Diphtheria, Tetanus, Acellular Pertussis, and Polio Vaccine (Intramuscular)

This vaccination combination is also known by its US brand names Quadracel and Kinrix. This vaccine works by pushing your body to produce its own antibodies to fight and protect against this disease.


Diphtheria, acellular pertussis vaccine and tetanus, combined with an inactivated poliovirus vaccine is a combination vaccine that is given to protect against infections caused by tetanus, diphtheria, pertussis, and poliovirus. The vaccination works by causing the body to produce its own antibodies to protect against these diseases. This vaccination is given only to children four to six years old.

Below are each of the conditions explained briefly:

Diphtheria is a serious condition that causes difficulty breathing, nerve damage, possible death, heart problems and pneumonia. There is a higher risk of complications in the elderly or young children.

Tetanus is a very serious illness that causes muscle spasms and seizures, that can be strong enough to cause bone fractures to the spine. The conditions continue to occur almost exclusively among people who do not obtain the vaccination or don't have enough protection from previous vaccines.

Pertussis is a serious disease that causes severe spells of coughing that can interfere with your breathing. It can also cause long-lasting bronchitis, brain damage, seizures, death and pneumonia.

Polio is an extremely serious infection that can cause paralysis of the muscles, including those that enable you to breathe and walk. It can leave a person unable to breathe without the assistance of a breathing machine. It can also leave a person unable to walk without the assistance of leg braces or being confined to a wheelchair. There is currently no cure for polio.

These vaccinations are to only be given by or under the supervision of a trained health professional. This product is available in the dosage form: suspension.

Condition(s) treated?

Type of medicine?

  • Suspension

Side Effects

Along with its intended effects, when receiving this vaccination, it can produce some unwanted side effects. Not all of these side effects may be present, but if they are, you may need to seek medical attention.

Inform your doctor immediately if you suffer from any of the following side effects after receiving this vaccination combination.

Rare side effects

  • Blurred vision

Incidence not known

  • Blood in the urine or stools

Some side effects of this combined vaccine that may occur that usually don't require medical attention. You usually find that these side effects begin to subside once your body begins adjusting to the medication. If these side effects are bothersome, contact your pharmacist or a healthcare professional for advice on ways to reduce or prevent these side effects.

More common side effects

  • Redness, pain or swelling at the injection site


The final dose of any medication will depend on a variety of factors. This will include your age, weight and height, current medications you are taking, and any other medications you are currently taking.

Typical Pediatric Dose for Poliomyelitis Prophylaxis

4 to 6 years old: 0.5 mL via injection. The preferred site for injection is in the deltoid muscle of the upper arm. Don't administer this product intradermally, intravenously or subcutaneously.

Usual Pediatric Dose for Diphtheria Prophylaxis

The dose requirements are the same as above.

Usual Pediatric Dose for Pertussis Prophylaxis

The dose requirements are the same as above.

Usual Pediatric Dose for Tetanus Prophylaxis

The dose requirements are the same as above.


Drug interactions can cause serious reactions and reduce the effective nature of each individual drug. To limit these interactions, it's important to give your health care professional or a doctor a full list of all the current and past medications you are taking. This list should include herbal products, vitamins, prescription and non-prescription drugs. Let your doctor know if you are suffering from any other medical conditions or if any conditions run in the family.

The use of vaccination with any of the following medications can cause an increased risk of some side effects, but sometimes both medications may need to be used as it's the best treatment option for you. If you are prescribed both medications together, your doctor may alter the dose or frequency in which you receive one or both medications.

  • Tetanus Toxoid, Meningococcal Vaccine and Conjugate Quadrivalent

This vaccination can interact with over 180 drugs. Let your doctor know if you are taking any of the following drugs.

