Delavirdine (oral route)

Delavirdine is used with other medications as a way to treat an infection that has been caused by HIV, or the human immunodeficiency virus.

Overview

The medication delavirdine is used alongside other appropriate medicines as a course of treatment. It is primarily used to treat patients with HIV, or human immunodeficiency virus, who have developed an infection as a result of this illness.

HIV is a contractible virus that results in an acquired immune deficiency syndrome (AIDS) over time. Delavirdine will not prevent the spread of either HIV infection or AIDS in patients suffering from this illness, so all necessary precautions should be taken, even when using this medication.

Delavirdine causes the destruction of the immune system to slow down, as well as preventing HIV from reproducing within the body. By increasing the time that it takes for the immune system to break down, this medication can delay some of the problems and conditions associated with HIV or AIDS. Despite slowing down the degradation of the patient’s immune system, this medication does not in any way prevent HIV from being passed onto other people.

Though delavirdine does help with some symptoms and conditions caused by HIV and AIDS, the patient may continue to suffer from other issues that are caused by AIDS or HIV.

This medication is not available over the counter, and can only be prescribed by your doctor.

Conditions treated:

• Human immunodeficiency virus (HIV)

Type of medicine:

• Tablet

Side effects

Along with the expected and required effects that delavirdine causes, other effects may become present during the course of treatment with this medication. The unwanted effects can occur at any time during treatment and there is a possibility that medical support and care will be required as a result of their appearance. It is highly unlikely that all of these side effects will occur, and some patients will not experience any of the listed.

It is important to consult with your doctor as soon as possible, should any of the following symptoms or side effects occur during your course of treatment with delavirdine:

• Yellowing of the eyes or skin
• Vomiting
• Unusual tiredness or weakness
• Swelling of face, ankles, or hands
• Stupor
• Sore throat
• Skin rash with other symptoms including fever, oral lesions, blistering, conjunctivitis, swelling, joint aches, or muscle aches
• Skin rash (severe) with itching
• Seizures (convulsions)
• Rapid weight gain
• Pale skin
• Nosebleeds
• Nausea
• Muscle twitching
• Loss of appetite
• Lethargy
• Irritability
• Incidence unknown
• Hostility
• Headache
• General body swelling
• Fever
• Fatigue
• Dizziness
• Difficulty in breathing
• Difficulty breathing
• Depression
• Decreased urine output
• Dark urine
• Confusion
• Coma
• Chills
• Bleeding gums
• Back or stomach pains
• Agitation

Other side effects that may occur while the patient is prescribed and actively taking delavirdine may not require medical support or attention. These side effects may disappear over the course of treatment as the body becomes more used to the medication. However, should any of the listed conditions persist after your treatment has completed or worsens in any way, it is vital to contact your doctor as soon as you can for help and advice.

Speak to a medical professional if any of the below listed symptoms occur, continue or become increasingly worrisome:

• Wheezing
• Voice changes
• Unable to sleep
• Trouble sleeping
• Trouble in swallowing
• Trouble concentrating
• Tiredness
• Tightness in chest
• Tender, swollen glands in neck
• Sweating
• Sneezing
• Sleeplessness
• Shortness of breath
• Shivering
• Runny nose
• Pain, localized
• Pain or tenderness at eyes and cheekbones
• Nervousness
• Nasal congestion
• Muscle aches and pains
• Loss of voice
• Loss of interest or pleasure
• Lack or loss of strength
• Joint pain
• Hoarseness
• General feeling of discomfort or illness
• Feeling sad or empty
• Fear
• Ear congestion
• Dryness or soreness of throat
• Discouragement
• Diarrhea
• Cough
• Body aches or pain
• Abdominal pain, generalized

Dosage

The amount of medication that is taken by the patient is dependent on the strength of the prescribed medication itself. This amount can also be affected by the number of times you take delavirdine per day or per dose, as well as factors like the length of time you are prescribed this medication for and the time between each dose.

