Diatrizoate (intravenous)

Diatrizoate is used to identify or find problems in the bladder of the patient. It is a radiographic contrast aid.

Overview

Diatrizoate is a radiopaque contrast agent that allows the doctor to examine the bladder for problems.

The injection is given to the patient for radiography of the bladder so a clear picture can be gained of the bladder for diagnosis. After injection into the vein, the contrast agent is transported rapidly to the kidneys and excreted in the urine to fill the bladder. The contrast agent will be unchanged by the kidneys before reaching the bladder.

This treatment should be given only under the direct supervision of a doctor before radiography is carried out on the patient.

The patient may be provided with a laxative to take in the evening preceding treatment and may be advised to follow a low residue diet on the previous day.

Condition treated

  • Bladder disorders

Type Of Medicine

  • Radiopaque contrast agent

Side Effects

In addition to the desired effects of allowing the radiotherapist to get a clear picture of the bladder in the patient, the use of Diatrizoate can cause some unwanted side effects too. In some cases, these side effects may require immediate medical attention.

Following treatment with Diatrizoate you should check with your doctor immediately if you experience any of the following side effects that may occur:

  • Bloody urine stream
  • Convulsions or seizures
  • Coughing
  • Decreased frequency of urination
  • Decreased volume of urine
  • Difficulty when swallowing
  • Dizziness
  • Hives
  • Inability to pass urine
  • Increased heartbeat
  • Itching
  • Pain or burning during urination
  • Puffy or swollen around the eyes, face, lips or tongue
  • Rash
  • Shortness of breath without exertion
  • Tightness across the chest
  • Unusual tiredness
  • Unusual weakness

Other side effects may occur from the use of Diatrizoate that may not have been listed herein. If you experience other side effects during or after use then you should inform your doctor. If you believe your immediate health to be at risk, however, then you should always contact the emergency services.

Dosage

This medication can only be administered in a hospital environment and in the presence of a supervising doctor. Diatrizoate will be injected.

Before the use of this treatment, you may be given a laxative to take the evening before. You will also be advised to follow a low residue diet in the lead up to the procedure to ease passing.

Your doctor will determine the appropriate dose for treatment. The following is a guideline only:

  • Adults 25-300ml dependant on the irritability of the patient's bladder. Greater doses may be administered where bladder capacity allows. The best results will be gained when the bladder is filled with the contrast agent.
  • Children 'Should be determined by the doctor. Refer to adult dosing.

Interactions

Interactions can occur between medications. Patients should always inform their doctor of all medications they are taking before beginning treatment with a new medication. In some cases, medications can stop one another from working or can have serious side effects on the patient's health. When taking Diatrizoate, it is especially important that you inform your doctor if you are taking any of the following treatments before use:

  • Zoledronic acid
  • Vancomycin
  • Valdecoxib
  • Valacyclovir
  • Tolmetin
  • Tobramycin
  • Temsirolimus
  • Telavancin
  • Tacrolimus
  • Sulindac
  • Sulfasalazine
  • Streptozocin
  • Streptomycin
  • Sirolimus
  • Salsalate
  • Rofecoxib
  • Polymyxin b
  • Piroxicam
  • Phenylbutazone
  • Pentamidine
  • Penicillamine
  • Pamidronate
  • Oxaprozin
  • Olsalazine
  • Netilmicin
  • Neomycin
  • Naproxen / sumatriptan
  • Naproxen / pseudoephedrine
  • Naproxen
  • Nabumetone
  • Methoxyflurane
  • Methotrexate
  • Metformin / sitagliptin
  • Metformin / saxagliptin
  • Metformin / rosiglitazone
  • Metformin / repaglinide
  • Metformin / pioglitazone
  • Metformin
  • Mesalamine
  • Meloxicam
  • Mefenamic acid
  • Meclofenamate
  • Lithium
  • Linagliptin / metformin
  • Ketorolaclansoprazole / naproxen
  • Ketoprofen
  • Kanamycin
  • Indomethacin
  • Ifosfamide / mesna
  • Ifosfamide
  • Ibuprofen / pseudoephedrine
  • Ibuprofen / phenylephrine
  • Ibuprofen / oxycodone
  • Ibuprofen
  • Ibandronate
  • Hydrocodone / ibuprofen
  • Glyburide / metformin
  • Glipizide / metformin
  • Gentamicin
  • Gallium nitrate
  • Foscarnet
  • Flurbiprofen
  • Fenoprofen
  • Famotidine / ibuprofen
  • Everolimus
  • Etodolac
  • Etidronate
  • Esomeprazole / naproxen
  • Emtricitabine / nelfinavir / tenofovir
  • Emtricitabine / lopinavir / ritonavir / tenofovir
  • Empagliflozin / metformin
  • Efavirenz / emtricitabine / tenofovir
  • Edetate disodium (edta)
  • Edetate calcium disodium
  • Diphenhydramine / naproxen
  • Diphenhydramine / ibuprofen
  • Diflunisal
  • Diclofenac / misoprostol
  • Diclofenac
  • Deferoxamine
  • Deferasirox
  • Dapagliflozin / metformin
  • Cyclosporine
  • Colistimethate
  • Clofarabine
  • Cisplatin
  • Cidofovir
  • Chlorpheniramine / ibuprofen / pseudoephedrine
  • Celecoxib
  • Capreomycin
  • Canagliflozin / metformin
  • Bromfenac
  • Balsalazide
  • Baclofen / flurbiprofen / lidocaine topical
  • Bacitracin
  • Amphotericin b liposomal
  • Amphotericin b lipid complex
  • Amphotericin b cholesteryl sulfate
  • Amphotericin b
  • Amikacin
  • Alogliptin / metformin
  • Adefovir
  • Acyclovir

