Difluprednate (Ophthalmic)

Difluprednate is a drug used to treat different eye problems. It's given via eyedrops.

Difluprednate is also known under US brand name Durezol. The eye drops are used in the treatment of a variety of eye problems including eye swelling or pain after surgery, redness or other eye conditions.

Overview

Difluprednate is used in the treatment of redness, swelling and eye pain caused by eye surgery. It's also used to treat an eye condition known as eye inflammation (endogenous anterior uveitis). This medication belongs to the group of drugs known as corticosteroids. This medication is only available via prescription from your doctor and is available in the dosage form of an emulsion.

Condition(s) treated?

  • Inflammation of the Eye Following Surgery
  • Postoperative Pain in Eye
  • Inflammation of the Front Portion of the Eye
  • Allergic Conjunctivitis
  • Inflammation of the Eye
  • Inflammation of the Iris the Colored Part of the Eyeball
  • Inflammation of the Ciliary Body of the Eye
  • Inflammation of the Iris and Ciliary Body of the Eye

Type of medicine?

  • Emulsion (eye drops)

Side Effects

Along with the intended effects of Difluprednate, the use of this drug can produce some unwanted side effects. Not all of these side effects may be present, but if they are, you may need to seek medical attention.

Inform your doctor or a healthcare professional immediately if you suffer from any of the following side effects while using difluprednate.

More common side effects

  • Change in color vision
  • Blurred vision
  • Decreased vision or other changes in vision
  • Eye discomfort
  • Difficulty seeing at night
  • Eye pain
  • Increase in blood flow to the whites of the eyes
  • Eye redness
  • Increased sensitivity of the eyes to sunlight
  • Sensitivity of the eyes to light
  • Painful irritation of the front clear part of the eye
  • Redness or swelling of the eye and lining of the eyelid

Less common side effects

  • Tearing
  • Watering of the eyes
  • Eyelid irritation and crusting
  • Throbbing eye pain

Some side effects may occur with the use of difluprednate, but usually don't require medical attention. It's normal for these side effects to reduce or disappear as your body begins adjusting to the new medication. If the side effects are bothering you in your daily life, you should contact your local pharmacist or doctor for advice on ways to reduce or prevent them.

Less common side effects

Rare side effects

  • Feeling of having something in the eye
  • Itching, burning or soreness of the eye

Not all side effects that could appear are listed here. You could suffer from other side effects. If you notice anything out of the ordinary, seek advice from a doctor or healthcare professional.

Remember you can report all side effects to the FDA on 1-800-FDA-1088.

Dosage

The final dose of any medication will depend on a variety of different factors. This includes your weight, height, and age, your current health conditions, your past health conditions, what medications you are currently taking and how you react to the first treatment. Do not stop, change or alter your dosage without consulting with your doctor or a healthcare professional beforehand. The following dosages are typical and should be only taken as guidance.

Typical Adult Dose for Post-operative Ocular Inflammation

Give one drop into the conjunctival sac of the eye that's affected four times a day, beginning 24 hours after surgery, and then continue this after the first two weeks post-operation. This should be followed twice daily for a week and then based on the response of the individual patient, a taper.

Typical Adult Dose for Uveitis

Give one drop into the conjunctival sac of the eyes that is affected four times daily for a 14 day period followed by tapering as indicated clinically.

Typical Pediatric Dose for Postoperative Ocular Inflammation

Give one drop in the affected conjunctival sac of the eye four times daily beginning 24 hours after surgery and then continue after the first two weeks post-operation. This should be followed by drops twice daily for a week and then a taper response based on the individual.

Typical Pediatric Dose for Uveitis

Give one drop into the affected conjunctival sac of the eye four times per day for a period of 14 days. This should be followed by tapering as indicated clinically.

Missed Dose

If you miss a dose of this medication, apply it as soon as you remember. However, if it's close to the scheduled time for your next dose, skip the dose that you missed and revert back to your regular dosing schedule.

Interactions

Drug interactions can reduce the effectiveness of drugs or produce unwanted and severe side effects. To limit these interactions, it's important you let your doctor know about all the current drugs you are taking and any medications you had taken in the past. This should include all prescription and nonprescription drugs, all herbal products and vitamins. You should also let your healthcare professional or doctor know of any current and past medical conditions you are suffering from and any that are present in your family history.

There are three drugs that interact with difluprednate. These drugs are not recommended with this drug.