  • Abatacept

Other medical conditions

The presence of other medical conditions can affect the use of this vaccination. Ensure you tell let your doctor or healthcare professional know if you have any other medical issues, especially:

  • Fever, high
  • Brain disease (eg, encephalopathy): This includes a decreased level of consciousness, coma, or seizures lasting a long time. Children who show these symptoms within a week of receiving a vaccination with pertussis should not receive this vaccination.
  • Severe or moderate illness, with or without fever: This vaccination may worsen these conditions worse or may increase the risk of side effects.
  • Immunodeficiency disorder
  • Guillain-Barr syndrome: If your child had this condition after receiving a vaccination with tetanus toxoid in it, you should speak to your doctor about the potential risks and benefits of receiving this vaccine.
  • Weakened immune system: This vaccination may not work as well in children suffering from this condition.
  • Progressive neurologic disorder: This includes progressive brain disease, infantile spasms or uncontrolled seizures. This vaccination should not be given until these conditions are treated and under control.
  • Previous serious reaction to a vaccine: If your child had a serious reaction to any other vaccination that contained pertussis, you should speak with your doctor about the potential risks and benefits of receiving this vaccination. Some serious reactions include crying continuously without stopping for over 3 hours, being less responsive than normal, having a seizure with or without fever, or having a fever that was above 105 degrees F.

Other interactions

Certain medications should not be used at or around the time of consuming food or eating some varieties of food since this can cause interactions. Discuss with a doctor or your healthcare professional about the use of certain types of food when receiving this vaccination.


There are a number of warnings and precautions to be aware of before agreeing with your child to receive this vaccination. These are listed below. Read carefully and if you have any queries or questions, contact your doctor or a healthcare professional for advice.

Use in pediatric population

No studies have not been conducted on the relationship of age to the effects of this vaccination in children younger than four years of age and children seven years or older. Therefore efficacy and safety have not been established.

Use in geriatric population

This vaccination is not recommended for in adult patients.

Use in pregnancy and breastfeeding

This drug is under FDA pregnancy category C, meaning there is no evidence that this drug can cause problems to an unknown child. With regards to breastfeeding, there have been no adequate studies conducted on the relationship of receiving this vaccination and this vaccination. Caution should be exercised.


Let your doctor know if your child has ever suffered from any allergic reactions to other vaccinations or if they have any allergies to food, animals, preservatives dyes, etc. This vaccine will contain "live" ingredients which could prompt an allergic reaction if precautions are not taken.

It's extremely important that the doctor checks your child's progress at regular visits to make sure this vacation is working properly and to monitor for unwanted side effects.

Inform your child's doctor about all other vaccinations your child has received. This vaccination might be used to finish a series of vaccines.

Contact a healthcare professional or your doctor urgently f your child has sudden weakness in the legs and arms. This could be a symptom showing the condition known as Guillain-Barré syndrome.

It's extremely important to inform your doctor if your child is allergic to latex rubber. This is because the tips of the caps which are on top of a prefilled syringe can contain dry natural latex rubber which could cause an allergic reaction.

This vaccination will not treat an active infection. If your child suffers from an infection due to tetanus, diphtheria, polio or pertussis they will need separate medications to treat these infections.

Fainting can occur after receiving this vaccination. Your doctor may observe your child after receiving the injection to manage or prevent fainting.

It's important to let your child's doctor know about any serious side effects that occur after they receive the vaccination. This could include crying that won't stop, seizures, a high fever, or severe swelling or redness where the shot was given.

Ensure your doctor knows if you are using medications that weaken the immune systems such as radiation treatment, cancer medicines, or steroids.

Your child may be given other vaccines at the same time as this one but in a different area of the body. You will receive information sheets about all of the different vaccination your child receives. Ensure you understand all of the information that you are given and ask questions if not.

Your child may also receive a medication to help treat or prevent some of the minor side effects of the vaccinations, such as soreness or fever.


This drug will be stored in a hospital setting. It should be stored under refrigeration of 36°F to 46°F (2°C to 8°C). Don't let this medication freeze. If it does freeze, it will need to be discarded as it can no longer be used in any circumstances.


When used correctly, Diphtheria, Tetanus, Acellular Pertussis, Polio Vaccine is successful in protecting your child against these diseases in the future. It's important to monitor your child closely after they have taken this vaccine due to side effects and drug interactions. A trained health professional or a nurse will give your child this vaccination. This vaccine will be given as one shot into one of your child's muscles. This is usually the shoulder muscle. Keep all scheduled medical appointments for vaccinations. A calendar is a good idea to act as a reminder. This drug is not usually given to adults. Be aware that vaccinations may not fully protect everyone who receives them.