Interactions with other medications may also occur that have not been listed herein. Ensure that your doctor is aware of all treatments you are undergoing before you begin use.

Interactions may also occur with other medical conditions from which you suffer. Before use, you should inform your doctor of all medical conditions that you have suffered, both in the past and present. In some cases, medical conditions can be worsened by the use of treatments meant for use in the treatment of other conditions. You should be especially clear to inform your doctor if you suffer from any of the following conditions:

  • Allergies to iodine
  • Allergies to any contrast agent
  • History of asthma
  • Current urinary tract infection

Warnings

It is possible to suffer from an overdose of this treatment. If you suspect that overdose has occurred then you should seek emergency medical attention straight away and inform them of the treatment received.

Allergies - You should inform your doctor of any allergies that you have suffered from in the past. This is especially important if you have ever reacted badly to medications in the past. You should inform your doctor of any allergy signs that you displayed and exactly what treatment you were receiving. Allergies to medications may prohibit the use of this treatment in some patients.

Thyroid problems can occur from the use of this medication. Some patients in the past have required treatment for this side effect. You should discuss this with your doctor before beginning use of this treatment.

Pregnancy - You should inform your doctor if you are pregnant before beginning use or if you plan to become pregnant. You will need to discuss the risks of doing so in relation to the benefits of use.

Breastfeeding ' Inform your doctor if you are breastfeeding before beginning this treatment. You may need to store milk for a short period while you are using this treatment before returning to nursing at the breast. Discuss this with your doctor before treatment.

Pediatric ' There are no known limitations to the use of this treatment in children. You should discuss use with your doctor before treatment.

Geriatric 'There are no known limitations to the use of this treatment in elderly patients. Elderly patients are more likely to suffer from conditions that may affect use of this treatment, however. Be cautious in looking for other medical conditions before use in the elderly.

Your doctor will need to monitor your health while you are using this treatment. Severe allergic reactions to use can occur. Symptoms of an allergic reaction include the following:

  • Hives
  • Inflammation at injection site
  • Rash
  • Reddening of skin
  • Seizures
  • Swelling of face or hands
  • Swelling of tongue
  • Tightness across the chest
  • Troubled breathing

The effects of certain tests may be affected by the use of this treatment. You should ensure that any doctor treating you is aware that you have recently received this treatment before any tests are carried out.

Do not take any other medications in conjunction with this treatment without consulting your doctor first.

Storage

  • Treatment should be stored at a controlled temperature between 20-25 °C.
  • Treatment must be stored by the hospital only.
  • Used medication should be disposed of safely as directed on the packaging.

Summary

Diatrizoate is a treatment used to enable the doctor to get a clear picture of the bladder during radiography.

The treatment is a contrast agent that allows the doctor to identify problems in the bladder and to diagnose them for further treatment. This medication will be administered in a hospital before radiography and is always administered under the supervision of a doctor.

To get the best effects from this treatment patients may be required to take a laxative in the evening before the treatment. They may also need to follow a low residue diet in the day preceding the treatment to ease passing.

Unwanted side effects can occur from the use of this treatment that may require further medical attention to be sought. Severe allergic reactions to this treatment can also be experienced from use of this treatment and patients will need to be closely monitored. Patients should ensure that the doctor is aware of any allergies they have before beginning treatment with this medication.

Before use of this treatment patients should ensure that they understand the risks of using it and weigh them against the benefits of use. Consider everything herein to reach this decision with your doctor.