Daunorubicin Citrate Liposome is also known by US brand name Daunoxome. It is used to treat advanced acquired immunodeficiency syndrome (otherwise known as AIDS), and the associated type of skin cancer known as Kaposi's sarcoma (KS).
Liposomal daunorubicin belongs to a group of medications known as antineoplastics. They are used to treat associated Kaposi's sarcoma (KS), a type of skin cancer and advanced acquired immunodeficiency syndrome (AIDS).
Liposomal daunorubicin works by interfering with the growth of cancerous cells, which are then destroyed, eventually. The growth of your normal body cells can also be affected by the use of this drug and some other effects can occur. These could be cause for concern and you should report them to a doctor or healthcare professional. Other effects, such as hair loss, may cause some concern. Some effects may not appear until years or months after the medication is used.
Before you begin treatment with this drug, you and your doctor should discuss the benefits and risks associated with taking this medication. This drug is to be administered only by or under the immediate supervision of a trained doctor or healthcare professional. This product is available in the dosage form of a solution, for injection.
Along with its intended effects, this drug can produce some unwanted side effects. Not all of these side effects may appear, but if they do, you may need to seek medical attention.
Inform a healthcare professional or your doctor immediately if you suffer from any of the following side effects whilst taking daunorubicin liposomal:
Some side effects of daunorubicin liposomal that occur usually don't require medical attention. You will usually find that these side effects begin to disappear as your body begins to adjust to the medication. If they are giving you bother, you should contact your healthcare professional or doctor for advice on how to prevent or reduce the side effects.
This drug can cause the urine to turn reddish in color, which can stain your clothes. Be aware that this is not blood. You should expect this to happen and it only lasts for one to two days after each dose is given.
This medication can often cause temporary and total loss of hair. After treatment with liposomal daunorubicin has finished, your normal hair growth should return.
The final dosage of any medication will depend on a number of factors. This includes your age, weight and height, the condition you are being treated for, its severity, any other medical conditions you may suffer from and how you react to the first dose.
If the patient has adequate blood cell counts and an acceptable benefit-cardiac risk ratio, then the recommended dose is 40 mg/m2 infused intravenously over a 60 minute period every two weeks.
Note that safety has not been established in patients with hepatic dysfunction.
Drug interactions can cause unwanted side effects and reduce the effectiveness of either drug. To limit the risk of these interactions, you should give your doctor or healthcare professional a complete list of all the medications you are currently taking and have taken in the past. This list should include prescription and non-prescription drugs, vitamins and herbal products. You should also let them know of any current medical conditions you are suffering from as well as any medical conditions that run in your family history.
The use of this medication alongside any of the following drugs is not recommended. Your doctor may decide to avoid treating you with this drug altogether or change some of the other medications you take.
The use of this medication alongside any of the following medications is not usually recommended. However, in some cases, it may be required. If you are prescribed both drugs together your doctor may alter the dose or frequency in which you use either medication.
A total of 430 drugs are known to interact with Daunorubicin Citrate Liposome. Some of them are listed below. This list is not complete which is why it's important to let your doctor know of all medications you are taking.
If you suffer from any other medical conditions, this could affect the use of this medication. Make sure you tell your doctor or a healthcare professional if you suffer from any other medical issues, especially:
There is currently no specific information that compares the use of this drug in children with use in any other age group. Therefore, efficacy and safety have not been established.
There is currently no specific information that compares the use of this drug in the elderly with the use in any other age group. Therefore, efficacy and safety have not been established.
This drug is under FDA pregnancy category D. It is not recommended for use during pregnancy as it can harm an unborn baby. If you become pregnant or think you could be pregnant, inform your doctor right away. To avoid pregnancy, both females and males who use this drug should use reliable form(s) of birth control (e.g. condoms or birth control pills) during treatment. Speak with your doctor or healthcare professional for details and to discuss effective forms of birth control.
With regards to breastfeeding, it's unknown whether this drug passes into breast milk. Due to the possible risk, you shouldn't breastfeed a child whilst taking this medication. Speak with your doctor or a healthcare professional before breastfeeding.
Before using this drug, you should let your pharmacist or doctor know if you are allergic to it, or any other types of anthracyclines or if you have any other allergies, including to animals, foods, dyes, preservatives etc. This drug can contain inactive ingredients, which can cause allergic reactions or other issues. Speak with your pharmacist for more details.
Don't have vaccinations or immunizations without the consent of your doctor, and avoid any contact with people who have recently received the flu vaccine or oral polio vaccine through the nose. Wash your hands well to prevent the spread of infections.
To minimise your risk of getting bruised, cut or injured, exercise caution with sharp objects like nail cutters and razors.
This drug can temporarily lower the number of white blood cells in your blood, which can increase your chance of getting an infection. It can also lower the number of platelets, which are needed for proper blood clotting. If this occurs, there are some precautions you should take, especially when your blood count is low, to help minimise the risk of bleeding or infection.
The vials should be stored intact at 36°F - 46°F (2°C - 8°C). You should not freeze this product and ensure it's protected from light. Diluted daunorubicin liposomal to be used for infusion in D5W can be refrigerated at 36°F - 46°F (2°C - 8°C ) for up to six hours if it is not used right away.
When used correctly, Daunorubicin Citrate Liposome is successful in the treatment of Kaposi's sarcoma and AIDs. This medication is given slowly via injection into a vein by a healthcare professional or your doctor. The final dosage is based on your body size, medical condition, and response to the first treatments. This drug is not recommended during pregnancy and breastfeeding. You should take extra precautions to avoid falling pregnant whilst on this drug. You should also let your doctor know if you fall pregnant. Due to a large number of interactions possible with this drug, it's vital you let your doctor know what medications you are currently taking.