  • ACAM2000 (smallpox vaccine)
  • Smallpox vaccine
  • Dryvax (smallpox vaccine)

Other Interactions

Certain medications should not be used at or around the time of eating food since interactions can occur. Using tobacco and alcohol with certain medications can also cause interactions to occur. Speak with your healthcare professional about the use of your medication alongside alcohol, food or tobacco.

Other Medical Problems

The presence of other medical conditions may affect the use of this medication. Ensure you tell your doctor if you have any other medical conditions, especially:

  • Cataract surgery¬†- caution should be exercised as it may cause a delayed healing.
  • Eye infection (mycobacterial, fungus)
  • com/health/coma/">Glaucoma¬†- caution should be exercised as it can make this condition worse.
  • Eye infection, virus (e.g., herpes simplex) this drug should not be used in people with this condition.

Warnings

Allergies

You should let your doctor or a healthcare professional know if you suffer from any unusual allergic reactions to this medication or any other medications. You should also inform them if you have any other types of allergies, such as to dyes, foods, animals or preservatives.

Use in pediatric population

Various studies have not been conducted, studying the effects of the use of difluprednate to the relationship of age in the younger population. Therefore efficacy and safety have not been established.

Use in geriatric population

Studies conducted to date have not indicated a geriatric-specific problem that could limit the effectiveness of difluprednate in the older population.

Use in pregnancy and breastfeeding

This drug is under FDA pregnancy category C. This means it is unknown whether this drug will cause harm to any unborn children. You should let your doctor know if you are pregnant and weigh up the pros and cons of taking this medication while pregnant.

With regards to breastfeeding, it's unknown whether difluprednate ophthalmic passes into breast milk or if it could harm a nursing infant. Let your doctor know if you are breast-feeding a baby.

Your eye doctor will want to regularly examine your eye(s) to make sure the medication is working correctly and is not causing any unwanted side effects.

Difluprednate eye drops are not designed for long periods of use. Steroid eye drops can cause a rare type of cataract known as posterior subcapsular cataracts or glaucoma (increased pressure inside the eye) if used for a long period of time. Delayed or slow healing can also occur while you are using this medication after surgery for cataracts. You will need to attend regular eye exams with your doctor to check for these issues.

If you develop an eye infection or hurt your eye, speak with your doctor right away. Your medication may need to be altered or you may need to stop using it altogether.

If your symptoms do not improve or if your condition becomes worse, speak with your doctor.

After you apply these eyedrops, your vision can become temporarily blurred. Do not use machinery, drive or do any activity that requires clear vision until you are sure you can perform these activities safely.

Proper use

Your eye doctor will let you know how much of this medication to use and the frequency in which you should do so. Don't use more medication or use it more frequently than your doctor tells you to. This medication is not for long-term use.

To use the eye drops:

Wash your hands, tilt your head back and press your finger gently on the skin just beneath the lower eyelid.

Next, pull the lower eyelid away from the eye to make a space.

Drop the medication into this space. Let go of the eyelid and gently close your eyes. Don't blink. Whilst keeping your eyes closed you should apply light pressure to the inner corner of your eye with your finger for one or two minutes to let the medication adsorb into the eye.

If you don't think you got the drop of medicine into your eye properly, then use another drop.

After using the eye drops, immediately wash your hands to remove any residue that may still be on them.

To keep the medication as germ-free as possible, don't touch the applicator tip to any surface and always keep the container tightly closed.

If you are using this medication after an eye surgery, only use one bottle for each eye. It's not recommended that you use the same bottle of eye drops for both eyes.

The preservative that is used in these eye drops can be absorbed by soft contact lenses and lead to irritation of your eyes. Contact lenses should be removed before you use difluprednate. You should put lenses back in the eyes 10 minutes after you have used the medication.

Storage

This medication should be kept out of the reach of children. You should not keep medication that is out of date or is no longer needed. Speak with your healthcare professional or pharmacist about how you should dispose of any of the medication you use in a safe environment.

Store the medication in a closed container at room temperature. Ensure it is kept away from moisture, heat and direct light. Do not let medication freeze.

Ensure the eye drop bottle is kept in the protective carton when not in use.

Summary

When used correctly, Difluprednate is successful in the treatment of various eye conditions. You should let your doctor know if you are pregnant or breastfeeding while using this medication. To get the most benefit from the medicine, you need to use it regularly and at your scheduled dosage time. Do not change your dose without speaking to your doctor first. If you do so, you could cause more problems. To help you remember, use the eye drops at a similar time each day and continue using it for the full time it has been prescribed. Let your doctor know if your condition does not improve or persists.