Desmopressin (oral)

Desmopressin is a treatment used to reduce the flow of urine in patients with certain medical conditions to prevent them from becoming dehydrated or to allow better bladder control.

Overview

Desmopressin is used to treat a range of different conditions in both children and adults. It works on the kidneys to reduce the flow of urine from the body and, in doing so, allows for better control of the bladder. It is used in the treatment of bedwetting, central cranial diabetes insipidus and the frequent need to urinate and increased thirst occurring following injuries or surgeries to the brain.

Desmopressin is an artificial substance that is similar to a hormone that is naturally produced in the body for the control of urine flow. This hormone acts as a natural anti-diuretic in normal bodily function and Desmopressin stimulates the same response in the kidney.

This medication is supplied as a DDAVP tablet and is available only with a prescription from a doctor. Dosing will differ greatly depending on the condition treated, age and other factors.

Conditions Treated

Type Of Medicine

  • Anti-diuretic
  • Vasopressin

Side Effects

In addition to the required effects of Desmopressin, there may also occur some unwanted side effects in the patient. While not all of the following side effects may be present, in some cases they may require that the patient seek medical attention urgently.

If you experience any of the following side effects during the use of Desmopressin, you will need to seek immediate medical attention:

  • Confusion or disorientation
  • Convulsions or spasms
  • Decreased output of urine
  • Dizziness
  • Irregularity of heartbeat
  • Increased heartbeat
  • Headaches
  • Increased thirstiness
  • Muscle pain
  • Muscle cramping
  • Nausea
  • Vomiting
  • Shortness of breath without exertion
  • Swollen face, ankles or hands
  • Unusual tiredness
  • Unusual weakness
  • Weight gain

Other side effects may occur that would not normally necessitate the seeking of medical attention. These are side effects that would normally abate during treatment and do not usually indicate more serious medical problems that could be occurring. If these side effects do become bothersome, however, you can consult your doctor to determine how best to alleviate them:

  • Seeing or hearing things that aren't there
  • Delusions about reality
  • Dementia
  • Diarrhea

Other side effects from the use of Desmopressin may also occur. If you experience other side effects then you should consult your doctor for advice.

Dosage

This medication should be taken only as directed by your doctor. You should never take more of it, take it more often nor take it for longer than you have been directed to by your doctor.

Your doctor may also ration your water intake during use of this treatment to prevent fluid levels in the body from becoming too high.

The dose of this treatment will differ for each patient and for each condition treated too. You should always follow the instructions as detailed by your doctor. The following information is for the purposes of acting a guideline only:

In the treatment of bedwetting:

  • Adults and children aged 6+ 0.2mg taken before going to sleep. May be adjusted up to 0.6mg daily.
  • Children aged under 6¬†' Use to be determined in individual cases by the prescribing doctor.

In the treatment of central cranial diabetes insipidus:

  • Adults and children aged 4+ 0.05mg taken twice daily. Dose can be adjusted up to a maximum total of 1.2mg daily.
  • Children aged under 4 Use to be determined in individual cases by the prescribing doctor.

Discuss what to do if a dose of this treatment is missed. The procedure will differ depending on what condition the treatment is for. Never take double doses of the treatment.

Interactions

Certain medications should not be taken together because they can interact with one another in the body. Patients should inform their doctor of all medications they are taking before they begin use of this treatment to prevent the use of interacting medications from occurring. Some medications must never be taken together while others will simply require that the dose or frequency of use is adjusted. For this medication, it is particularly important that patients inform their doctor if they are taking any of the following medications:

  • Tricyclic antidepressants
  • Tolvaptan
  • Selective serotonin reuptake inhibitors
  • Non-steroidal anti-inflammatory medications
  • Narcotic pain relievers
  • Loperamide
  • Lithium
  • Lamotrigine
  • Diuretics
  • Clofibrate
  • Chlorpromazine
  • Carbamazepine

Interactions with other medications not listed herein may also occur. Ensure that you inform your doctor of all treatments you are taking, including any non prescription treatments.

