Dapsone (oral)

Dapsone oral is an anti-infective used to treat certain skin conditions, including leprosy (also known as Hansen's disease) and dermatitis herpetiformis.

Overview

Dapsone oral is an anti-infective drug used to treat certain skin conditions, including leprosy and dermatitis herpetiformis. It is often taken with other medications and dietary plans.

Dapsone was developed based on the work of Gerhard Domagk, who in 1932 discovered the antibacterial prontosil red. Further research into these chemicals led to the development of Dapsone by Ernest Fourneau in France and Gladwin Buttle in the U.K., independently of one another. From 1936 to 1996, Dapsone was used to treat a variety of issues, including malaria and leprosy.

Dapsone became popular in pharmaceuticals because of the emergence of drug-resistant malaria in Africa. GlaxoSmithKline developed a drug using Dapsone, which could help treat malaria during this time. Though this drug is not widely used today, it led to increased usage of Dapsone for certain other conditions.

Because Dapsone is a generic medication, any pharmaceutical company can produce and sell it. Most commonly in the U.S., it is sold under its brand name by GlaxoSmithKline Pharmaceuticals. The cost of generic Dapsone is generally about $60 for 30 tablets in the U.S. and may be covered under health insurance policies.

Dapsone is anti-inflammatory and works by inhibiting the enzyme myeloperoxidase. This means that it prevents serious tissue damage when skin is inflamed and lessens the effects of many skin conditions, including leprosy.

Conditions Treated

  • Leprosy (also known as Hansen's disease)

Type Of Medicine

  • Sulfone

Side Effects

Like all medications, Dapsone can cause a number of different side effects. If you experience any of these common side effects, you should tell your doctor if they worsen or seriously impede your daily life. There may be other treatments options more suited to your needs. Common, less serious side effects of Dapsone include:

  • Nausea and vomiting

There are also more serious side effects that can occur when taking Dapsone. If you experience any of the following side effects, you should alert your doctor immediately:

  • Unusually fast heartbeat

Aside from side effects, you should also watch for signs of an allergic reaction to Dapsone. If you experience any signs of an allergic reaction, you should alert a medical professional immediately. You may need to stop taking Dapsone. Signs of an allergic reaction include:

  • Swelling, especially of the face, tongue, or lips

Side effects of Dapsone may change over time, or depending on factors like age, weight, and lifestyle habits. Always tell your doctor if you begin any new medications or dietary supplements or about sudden changes in your lifestyle. If any new side effects appear or if current ones worsen, alert your doctor.

Dosage

Dapsone oral comes in a tablet form. Dapsone is usually prescribed with other medications or a planned diet and lifestyle regime to treat skin conditions. When taking Dapsone, be sure to follow all directions and take all other medications from your doctor. If you miss a dose of Dapsone, you should take the dose as soon as you remember. If it is almost time for another dose anyway, wait and continue taking your dosage as usual. Do not take a double dose to make up for a missed one.

The recommended dosage of oral Dapsone depends on what it is being used to treat. Oral tablets of Dapsone usually come in 25 mg and 100 mg doses.

For adults with leprosy, the recommended dosage is 50 mg to 100 mg, taken once daily. This dosage is generally taken for two to five years. For certain types of leprosy, this dosage may be taken for only six months. Dapsone is also usually taken with other medications when being used to treat leprosy.

For adults with Dermatitis Herpetiformis, the recommended dosage is 50 mg, taken once daily for life. This dosage can be adjusted depending on the patient, with 300 mg being the maximum recommended daily dosage.

For adults with Pneumocystis Pneumonia, the recommended daily dosage is 100 mg, taken once daily for two to three weeks. When used to treat Pneumocystis Pneumonia, Dapsone is usually taken with trimethoprim.

For adults with Toxoplasmosis Prophylaxis, the recommended dosage is 100 mg, taken twice per week for life.

For children under the age of 18, the dosage of Dapsone depends on the child's weight. Generally, the recommended dosage for leprosy in children is 1 mg to 2 mg per kg of weight, taken once daily. The maximum recommended dosage of Dapsone in patients under 18 is 100 mg per day. Consult your doctor before giving children Dapsone, as they will best be able to prescribe the appropriate dosage.

Patients with high acetylation rates may need an adjusted dosage of Dapsone, and should speak to their doctor.

Interactions

Dapsone can interact with a number of different drugs, which is why it is important to tell your doctor about other medications you are taking and any you want to begin taking while on Dapsone.