Because of this ambiguity in the dosage levels for each patient, it is highly recommended that you completely follow the advice given to you by a relevant medical professional, as it is likely your dosage has been worked out specifically for you. Failure to follow the advice of your doctor can lead to additional symptoms, your medication not working correctly and other side effects.

Dosage for oral medication (tablets) for the treatment of HIV infection:

Adults: 400mg three times per day, in combination with other prescribed antiretroviral drugs. Your doctor will determine the scheduling of all of your medicines that are required and the amount in each dose.

Children that are 16 years old or less: Dosage of medication will be decided by a medical professional to match exact requirements and needs.

Should you forget to take a dose of delavirdine, it is important that you try to take the missed dose as soon as possible after the time you are supposed to. However, if you have missed your dose by a long amount of time and it is almost time for your next dose, do not take the missed tablet. Instead, you should skip the missed dose, after which you should go back to your regular dosing schedule. Never double doses unless you are told to do so explicitly by your doctor.

Interactions

Due to the possible problems with the mixture of certain chemicals within the body, it is advised that certain medications should not be used together at any time. However, depending on the individual needs and requirements of a patient, a doctor may choose to prescribe otherwise incompatible drugs together – despite the risk of interaction occurring.

When you are prescribed any medication, including delavirdine, it is very important that your doctor has a full and comprehensive overview of your medical history, which should include notification of any of the listed medications. The interactions listed for delavirdine may not be all-inclusive, but they are considered the most relevant. A doctor will be able to give you the best idea of if your medications will interact with one another.

Taking delavirdine with any of the following drugs is not recommended in the majority of circumstances. It is down to the discretion of a medical professional and yourself as to whether the risks outweigh the rewards when taking any of the following medications:

• Triazolam
• Tolvaptan
• Terfenadine
• Primidone
• Pimozide
• Phenytoin
• Nimodipine
• Naloxegol
• Midazolam
• Methylergonovine
• Isavuconazonium sulfate
• Fosphenytoin
• Fosamprenavir
• Ergotamine
• Ergonovine
• Eliglustat
• Dihydroergotamine
• Conivaptan
• Cisapride
• Carbamazepine
• Astemizole
• Alprazolam

Taking delavirdine with any of the below listed medicines is generally not recommended. However, due to the preventative nature of this medication, additional medications may be required that are not fully compatible. If both drugs are prescribed at the same time, there is a possibility that your doctor will choose to change your dose or alter your schedule of medication.

• Voriconazole
• Vilazodone
• Tacrolimus
• St John's wort
• Simvastatin
• Simeprevir
• Saquinavir
• Ruxolitinib
• Rilpivirine
• Rifampin
• Rifabutin
• Ranitidine
• Quinidine
• Propafenone
• Piperaquine
• Phenobarbital
• Paroxetine
• Panobinostat
• Omeprazole
• Olaparib
• Nizatidine
• Nevirapine
• Methadone
• Lurasidone
• Lumefantrine
• Lovastatin
• Lidocaine
• Lansoprazole
• Ketoconazole
• Ixabepilone
• Ifosfamide
• Idelalisib
• Flecainide
• Fentanyl
• Famotidine
• Etravirine
• Doxorubicin hydrochloride liposome
• Doxorubicin
• Domperidone
• Delamanid
• Darunavir
• Crizotinib
• Cobicistat
• Cimetidine
• Cilostazol
• Ceritinib
• Cabazitaxel
• Bupropion
• Brentuximab vedotin
• Bosutinib
• Bepridil
• Bedaquiline
• Artemether
• Amiodarone

In addition to the above medications, taking delavirdine alongside any of the following drugs may result in an increased risk of specific side effects or conditions. However, depending on individual circumstance your doctor may choose to prescribe both medicines together.

