Diclofenac (Intravenous)

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) used alone for mild to moderate pain in an effort to minimize the use of narcotic drugs (opioid).


Diclofenac is used for short-term treatment of adult pain, before or after medical procedures and surgery. It belongs to the family of nonsteroidal anti-inflammatory drugs (NSAIDs), and reduce the level of pain by blocking the body's production of natural substances causing inflammation, swelling and fever.

It's dispensed only with a doctor's supervision into a vein, every 6 hours or as needed during a medical procedure. It works better at the first sign of pain rather than waiting for the pain to worsen ' in this case, it may take longer for you to feel the effects.

We rely on medicines for assistance to treat diseases and improve our health. Although medicines do make us feel better, there will always be some level of risk. Diclofenac injections treat numerous painful conditions for adults, the elderly and children over 12 years of age. Depending on the severity of pain and your health, your doctor will adjust the frequency and dosage for you.

Warnings have been posted on this medicine pertaining to fatal cardiovascular events. Individuals diagnosed with cardiovascular disease and over the age of 65 are at higher risk for one of these incidents.

  • Thrombosis 'blood clot inside a blood vessel, inhibiting the flow of blood through the circulatory system.
  • Myocardial infarction (heart attack) 'blood clot in the coronary artery, preventing the blood flow to the heart.
  • Stroke 'occurs when the blood flow to an area of the brain is blocked.

Conditions Treated

  • Pain

Type Of Medicine

  • Painkiller

Side Effects

There are side effects when receiving treatment with the medicine and they will vary from person to person. To avoid or reduce the effects, follow the doctor's instructions. You need to learn and understand how this medicine works to avoid unwanted outcomes.

Depending on the cause of your pain and the severity of the condition, each person undergoing treatment will experience different levels of side effects. Before using this medication, be sure to share your medical history and health conditions with your doctor. If you have any allergies or a history of asthma with reactions after taking aspirin or other NSAIDs, tell your doctor' you may be at risk for experiencing more severe side effects.

  • Rashes
  • Severe itching
  • Trouble breathing
  • Swelling of the mouth, throat or tongue

Not all side effects need medical attention'your body will adjust to this medication and the effects will fade as you recover. The list is broken into three categories: most common, least common and rare. There may be other side effects not listed, so if you experience one not listed or the effects that are listed worsen, tell your doctor. There are solutions to ease the discomfort or prevent the side effects from occurring.

Most common

Let your doctor know if the pain still exists even after receiving the medication. If any of the side effects continue or worsen, talk to your doctor immediately. It helps to learn more about the side effects related to your existing health disorders before starting treatment with this drug. The chances of an effect or adverse reaction increase when multiple disorders are treated at the same time. Your ability to identify the effect can make a difference in a life-threatening situation.

Least Common

  • Changes in urine or stools
  • Confusion
  • Diarrhea
  • Double vision
  • Fatigue
  • Fever or chills
  • Headache
  • Heartburn or indigestion
  • Increased thirst
  • Loss of appetite
  • Nausea or vomiting
  • More Pain
  • Severe stomach pain
  • Skin lesions
  • Stomach discomfort
  • Swelling
  • Vomiting


  • Respiratory System
  • Skin reactions
  • Urogenital System

There have been reports of adverse reactions occurring when using medicine based on the pharmacological similarities with other drugs. Precautions are recommended, so be sure to talk to your doctor. There may be a solution or alternatives to help ease unexpected reactions.

Your doctor will make sure any existing conditions along with the current situation is treated. When two different drugs come into contact, there is a certain amount of risk to the individual and their health disorders. The first action of response is changing the dosage of one or both medicines.

Individuals taking diclofenac or other NSAIDs report adverse reactions associated with the body's systems and functions. The side effects occur in less than 10 percent of patients.

  • Cardiovascular System
  • Digestive System
  • Gastrointestinal
  • Hemic and Lymphatic System
  • Metabolic and Nutritional
  • Nervous System

These symptoms may be related to changes in our metabolic functions and NSAIDs may be the cause. Tell your doctor if you experience any of these effects. There's a medical guide with information about taking this medication, so ask your doctor or a medical professional for a copy. It's important to understand the risks and benefits of treating your pain with diclofenac.

  • Nausea
  • Change in appetite
  • Jaundice
  • Dark urine

Sometimes, when an individual has been taking a single drug for a long duration, the accumulation can cause the body to have a severe reaction or prompt the development of another heath disorder. Introducing another medicine may have the same effect.

Other health disorders affecting your response to diclofenac include:

  • Blood disorders
  • Bleeding or clotting problems
  • Kidney problems
  • Liver disease
  • Stomach or intestinal problems

Drug Induced Effects

Another effect caused by diclofenac is increased blood pressure. Your doctor will check your blood pressure regularly to make sure you are safe. Sometimes dehydration can cause problems, so be sure to drink enough fluids unless your doctor advises against it.

