregularity. Women can experience irregular periods every month, or they may not even receive their period at all. If you do not get your regular period after you are finished taking danazol, consult with your physician immediately.

Women who have atypical growth of hair, voice deepening, or an enlarged clitoris should alert their physician immediately. These side effects could potentially become worse, which is why your physician may choose to recommend you stop the use of danazol.

Cease use immediately and consult with your physician if you experience any of the subsequent signs while on danazol: headache, blurred vision, nausea, vomiting, or a shift in aptitude to visually recognize colours (specifically yellow or blue).

Individuals with diabetes must be aware that danazol can impact overall levels of blood sugar. Consult with your physician if you observe any variations in your urine sugar or blood sugar tests.

Patients who require medical tests must inform their physician that you are on danazol. Certain medical tests may be skewed due to this medication.

Occasionally, your skin could become additionally sensitive to sunlight in particular than it typically is. Patients who come into direct contact with sunshine could experience skin discolouration, redness, itching, skin rash, or serious sunburn. Consult with your physician if you encounter any of these effects.

Never take other medications at the same time as danazol unless your physician has already approved them, regardless of if they are nonprescription or prescription medications, and herbal or vitamin supplements.

Patients should compare the potential risks of taking danazol against the benefits they may receive. You must make this decision carefully with your physician. Consider the following points prior to taking danazol.

Allergies

Inform your physician if you've previously experienced allergic or unusual reactions to any medications. Be sure to also inform your physician of other kinds of allergies you may have, including to animals, preservatives, dyes, or foods. Read the container label listing the ingredients cautiously for products that are non-prescription.

Specific Demographic Use

Pediatric

It has not yet been determined whether or not it is both safe and effective for children to take danazol, as appropriate research has not yet been conducted.

Geriatric

While danazol has not yet been studied in regards to the elderly population, issues with elderly patients have not been significant.

Pregnancy

There is a likelihood that abnormalities can happen for the fetus for women who have taken danazol while pregnant. Women who are currently or who could become pregnant have an increased likelihood of dangerous effects.

Breastfeeding

It has not yet been determined whether or not women pose a risk for their baby if they take danazol while breastfeeding. Women should consider both the benefits and risks of this medicine prior to taking it.

Storage

Danazol must be stored in a sealed container and kept far from freezing, heat, direct light, or moisture. It should be kept at or around room temperature.

Keep far away from children's reach. Never keep medication that is expired or not required anymore.

Consult with your medical care professional in regards to properly disposing of medication you are finished with.

Summary

This medication aids in reduction of inflammation or endometrial tissue swelling in areas other than the uterus. Danazol lowers the number of hormones the ovaries produce which cause the noncancerous growths to develop. It's important to remember that danazol can interfere with medical tests, so inform your physician prior to any major health exams.