Diflorasone (Topical)

Diflorasone is a steroid that prevents the release of substances in the body that cause inflammation.

Diflorasone is also known under US brand names Apexicon E, Apexicon, Maxiflor, Psorcon E and Psorcon. It is a steroid that prevents the release of substances in the body that causes inflammation.


Diflorasone is a steroid used to help relieve itching, redness, swelling, or other discomforts caused by skin conditions. This medication is a corticosteroid (steroid or cortisone-like medicine). This medication is only available via prescription from your doctor. This product is available in the dosage form, cream, and ointment.

Conditions treated?

Type of medications

  • Cream

Side effects

Along with its intended effects, there are some side effects associated with taking diflorasone. Not all of these side effects may be present, but if they are, you may require medical attention.

Inform your doctor immediately if you suffer from any of the following side effects while taking diflorasone:

Incidence not known

  • Burning, blistering, crusting, dryness, or flaking of the skin

Some side effects of diflorasone topical that can occur that usually don't need urgent medical attention. You will usually find that these side effects begin to ease and disappear during treatment as your body begins adjusting to the medication. If you require help, you should contact your doctor or health care professional for ways to reduce these side effects or prevent them altogether. Check with your doctor or physician if any of the following side effects continue or if you have any questions.

Incidence not known

  • Itching and burning of the skin with pinhead-sized red blisters

Not all of the side effects associated with diflorasone topical are not listed below. You can report side effects to the FDA on 1-800-FDA-1088.


The final dose of this medication will depend on each individual patient. It will be based on a variety of factors such as your weight, age and height, your previous medical history, any current medications you are taking and your response to the first dose. Do not change or alter your dose unless your doctor tells you to do so. Follow the directions on the label or your health care professional's advice.

For itching, redness, and swelling of the skin

For topical cream dosage form:

The typical dose for adult patients: apply to the affected area of the skin twice a day.

The typical dose for children patients: The dose and use must be determined by your health care professional or doctor.

For topical ointment dosage form

The typical dose for adult patients: apply to the affected area of the skin one to three each day.

The typical dose for children patients: apply to the affected area of the skin one to three times each day.

Missed dose

If you ever miss a dose of this medication, apply it as soon as you remember. However, if it's close to the next time for your scheduled dose, skip the missed dose and head back to your dosing schedule.


Drug interactions can cause severe side effects and reduce the effectiveness of either drug. To limit these interactions, you should give your doctor a full list of all the medications you are currently taking and any medications you have taken in the past. This list should include all prescription and nonprescription drugs, all vitamins and herbal products. Inform your doctor of any other medical conditions you suffer from, alongside any other medical conditions that run in your family.

There are over 60 drugs that interact with diflorasone. Let your doctor know if you are taking any of these medications as they may need to alter doses or change the frequency in which you take either medication.

  • Acarbose

Other Interactions

Some medications should not be used when eating certain foods, since interactions can occur. Using tobacco or alcohol certain medications may also cause interactions to occur. You should discuss with your doctor or healthcare professional about the use of your medication with alcohol, food or tobacco.

Other Medical Problems

The presence of other medical conditions can affect the use of this medication. Ensure you let your doctor know if you have any other medical issues, especially:

  • Diabetes

Rosacea (skin problem) - This drug should not be used in those who suffer from this condition.



Inform your healthcare professional or doctor if you have ever had any unusual allergic reactions to this medication or any other medications. Also tell your doctor if you suffer from any other allergic reactions such as dyes, foods, animals or preservatives.

Use in pediatric population

Studies that have been performed to date have not indicated a pediatric-specific problem that could limit the usefulness of this drug in the pediatric population. However, because of this medication's toxicity, caution should be exercised with use. Children can be affected by serious side effects if they absorb large amounts via the skin. If your child is using this medication, follow your doctor's instructions carefully. For the cream form of this drug, efficacy and safety have not yet been established.

Use in geriatric population

There is currently no information regarding the relationship of age to the effects of this drug in geriatric patients.

Use during pregnancy and breastfeeding

This drug is under FDA pregnancy category C, meaning it's unknown whether this drug can harm an unborn child. It's important to let your doctor know if you are pregnant or intend to become pregnant. There are no adequate studies conducted in women for determining the risk to a child when using this drug during breastfeeding. You should speak with your doctor and weigh up the potential risk and benefits before taking this medicine while breastfeeding.

It's important that your doctor regularly checks your progress or the progress of your child when taking this drug. This is to monitor for any unwanted side effects that this medication can cause.

If you or your child's symptoms don't improve within a few days of taking this drug or your symptoms worsen, you should seek advice from your doctor or a healthcare professional.

Using too much of this medication or using it for long periods of time could increase your risk of having adrenal gland problems. This risk is greater for patients who use large amounts for a long time or for children. Speak with your doctor immediately if you or your child experiences one or more of these signs or symptoms when using this medication: dizziness, blurred vision, fainting, a fast, irregular or pounding heartbeat, increased urination or thirst, irritability, or unusual weakness or tiredness.

Stop using this medication immediately and check with your doctor or healthcare professional immediately if you or your child experiencing burning, skin rash, swelling, stinging or irritation on the skin.

Don't use skin care products or cosmetics in the treated areas.

Proper use

It is extremely important that you use this medication only as your doctor has directed. Do not use a higher quality, do not use it more often and do not use it for a longer period of time than ordered. If you do so, you could cause skin irritation or unwanted side effects.

This medication is for use on the skin only. Don't get it inside your eyes or use it on skin areas that have scrapes, cuts or burns. If you do get it in these areas, make sure you rinse it off immediately with water.

This medication should only be used for skin conditions that your doctor is treating. Speak with your doctor before using it for other conditions. This medication should not be used to treat certain kinds of conditions or skin infection, such as severe burns.

Don't use this drug on the groin, face or underarms unless directed to do so by a healthcare professional or doctor.

To use:

  • Wash your hands with water and soap before and after using this medication.
  • Apply only a thin layer of this medication to the affected area of the skin and rub it in gently.
  • Do not wrap up the skin or bandage it unless you have been told to do so by your doctor.
  • If the medication is applied to the diaper area of a child, don't use plastic pants or tight-fitting diapers unless directed to do so by your doctor.
  • If your doctor ordered an airtight covering or occlusive dressing or to be applied to the medication, ensure sure you know how to apply it. This is because occlusive dressings increase the amount of medication that is absorbed via your skin, so it should also be used as directed. Speak with your doctor if you have any questions.


This medication should be stored in a closed container at room temperature. Keep it away from moisture, heat and direct light. Make sure you keep this product from freezing.

Keep this medication out of the reach of children.

Do not keep medication you no longer need or has gone out of date.

Speak with your doctor or healthcare professional about how you should dispose of any medication you do not use.


When used correctly, diflorasone is successful in the treatment of various skin conditions. Due to the large number of reactions that could happen with this medication, it's important that you give your doctor a full list of all the medications you are currently taking. You should exercise caution with the use of this medication in children. The safety and efficacy of this medication have not been established in pregnancy, so you should discuss with your doctor if you are currently pregnant or wish to fall pregnant. You should also let your doctor know if you are breastfeeding, or intend on breastfeeding whilst using this medication.