Alcohol or other drugs, legal or not can cause bleeding in the stomach when under treatment with this medication. Diets and lifestyle regimes, including health food supplements, herbal products, and nonprescription medicines can change your response to this medication. Before having any surgery or dental care, be sure to tell your doctors about the medicines you are taking now.

If you are pregnant now or trying to get pregnant, talk with your doctor. Although there are benefits to using this drug, there are risks of com/health/miscarriage/">miscarriage or you may have trouble conceiving.

This medication is not recommended for pregnant women. It may harm the unborn infant or disrupt a normal delivery. Treatment after pregnancy may pass the chemical compounds on to the infant if you are breastfeeding. Talk with your doctor to make sure you understand the risk and the side effects to your health and your newborn child.

Toxic epidermal necrolysis (TEN) is drug induced and life-threatening complication of an infection. It happens when chemicals like diclofenac enter the bloodstream and trigger inflammatory responses throughout the body. The inflammation can cause damage to multiple organ systems, instigating them to fail, leading to death.

  • The elderly are more susceptible since they have a weakened immune system.
  • Serious side effects or adverse reactions happen when taking more than one medicine.


Diclofenac is intravenously administered and only under the direction of your doctor. The dose will vary for each person, depending on your response and health status. Your doctor may start with the lowest effective dose for a short duration to control your pain.


  • 37.5 milligrams (mg) over 15 seconds every 6 hours as needed for pain.
  • 150 mg is the maximum dose per day

Children ' safety and effectiveness have not been established for children under the age of 18 years.

For Other Pain Conditions

Diclofenac injections are used to treat painful conditions for adults, the elderly and children over 12 years of age. This dosage is an average; your doctor may adjust the dose depending on the severity of the pain and your health.

There are times when a patient cannot be treated with oral medicine for pain. Under these circumstances, adults and children are administered this medication by injection.

  • Back pain
  • Gout (formation of crystals in joints)
  • Injuries and fractures
  • Kidney stone
  • Osteoarthritis (degeneration of joints)
  • Rheumatoid arthritis (inflammation of joints)


  • 75 mg in 3 milliliter (ml) into the muscle or intravenously

Children over 12 years of age

  • 75 mg in 3 ml into the muscle or intravenously


  • Hydrating the patient before injections will reduce the risk of renal adverse reactions.

If you are taking other medicines continue with your schedule but talk with your doctor. DO NOT stop taking your medications. Your doctor may adjust the doses to avoid any harmful reactions to your health.


Interactions change how you respond to this medicine ' in some cases, the interactions can escalate side effects increasing the health risks. Depending on your existing health disorders, diclofenac may trigger other more serious health ailments.

All medicines share a similar goal ' to treat a condition and restore our health. There are circumstances where two different medications work together, but sometimes they interact with each other and cause serious effects. Your doctor will make sure this treatment is safe to use.

Here's a list of medications known to interact with diclofenac. There may be others not listed but your doctor will check your response and health condition throughout treatment. If you are taking a medication not listed you need tell your doctor, otherwise an unexpected interaction could occur.