• Sildenafil
• Ritonavir
• Rifapentine
• Quinupristin
• Norgestrel
• Norgestimate
• Norethindrone
• Norelgestromin
• Nilvadipine
• Nelfinavir
• Mestranol
• Medroxyprogesterone acetate
• Manidipine
• Magnesium trisilicate
• Magnesium oxide
• Magnesium hydroxide
• Magnesium carbonate
• Magaldrate
• Levonorgestrel
• Lercanidipine
• Lacidipine
• Indinavir
• Fluoxetine
• Etonogestrel
• Ethynodiol diacetate
• Ethinyl estradiol
• Estradiol valerate
• Estradiol cypionate
• Ergoloid mesylates
• Drospirenone
• Dihydroxyaluminum sodium carbonate
• Dihydroxyaluminum aminoacetate
• Dienogest
• Didanosine
• Desogestrel
• Dalfopristin
• Clarithromycin
• Cerivastatin
• Amprenavir
• Aluminum phosphate
• Aluminum hydroxide
• Aluminum carbonate, basic

In addition to drug-based interaction, certain specific medications should not be used at the same time as food or around the time of eating, as this can cause interaction. Though there has been no known reporting of food, alcohol or tobacco creating interactions with delavirdine, it’s important to talk to a doctor before starting any medication for special rules or conditions regarding food, smoking and alcohol.

Pre-existing or recent medication conditions may affect the way that delavirdine works. Your doctor may be able to provide you with alternatives by any of the following conditions.

• Achlorhydria
• Liver disease

Warnings

It is vital that you always inform your doctor if you suffer from allergies of any kind so that this is included in your medical history. It is critical that a medical professional is notified if you have an allergy to medication, but also an allergy to dyes, animals, preservatives or foods.

Delavirdine is listed under FDA category C for pregnancy, which indicates that there have not been enough studies to determine if this medication can cause harm to an unknown baby. It is essential to inform your doctor if you are pregnant or are planning to become pregnant so they can evaluate the risks of this medication.

There are also not enough conclusive studies about delavirdine in breastfeeding women to know if this medication may cause risk to an infant. It is important to weight the benefits of delavirdine against the risks before choosing to be prescribed this medication.

When taking delavirdine, it is essential to avoid taking certain herbal medicines, such as St. John's wort, to prevent any adverse effects. You should also try to avoid taking any antacid drugs within an hour before or after you take your medication.

This medication does not prevent HIV from spreading to other people. Therefore, all the same precautions should be taken as in patients with HIV who are not taking treatment. These can include not having unprotected sex, not sharing a razor or toothbrush and never sharing drug or medicine needles. It is recommended that you consult with your doctor about the safest ways to prevent HIV transmission during sex and other activities.

When taking delavirdine, it is most effective to swallow both the 100mg and 200mg tablets whole. However, if you are struggling to swallow these medications, the 100mg tablet can be dissolved in water (at least 3oz), allowed to sit for several minutes and then be stirred to mix. Drink this mixture right away, then rinse the glass and drink that rinse to ensure the full dose is taken.

Patients suffering from achlorhydria (absence of stomach acid) should take their medication with a glass of orange juice or cranberry juice.

Keep taking delavirdine for the full time that it is prescribed unless otherwise told by your doctor, regardless of whether you start to feel better.

Storage

Delavirdine should be stored in the container it is dispensed in at room temperature. It should be stored away from any heat and moisture, as well as direct light. This medicine should never be frozen.

Ensure that delavirdine is always kept out of the reach of pets and children.

Summary

Delavirdine is primarily used to treat patients with HIV, or human immunodeficiency virus, when they have developed infection as a result of this condition. This medicine is used alongside other prescribed medications as a course of treatment.

HIV is a contractible, highly contagious virus within the blood that develops into an acquired immune deficiency syndrome (AIDS). This medicine is not designed to prevent the infectious effects of either HIV or AIDS, so all the usual precautions need to be taken, even when taking this drug.

Delavirdine acts to slow down the destruction of the immune system, as well as to stop HIV reproducing in the body of the patient. By decreasing the speed at which it takes for the immune system to become broken down, delavirdine can work to delay some of the problems and illnesses that are associated with HIV or AIDS.

Though delavirdine does work to prevent or reduce some of the symptoms and conditions that are caused by HIV and AIDS, the patient is likely to continue to suffer from other issues that are associated with AIDS or HIV.

This medication is strictly available through prescription and can never be purchased over the counter.