Certain medical conditions may also prohibit the use of certain medications. You should inform your doctor of any and all medical conditions that you have suffered from, including conditions you have recovered from. For the use of Desmopressin it is especially important that you inform your doctor of the following conditions:

Side effects may be worsened in patients suffering from the following:

The following condition may be worsened by use of Desmopressin:

Do not treat patients who suffer from the following with Desmopressin:

  • Hyponatremia
  • Kidney disease

Other medical conditions not listed herein may also prohibit use of this treatment. Disclose full medical history to your doctor before use.

Warnings

Before beginning treatment with this medication, it is important that the patient considers the risks in relation to the benefits of use. This decision should be made by you and your doctor, having ensured that all of the following has been considered:

Allergies' Inform your doctor of any and all allergic reactions you have suffered in the past. This is particularly important where you have had an allergic reaction to medication.

Pediatric ' Safety and efficiency of use in children has been established in children with the following exceptions

  • Safety and efficiency of use is unknown for the treatment of central cranial diabetes insipius in children below the age of 4.
  • Safety and efficiency of use is unknown for the treatment of bedwetting in children below the age of 6.

Geriatric 'No age-related limitations have been observed beyond the increased likelihood of other medical conditions being present that may inhibit safe and efficient use.

Pregnancy ' Inform your doctor if you a pregnant before beginning use. There is a limited risk to the fetus and treatment can be used in pregnant women.

Breastfeeding 'Only minimal risk is posed to the infant when used during breastfeeding. Discuss with your doctor before use of this treatment.

Your doctor will need to examine you during use of this treatment to both determine effective use and look for unwanted effects that may be occurring. Blood and urine tests may be required.

This medication may lower the levels of sodium in your blood. This can, in turn, cause other medical problems. If you experience the following symptoms, you should contact your doctor as soon as possible:

  • Confusion
  • Nausea
  • Tiredness
  • Weakness
  • Spasms
  • Muscle cramping
  • Nausea
  • Vomiting

If you suffer a fever, diarrhea or vomiting, you may lose too much liquid. You should consult your doctor as soon as these conditions begin to occur.

Drinking too much water can result in serious unwanted effects. If the body has too much liquid, the brain can be placed under too much pressure and severe effects can occur. You should monitor your water intake to ensure that you do not exceed safe levels. You will need to pay particular attention to your water intake when you are exercising or are out in hot weather. Discuss this with your doctor to determine how you should monitor your fluid intake.

Do not take any other medications in conjunction with Desmopressin unless you have discussed this with your doctor first.

Storage

Medication should be stored at room temperature. Keep away from heat, direct sunlight and moisture at all times. Prevent from freezing.

Keep medication out of the reach of children.

Dispose of outdated or unwanted medication as soon as possible and as directed by your doctor or pharmacist.

Summary

Desmopressin is a treatment used in a range of different conditions to regulate the flow of urine through the kidneys. In doing so, the patient is better able to control the fluid in their bodies and is better able to control their bladder.

Desmopressin is an artificial vasopressin that mimics a hormone that the body uses as a natural anti-diuretic. By taking this treatment, patients are able to lessen the flow of urine from the kidney and in doing so reduce the frequency of the need to urinate.

This treatment is used in patients suffering from bedwetting as well as patients recovering from brain injuries or surgeries and patients suffering from Central cranial diabetes insipidus.

Desmopressin is available only with a prescription from a doctor and is taken in tablet form either once or twice daily, depending on the condition being treated.

This treatment can interact with a wide range of medications and should not be used in patients with a range of medical conditions. Patients should always ensure that their doctor knows of their full medical history before beginning treatment with this medication.

This treatment may cause unwanted side effects in the patient that may need to be treated with further medication or which may require cessation of treatment. Patients should ensure that they are aware of the potential side effects of use and of the potential risks of use before beginning treatment with Desmopressin.

This medication can be administered to both children and adults for the treatment of a range of conditions.