  • Acebutolol
  • Acemetacin
  • Alacepril
  • Amiloride
  • Amineptine
  • Amitriptyline
  • Amitriptylinoxide
  • Amoxapine
  • Apixaban
  • Ardeparin
  • Argatroban
  • Aspirin
  • Atenolol
  • Azilsartan
  • Azilsartan Medoxomil
  • Balsalazide
  • Bemiparin
  • Benazepril
  • Bendroflumethiazide
  • Benzthiazide
  • Betamethasone
  • Betaxolol
  • Bismuth Subsalicylate
  • Bisoprolol
  • Bromfenac
  • Budesonide
  • Bumetanide
  • Captopril
  • Carteolol
  • Celecoxib
  • Celiprolol
  • Certoparin
  • Chlorothiazide
  • Chlorthalidone
  • Choline Salicylate
  • Cilostazol
  • Ciprofloxacin
  • Citalopram
  • Clomipramine
  • Clonixin
  • Cortisone
  • Cyclopenthiazide
  • Cyclosporine
  • Dalteparin
  • Danaparoid
  • Deferiprone
  • Deflazacort
  • Delapril
  • Desipramine
  • Desvenlafaxine
  • Dexamethasone
  • Dexibuprofen
  • Diazoxide
  • Diclofenac
  • Dipyrone
  • Dothiepin
  • Doxepin
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Enalapril
  • Enoxaparin
  • Eplerenone
  • Epoprostenol
  • Eprosartan
  • Eptifibatide
  • Escitalopram
  • Ethacrynic Acid
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Feverfew
  • Floctafenine
  • Flufenamic Acid
  • Fluocortolone
  • Fluoxetine
  • Flurbiprofen
  • Fluvoxamine
  • Fondaparinux
  • Fosinopril
  • Furosemide
  • Ginkgo
  • Heparin
  • Hydrochlorothiazide
  • Hydrocortisone
  • Hydroflumethiazide
  • Ibuprofen
  • Imipramine
  • Ketoprofen
  • Labetalol
  • Lepirudin
  • Levomilnacipran
  • Lisinopril
  • Lithium
  • Lofepramine
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Magnesium Salicylate
  • Mefenamic Acid
  • Mesalamine
  • Methotrexate
  • Methyclothiazide
  • Methylprednisolone
  • Metolazone
  • Metoprolol
  • Milnacipran
  • Nadolol
  • Nadroparin
  • Naproxen
  • Nefazodone
  • Nepafenac
  • Nortriptyline
  • Olsalazine
  • Opipramol
  • Oxaprozin
  • Oxprenolol
  • Oxyphenbutazone
  • Paramethasone
  • Parecoxib
  • Parnaparin
  • Paroxetine
  • Pemetrexed
  • Penbutolol
  • Pentopril
  • Perindopril
  • Phenindione
  • Phenyl Salicylate
  • Pindolol
  • Piroxicam
  • Polythiazide
  • Practolol
  • Pralatrexate
  • Prasugrel
  • Prednisolone
  • Prednisone
  • Proglumetacin
  • Propranolol
  • Ramipril
  • Reviparin
  • Rivaroxaban
  • Rofecoxib
  • Salicylamide
  • Salicylic Acid
  • Salsalate
  • Sertraline
  • Spirapril
  • Spironolactone
  • Sulfasalazine
  • Temocapril
  • Tenoxicam
  • Tianeptine
  • Tiaprofenic Acid
  • Tinzaparin
  • Tirofiban
  • Tolfenamic Acid
  • Tolmetin
  • Torsemide
  • Trandolapril
  • Treprostinil
  • Trichlormethiazide
  • Trimipramine
  • Trolamine Salicylate
  • Valsartan
  • Venlafaxine
  • Vilazodone
  • Vorapaxar
  • Vortioxetine
  • Warfarin
  • Xipamide
  • Zofenopril

Other Health Conditions

If you suffer from these health conditions ' your doctor may not recommend this medicine for you. There are other pain medicines or alternative methods of easing your pain and avoiding serious consequences to your health.

If you are scheduled for surgery with a heart condition, this medicine should not be used to relieve pain before or after the surgery.


There are several warnings posted by the U.S. Food and Drug Administration (FDA) for this medicine. Some are fatal and can occur at any time during treatment with no signs or symptoms.

  • NSAIDS can cause serious adverse effects related to gastrointestinal (GI) events from bleeding, ulceration and perforation of the stomach and intestine.
  • Elderly patients with a history of peptic ulcer diseases or GI problems are at greater risk.

There's a boxed warning indicating the potential of cardiovascular incidents, increasing the risks with a long duration of treatment.

  • Diclofenac should not be used for the management of acute pain in an opioid dependent situation.
  • Serious skin reactions include exfoliative dermatitis, and toxic epidermal necrolysis (TEN) can be fatal.
  • Adverse reactions include nausea, constipation, headache, injection site pain and insomnia.

It's important that you understand the form of treatment your doctor is using, the risks associated with the chosen drug and the warnings issued by the FDA. The responses and effects of this drug will differ from person to person.

Knowing about the medications used to treat your condition helps you understand how your body recovers. During a clinical study, several health concerns linked to this medicine and systemic symptoms were noted. Each condition prompted an adverse reaction to the following health disorders:

  • Anaphylactic Reactions
  • Heart Failure and Edema
  • Hematologic Toxicity
  • Hepatotoxicity
  • Hypertension
  • Renal Toxicity and Hyperkalemia
  • Serious Skin Reactions

You need to talk with your doctor and discuss methods of minimizing the potential risk of triggering these effects. Using diclofenac at the lowest dosage for short durations will help to reduce or prevent these reactions ' talk with your doctor for more information and your probable reaction to this drug.

Population Groups

Pediatric 'diclofenac is not recommended for children.


Older patients have increased adverse reactions to NSAIDs. Precautions exist for all ages, but the elderly are more susceptible to diseases as a matter of natural aging. Medical and health histories play a role in cardiovascular events in this segment of the population.

Using diclofenac showed no increase in risks when health disorders were monitored, leading to the conclusion this medicine may benefit this group.


Hospital staff or professional healthcare providers are responsible for storing this medicine (injection for IV use). In preparation for administration, it is stored at room temperature (68 to 77 Fahrenheit).

Used medical supplies and unused portions are disposed of according to healthcare guidelines.


Pain is the most frequent reason for seeing a doctor. Diclofenac is known as the most effective nonsteroidal anti-inflammatory drug used to relieve the pain for several health conditions and elective surgery procedures. This medicine is also a chosen non-opioid administered in low dosages for chronic and acute levels of pain.