Serious and dangerous drug interactions include the following. You should not take any of the following while on Dapsone, and alert your doctor if you need one of the following so that they can recommend an alternative solution.

  • Aluminum hydroxide

There are a number of medications that interact moderately with Dapsone. These medications may be taken with Dapsone, but you should tell your doctor before taking them and monitor for any side effects or complications. This list is extensive, but a few include:

  • Conjugated estrogens

This list is not exhaustive, and you should always check with your doctor about other possible drug interactions.

There are also a number of medications that have minor interactions with Dapsone. Alert your doctor if you take any of these medications or if you start using them. This list includes:

  • Hea, herbal

This list is not exhaustive, and you should always check with your doctor about other possible drug interactions.

Warnings

Dapsone may cause adverse effects in people who have experienced certain health conditions. Tell your doctor before taking Dapsone if you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency, hemoglobin M deficiency, liver disease, heart disease, lung disease, or anemia.

Dapsone can cause fatigue or dizziness. Do not drive or operate heavy machinery when you start Dapsone until you know how you respond to it. Also be careful not to drive or operate heavy machinery if you change dosages of Dapsone, as you may respond differently to different levels of it.

It is possible to overdose on Dapsone. If you think that you or someone you know has overdosed on Dapsone, you should alert a medical professional immediately for emergency treatment or call 1-800-222-1222.

Signs of an overdose include:

  • Seizures

Patients who are pregnant or planning to become pregnant should consult their doctor when taking Dapsone. You should not breastfeed while taking Dapsone, as it can pass through breast milk to the baby and be harmful.

Always tell your doctor when you start or stop using any other medications, dietary supplements, or other vitamins and minerals.

Storage

Dapsone should be stored in a secure location at room temperature (about 68-77 degrees F), out of direct sunlight and out of a moist environment. Bathrooms are often too moist for safe storage of Dapsone. Ensure that all child safety locks and lids are placed correctly when storing Dapsone.

If your prescription changes, do not take your old dosage or medicine unless otherwise instructed. If you get a new prescription with tablets of a different power, safely dispose of your old prescription. If your prescription of Dapsone expires or you have expired Dapsone in storage, be sure to dispose of it safely. The best way to dispose of expired or unneeded medications is through a medicine take-back program. You can talk to your local pharmacist about where and when these take-back programs take place. If your local community does not have these take-back programs, you should refer to the FDA's Safe Disposal of Medicines guidance. Never throw your prescription of Dapsone in the trash with general waste or flush it down the toilet.

Summary

(Write no more than 15% of article for Summary):

Dapsone is an anti-infective drug used to treat certain skin conditions, including leprosy and dermatitis herpetiformis. It is often taken with other medications and dietary plans to treat these certain skin conditions.

Dapsone is anti-inflammatory and works by inhibiting the enzyme myeloperoxidase. This means that it prevents serious tissue damage when skin is inflamed, and lessens the effects of many skin conditions, including leprosy.

The recommended dosage of oral Dapsone depends on what it is being used to treat. Oral tablets of Dapsone usually come in 25 mg and 100 mg doses. For adults with leprosy, the recommended dosage is 50 mg to 100 mg, taken once daily. This dosage is generally taken for two to five years. For adults with Dermatitis Herpetiformis, the recommended dosage is 50 mg, taken once daily for life.

Dapsone can cause a number of different side effects. Common and less serious side effects of Dapsone include:

  • Nausea and vomiting

More serious side effects that can occur when taking Dapsone and should be brought to the attention of a doctor include:

  • Nusually fast heartbeat

Dapsone may cause adverse effects in people who have experienced certain health conditions. Tell your doctor before taking Dapsone if you have a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency, hemoglobin M deficiency, liver disease, heart disease, lung disease, or anemia.

Dapsone can cause fatigue or dizziness. Do not drive or operate heavy machinery when you start Dapsone and when you change dosages until you know how you respond to it.

It is possible to overdose on Dapsone, and signs of an overdose include seizures, bluish skin, and sudden changes or loss of vision. If you think that you or someone you know has overdosed on Dapsone, you should alert a medical professional immediately for emergency treatment or call 1-800-222-1222.

Patients who are pregnant or planning to become pregnant should consult their doctor when taking Dapsone. You should not breastfeed while taking Dapsone, as it can pass through breast milk to the baby.

Always tell your doctor when you start or stop using any other medications, dietary supplements, or other vitamins and minerals.

Dapsone should be stored in a secure location at room temperature, out of direct light and out of a moist environment.